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Protein

Cullin-associated NEDD8-dissociated protein 2

Gene

CAND2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • protein ubiquitination Source: GO_Central
  • SCF complex assembly Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Ubl conjugation pathway

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75155

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cullin-associated NEDD8-dissociated protein 2
Alternative name(s):
Cullin-associated and neddylation-dissociated protein 2
Epididymis tissue protein Li 169
TBP-interacting protein of 120 kDa B
Short name:
TBP-interacting protein 120B
p120 CAND2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAND2
Synonyms:KIAA0667, TIP120B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000144712.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30689 CAND2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610403 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75155

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23066

Open Targets

More...
OpenTargetsi
ENSG00000144712

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672208

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAND2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000892972 – 1236Cullin-associated NEDD8-dissociated protein 2Add BLAST1235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated and targeted for proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75155

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75155

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75155

PeptideAtlas

More...
PeptideAtlasi
O75155

PRoteomics IDEntifications database

More...
PRIDEi
O75155

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49823
49824 [O75155-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75155

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75155

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144712 Expressed in 208 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis

CleanEx database of gene expression profiles

More...
CleanExi
HS_CAND2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75155 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75155 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005777

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds TBP, CNOT3 and UBE3C.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116701, 42 interactors

Protein interaction database and analysis system

More...
IntActi
O75155, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387641

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75155

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75155

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2 – 39HEAT 1Add BLAST38
Repeati44 – 81HEAT 2Add BLAST38
Repeati83 – 119HEAT 3Add BLAST37
Repeati129 – 167HEAT 4Add BLAST39
Repeati171 – 208HEAT 5Add BLAST38
Repeati210 – 246HEAT 6Add BLAST37
Repeati254 – 291HEAT 7Add BLAST38
Repeati327 – 368HEAT 8Add BLAST42
Repeati372 – 409HEAT 9Add BLAST38
Repeati432 – 469HEAT 10Add BLAST38
Repeati517 – 554HEAT 11Add BLAST38
Repeati565 – 604HEAT 12Add BLAST40
Repeati608 – 645HEAT 13Add BLAST38
Repeati648 – 685HEAT 14Add BLAST38
Repeati690 – 727HEAT 15Add BLAST38
Repeati731 – 770HEAT 16Add BLAST40
Repeati772 – 813HEAT 17Add BLAST42
Repeati857 – 894HEAT 18Add BLAST38
Repeati896 – 931HEAT 19Add BLAST36
Repeati933 – 966HEAT 20Add BLAST34
Repeati967 – 1003HEAT 21Add BLAST37
Repeati1007 – 1044HEAT 22Add BLAST38
Repeati1048 – 1084HEAT 23Add BLAST37
Repeati1105 – 1141HEAT 24Add BLAST37
Repeati1157 – 1194HEAT 25Add BLAST38
Repeati1204 – 1236HEAT 26Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi343 – 346Poly-Asp4
Compositional biasi490 – 493Poly-Ser4
Compositional biasi614 – 618Poly-Leu5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAND family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1824 Eukaryota
ENOG410XPK4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017740

