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Protein

Phosphatase and actin regulator 2

Gene

PHACTR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Protein phosphatase inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatase and actin regulator 2
Gene namesi
Name:PHACTR2
Synonyms:C6orf56, KIAA0680
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112419.14
HGNCiHGNC:20956 PHACTR2
MIMi608724 gene
neXtProtiNX_O75167

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9749
OpenTargetsiENSG00000112419
PharmGKBiPA134944445

Polymorphism and mutation databases

BioMutaiPHACTR2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001266361 – 634Phosphatase and actin regulator 2Add BLAST634
Isoform 2 (identifier: O75167-2)
Initiator methionineiRemoved1 Publication
Isoform 4 (identifier: O75167-4)
Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei25PhosphothreonineCombined sources1
Modified residuei423PhosphoserineBy similarity1
Modified residuei522PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Isoform 2 (identifier: O75167-2)
Lipidationi2N-myristoyl glycine1 Publication1
Isoform 4 (identifier: O75167-4)
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiO75167
MaxQBiO75167
PaxDbiO75167
PeptideAtlasiO75167
PRIDEiO75167
ProteomicsDBi49831
49832 [O75167-2]
49833 [O75167-4]
49834 [O75167-5]

PTM databases

iPTMnetiO75167
PhosphoSitePlusiO75167

Expressioni

Gene expression databases

BgeeiENSG00000112419 Expressed in 230 organ(s), highest expression level in placenta
CleanExiHS_PHACTR2
ExpressionAtlasiO75167 baseline and differential
GenevisibleiO75167 HS

Organism-specific databases

HPAiHPA031719
HPA031720
HPA031725

Interactioni

Subunit structurei

Binds PPP1CA and actin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1754409,EBI-389883

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115097, 11 interactors
IntActiO75167, 6 interactors
STRINGi9606.ENSP00000417038

Structurei

3D structure databases

ProteinModelPortaliO75167
SMRiO75167
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati60 – 85RPEL 1Add BLAST26
Repeati477 – 502RPEL 2Add BLAST26
Repeati515 – 540RPEL 3Add BLAST26
Repeati553 – 578RPEL 4Add BLAST26

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4339 Eukaryota
ENOG4111M01 LUCA
GeneTreeiENSGT00390000004420
HOVERGENiHBG108246
InParanoidiO75167
OMAiNHSETPA
OrthoDBiEOG091G0HBF
PhylomeDBiO75167
TreeFamiTF316316

Family and domain databases

InterProiView protein in InterPro
IPR029991 Phactr2
IPR004018 RPEL_repeat
PANTHERiPTHR12751:SF5 PTHR12751:SF5, 1 hit
PfamiView protein in Pfam
PF02755 RPEL, 4 hits
SMARTiView protein in SMART
SM00707 RPEL, 4 hits
PROSITEiView protein in PROSITE
PS51073 RPEL, 4 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75167-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNAVDGLDK ASIANSDGPT AGSQTPPFKR KGKLSTIGKI FKPWKWRKKK
60 70 80 90 100
TSDKFRETSA VLERKISTRQ SREELIRRGV LKELPDQDGD VTVNFENSNG
110 120 130 140 150
HMIPIGEEST REENVVKSEE GNGSVSEKTP PLEEQAEDKK ENTENHSETP
160 170 180 190 200
AAPALPPSAP PKPRPKPKPK KSPVPPKGAT AGASHKGDEV PPIKKNTKAP
210 220 230 240 250
GKQAPVPPPK PASRNTTREA AGSSHSKKTT GSKASASPST SSTSSRPKAS
260 270 280 290 300
KETVSSKAGT VGTTKGKRKT DKQPITSHLS SDTTTSGTSD LKGEPAETRV
310 320 330 340 350
ESFKLEQTVP GAEEQNTGKF KSMVPPPPVA PAPSPLAPPL PLEDQCITAS
360 370 380 390 400
DTPVVLVSVG ADLPVSALDP SQLLWAEEPT NRTTLYSGTG LSVNRENAKC
410 420 430 440 450
FTTKEELGKT VPQLLTPGLM GESSESFSAS EDEGHREYQA NDSDSDGPIL
460 470 480 490 500
YTDDEDEDED EDGSGESALA SKIRRRDTLA IKLGNRPSKK ELEDKNILQR
510 520 530 540 550
TSEEERQEIR QQIGTKLVRR LSQRPTTEEL EQRNILKQKN EEEEQEAKME
560 570 580 590 600
LKRRLSRKLS LRPTVAELQA RRILRFNEYV EVTDSPDYDR RADKPWARLT
610 620 630
PADKAAIRKE LNEFKSTEME VHEESRQFTR FHRP
Length:634
Mass (Da):69,700
Last modified:July 22, 2008 - v2
Checksum:iB45A5C5F2E389779
GO
Isoform 2 (identifier: O75167-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MDNA → MGQTSVSTLSPQPGS
     141-220: Missing.

