UniProtKB - O75152 (ZC11A_HUMAN)
Protein
Zinc finger CCCH domain-containing protein 11A
Gene
ZC3H11A
Organism
Homo sapiens (Human)
Status
Functioni
Involved in nuclear mRNA export; probably mediated by association with the TREX complex.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 2 – 29 | C3H1-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 31 – 57 | C3H1-type 2PROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 60 – 86 | C3H1-type 3PROSITE-ProRule annotationAdd BLAST | 27 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- mRNA binding Source: GO_Central
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA 3'-end processing Source: Reactome
- mRNA export from nucleus Source: Reactome
- poly(A)+ mRNA export from nucleus Source: UniProtKB
- RNA export from nucleus Source: Reactome
Keywordsi
Biological process | mRNA transport, Transport |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O75152 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger CCCH domain-containing protein 11A |
Gene namesi | Name:ZC3H11A Synonyms:KIAA0663, ZC3HDC11A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000058673.15 |
HGNCi | HGNC:29093, ZC3H11A |
MIMi | 613513, gene |
neXtProti | NX_O75152 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9877 |
OpenTargetsi | ENSG00000058673 ENSG00000257315 |
PharmGKBi | PA142670535 |
Miscellaneous databases
Pharosi | O75152, Tbio |
Polymorphism and mutation databases
BioMutai | ZC3H11A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213905 | 1 – 810 | Zinc finger CCCH domain-containing protein 11AAdd BLAST | 810 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 108 | PhosphoserineCombined sources | 1 | |
Cross-linki | 114 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 124 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 132 | PhosphoserineCombined sources | 1 | |
Cross-linki | 140 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 149 | PhosphoserineCombined sources | 1 | |
Modified residuei | 171 | PhosphoserineCombined sources | 1 | |
Modified residuei | 290 | PhosphoserineCombined sources | 1 | |
Modified residuei | 321 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 370 | PhosphoserineCombined sources | 1 | |
Cross-linki | 478 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 619 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1020 |
EPDi | O75152 |
jPOSTi | O75152 |
MassIVEi | O75152 |
MaxQBi | O75152 |
PaxDbi | O75152 |
PeptideAtlasi | O75152 |
PRIDEi | O75152 |
ProteomicsDBi | 49818 |
PTM databases
iPTMneti | O75152 |
MetOSitei | O75152 |
PhosphoSitePlusi | O75152 |
Expressioni
Gene expression databases
Bgeei | ENSG00000058673, Expressed in forebrain and 256 other tissues |
ExpressionAtlasi | O75152, baseline and differential |
Genevisiblei | O75152, HS |
Organism-specific databases
HPAi | ENSG00000058673, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent and indicative for an association with the TREX complex.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 115208, 76 interactors |
IntActi | O75152, 39 interactors |
MINTi | O75152 |
STRINGi | 9606.ENSP00000438527 |
Miscellaneous databases
RNActi | O75152, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 362 – 423 | Sequence analysisAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 161 – 168 | Poly-Asp | 8 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 2 – 29 | C3H1-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 31 – 57 | C3H1-type 2PROSITE-ProRule annotationAdd BLAST | 27 | |
Zinc fingeri | 60 – 86 | C3H1-type 3PROSITE-ProRule annotationAdd BLAST | 27 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG4791, Eukaryota |
GeneTreei | ENSGT00920000149095 |