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000264713

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053467

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75155

Identification of Orthologs from Complete Genome Data

More...
OMAi
KCMAALI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G017Q

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75155

TreeFam database of animal gene trees

More...
TreeFami
TF300355

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120

The PANTHER Classification System

More...
PANTHERi
PTHR12696 PTHR12696, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08623 TIP120, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75155-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTAAFHISS LLEKMTSSDK DFRFMATSDL MSELQKDSIQ LDEDSERKVV
60 70 80 90 100
KMLLRLLEDK NGEVQNLAVK CLGPLVVKVK EYQVETIVDT LCTNMRSDKE
110 120 130 140 150
QLRDIAGIGL KTVLSELPPA ATGSGLATNV CRKITGQLTS AIAQQEDVAV
160 170 180 190 200
QLEALDILSD MLSRLGVPLG AFHASLLHCL LPQLSSPRLA VRKRAVGALG
210 220 230 240 250
HLAAACSTDL FVELADHLLD RLPGPRVPTS PTAIRTLIQC LGSVGRQAGH
260 270 280 290 300
RLGAHLDRLV PLVEDFCNLD DDELRESCLQ AFEAFLRKCP KEMGPHVPNV
310 320 330 340 350
TSLCLQYIKH DPNYNYDSDE DEEQMETEDS EFSEQESEDE YSDDDDMSWK
360 370 380 390 400
VRRAAAKCIA ALISSRPDLL PDFHCTLAPV LIRRFKEREE NVKADVFTAY
410 420 430 440 450
IVLLRQTQPP KGWLEAMEEP TQTGSNLHML RGQVPLVVKA LQRQLKDRSV
460 470 480 490 500
RARQGCFSLL TELAGVLPGS LAEHMPVLVS GIIFSLADRS SSSTIRMDAL
510 520 530 540 550
AFLQGLLGTE PAEAFHPHLP ILLPPVMACV ADSFYKIAAE ALVVLQELVR
560 570 580 590 600
ALWPLHRPRM LDPEPYVGEM SAVTLARLRA TDLDQEVKER AISCMGHLVG
610 620 630 640 650
HLGDRLGDDL EPTLLLLLDR LRNEITRLPA IKALTLVAVS PLQLDLQPIL
660 670 680 690 700
AEALHILASF LRKNQRALRL ATLAALDALA QSQGLSLPPS AVQAVLAELP
710 720 730 740 750
ALVNESDMHV AQLAVDFLAT VTQAQPASLV EVSGPVLSEL LRLLRSPLLP
760 770 780 790 800
AGVLAAAEGF LQALVGTRPP CVDYAKLISL LTAPVYEQAV DGGPGLHKQV
810 820 830 840 850
FHSLARCVAA LSAACPQEAA STASRLVCDA RSPHSSTGVK VLAFLSLAEV
860 870 880 890 900
GQVAGPGHQR ELKAVLLEAL GSPSEDVRAA ASYALGRVGA GSLPDFLPFL
910 920 930 940 950
LEQIEAEPRR QYLLLHSLRE ALGAAQPDSL KPYAEDIWAL LFQRCEGAEE
960 970 980 990 1000
GTRGVVAECI GKLVLVNPSF LLPRLRKQLA AGRPHTRSTV ITAVKFLISD
1010 1020 1030 1040 1050
QPHPIDPLLK SFIGEFMESL QDPDLNVRRA TLAFFNSAVH NKPSLVRDLL
1060 1070 1080 1090 1100
DDILPLLYQE TKIRRDLIRE VEMGPFKHTV DDGLDVRKAA FECMYSLLES
1110 1120 1130 1140 1150
CLGQLDICEF LNHVEDGLKD HYDIRMLTFI MVARLATLCP APVLQRVDRL
1160 1170 1180 1190 1200
IEPLRATCTA KVKAGSVKQE FEKQDELKRS AMRAVAALLT IPEVGKSPIM
1210 1220 1230
ADFSSQIRSN PELAALFESI QKDSASAPST DSMELS
Length:1,236
Mass (Da):135,256
Last modified:May 5, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38F43A7C1B8322A8
GO
Isoform 2 (identifier: O75155-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-71: C → W
     72-164: Missing.
     1014-1037: Missing.

