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Entry version 152 (13 Feb 2019)
Sequence version 2 (15 Jan 2008)
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Protein

Serine/threonine-protein phosphatase 6 regulatory subunit 2

Gene

PPP6R2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory subunit 2
Alternative name(s):
SAPS domain family member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP6R2
Synonyms:KIAA0685, PP6R2, SAPS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000100239.15

Human Gene Nomenclature Database

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HGNCi
HGNC:19253 PPP6R2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610877 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75170

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9701

Open Targets

More...
OpenTargetsi
ENSG00000100239

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165378360

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP6R2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000460981 – 966Serine/threonine-protein phosphatase 6 regulatory subunit 2Add BLAST966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei289PhosphoserineCombined sources1
Modified residuei771PhosphoserineBy similarity1
Modified residuei828PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75170

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75170

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75170

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75170

PeptideAtlas

More...
PeptideAtlasi
O75170

PRoteomics IDEntifications database

More...
PRIDEi
O75170

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49835
49836 [O75170-2]
49837 [O75170-3]
49838 [O75170-4]
49839 [O75170-5]
49840 [O75170-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75170

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75170

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed with strongest expression in the testis followed by liver, heart, kidney, brain and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100239 Expressed in 214 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75170 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75170 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034919
HPA030656

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115053, 73 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O75170

Database of interacting proteins

More...
DIPi
DIP-27539N

Protein interaction database and analysis system

More...
IntActi
O75170, 31 interactors

Molecular INTeraction database

More...
MINTi
O75170

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379090

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75170

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi820 – 825Poly-Ser6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAPS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2073 Eukaryota
ENOG410XRM1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009899

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG069733

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O75170

KEGG Orthology (KO)

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KOi
K15500

Identification of Orthologs from Complete Genome Data

More...
OMAi
ILHGIEP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75170

TreeFam database of animal gene trees

More...
TreeFami
TF313227

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR007587 SAPS

The PANTHER Classification System

More...
PANTHERi
PTHR12634 PTHR12634, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04499 SAPS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75170-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR
60 70 80 90 100
QQCMEELVSL ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE
110 120 130 140 150
SLLSLLYDFL DHEPPLNPLL ASFFSKTIGN LIARKTEQVI TFLKKKDKFI
160 170 180 190 200
SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ DVLHWLNEEK VIQRLVELIH
210 220 230 240 250
PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT ALESQDCVEQ
260 270 280 290 300
LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV
310 320 330 340 350
SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM
360 370 380 390 400
AALLHTNTPS INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS
410 420 430 440 450
HAAREERTEA SGSESRVEPP HENGNRSLET PQPAASLPDN TMVTHLFQKC
460 470 480 490 500
CLVQRILEAW EANDHTQAAG GMRRGNMGHL TRIANAVVQN LERGPVQTHI
510 520 530 540 550
SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL HSSSEDEDIE
560 570 580 590 600
GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI
610 620 630 640 650
AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV
660 670 680 690 700
MARPRFGAPH ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE
710 720 730 740 750
APPVEGDSEG AMWTAVFDEP ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG
760 770 780 790 800
WAKFTDFQPF CCSESGPRCS SPVDTECSHA EGSRSQGPEK ASQASYFAVS
810 820 830 840 850
PASPCAWNVC VTRKAPLLAS DSSSSGGSHS EDGDQKAASA MDAVSRGPGR
860 870 880 890 900
EAPPLPTVAR TEEAVGRVGC ADSRLLSPAC PAPKEVTAAP AVAVPPEATV
910 920 930 940 950
AITTALSKAG PAIPTPAVSS ALAVAVPLGP IMAVTAAPAM VATLGTVTKD
960
GKTDAPPEGA ALNGPV
Note: No experimental confirmation available.
Length:966
Mass (Da):104,942
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3BC10EADB98FB62
GO
Isoform 2 (identifier: O75170-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-561: Missing.
     709-709: E → EA
     792-799: SQASYFAV → F
     952-966: KTDAPPEGAALNGPV → QMPRQKELP

