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Protein

Serine/threonine-protein phosphatase 6 regulatory subunit 2

Gene

PPP6R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory subunit 2
Alternative name(s):
SAPS domain family member 2
Gene namesi
Name:PPP6R2
Synonyms:KIAA0685, PP6R2, SAPS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100239.15
HGNCiHGNC:19253 PPP6R2
MIMi610877 gene
neXtProtiNX_O75170

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9701
OpenTargetsiENSG00000100239
PharmGKBiPA165378360

Polymorphism and mutation databases

BioMutaiPPP6R2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000460981 – 966Serine/threonine-protein phosphatase 6 regulatory subunit 2Add BLAST966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei289PhosphoserineCombined sources1
Modified residuei771PhosphoserineBy similarity1
Modified residuei828PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75170
MaxQBiO75170
PaxDbiO75170
PeptideAtlasiO75170
PRIDEiO75170
ProteomicsDBi49835
49836 [O75170-2]
49837 [O75170-3]
49838 [O75170-4]
49839 [O75170-5]
49840 [O75170-6]

PTM databases

iPTMnetiO75170
PhosphoSitePlusiO75170

Expressioni

Tissue specificityi

Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta.1 Publication

Gene expression databases

BgeeiENSG00000100239 Expressed in 214 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SAPS2
ExpressionAtlasiO75170 baseline and differential
GenevisibleiO75170 HS

Organism-specific databases

HPAiCAB034919
HPA030656

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115053, 71 interactors
CORUMiO75170
DIPiDIP-27539N
IntActiO75170, 31 interactors
MINTiO75170
STRINGi9606.ENSP00000379090

Structurei

3D structure databases

ProteinModelPortaliO75170
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi820 – 825Poly-Ser6

Sequence similaritiesi

Belongs to the SAPS family.Curated

Phylogenomic databases

eggNOGiKOG2073 Eukaryota
ENOG410XRM1 LUCA
GeneTreeiENSGT00390000009899
HOVERGENiHBG069733
InParanoidiO75170
KOiK15500
OMAiESGPRCS
OrthoDBiEOG091G0893
PhylomeDBiO75170
TreeFamiTF313227

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007587 SAPS
PANTHERiPTHR12634 PTHR12634, 1 hit
PfamiView protein in Pfam
PF04499 SAPS, 2 hits
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75170-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR
60 70 80 90 100
QQCMEELVSL ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE
110 120 130 140 150
SLLSLLYDFL DHEPPLNPLL ASFFSKTIGN LIARKTEQVI TFLKKKDKFI
160 170 180 190 200
SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ DVLHWLNEEK VIQRLVELIH
210 220 230 240 250
PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT ALESQDCVEQ
260 270 280 290 300
LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV
310 320 330 340 350
SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM
360 370 380 390 400
AALLHTNTPS INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS
410 420 430 440 450
HAAREERTEA SGSESRVEPP HENGNRSLET PQPAASLPDN TMVTHLFQKC
460 470 480 490 500
CLVQRILEAW EANDHTQAAG GMRRGNMGHL TRIANAVVQN LERGPVQTHI
510 520 530 540 550
SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL HSSSEDEDIE
560 570 580 590 600
GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI
610 620 630 640 650
AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV
660 670 680 690 700
MARPRFGAPH ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE
710 720 730 740 750
APPVEGDSEG AMWTAVFDEP ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG
760 770 780 790 800
WAKFTDFQPF CCSESGPRCS SPVDTECSHA EGSRSQGPEK ASQASYFAVS
810 820 830 840 850
PASPCAWNVC VTRKAPLLAS DSSSSGGSHS EDGDQKAASA MDAVSRGPGR
860 870 880 890 900
EAPPLPTVAR TEEAVGRVGC ADSRLLSPAC PAPKEVTAAP AVAVPPEATV
910 920 930 940 950
AITTALSKAG PAIPTPAVSS ALAVAVPLGP IMAVTAAPAM VATLGTVTKD
960
GKTDAPPEGA ALNGPV
Note: No experimental confirmation available.
Length:966
Mass (Da):104,942
Last modified:January 15, 2008 - v2
Checksum:iD3BC10EADB98FB62
GO
Isoform 2 (identifier: O75170-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-561: Missing.
     709-709: E → EA
     792-799: SQASYFAV → F
     952-966: KTDAPPEGAALNGPV → QMPRQKELP

