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Entry version 163 (16 Oct 2019)
Sequence version 5 (02 Nov 2010)
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Protein

DnaJ homolog subfamily C member 13

Gene

DNAJC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499).3 Publications

Caution

In human, WASHC2 has undergone evolutionary duplication giving rise to highly homologous family members. A WASHC2C construct with WASHC2A-specific sequence insertions (of 2 aa and 21 aa length resulting in a construct length of 1341 aa similar to WASHC2A length) has been used to demonstrate the interaction with WASHC2 (PubMed:24643499).Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DnaJ homolog subfamily C member 13
Alternative name(s):
Required for receptor-mediated endocytosis 8
Short name:
RME-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAJC13
Synonyms:KIAA0678, RME8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30343 DNAJC13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614334 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75165

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Parkinson disease (PARK)2 Publications
The gene represented in this entry may be involved in disease pathogenesis. Genetic variants in DNAJC13 (PubMed:24218364, PubMed:25393719) and TMEM230 (PubMed:27270108) have been found in the same large multigenerational family with adult-onset Parkinson disease. The pathological role of each gene and therefore the exact molecular basis of the disease is unclear.1 Publication
Disease descriptionA complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076718722V → L in PARK; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs146930051Ensembl.1
Natural variantiVAR_073785855N → S in PARK; unknown pathological significance; affects regulation of endosomal membrane trafficking as indicated by accumulation of transferrin in endosomal compartments. 2 PublicationsCorresponds to variant dbSNP:rs387907571EnsemblClinVar.1
Natural variantiVAR_0767221266R → Q in PARK; sporadic case; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766013346Ensembl.1
Natural variantiVAR_0767261895T → M in PARK; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs145242123Ensembl.1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism

Organism-specific databases

DisGeNET

More...
DisGeNETi
23317

MalaCards human disease database

More...
MalaCardsi
DNAJC13
MIMi168600 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000138246

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
411602 Hereditary late-onset Parkinson disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134947358

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75165

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DNAJC13

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000710721 – 2243DnaJ homolog subfamily C member 13Add BLAST2243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei84N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75165

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75165

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O75165

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75165

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75165

PeptideAtlas

More...
PeptideAtlasi
O75165

PRoteomics IDEntifications database

More...
PRIDEi
O75165

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
49830

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75165

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75165

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O75165

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138246 Expressed in 241 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75165 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75165 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036923
HPA036924

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WASHC2C; mediates the association with the WASH complex (PubMed:24643499).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116908, 71 interactors

Protein interaction database and analysis system

More...
IntActi
O75165, 44 interactors

Molecular INTeraction database

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MINTi
O75165

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260818

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1301 – 1366JPROSITE-ProRule annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 453Involved in membrane association1 PublicationAdd BLAST453

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1789 Eukaryota
ENOG410XRI2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017582

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75165

KEGG Orthology (KO)

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KOi
K09533

Identification of Orthologs from Complete Genome Data

More...
OMAi
NIPNEFV

Database of Orthologous Groups

More...
OrthoDBi
716326at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75165