Note: No experimental confirmation available.
Show »
Length:927
Mass (Da):101,007
Checksum:iDE1A1A4F2F66A0F9
GO
Isoform 3 (identifier: O75170-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-244: S → SR
     535-561: Missing.
     792-799: SQASYFAV → F

Show »
Length:933
Mass (Da):101,402
Checksum:iD74E382158135767
GO
Isoform 4 (identifier: O75170-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-561: Missing.
     792-799: SQASYFAV → F

Show »
Length:932
Mass (Da):101,246
Checksum:i0E22A2912F2A1F2A
GO
Isoform 5 (identifier: O75170-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     792-799: SQASYFAV → F

Show »
Length:959
Mass (Da):104,235
Checksum:i6C9F6F32B2768517
GO
Isoform 6 (identifier: O75170-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-84: Missing.
     535-561: Missing.
     792-799: SQASYFAV → F

Show »
Length:905
Mass (Da):98,126
Checksum:i2B49E60FADD6D84D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
T1ECW5T1ECW5_HUMAN
Serine/threonine-protein phosphatas...
PPP6R2
685Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSJ8A0A0A0MSJ8_HUMAN
Serine/threonine-protein phosphatas...
PPP6R2
562Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31660 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti224D → G in BAH13719 (PubMed:14702039).Curated1
Sequence conflicti806A → T in BAH13719 (PubMed:14702039).Curated1
Sequence conflicti835Q → H in AAH52995 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058402633D → E. Corresponds to variant dbSNP:rs11555194Ensembl.1
Natural variantiVAR_058403732R → K. Corresponds to variant dbSNP:rs13057311Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03776758 – 84Missing in isoform 6. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_037768244S → SR in isoform 3. 1 Publication1
Alternative sequenceiVSP_030758535 – 561Missing in isoform 2, isoform 3, isoform 4 and isoform 6. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_030759709E → EA in isoform 2. 1 Publication1
Alternative sequenceiVSP_030760792 – 799SQASYFAV → F in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 3 Publications8
Alternative sequenceiVSP_030761952 – 966KTDAP…LNGPV → QMPRQKELP in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB014585 mRNA Translation: BAA31660.2 Different initiation.
AK302472 mRNA Translation: BAH13719.1
AL096767 Genomic DNA No translation available.
AL671545 Genomic DNA No translation available.
AL954743 Genomic DNA No translation available.
BC000976 mRNA Translation: AAH00976.2
BC006568 mRNA Translation: AAH06568.1
BC032664 mRNA Translation: AAH32664.1
BC041698 mRNA Translation: AAH41698.1
BC052995 mRNA Translation: AAH52995.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33681.1 [O75170-4]
CCDS56235.1 [O75170-3]
CCDS56236.1 [O75170-2]
CCDS74881.1 [O75170-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00357

NCBI Reference Sequences

More...
RefSeqi
NP_001229827.1, NM_001242898.1 [O75170-5]
NP_001229828.1, NM_001242899.1 [O75170-3]
NP_001229829.1, NM_001242900.1 [O75170-2]
NP_055493.2, NM_014678.4 [O75170-4]
XP_006724497.1, XM_006724434.1 [O75170-1]
XP_016884612.1, XM_017029123.1 [O75170-1]
XP_016884613.1, XM_017029124.1 [O75170-1]
XP_016884617.1, XM_017029128.1
XP_016884620.1, XM_017029131.1
XP_016884621.1, XM_017029132.1 [O75170-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.449098
Hs.733531
Hs.740776

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216061; ENSP00000216061; ENSG00000100239 [O75170-1]
ENST00000359139; ENSP00000352051; ENSG00000100239 [O75170-2]
ENST00000395741; ENSP00000379090; ENSG00000100239 [O75170-3]
ENST00000395744; ENSP00000379093; ENSG00000100239 [O75170-4]
ENST00000612753; ENSP00000478417; ENSG00000100239 [O75170-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9701