Note: No experimental confirmation available.
Show »
Length:927
Mass (Da):101,007
Checksum:iDE1A1A4F2F66A0F9
GO
Isoform 3 (identifier: O75170-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-244: S → SR
     535-561: Missing.
     792-799: SQASYFAV → F

Show »
Length:933
Mass (Da):101,402
Checksum:iD74E382158135767
GO
Isoform 4 (identifier: O75170-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-561: Missing.
     792-799: SQASYFAV → F

Show »
Length:932
Mass (Da):101,246
Checksum:i0E22A2912F2A1F2A
GO
Isoform 5 (identifier: O75170-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     792-799: SQASYFAV → F

Show »
Length:959
Mass (Da):104,235
Checksum:i6C9F6F32B2768517
GO
Isoform 6 (identifier: O75170-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-84: Missing.
     535-561: Missing.
     792-799: SQASYFAV → F

Show »
Length:905
Mass (Da):98,126
Checksum:i2B49E60FADD6D84D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
T1ECW5T1ECW5_HUMAN
Serine/threonine-protein phosphatas...
PPP6R2
685Annotation score:
A0A0A0MSJ8A0A0A0MSJ8_HUMAN
Serine/threonine-protein phosphatas...
PPP6R2
562Annotation score:

Sequence cautioni

The sequence BAA31660 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti224D → G in BAH13719 (PubMed:14702039).Curated1
Sequence conflicti806A → T in BAH13719 (PubMed:14702039).Curated1
Sequence conflicti835Q → H in AAH52995 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058402633D → E. Corresponds to variant dbSNP:rs11555194Ensembl.1
Natural variantiVAR_058403732R → K. Corresponds to variant dbSNP:rs13057311Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03776758 – 84Missing in isoform 6. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_037768244S → SR in isoform 3. 1 Publication1
Alternative sequenceiVSP_030758535 – 561Missing in isoform 2, isoform 3, isoform 4 and isoform 6. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_030759709E → EA in isoform 2. 1 Publication1
Alternative sequenceiVSP_030760792 – 799SQASYFAV → F in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 3 Publications8
Alternative sequenceiVSP_030761952 – 966KTDAP…LNGPV → QMPRQKELP in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014585 mRNA Translation: BAA31660.2 Different initiation.
AK302472 mRNA Translation: BAH13719.1
AL096767 Genomic DNA No translation available.
AL671545 Genomic DNA No translation available.
AL954743 Genomic DNA No translation available.
BC000976 mRNA Translation: AAH00976.2
BC006568 mRNA Translation: AAH06568.1
BC032664 mRNA Translation: AAH32664.1
BC041698 mRNA Translation: AAH41698.1
BC052995 mRNA Translation: AAH52995.1
CCDSiCCDS33681.1 [O75170-4]
CCDS56235.1 [O75170-3]
CCDS56236.1 [O75170-2]
CCDS74881.1 [O75170-5]
PIRiT00357
RefSeqiNP_001229827.1, NM_001242898.1 [O75170-5]
NP_001229828.1, NM_001242899.1 [O75170-3]
NP_001229829.1, NM_001242900.1 [O75170-2]
NP_055493.2, NM_014678.4 [O75170-4]
XP_006724497.1, XM_006724434.1 [O75170-1]
XP_016884612.1, XM_017029123.1 [O75170-1]
XP_016884613.1, XM_017029124.1 [O75170-1]
XP_016884617.1, XM_017029128.1
XP_016884620.1, XM_017029131.1
XP_016884621.1, XM_017029132.1 [O75170-4]
UniGeneiHs.449098
Hs.733531
Hs.740776