TreeFam database of animal gene trees

More...
TreeFami
TF105172

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06257 DnaJ, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.110, 1 hit
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001623 DnaJ_domain
IPR035445 GYF-like_dom_sf
IPR025640 GYF_2
IPR036869 J_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00226 DnaJ, 1 hit
PF14237 GYF_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00271 DnaJ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46565 SSF46565, 1 hit
SSF48371 SSF48371, 3 hits
SSF55277 SSF55277, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50076 DNAJ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O75165-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIIRENKDL ACFYTTKHSW RGKYKRVFSV GTHAITTYNP NTLEVTNQWP
60 70 80 90 100
YGDICSISPV GKGQGTEFNL TFRKGSGKKS ETLKFSTEHR TELLTEALRF
110 120 130 140 150
RTDFSEGKIT GRRYNCYKHH WSDSRKPVIL EVTPGGFDQI NPATNRVLCS
160 170 180 190 200
YDYRNIEGFV DLSDYQGGFC ILYGGFSRLH LFASEQREEI IKSAIDHAGN
210 220 230 240 250
YIGISLRIRK EPLEFEQYLN LRFGKYSTDE SITSLAEFVV QKISPRHSEP
260 270 280 290 300
VKRVLALTET CLVERDPATY NIATLKPLGE VFALVCDSEN PQLFTIEFIK
310 320 330 340 350
GQVRKYSSTE RDSLLASLLD GVRASGNRDV CVKMTPTHKG QRWGLLSMPV
360 370 380 390 400
DEEVESLHLR FLATPPNGNF ADAVFRFNAN ISYSGVLHAV TQDGLFSENK
410 420 430 440 450
EKLINNAITA LLSQEGDVVA SNAELESQFQ AVRRLVASKA GFLAFTQLPK
460 470 480 490 500
FRERLGVKVV KALKRSNNGI IHAAVDMLCA LMCPMHDDYD LRQEQLNKAS
510 520 530 540 550
LLSSKKFLEN LLEKFNSHVD HGTGALVISS LLDFLTFALC APYSETTEGQ
560 570 580 590 600
QFDMLLEMVA SNGRTLFKLF QHPSMAIIKG AGLVMKAIIE EGDKEIATKM
610 620 630 640 650
QELALSEGAL PRHLHTAMFT ISSDQRMLTN RQLSRHLVGL WTADNATATN
660 670 680 690 700
LLKRILPPGL LAYLESSDLV PEKDADRMHV RDNVKIAMDQ YGKFNKVPEW
710 720 730 740 750
QRLAGKAAKE VEKFAKEKVD LVLMHWRDRM GIAQKENINQ KPVVLRKRRQ
760 770 780 790 800
RIKIEANWDL FYYRFGQDHA RSNLIWNFKT REELKDTLES EMRAFNIDRE
810 820 830 840 850
LGSANVISWN HHEFEVKYEC LAEEIKIGDY YLRLLLEEDE NEESGSIKRS
860 870 880 890 900
YEFFNELYHR FLLTPKVNMK CLCLQALAIV YGRCHEEIGP FTDTRYIIGM
910 920 930 940 950
LERCTDKLER DRLILFLNKL ILNKKNVKDL MDSNGIRILV DLLTLAHLHV
960 970 980 990 1000
SRATVPLQSN VIEAAPDMKR ESEKEWYFGN ADKERSGPYG FHEMQELWTK
1010 1020 1030 1040 1050
GMLNAKTRCW AQGMDGWRPL QSIPQLKWCL LASGQAVLNE TDLATLILNM
1060 1070 1080 1090 1100
LITMCGYFPS RDQDNAIIRP LPKVKRLLSD STCLPHIIQL LLTFDPILVE
1110 1120 1130 1140 1150
KVAILLYHIM QDNPQLPRLY LSGVFFFIMM YTGSNVLPVA RFLKYTHTKQ
1160 1170 1180 1190 1200
AFKSEETKGQ DIFQRSILGH ILPEAMVCYL ENYEPEKFSE IFLGEFDTPE
1210 1220 1230 1240 1250
AIWSSEMRRL MIEKIAAHLA DFTPRLQSNT RALYQYCPIP IINYPQLENE
1260 1270 1280 1290 1300
LFCNIYYLKQ LCDTLRFPDW PIKDPVKLLK DTLDAWKKEV EKKPPMMSID
1310 1320 1330 1340 1350
DAYEVLNLPQ GQGPHDESKI RKAYFRLAQK YHPDKNPEGR DMFEKVNKAY
1360 1370 1380 1390 1400
EFLCTKSAKI VDGPDPENII LILKTQSILF NRHKEDLQPY KYAGYPMLIR
1410 1420 1430 1440 1450
TITMETSDDL LFSKESPLLP AATELAFHTV NCSALNAEEL RRENGLEVLQ
1460 1470 1480 1490 1500
EAFSRCVAVL TRASKPSDMS VQVCGYISKC YSVAAQFEEC REKITEMPSI
1510 1520 1530 1540 1550
IKDLCRVLYF GKSIPRVAAL GVECVSSFAV DFWLQTHLFQ AGILWYLLGF
1560 1570 1580 1590 1600
LFNYDYTLEE SGIQKSEETN QQEVANSLAK LSVHALSRLG GYLAEEQATP
1610 1620 1630 1640 1650
ENPTIRKSLA GMLTPYVARK LAVASVTEIL KMLNSNTESP YLIWNNSTRA
1660 1670 1680 1690 1700
ELLEFLESQQ ENMIKKGDCD KTYGSEFVYS DHAKELIVGE IFVRVYNEVP
1710 1720 1730 1740 1750
TFQLEVPKAF AASLLDYIGS QAQYLHTFMA ITHAAKVESE QHGDRLPRVE
1760 1770 1780 1790 1800
MALEALRNVI KYNPGSESEC IGHFKLIFSL LRVHGAGQVQ QLALEVVNIV
1810 1820 1830 1840 1850
TSNQDCVNNI AESMVLSSLL ALLHSLPSSR QLVLETLYAL TSSTKIIKEA
1860 1870 1880 1890 1900
MAKGALIYLL DMFCNSTHPQ VRAQTAELFA KMTADKLIGP KVRITLMKFL
1910 1920 1930 1940 1950
PSVFMDAMRD NPEAAVHIFE GTHENPELIW NDNSRDKVST TVREMMLEHF
1960 1970 1980 1990 2000
KNQQDNPEAN WKLPEDFAVV FGEAEGELAV GGVFLRIFIA QPAWVLRKPR
2010 2020 2030 2040 2050
EFLIALLEKL TELLEKNNPH GETLETLTMA TVCLFSAQPQ LADQVPPLGH
2060 2070 2080 2090 2100
LPKVIQAMNH RNNAIPKSAI RVIHALSENE LCVRAMASLE TIGPLMNGMK
2110 2120 2130 2140 2150
KRADTVGLAC EAINRMFQKE QSELVAQALK ADLVPYLLKL LEGIGLENLD
2160 2170 2180 2190 2200
SPAATKAQIV KALKAMTRSL QYGEQVNEIL CRSSVWSAFK DQKHDLFISE
2210 2220 2230 2240
SQTAGYLTGP GVAGYLTAGT STSVMSNLPP PVDHEAGDLG YQT
Length:2,243
Mass (Da):254,415