Show »
Length:565
Mass (Da):62,485
Checksum:i07F754786B22BA74
GO
Isoform 4 (identifier: O75167-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MDNA → MGQTSVSTLSPQPGS

Show »
Length:645
Mass (Da):70,727
Checksum:iDEF58BCDD6F51EC5
GO
Isoform 5 (identifier: O75167-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-220: Missing.

Show »
Length:554
Mass (Da):61,458
Checksum:i85281EC838ED5CA4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KP75J3KP75_HUMAN
Phosphatase and actin regulator
PHACTR2
622Annotation score:
F5H858F5H858_HUMAN
Phosphatase and actin regulator
PHACTR2
166Annotation score:
F6TH74F6TH74_HUMAN
Phosphatase and actin regulator
PHACTR2
178Annotation score:
H9KVA6H9KVA6_HUMAN
Phosphatase and actin regulator
PHACTR2 hCG_2030226
153Annotation score:

Sequence cautioni

The sequence BAA31655 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG60527 differs from that shown. Reason: Erroneous termination at position 46. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197T → I in AAI50631 (PubMed:15489334).Curated1
Sequence conflicti436R → K in BAG60138 (PubMed:14702039).Curated1
Sequence conflicti558K → R in BAG60138 (PubMed:14702039).Curated1
Sequence conflicti610E → G in BAG60138 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045628165P → S2 PublicationsCorresponds to variant dbSNP:rs2073214Ensembl.1
Natural variantiVAR_053646449I → V. Corresponds to variant dbSNP:rs2295201Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0122721 – 4MDNA → MGQTSVSTLSPQPGS in isoform 2 and isoform 4. 2 Publications4
Alternative sequenceiVSP_012273141 – 220Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014580 mRNA Translation: BAA31655.2 Different initiation.
AK297799 mRNA Translation: BAG60138.1
AK298263 mRNA Translation: BAG60527.1 Sequence problems.
AK300221 mRNA Translation: BAG61989.1
CR749345 mRNA Translation: CAH18198.1
AL049844 Genomic DNA No translation available.
AL078593 Genomic DNA No translation available.
AL357117 Genomic DNA No translation available.
BC150630 mRNA Translation: AAI50631.1
BC152416 mRNA Translation: AAI52417.1
CCDSiCCDS43512.1 [O75167-5]
CCDS47492.1 [O75167-1]
CCDS47493.1 [O75167-4]
CCDS47494.1 [O75167-2]
PIRiT00359
RefSeqiNP_001093634.1, NM_001100164.1 [O75167-4]
NP_001093635.1, NM_001100165.1 [O75167-2]
NP_001093636.1, NM_001100166.1 [O75167-5]
NP_055536.2, NM_014721.2 [O75167-1]
UniGeneiHs.102471

