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Entry version 137 (16 Oct 2019)
Sequence version 2 (22 Jul 2008)
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Protein

Phosphatase and actin regulator 2

Gene

PHACTR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Protein phosphatase inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatase and actin regulator 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHACTR2
Synonyms:C6orf56, KIAA0680
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20956 PHACTR2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608724 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75167

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000112419

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134944445

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75167

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PHACTR2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001266361 – 634Phosphatase and actin regulator 2Add BLAST634
Isoform 2 (identifier: O75167-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
Isoform 4 (identifier: O75167-4)
Initiator methionineiRemoved1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineCombined sources1
Modified residuei25PhosphothreonineCombined sources1
Modified residuei423PhosphoserineBy similarity1
Modified residuei522PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Isoform 2 (identifier: O75167-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
Isoform 4 (identifier: O75167-4)
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-989

Encyclopedia of Proteome Dynamics

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EPDi
O75167

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75167

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O75167

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75167

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75167

PeptideAtlas

More...
PeptideAtlasi
O75167

PRoteomics IDEntifications database

More...
PRIDEi
O75167

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49831 [O75167-1]
49832 [O75167-2]
49833 [O75167-4]
49834 [O75167-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75167

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75167

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112419 Expressed in 230 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75167 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75167 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031719
HPA031720
HPA031725

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds PPP1CA and actin.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1754409,EBI-389883

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115097, 12 interactors

Protein interaction database and analysis system

More...
IntActi
O75167, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417038

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75167

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati60 – 85RPEL 1Add BLAST26
Repeati477 – 502RPEL 2Add BLAST26
Repeati515 – 540RPEL 3Add BLAST26
Repeati553 – 578RPEL 4Add BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4339 Eukaryota
ENOG4111M01 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157628

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75167

Identification of Orthologs from Complete Genome Data

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OMAi
KQSAPRT

Database of Orthologous Groups

More...
OrthoDBi
1205245at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75167

TreeFam database of animal gene trees

More...
TreeFami
TF316316

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029991 Phactr2
IPR004018 RPEL_repeat

The PANTHER Classification System

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PANTHERi
PTHR12751:SF5 PTHR12751:SF5, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02755 RPEL, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00707 RPEL, 4 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51073 RPEL, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75167-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNAVDGLDK ASIANSDGPT AGSQTPPFKR KGKLSTIGKI FKPWKWRKKK
60 70 80 90 100
TSDKFRETSA VLERKISTRQ SREELIRRGV LKELPDQDGD VTVNFENSNG
110 120 130 140 150
HMIPIGEEST REENVVKSEE GNGSVSEKTP PLEEQAEDKK ENTENHSETP
160 170 180 190 200
AAPALPPSAP PKPRPKPKPK KSPVPPKGAT AGASHKGDEV PPIKKNTKAP
210 220 230 240 250
GKQAPVPPPK PASRNTTREA AGSSHSKKTT GSKASASPST SSTSSRPKAS
260 270 280 290 300
KETVSSKAGT VGTTKGKRKT DKQPITSHLS SDTTTSGTSD LKGEPAETRV
310 320 330 340 350
ESFKLEQTVP GAEEQNTGKF KSMVPPPPVA PAPSPLAPPL PLEDQCITAS
360 370 380 390 400
DTPVVLVSVG ADLPVSALDP SQLLWAEEPT NRTTLYSGTG LSVNRENAKC
410 420 430 440 450
FTTKEELGKT VPQLLTPGLM GESSESFSAS EDEGHREYQA NDSDSDGPIL
460 470 480 490 500
YTDDEDEDED EDGSGESALA SKIRRRDTLA IKLGNRPSKK ELEDKNILQR
510 520 530 540 550
TSEEERQEIR QQIGTKLVRR LSQRPTTEEL EQRNILKQKN EEEEQEAKME
560 570 580 590 600
LKRRLSRKLS LRPTVAELQA RRILRFNEYV EVTDSPDYDR RADKPWARLT
610 620 630
PADKAAIRKE LNEFKSTEME VHEESRQFTR FHRP
Length:634
Mass (Da):69,700
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB45A5C5F2E389779
GO
Isoform 2 (identifier: O75167-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MDNA → MGQTSVSTLSPQPGS
     141-220: Missing.

Show »
Length:565
Mass (Da):62,485
Checksum:i07F754786B22BA74
GO
Isoform 4 (identifier: O75167-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MDNA → MGQTSVSTLSPQPGS

Show »
Length:645
Mass (Da):70,727
Checksum:iDEF58BCDD6F51EC5
GO
Isoform 5 (identifier: O75167-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-220: Missing.