Last modified:November 2, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6D292837DE1F170
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8Q2H0Y8Q2_HUMAN
DnaJ homolog subfamily C member 13
DNAJC13
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA63H0YA63_HUMAN
DnaJ homolog subfamily C member 13
DNAJC13
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRM0A0A3B3IRM0_HUMAN
DnaJ homolog subfamily C member 13
DNAJC13
631Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH43583 differs from that shown. Probable cloning artifact.Curated
The sequence BAA31653 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC86133 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC86835 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC86835 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti476D → E in BAA31653 (PubMed:9734811).Curated1
Sequence conflicti562N → D in AAH43583 (PubMed:15489334).Curated1
Sequence conflicti1097I → T in BAC86133 (PubMed:14702039).Curated1
Sequence conflicti1148T → I in BAC86835 (PubMed:14702039).Curated1
Sequence conflicti1227Q → H in BAA31653 (PubMed:9734811).Curated1
Sequence conflicti1230T → A in BAC86835 (PubMed:14702039).Curated1
Sequence conflicti1269D → N in BAC86133 (PubMed:14702039).Curated1
Sequence conflicti2041L → P in BAC86835 (PubMed:14702039).Curated1
Sequence conflicti2091T → A in BAC86835 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073784264E → Q1 Publication1
Natural variantiVAR_076716556L → S1 PublicationCorresponds to variant dbSNP:rs749000301Ensembl.1
Natural variantiVAR_076717674D → A1 PublicationCorresponds to variant dbSNP:rs199541720Ensembl.1
Natural variantiVAR_076718722V → L in PARK; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs146930051Ensembl.1
Natural variantiVAR_073785855N → S in PARK; unknown pathological significance; affects regulation of endosomal membrane trafficking as indicated by accumulation of transferrin in endosomal compartments. 2 PublicationsCorresponds to variant dbSNP:rs387907571EnsemblClinVar.1
Natural variantiVAR_076719903R → K1 PublicationCorresponds to variant dbSNP:rs141952333Ensembl.1
Natural variantiVAR_076720997L → F1 PublicationCorresponds to variant dbSNP:rs752189478Ensembl.1
Natural variantiVAR_0737861082T → I1 PublicationCorresponds to variant dbSNP:rs202127368Ensembl.1
Natural variantiVAR_0767211135N → S1 PublicationCorresponds to variant dbSNP:rs751747947Ensembl.1
Natural variantiVAR_0767221266R → Q in PARK; sporadic case; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766013346Ensembl.1
Natural variantiVAR_0767231291E → G1 PublicationCorresponds to variant dbSNP:rs61748101Ensembl.1
Natural variantiVAR_0474581463A → S2 PublicationsCorresponds to variant dbSNP:rs3762672Ensembl.1
Natural variantiVAR_0474591487F → C. Corresponds to variant dbSNP:rs4405917Ensembl.1
Natural variantiVAR_0611441515P → S. Corresponds to variant dbSNP:rs55825559Ensembl.1
Natural variantiVAR_0767241516R → H1 PublicationCorresponds to variant dbSNP:rs139620588Ensembl.1
Natural variantiVAR_0767251740E → Q1 PublicationCorresponds to variant dbSNP:rs142160751Ensembl.1
Natural variantiVAR_0767261895T → M in PARK; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs145242123Ensembl.1
Natural variantiVAR_0474601995V → I. Corresponds to variant dbSNP:rs10935014Ensembl.1
Natural variantiVAR_0767272057A → S1 PublicationCorresponds to variant dbSNP:rs138693725Ensembl.1
Natural variantiVAR_0737872115R → L1 PublicationCorresponds to variant dbSNP:rs770715465Ensembl.1
Natural variantiVAR_0767282170L → W1 PublicationCorresponds to variant dbSNP:rs140537885Ensembl.1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY779857 mRNA Translation: AAV41096.1
AB014578 mRNA Translation: BAA31653.2 Different initiation.
AC020632 Genomic DNA No translation available.
AC020633 Genomic DNA No translation available.
AC026374 Genomic DNA No translation available.
BC000164 mRNA Translation: AAH00164.2
BC009630 mRNA Translation: AAH09630.1
BC040638 mRNA Translation: AAH40638.1
BC043583 mRNA Translation: AAH43583.1 Sequence problems.
AK125330 mRNA Translation: BAC86133.1 Different initiation.
AK127112 mRNA Translation: BAC86835.1 Sequence problems.
AY369172 mRNA Translation: AAQ57271.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33857.1