Show »
Length:1,119
Mass (Da):122,664
Checksum:i8206517AA2F8DBD4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JH00C9JH00_HUMAN
Cullin-associated NEDD8-dissociated...
CAND2
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBB8F8WBB8_HUMAN
Cullin-associated NEDD8-dissociated...
CAND2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI36593 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti204A → T in BAA31642 (PubMed:9734811).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055023408Q → R1 PublicationCorresponds to variant dbSNP:rs2305398Ensembl.1
Natural variantiVAR_055024476P → L. Corresponds to variant dbSNP:rs2305397Ensembl.1
Natural variantiVAR_055025533S → P. Corresponds to variant dbSNP:rs3732675Ensembl.1
Natural variantiVAR_055026655H → R. Corresponds to variant dbSNP:rs9838943Ensembl.1
Natural variantiVAR_055027845L → F. Corresponds to variant dbSNP:rs17037287Ensembl.1
Natural variantiVAR_055028858H → P2 PublicationsCorresponds to variant dbSNP:rs3732678Ensembl.1
Natural variantiVAR_055029990V → I. Corresponds to variant dbSNP:rs3817121Ensembl.1
Natural variantiVAR_0550301225A → T1 PublicationCorresponds to variant dbSNP:rs12629133Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03724071C → W in isoform 2. 1 Publication1
Alternative sequenceiVSP_03724172 – 164Missing in isoform 2. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_0372421014 – 1037Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GU727621 mRNA Translation: ADU87623.1
AC034198 Genomic DNA No translation available.
BC136592 mRNA Translation: AAI36593.1 Different initiation.
AB014567 mRNA Translation: BAA31642.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43053.1 [O75155-2]
CCDS54554.1 [O75155-1]

Protein sequence database of the Protein Information Resource

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PIRi
T01239

NCBI Reference Sequences

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RefSeqi
NP_001155971.1, NM_001162499.1 [O75155-1]
NP_036430.1, NM_012298.2 [O75155-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.343664

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000295989; ENSP00000295989; ENSG00000144712 [O75155-2]
ENST00000456430; ENSP00000387641; ENSG00000144712 [O75155-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23066

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23066

UCSC genome browser

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UCSCi
uc003bxj.3 human [O75155-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727621 mRNA Translation: ADU87623.1
AC034198 Genomic DNA No translation available.
BC136592 mRNA Translation: AAI36593.1 Different initiation.
AB014567 mRNA Translation: BAA31642.1
CCDSiCCDS43053.1 [O75155-2]
CCDS54554.1 [O75155-1]
PIRiT01239
RefSeqiNP_001155971.1, NM_001162499.1 [O75155-1]
NP_036430.1, NM_012298.2 [O75155-2]
UniGeneiHs.343664

3D structure databases

ProteinModelPortaliO75155
SMRiO75155
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116701, 42 interactors
IntActiO75155, 7 interactors
STRINGi9606.ENSP00000387641

PTM databases

iPTMnetiO75155
PhosphoSitePlusiO75155

Polymorphism and mutation databases

BioMutaiCAND2

Proteomic databases

EPDiO75155
MaxQBiO75155
PaxDbiO75155
PeptideAtlasiO75155
PRIDEiO75155
ProteomicsDBi49823
49824 [O75155-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295989; ENSP00000295989; ENSG00000144712 [O75155-2]
ENST00000456430; ENSP00000387641; ENSG00000144712 [O75155-1]
GeneIDi23066
KEGGihsa:23066
UCSCiuc003bxj.3 human [O75155-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23066
DisGeNETi23066
EuPathDBiHostDB:ENSG00000144712.11

GeneCards: human genes, protein and diseases

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GeneCardsi
CAND2
HGNCiHGNC:30689 CAND2
HPAiHPA005777
MIMi610403 gene
neXtProtiNX_O75155
OpenTargetsiENSG00000144712
PharmGKBiPA142672208

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1824 Eukaryota
ENOG410XPK4 LUCA
GeneTreeiENSGT00390000017740
HOGENOMiHOG000264713
HOVERGENiHBG053467
InParanoidiO75155
OMAiKCMAALI
OrthoDBiEOG091G017Q
PhylomeDBiO75155
TreeFamiTF300355

Enzyme and pathway databases

SIGNORiO75155

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CAND2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23066

Protein Ontology

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PROi
PR:O75155

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144712 Expressed in 208 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_CAND2
ExpressionAtlasiO75155 baseline and differential
GenevisibleiO75155 HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120
PANTHERiPTHR12696 PTHR12696, 1 hit
PfamiView protein in Pfam
PF08623 TIP120, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAND2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75155
Secondary accession number(s): B9EGM9, E9KL24
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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