Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 155 (16 Oct 2019)
Sequence version 2 (15 Feb 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Clustered mitochondria protein homolog

Gene

CLUH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.UniRule annotation1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clustered mitochondria protein homologUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLUH
Synonyms:KIAA0664
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29094 CLUH

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616184 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75153

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23277

Open Targets

More...
OpenTargetsi
ENSG00000132361

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671614

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75153

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLUH

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001235531 – 1309Clustered mitochondria protein homologAdd BLAST1309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei279PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei654PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei723PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75153

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75153

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O75153

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75153

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75153

PeptideAtlas

More...
PeptideAtlasi
O75153

PRoteomics IDEntifications database

More...
PRIDEi
O75153

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49819

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75153

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75153

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O75153

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132361 Expressed in 223 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75153 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75153 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031505
HPA044346

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116878, 63 interactors

Protein interaction database and analysis system

More...
IntActi
O75153, 28 interactors

Molecular INTeraction database

More...
MINTi
O75153

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000458986

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini335 – 577CluPROSITE-ProRule annotationAdd BLAST243
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati978 – 1011TPR 1Add BLAST34
Repeati1020 – 1053TPR 2Add BLAST34
Repeati1104 – 1137TPR 3Add BLAST34
Repeati1146 – 1179TPR 4Add BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLU family.UniRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1839 Eukaryota
ENOG410XQUQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012485

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113156

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75153

KEGG Orthology (KO)

More...
KOi
K03255

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFPMDGQ

Database of Orthologous Groups

More...
OrthoDBi
60958at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75153

TreeFam database of animal gene trees

More...
TreeFami
TF300565

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15466 CLU-central, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03013 CLU, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027523 CLU
IPR033646 CLU-central
IPR025697 CLU_dom
IPR028275 CLU_N
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13236 CLU, 1 hit
PF15044 CLU_N, 1 hit
PF12807 eIF3_p135, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51823 CLU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O75153-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLNGDCPES LKKEAAAAEP PRENGLDEAG PGDETTGQEV IVIQDTGFSV
60 70 80 90 100
KILAPGIEPF SLQVSPQEMV QEIHQVLMDR EDTCHRTCFS LHLDGNVLDH
110 120 130 140 150
FSELRSVEGL QEGSVLRVVE EPYTVREARI HVRHVRDLLK SLDPSDAFNG
160 170 180 190 200
VDCNSLSFLS VFTDGDLGDS GKRKKGLEMD PIDCTPPEYI LPGSRERPLC
210 220 230 240 250
PLQPQNRDWK PLQCLKVLTM SGWNPPPGNR KMHGDLMYLF VITAEDRQVS
260 270 280 290 300
ITASTRGFYL NQSTAYHFNP KPASPRFLSH SLVELLNQIS PTFKKNFAVL
310 320 330 340 350
QKKRVQRHPF ERIATPFQVY SWTAPQAEHA MDCVRAEDAY TSRLGYEEHI
360 370 380 390 400
PGQTRDWNEE LQTTRELPRK NLPERLLRER AIFKVHSDFT AAATRGAMAV
410 420 430 440 450
IDGNVMAINP SEETKMQMFI WNNIFFSLGF DVRDHYKDFG GDVAAYVAPT
460 470 480 490 500
NDLNGVRTYN AVDVEGLYTL GTVVVDYRGY RVTAQSIIPG ILERDQEQSV
510 520 530 540 550
IYGSIDFGKT VVSHPRYLEL LERTSRPLKI LRHQVLNDRD EEVELCSSVE
560 570 580 590 600
CKGIIGNDGR HYILDLLRTF PPDLNFLPVP GEELPEECAR AGFPRAHRHK
610 620 630 640 650
LCCLRQELVD AFVEHRYLLF MKLAALQLMQ QNASQLETPS SLENGGPSSL
660 670 680 690 700
ESKSEDPPGQ EAGSEEEGSS ASGLAKVKEL AETIAADDGT DPRSREVIRN
710 720 730 740 750
ACKAVGSISS TAFDIRFNPD IFSPGVRFPE SCQDEVRDQK QLLKDAAAFL
760 770 780 790 800
LSCQIPGLVK DCMEHAVLPV DGATLAEVMR QRGINMRYLG KVLELVLRSP
810 820 830 840 850
ARHQLDHVFK IGIGELITRS AKHIFKTYLQ GVELSGLSAA ISHFLNCFLS
860 870 880 890 900
SYPNPVAHLP ADELVSKKRN KRRKNRPPGA ADNTAWAVMT PQELWKNICQ
910 920 930 940 950
EAKNYFDFDL ECETVDQAVE TYGLQKITLL REISLKTGIQ VLLKEYSFDS
960 970 980 990 1000
RHKPAFTEED VLNIFPVVKH VNPKASDAFH FFQSGQAKVQ QGFLKEGCEL
1010 1020 1030 1040 1050
INEALNLFNN VYGAMHVETC ACLRLLARLH YIMGDYAEAL SNQQKAVLMS
1060 1070 1080 1090 1100
ERVMGTEHPN TIQEYMHLAL YCFASSQLST ALSLLYRARY LMLLVFGEDH
1110 1120 1130 1140 1150
PEMALLDNNI GLVLHGVMEY DLSLRFLENA LAVSTKYHGP KALKVALSHH
1160 1170 1180 1190 1200
LVARVYESKA EFRSALQHEK EGYTIYKTQL GEDHEKTKES SEYLKCLTQQ
1210 1220 1230 1240 1250
AVALQRTMNE IYRNGSSANI PPLKFTAPSM ASVLEQLNVI NGILFIPLSQ
1260 1270 1280 1290 1300
KDLENLKAEV ARRHQLQEAS RNRDRAEEPM ATEPAPAGAP GDLGSQPPAA