Protein sequence database of the Protein Information Resource

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PIRi
T00361

NCBI Reference Sequences

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RefSeqi
NP_056083.3, NM_015268.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000260818; ENSP00000260818; ENSG00000138246

Database of genes from NCBI RefSeq genomes

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GeneIDi
23317

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23317

UCSC genome browser

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UCSCi
uc003eor.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY779857 mRNA Translation: AAV41096.1
AB014578 mRNA Translation: BAA31653.2 Different initiation.
AC020632 Genomic DNA No translation available.
AC020633 Genomic DNA No translation available.
AC026374 Genomic DNA No translation available.
BC000164 mRNA Translation: AAH00164.2
BC009630 mRNA Translation: AAH09630.1
BC040638 mRNA Translation: AAH40638.1
BC043583 mRNA Translation: AAH43583.1 Sequence problems.
AK125330 mRNA Translation: BAC86133.1 Different initiation.
AK127112 mRNA Translation: BAC86835.1 Sequence problems.
AY369172 mRNA Translation: AAQ57271.1
CCDSiCCDS33857.1
PIRiT00361
RefSeqiNP_056083.3, NM_015268.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116908, 71 interactors
IntActiO75165, 44 interactors
MINTiO75165
STRINGi9606.ENSP00000260818

PTM databases

iPTMnetiO75165
PhosphoSitePlusiO75165
SwissPalmiO75165

Polymorphism and mutation databases

BioMutaiDNAJC13

Proteomic databases

EPDiO75165
jPOSTiO75165
MassIVEiO75165
MaxQBiO75165
PaxDbiO75165
PeptideAtlasiO75165
PRIDEiO75165
ProteomicsDBi49830

Genome annotation databases

EnsembliENST00000260818; ENSP00000260818; ENSG00000138246
GeneIDi23317
KEGGihsa:23317
UCSCiuc003eor.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23317
DisGeNETi23317

GeneCards: human genes, protein and diseases

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GeneCardsi
DNAJC13
HGNCiHGNC:30343 DNAJC13
HPAiHPA036923
HPA036924
MalaCardsiDNAJC13
MIMi168600 phenotype
614334 gene
neXtProtiNX_O75165
OpenTargetsiENSG00000138246
Orphaneti411602 Hereditary late-onset Parkinson disease
PharmGKBiPA134947358

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1789 Eukaryota
ENOG410XRI2 LUCA
GeneTreeiENSGT00390000017582
InParanoidiO75165
KOiK09533
OMAiNIPNEFV
OrthoDBi716326at2759
PhylomeDBiO75165
TreeFamiTF105172

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DNAJC13 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DNAJC13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23317
PharosiO75165

Protein Ontology

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PROi
PR:O75165

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138246 Expressed in 241 organ(s), highest expression level in intestine
ExpressionAtlasiO75165 baseline and differential
GenevisibleiO75165 HS

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001623 DnaJ_domain
IPR035445 GYF-like_dom_sf
IPR025640 GYF_2
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF14237 GYF_2, 1 hit
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF48371 SSF48371, 3 hits
SSF55277 SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDJC13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75165
Secondary accession number(s): Q3L0T1
, Q6PI82, Q6UJ77, Q6ZSW1, Q6ZUT5, Q86XG3, Q96DC1, Q9BWK9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 2, 2010
Last modified: October 16, 2019
This is version 163 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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