HOGENOMi | CLU_019514_1_0_1 |
InParanoidi | O75152 |
OMAi | YFYSTCT |
OrthoDBi | 265128at2759 |
PhylomeDBi | O75152 |
TreeFami | TF335608 |
Family and domain databases
InterProi | View protein in InterPro IPR041686, Znf-CCCH_3 IPR000571, Znf_CCCH |
Pfami | View protein in Pfam PF15663, zf-CCCH_3, 1 hit |
SMARTi | View protein in SMART SM00356, ZnF_C3H1, 3 hits |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O75152-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPNQGEDCYF FFYSTCTKGD SCPFRHCEAA IGNETVCTLW QEGRCFRQVC
60 70 80 90 100
RFRHMEIDKK RSEIPCYWEN QPTGCQKLNC AFHHNRGRYV DGLFLPPSKT
110 120 130 140 150
VLPTVPESPE EEVKASQLSV QQNKLSVQSN PSPQLRSVMK VESSENVPSP
160 170 180 190 200
THPPVVINAA DDDEDDDDQF SEEGDETKTP TLQPTPEVHN GLRVTSVRKP
210 220 230 240 250
AVNIKQGECL NFGIKTLEEI KSKKMKEKSK KQGEGSSGVS SLLLHPEPVP
260 270 280 290 300
GPEKENVRTV VRTVTLSTKQ GEEPLVRLSL TERLGKRKFS AGGDSDPPLK
310 320 330 340 350
RSLAQRLGKK VEAPETNIDK TPKKAQVSKS LKERLGMSAD PDNEDATDKV
360 370 380 390 400
NKVGEIHVKT LEEILLERAS QKRGELQTKL KTEGPSKTDD STSGARSSST
410 420 430 440 450
IRIKTFSEVL AEKKHRQQEA ERQKSKKDTT CIKLKIDSEI KKTVVLPPIV
460 470 480 490 500
ASRGQSEEPA GKTKSMQEVH IKTLEEIKLE KALRVQQSSE SSTSSPSQHE
510 520 530 540 550
ATPGARRLLR ITKRTGMKEE KNLQEGNEVD SQSSIRTEAK EASGETTGVD
560 570 580 590 600
ITKIQVKRCE TMREKHMQKQ QEREKSVLTP LRGDVASCNT QVAEKPVLTA
610 620 630 640 650
VPGITRHLTK RLPTKSSQKV EVETSGIGDS LLNVKCAAQT LEKRGKAKPK
660 670 680 690 700
VNVKPSVVKV VSSPKLAPKR KAVEMHAAVI AAVKPLSSSS VLQEPPAKKA
710 720 730 740 750
AVAVVPLVSE DKSVTVPEAE NPRDSLVLPP TQSSSDSSPP EVSGPSSSQM
760 770 780 790 800
SMKTRRLSSA STGKPPLSVE DDFEKLIWEI SGGKLEAEID LDPGKDEDDL
810
LLELSEMIDS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PBY7 | E9PBY7_HUMAN | Zinc finger CCCH domain-containing ... | ZC3H11A | 515 | Annotation score: | ||
E9PQ61 | E9PQ61_HUMAN | Zinc finger CCCH domain-containing ... | ZC3H11A | 652 | Annotation score: | ||
A0A1W2PPR9 | A0A1W2PPR9_HUMAN | Zinc finger CCCH domain-containing ... | ZC3H11A | 301 | Annotation score: | ||
C9J0L0 | C9J0L0_HUMAN | Zinc finger CCCH domain-containing ... | ZC3H11A | 50 | Annotation score: |
Sequence cautioni
The sequence BAA31638 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH10553 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 80 | C → Y in CAH10553 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 246 | P → L in CAH10530 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 266 | L → P in CAH10525 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 277 | R → G in CAH10530 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 409 | V → G in CAH10525 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 412 | E → K in CAH10525 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 616 | S → P in CAH10566 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052967 | 640 | T → N. Corresponds to variant dbSNP:rs11240604Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB014563 mRNA Translation: BAA31638.2 Different initiation. CR627439 mRNA Translation: CAH10525.1 CR627446 mRNA Translation: CAH10530.1 BX648271 mRNA Translation: CAH10553.1 Sequence problems. BX649148 mRNA Translation: CAH10566.1 BC014268 mRNA Translation: AAH14268.1 |
CCDSi | CCDS30978.1 |
PIRi | T00368 |
RefSeqi | NP_001306167.1, NM_001319238.1 NP_001306168.1, NM_001319239.1 NP_055642.3, NM_014827.5 XP_005245700.1, XM_005245643.2 XP_005245701.1, XM_005245644.3 XP_006711736.1, XM_006711673.2 XP_011508501.1, XM_011510199.1 XP_011508502.1, XM_011510200.1 XP_011508503.1, XM_011510201.1 XP_011508504.1, XM_011510202.1 XP_016858445.1, XM_017002956.1 XP_016858446.1, XM_017002957.1 XP_016858447.1, XM_017002958.1 XP_016858448.1, XM_017002959.1 |