Show »
Length:554
Mass (Da):61,458
Checksum:i85281EC838ED5CA4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KP75J3KP75_HUMAN
Phosphatase and actin regulator
PHACTR2
622Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H858F5H858_HUMAN
Phosphatase and actin regulator
PHACTR2
166Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TH74F6TH74_HUMAN
Phosphatase and actin regulator
PHACTR2
178Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KVA6H9KVA6_HUMAN
Phosphatase and actin regulator
PHACTR2 hCG_2030226
153Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31655 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG60527 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti197T → I in AAI50631 (PubMed:15489334).Curated1
Sequence conflicti436R → K in BAG60138 (PubMed:14702039).Curated1
Sequence conflicti558K → R in BAG60138 (PubMed:14702039).Curated1
Sequence conflicti610E → G in BAG60138 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_045628165P → S2 PublicationsCorresponds to variant dbSNP:rs2073214Ensembl.1
Natural variantiVAR_053646449I → V. Corresponds to variant dbSNP:rs2295201Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0122721 – 4MDNA → MGQTSVSTLSPQPGS in isoform 2 and isoform 4. 2 Publications4
Alternative sequenceiVSP_012273141 – 220Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB014580 mRNA Translation: BAA31655.2 Different initiation.
AK297799 mRNA Translation: BAG60138.1
AK298263 mRNA Translation: BAG60527.1 Sequence problems.
AK300221 mRNA Translation: BAG61989.1
CR749345 mRNA Translation: CAH18198.1
AL049844 Genomic DNA No translation available.
AL078593 Genomic DNA No translation available.
AL357117 Genomic DNA No translation available.
BC150630 mRNA Translation: AAI50631.1
BC152416 mRNA Translation: AAI52417.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43512.1 [O75167-5]
CCDS47492.1 [O75167-1]
CCDS47493.1 [O75167-4]
CCDS47494.1 [O75167-2]

Protein sequence database of the Protein Information Resource

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PIRi
T00359

NCBI Reference Sequences

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RefSeqi
NP_001093634.1, NM_001100164.1 [O75167-4]
NP_001093635.1, NM_001100165.1 [O75167-2]
NP_001093636.1, NM_001100166.1 [O75167-5]
NP_055536.2, NM_014721.2 [O75167-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305766; ENSP00000305530; ENSG00000112419 [O75167-5]
ENST00000367582; ENSP00000356554; ENSG00000112419 [O75167-2]
ENST00000427704; ENSP00000391763; ENSG00000112419 [O75167-1]
ENST00000440869; ENSP00000417038; ENSG00000112419 [O75167-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9749

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9749

UCSC genome browser

More...
UCSCi
uc003qjq.4 human [O75167-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014580 mRNA Translation: BAA31655.2 Different initiation.
AK297799 mRNA Translation: BAG60138.1
AK298263 mRNA Translation: BAG60527.1 Sequence problems.
AK300221 mRNA Translation: BAG61989.1
CR749345 mRNA Translation: CAH18198.1
AL049844 Genomic DNA No translation available.
AL078593 Genomic DNA No translation available.
AL357117 Genomic DNA No translation available.
BC150630 mRNA Translation: AAI50631.1
BC152416 mRNA Translation: AAI52417.1
CCDSiCCDS43512.1 [O75167-5]
CCDS47492.1 [O75167-1]
CCDS47493.1 [O75167-4]
CCDS47494.1 [O75167-2]
PIRiT00359
RefSeqiNP_001093634.1, NM_001100164.1 [O75167-4]
NP_001093635.1, NM_001100165.1 [O75167-2]
NP_001093636.1, NM_001100166.1 [O75167-5]
NP_055536.2, NM_014721.2 [O75167-1]

3D structure databases

SMRiO75167
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115097, 12 interactors
IntActiO75167, 17 interactors
STRINGi9606.ENSP00000417038

PTM databases

iPTMnetiO75167
PhosphoSitePlusiO75167

Polymorphism and mutation databases

BioMutaiPHACTR2

Proteomic databases

CPTACiCPTAC-989
EPDiO75167
jPOSTiO75167
MassIVEiO75167
MaxQBiO75167
PaxDbiO75167
PeptideAtlasiO75167
PRIDEiO75167
ProteomicsDBi49831 [O75167-1]
49832 [O75167-2]
49833 [O75167-4]
49834 [O75167-5]

Genome annotation databases

EnsembliENST00000305766; ENSP00000305530; ENSG00000112419 [O75167-5]
ENST00000367582; ENSP00000356554; ENSG00000112419 [O75167-2]
ENST00000427704; ENSP00000391763; ENSG00000112419 [O75167-1]
ENST00000440869; ENSP00000417038; ENSG00000112419 [O75167-4]
GeneIDi9749
KEGGihsa:9749
UCSCiuc003qjq.4 human [O75167-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9749

GeneCards: human genes, protein and diseases

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GeneCardsi
PHACTR2
HGNCiHGNC:20956 PHACTR2
HPAiHPA031719
HPA031720
HPA031725
MIMi608724 gene
neXtProtiNX_O75167
OpenTargetsiENSG00000112419
PharmGKBiPA134944445

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4339 Eukaryota
ENOG4111M01 LUCA
GeneTreeiENSGT00940000157628
InParanoidiO75167
OMAiKQSAPRT
OrthoDBi1205245at2759
PhylomeDBiO75167
TreeFamiTF316316

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PHACTR2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9749
PharosiO75167

Protein Ontology

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PROi
PR:O75167

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112419 Expressed in 230 organ(s), highest expression level in placenta
ExpressionAtlasiO75167 baseline and differential
GenevisibleiO75167 HS

Family and domain databases

InterProiView protein in InterPro
IPR029991 Phactr2
IPR004018 RPEL_repeat
PANTHERiPTHR12751:SF5 PTHR12751:SF5, 1 hit
PfamiView protein in Pfam
PF02755 RPEL, 4 hits
SMARTiView protein in SMART
SM00707 RPEL, 4 hits
PROSITEiView protein in PROSITE
PS51073 RPEL, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHAR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75167
Secondary accession number(s): A6NKP5
, A7MCZ5, A8MZC0, B2RWP7, B4DN76, B4DPB5, B4DTH7, Q5TFA0, Q68DM2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 22, 2008
Last modified: October 16, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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