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9701

UCSC genome browser

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UCSCi
uc003bky.3 human [O75170-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014585 mRNA Translation: BAA31660.2 Different initiation.
AK302472 mRNA Translation: BAH13719.1
AL096767 Genomic DNA No translation available.
AL671545 Genomic DNA No translation available.
AL954743 Genomic DNA No translation available.
BC000976 mRNA Translation: AAH00976.2
BC006568 mRNA Translation: AAH06568.1
BC032664 mRNA Translation: AAH32664.1
BC041698 mRNA Translation: AAH41698.1
BC052995 mRNA Translation: AAH52995.1
CCDSiCCDS33681.1 [O75170-4]
CCDS56235.1 [O75170-3]
CCDS56236.1 [O75170-2]
CCDS74881.1 [O75170-5]
PIRiT00357
RefSeqiNP_001229827.1, NM_001242898.1 [O75170-5]
NP_001229828.1, NM_001242899.1 [O75170-3]
NP_001229829.1, NM_001242900.1 [O75170-2]
NP_055493.2, NM_014678.4 [O75170-4]
XP_006724497.1, XM_006724434.1 [O75170-1]
XP_016884612.1, XM_017029123.1 [O75170-1]
XP_016884613.1, XM_017029124.1 [O75170-1]
XP_016884617.1, XM_017029128.1
XP_016884620.1, XM_017029131.1
XP_016884621.1, XM_017029132.1 [O75170-4]
UniGeneiHs.449098
Hs.733531
Hs.740776

3D structure databases

ProteinModelPortaliO75170
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115053, 73 interactors
CORUMiO75170
DIPiDIP-27539N
IntActiO75170, 31 interactors
MINTiO75170
STRINGi9606.ENSP00000379090

PTM databases

iPTMnetiO75170
PhosphoSitePlusiO75170

Polymorphism and mutation databases

BioMutaiPPP6R2

Proteomic databases

EPDiO75170
jPOSTiO75170
MaxQBiO75170
PaxDbiO75170
PeptideAtlasiO75170
PRIDEiO75170
ProteomicsDBi49835
49836 [O75170-2]
49837 [O75170-3]
49838 [O75170-4]
49839 [O75170-5]
49840 [O75170-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216061; ENSP00000216061; ENSG00000100239 [O75170-1]
ENST00000359139; ENSP00000352051; ENSG00000100239 [O75170-2]
ENST00000395741; ENSP00000379090; ENSG00000100239 [O75170-3]
ENST00000395744; ENSP00000379093; ENSG00000100239 [O75170-4]
ENST00000612753; ENSP00000478417; ENSG00000100239 [O75170-5]
GeneIDi9701
KEGGihsa:9701
UCSCiuc003bky.3 human [O75170-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9701
DisGeNETi9701
EuPathDBiHostDB:ENSG00000100239.15

GeneCards: human genes, protein and diseases

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GeneCardsi
PPP6R2
HGNCiHGNC:19253 PPP6R2
HPAiCAB034919
HPA030656
MIMi610877 gene
neXtProtiNX_O75170
OpenTargetsiENSG00000100239
PharmGKBiPA165378360

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2073 Eukaryota
ENOG410XRM1 LUCA
GeneTreeiENSGT00390000009899
HOVERGENiHBG069733
InParanoidiO75170
KOiK15500
OMAiILHGIEP
PhylomeDBiO75170
TreeFamiTF313227

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPP6R2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9701

Protein Ontology

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PROi
PR:O75170

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100239 Expressed in 214 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiO75170 baseline and differential
GenevisibleiO75170 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007587 SAPS
PANTHERiPTHR12634 PTHR12634, 1 hit
PfamiView protein in Pfam
PF04499 SAPS, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPP6R2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75170
Secondary accession number(s): A6PVG3
, B7Z7T3, Q5U5P3, Q7Z2L2, Q7Z5G5, Q7Z731, Q9UGB9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: January 15, 2008
Last modified: February 13, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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