Genome annotation databases

EnsembliENST00000216061; ENSP00000216061; ENSG00000100239 [O75170-1]
ENST00000359139; ENSP00000352051; ENSG00000100239 [O75170-2]
ENST00000395741; ENSP00000379090; ENSG00000100239 [O75170-3]
ENST00000395744; ENSP00000379093; ENSG00000100239 [O75170-4]
ENST00000612753; ENSP00000478417; ENSG00000100239 [O75170-5]
GeneIDi9701
KEGGihsa:9701
UCSCiuc003bky.3 human [O75170-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014585 mRNA Translation: BAA31660.2 Different initiation.
AK302472 mRNA Translation: BAH13719.1
AL096767 Genomic DNA No translation available.
AL671545 Genomic DNA No translation available.
AL954743 Genomic DNA No translation available.
BC000976 mRNA Translation: AAH00976.2
BC006568 mRNA Translation: AAH06568.1
BC032664 mRNA Translation: AAH32664.1
BC041698 mRNA Translation: AAH41698.1
BC052995 mRNA Translation: AAH52995.1
CCDSiCCDS33681.1 [O75170-4]
CCDS56235.1 [O75170-3]
CCDS56236.1 [O75170-2]
CCDS74881.1 [O75170-5]
PIRiT00357
RefSeqiNP_001229827.1, NM_001242898.1 [O75170-5]
NP_001229828.1, NM_001242899.1 [O75170-3]
NP_001229829.1, NM_001242900.1 [O75170-2]
NP_055493.2, NM_014678.4 [O75170-4]
XP_006724497.1, XM_006724434.1 [O75170-1]
XP_016884612.1, XM_017029123.1 [O75170-1]
XP_016884613.1, XM_017029124.1 [O75170-1]
XP_016884617.1, XM_017029128.1
XP_016884620.1, XM_017029131.1
XP_016884621.1, XM_017029132.1 [O75170-4]
UniGeneiHs.449098
Hs.733531
Hs.740776

3D structure databases

ProteinModelPortaliO75170
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115053, 71 interactors
CORUMiO75170
DIPiDIP-27539N
IntActiO75170, 31 interactors
MINTiO75170
STRINGi9606.ENSP00000379090

PTM databases

iPTMnetiO75170
PhosphoSitePlusiO75170

Polymorphism and mutation databases

BioMutaiPPP6R2

Proteomic databases

EPDiO75170
MaxQBiO75170
PaxDbiO75170
PeptideAtlasiO75170
PRIDEiO75170
ProteomicsDBi49835
49836 [O75170-2]
49837 [O75170-3]
49838 [O75170-4]
49839 [O75170-5]
49840 [O75170-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216061; ENSP00000216061; ENSG00000100239 [O75170-1]
ENST00000359139; ENSP00000352051; ENSG00000100239 [O75170-2]
ENST00000395741; ENSP00000379090; ENSG00000100239 [O75170-3]
ENST00000395744; ENSP00000379093; ENSG00000100239 [O75170-4]
ENST00000612753; ENSP00000478417; ENSG00000100239 [O75170-5]
GeneIDi9701
KEGGihsa:9701
UCSCiuc003bky.3 human [O75170-1]

Organism-specific databases

CTDi9701
DisGeNETi9701
EuPathDBiHostDB:ENSG00000100239.15
GeneCardsiPPP6R2
HGNCiHGNC:19253 PPP6R2
HPAiCAB034919
HPA030656
MIMi610877 gene
neXtProtiNX_O75170
OpenTargetsiENSG00000100239
PharmGKBiPA165378360
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2073 Eukaryota
ENOG410XRM1 LUCA
GeneTreeiENSGT00390000009899
HOVERGENiHBG069733
InParanoidiO75170
KOiK15500
OMAiESGPRCS
OrthoDBiEOG091G0893
PhylomeDBiO75170
TreeFamiTF313227

Miscellaneous databases

ChiTaRSiPPP6R2 human
GenomeRNAii9701
PROiPR:O75170
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100239 Expressed in 214 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_SAPS2
ExpressionAtlasiO75170 baseline and differential
GenevisibleiO75170 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007587 SAPS
PANTHERiPTHR12634 PTHR12634, 1 hit
PfamiView protein in Pfam
PF04499 SAPS, 2 hits
SUPFAMiSSF48371 SSF48371, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPP6R2_HUMAN
AccessioniPrimary (citable) accession number: O75170
Secondary accession number(s): A6PVG3
, B7Z7T3, Q5U5P3, Q7Z2L2, Q7Z5G5, Q7Z731, Q9UGB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: January 15, 2008
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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