Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Suppressor of cytokine signaling 5

Gene

SOCS5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-8951664 Neddylation
SignaLinkiO75159
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 5
Short name:
SOCS-5
Alternative name(s):
Cytokine-inducible SH2 protein 6
Short name:
CIS-6
Cytokine-inducible SH2-containing protein 5
Gene namesi
Name:SOCS5
Synonyms:CIS6, CISH5, CISH6, KIAA0671
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000171150.7
HGNCiHGNC:16852 SOCS5
MIMi607094 gene
neXtProtiNX_O75159

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi406R → K: Abrogates the ability to induce EGFR degradation. 1 Publication1
Mutagenesisi484L → P: Abrogates the interaction with ELOB and ELOC and the ability to suppress EGFR signaling; when associated with F-488. 1 Publication1
Mutagenesisi488C → F: Abrogates the interaction with ELOB and ELOC and the ability to suppress EGFR signaling; when associated with P-484. 1 Publication1

Organism-specific databases

DisGeNETi9655
OpenTargetsiENSG00000171150
PharmGKBiPA134884627

Polymorphism and mutation databases

BioMutaiSOCS5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812491 – 536Suppressor of cytokine signaling 5Add BLAST536

Post-translational modificationi

Phosphorylated. Phosphorylation is induced by EGF.1 Publication

Proteomic databases

PaxDbiO75159
PeptideAtlasiO75159
PRIDEiO75159
ProteomicsDBi49827

PTM databases

iPTMnetiO75159
PhosphoSitePlusiO75159

Expressioni

Inductioni

Up-regulated by EGF (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000171150
CleanExiHS_SOCS5
GenevisibleiO75159 HS

Organism-specific databases

HPAiCAB025510
HPA020884

Interactioni

Subunit structurei

Interacts with IL4R; inhibits IL4 signaling (By similarity). Interacts with EGFR. Interacts with ELOB and ELOC; mediates EGFR ubiquitination and degradation.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
METP085812EBI-970130,EBI-1039152

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: Ensembl
  • receptor tyrosine kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115013, 11 interactors
IntActiO75159, 6 interactors
MINTiO75159
STRINGi9606.ENSP00000305133

Structurei

3D structure databases

ProteinModelPortaliO75159
SMRiO75159
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini381 – 476SH2PROSITE-ProRule annotationAdd BLAST96
Domaini471 – 520SOCS boxPROSITE-ProRule annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 50Required for interaction with IL4RBy similarityAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000027791
HOVERGENiHBG054138
InParanoidiO75159
KOiK04698
OMAiQVSGDSH
OrthoDBiEOG091G0EQ0
PhylomeDBiO75159
TreeFamiTF321368

Family and domain databases

CDDicd03739 SOCS_SOCS5, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR022252 SOCS4/SOCS5_dom
IPR028420 SOCS5
IPR037343 SOCS5_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR44282:SF3 PTHR44282:SF3, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF12610 SOCS, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

O75159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV KEKNISIGDS
60 70 80 90 100
TPQQQSSPLR ENIALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDNDS
110 120 130 140 150
CVTPGTRLAR RDSYSRHAPW GGKKKHSCST KTQSSLDADK KFGRTRSGLQ
160 170 180 190 200
RRERRYGVSS VHDMDSVSSR TVGSRSLRQR LQDTVGLCFP MRTYSKQSKP
210 220 230 240 250
LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV SPHSTFFDTF
260 270 280 290 300
DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG
310 320 330 340 350
PKLAPGMTEI SGDSSAIPQA NCDSEEDTTT LCLQSRRQKQ RQISGDSHTH
360 370 380 390 400
VSRQGAWKVH TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE
410 420 430 440 450
GTFLLRDSAQ EDYLFSVSFR RYNRSLHARI EQWNHNFSFD AHDPCVFHSS
460 470 480 490 500
TVTGLLEHYK DPSSCMFFEP LLTISLNRTF PFSLQYICRA VICRCTTYDG
510 520 530
IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK
Length:536
Mass (Da):61,246
Last modified:November 1, 1998 - v1
Checksum:i0629CDCF2A97E9D8
GO

Sequence cautioni

The sequence BAA31646 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti478R → M in AAH32862 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073958 mRNA Translation: AAD40484.1
AB014571 mRNA Translation: BAA31646.2 Different initiation.
AL136896 mRNA Translation: CAB66830.1
AK290194 mRNA Translation: BAF82883.1
AC020604 Genomic DNA Translation: AAY24289.1
CH471053 Genomic DNA Translation: EAX00236.1
CH471053 Genomic DNA Translation: EAX00237.1
BC032862 mRNA Translation: AAH32862.1
CCDSiCCDS1830.1
PIRiT46499
RefSeqiNP_054730.1, NM_014011.4
NP_659198.1, NM_144949.2
UniGeneiHs.468426

Genome annotation databases

EnsembliENST00000306503; ENSP00000305133; ENSG00000171150
ENST00000394861; ENSP00000378330; ENSG00000171150
GeneIDi9655
KEGGihsa:9655
UCSCiuc002rvf.4 human

Similar proteinsi

Entry informationi

Entry nameiSOCS5_HUMAN
AccessioniPrimary (citable) accession number: O75159
Secondary accession number(s): Q53SD4, Q8IYZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health