Genome annotation databases

EnsembliENST00000305766; ENSP00000305530; ENSG00000112419 [O75167-5]
ENST00000367582; ENSP00000356554; ENSG00000112419 [O75167-2]
ENST00000427704; ENSP00000391763; ENSG00000112419 [O75167-1]
ENST00000440869; ENSP00000417038; ENSG00000112419 [O75167-4]
GeneIDi9749
KEGGihsa:9749
UCSCiuc003qjq.4 human [O75167-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014580 mRNA Translation: BAA31655.2 Different initiation.
AK297799 mRNA Translation: BAG60138.1
AK298263 mRNA Translation: BAG60527.1 Sequence problems.
AK300221 mRNA Translation: BAG61989.1
CR749345 mRNA Translation: CAH18198.1
AL049844 Genomic DNA No translation available.
AL078593 Genomic DNA No translation available.
AL357117 Genomic DNA No translation available.
BC150630 mRNA Translation: AAI50631.1
BC152416 mRNA Translation: AAI52417.1
CCDSiCCDS43512.1 [O75167-5]
CCDS47492.1 [O75167-1]
CCDS47493.1 [O75167-4]
CCDS47494.1 [O75167-2]
PIRiT00359
RefSeqiNP_001093634.1, NM_001100164.1 [O75167-4]
NP_001093635.1, NM_001100165.1 [O75167-2]
NP_001093636.1, NM_001100166.1 [O75167-5]
NP_055536.2, NM_014721.2 [O75167-1]
UniGeneiHs.102471

3D structure databases

ProteinModelPortaliO75167
SMRiO75167
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115097, 11 interactors
IntActiO75167, 6 interactors
STRINGi9606.ENSP00000417038

PTM databases

iPTMnetiO75167
PhosphoSitePlusiO75167

Polymorphism and mutation databases

BioMutaiPHACTR2

Proteomic databases

EPDiO75167
MaxQBiO75167
PaxDbiO75167
PeptideAtlasiO75167
PRIDEiO75167
ProteomicsDBi49831
49832 [O75167-2]
49833 [O75167-4]
49834 [O75167-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305766; ENSP00000305530; ENSG00000112419 [O75167-5]
ENST00000367582; ENSP00000356554; ENSG00000112419 [O75167-2]
ENST00000427704; ENSP00000391763; ENSG00000112419 [O75167-1]
ENST00000440869; ENSP00000417038; ENSG00000112419 [O75167-4]
GeneIDi9749
KEGGihsa:9749
UCSCiuc003qjq.4 human [O75167-1]

Organism-specific databases

CTDi9749
DisGeNETi9749
EuPathDBiHostDB:ENSG00000112419.14
GeneCardsiPHACTR2
H-InvDBiHIX0006269
HGNCiHGNC:20956 PHACTR2
HPAiHPA031719
HPA031720
HPA031725
MIMi608724 gene
neXtProtiNX_O75167
OpenTargetsiENSG00000112419
PharmGKBiPA134944445
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4339 Eukaryota
ENOG4111M01 LUCA
GeneTreeiENSGT00390000004420
HOVERGENiHBG108246
InParanoidiO75167
OMAiNHSETPA
OrthoDBiEOG091G0HBF
PhylomeDBiO75167
TreeFamiTF316316

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRSiPHACTR2 human
GenomeRNAii9749
PROiPR:O75167
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112419 Expressed in 230 organ(s), highest expression level in placenta
CleanExiHS_PHACTR2
ExpressionAtlasiO75167 baseline and differential
GenevisibleiO75167 HS

Family and domain databases

InterProiView protein in InterPro
IPR029991 Phactr2
IPR004018 RPEL_repeat
PANTHERiPTHR12751:SF5 PTHR12751:SF5, 1 hit
PfamiView protein in Pfam
PF02755 RPEL, 4 hits
SMARTiView protein in SMART
SM00707 RPEL, 4 hits
PROSITEiView protein in PROSITE
PS51073 RPEL, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPHAR2_HUMAN
AccessioniPrimary (citable) accession number: O75167
Secondary accession number(s): A6NKP5
, A7MCZ5, A8MZC0, B2RWP7, B4DN76, B4DPB5, B4DTH7, Q5TFA0, Q68DM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 22, 2008
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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