KDPSPSVQG
Length:1,309
Mass (Da):146,670
Last modified:February 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i715A7BA3A9874D2E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C0R8A0A494C0R8_HUMAN
Clustered mitochondria protein homo...
CLUH
1,348Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2B0I3L2B0_HUMAN
Clustered mitochondria protein homo...
CLUH
1,297Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIG1K7EIG1_HUMAN
Clustered mitochondria protein homo...
CLUH
1,251Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L318I3L318_HUMAN
Clustered mitochondria protein homo...
CLUH
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L350I3L350_HUMAN
Clustered mitochondria protein homo...
CLUH
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3A3I3L3A3_HUMAN
Clustered mitochondria protein homo...
CLUH
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4B5I3L4B5_HUMAN
Clustered mitochondria protein homo...
CLUH
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK023003 differs from that shown. Reason: Frameshift.Curated
The sequence AK125717 differs from that shown. Reason: Frameshift.Curated
The sequence CAH10532 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti220M → T in AK125717 (PubMed:14702039).Curated1
Sequence conflicti432V → A in AAH63786 (PubMed:15489334).Curated1
Sequence conflicti610D → G in AK125717 (PubMed:14702039).Curated1
Sequence conflicti690T → TA in AK023003 (PubMed:14702039).Curated1
Sequence conflicti690T → TA in CAH10532 (PubMed:17974005).Curated1
Sequence conflicti690T → TA in AAH63786 (PubMed:15489334).Curated1
Sequence conflicti868K → E in AK125717 (PubMed:14702039).Curated1
Sequence conflicti1104A → G in AK023003 (PubMed:14702039).Curated1
Sequence conflicti1134S → N in CAH10532 (PubMed:17974005).Curated1
Sequence conflicti1209N → S in AK125717 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034008633A → V1 PublicationCorresponds to variant dbSNP:rs11078312Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK125717 mRNA No translation available.
AK023003 mRNA No translation available.
CR627449 mRNA Translation: CAH10532.1 Different initiation.
AB014564 mRNA Translation: BAA31639.1
BC004266 mRNA Translation: AAH04266.1
BC033614 mRNA Translation: AAH33614.1
BC063786 mRNA Translation: AAH63786.1

NCBI Reference Sequences

More...
RefSeqi
NP_056044.3, NM_015229.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000435359; ENSP00000388872; ENSG00000132361
ENST00000570628; ENSP00000458986; ENSG00000132361

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23277

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23277

UCSC genome browser

More...
UCSCi
uc002fuy.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125717 mRNA No translation available.
AK023003 mRNA No translation available.
CR627449 mRNA Translation: CAH10532.1 Different initiation.
AB014564 mRNA Translation: BAA31639.1
BC004266 mRNA Translation: AAH04266.1
BC033614 mRNA Translation: AAH33614.1
BC063786 mRNA Translation: AAH63786.1
RefSeqiNP_056044.3, NM_015229.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116878, 63 interactors
IntActiO75153, 28 interactors
MINTiO75153
STRINGi9606.ENSP00000458986

PTM databases

iPTMnetiO75153
PhosphoSitePlusiO75153
SwissPalmiO75153

Polymorphism and mutation databases

BioMutaiCLUH

Proteomic databases

EPDiO75153
jPOSTiO75153
MassIVEiO75153
MaxQBiO75153
PaxDbiO75153
PeptideAtlasiO75153
PRIDEiO75153
ProteomicsDBi49819

Genome annotation databases

EnsembliENST00000435359; ENSP00000388872; ENSG00000132361
ENST00000570628; ENSP00000458986; ENSG00000132361
GeneIDi23277
KEGGihsa:23277
UCSCiuc002fuy.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23277
DisGeNETi23277

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CLUH
HGNCiHGNC:29094 CLUH
HPAiHPA031505
HPA044346
MIMi616184 gene
neXtProtiNX_O75153
OpenTargetsiENSG00000132361
PharmGKBiPA142671614

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1839 Eukaryota
ENOG410XQUQ LUCA
GeneTreeiENSGT00390000012485
HOGENOMiHOG000113156
InParanoidiO75153
KOiK03255
OMAiGFPMDGQ
OrthoDBi60958at2759
PhylomeDBiO75153
TreeFamiTF300565

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23277
PharosiO75153

Protein Ontology

More...
PROi
PR:O75153

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132361 Expressed in 223 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiO75153 baseline and differential
GenevisibleiO75153 HS

Family and domain databases

CDDicd15466 CLU-central, 1 hit
Gene3Di1.25.40.10, 1 hit
HAMAPiMF_03013 CLU, 1 hit
InterProiView protein in InterPro
IPR027523 CLU
IPR033646 CLU-central
IPR025697 CLU_dom
IPR028275 CLU_N
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13236 CLU, 1 hit
PF15044 CLU_N, 1 hit
PF12807 eIF3_p135, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS51823 CLU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLU_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75153
Secondary accession number(s): Q6AHY2
, Q6P3X7, Q6ZUG8, Q8N4U7, Q9BTA3, Q9H979
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 15, 2005
Last modified: October 16, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again