Genome annotation databases
Ensembli | ENST00000332127; ENSP00000333253; ENSG00000058673 ENST00000367210; ENSP00000356179; ENSG00000058673 ENST00000367212; ENSP00000356181; ENSG00000058673 ENST00000367214; ENSP00000356183; ENSG00000058673 ENST00000639812; ENSP00000491830; ENSG00000058673 |
GeneIDi | 9877 |
KEGGi | hsa:9877 |
UCSCi | uc001hac.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB014563 mRNA Translation: BAA31638.2 Different initiation. CR627439 mRNA Translation: CAH10525.1 CR627446 mRNA Translation: CAH10530.1 BX648271 mRNA Translation: CAH10553.1 Sequence problems. BX649148 mRNA Translation: CAH10566.1 BC014268 mRNA Translation: AAH14268.1 |
CCDSi | CCDS30978.1 |
PIRi | T00368 |
RefSeqi | NP_001306167.1, NM_001319238.1 NP_001306168.1, NM_001319239.1 NP_055642.3, NM_014827.5 XP_005245700.1, XM_005245643.2 XP_005245701.1, XM_005245644.3 XP_006711736.1, XM_006711673.2 XP_011508501.1, XM_011510199.1 XP_011508502.1, XM_011510200.1 XP_011508503.1, XM_011510201.1 XP_011508504.1, XM_011510202.1 XP_016858445.1, XM_017002956.1 XP_016858446.1, XM_017002957.1 XP_016858447.1, XM_017002958.1 XP_016858448.1, XM_017002959.1 |
3D structure databases
SMRi | O75152 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115208, 76 interactors |
IntActi | O75152, 39 interactors |
MINTi | O75152 |
STRINGi | 9606.ENSP00000438527 |
PTM databases
iPTMneti | O75152 |
MetOSitei | O75152 |
PhosphoSitePlusi | O75152 |
Polymorphism and mutation databases
BioMutai | ZC3H11A |
Proteomic databases
CPTACi | CPTAC-1020 |
EPDi | O75152 |
jPOSTi | O75152 |
MassIVEi | O75152 |
MaxQBi | O75152 |
PaxDbi | O75152 |
PeptideAtlasi | O75152 |
PRIDEi | O75152 |
ProteomicsDBi | 49818 |
Protocols and materials databases
Antibodypediai | 34548, 133 antibodies |
Genome annotation databases
Ensembli | ENST00000332127; ENSP00000333253; ENSG00000058673 ENST00000367210; ENSP00000356179; ENSG00000058673 ENST00000367212; ENSP00000356181; ENSG00000058673 ENST00000367214; ENSP00000356183; ENSG00000058673 ENST00000639812; ENSP00000491830; ENSG00000058673 |
GeneIDi | 9877 |
KEGGi | hsa:9877 |
UCSCi | uc001hac.4, human |
Organism-specific databases
CTDi | 9877 |
DisGeNETi | 9877 |
EuPathDBi | HostDB:ENSG00000058673.15 |
GeneCardsi | ZC3H11A |
HGNCi | HGNC:29093, ZC3H11A |
HPAi | ENSG00000058673, Low tissue specificity |
MIMi | 613513, gene |
neXtProti | NX_O75152 |
OpenTargetsi | ENSG00000058673 ENSG00000257315 |
PharmGKBi | PA142670535 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4791, Eukaryota |
GeneTreei | ENSGT00920000149095 |
HOGENOMi | CLU_019514_1_0_1 |
InParanoidi | O75152 |
OMAi | YFYSTCT |
OrthoDBi | 265128at2759 |
PhylomeDBi | O75152 |
TreeFami | TF335608 |
Enzyme and pathway databases
PathwayCommonsi | O75152 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
Miscellaneous databases
BioGRID-ORCSi | 9877, 43 hits in 845 CRISPR screens |
ChiTaRSi | ZC3H11A, human |
GeneWikii | ZC3H11A |
GenomeRNAii | 9877 |
Pharosi | O75152, Tbio |
PROi | PR:O75152 |
RNActi | O75152, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000058673, Expressed in forebrain and 256 other tissues |
ExpressionAtlasi | O75152, baseline and differential |
Genevisiblei | O75152, HS |
Family and domain databases
InterProi | View protein in InterPro IPR041686, Znf-CCCH_3 IPR000571, Znf_CCCH |
Pfami | View protein in Pfam PF15663, zf-CCCH_3, 1 hit |
SMARTi | View protein in SMART SM00356, ZnF_C3H1, 3 hits |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZC11A_HUMAN | |
Accessioni | O75152Primary (citable) accession number: O75152 Secondary accession number(s): Q6AHY4 Q86XZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | August 16, 2005 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations