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UniProtKB - O75152 (ZC11A_HUMAN)

Entry version 174 (29 Sep 2021)
Sequence version 3 (16 Aug 2005)
Previous versions | rss
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Protein

Zinc finger CCCH domain-containing protein 11A

Gene

ZC3H11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that interacts with purine-rich sequences and is involved in nuclear mRNA export; probably mediated by association with the TREX complex.

2 Publications

(Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA Export.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2 – 29C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri31 – 57C3H1-type 2PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri60 – 86C3H1-type 3PROSITE-ProRule annotationAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • poly(A)+ mRNA export from nucleus Source: UniProtKB
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75152

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187, mRNA 3'-end processing
R-HSA-73856, RNA Polymerase II Transcription Termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 11A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3H11A
Synonyms:KIAA0663, ZC3HDC11A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29093, ZC3H11A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613513, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75152

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000058673

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9877

Open Targets

More...OpenTargetsi		ENSG00000058673

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670535

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75152, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZC3H11A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002139051 – 810Zinc finger CCCH domain-containing protein 11AAdd BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei108PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei132PhosphoserineCombined sources1
Cross-linki140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei149PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei321PhosphothreonineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki619Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1020

Encyclopedia of Proteome Dynamics

More...EPDi		O75152

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75152

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75152

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75152

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75152

PeptideAtlas

More...PeptideAtlasi		O75152

PRoteomics IDEntifications database

More...PRIDEi		O75152

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49818

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O75152, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75152

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O75152

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75152

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By heat shock treatment.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000058673, Expressed in forebrain and 257 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75152, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75152, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000058673, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent and indicative for an association with the TREX complex.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115208, 89 interactors

Protein interaction database and analysis system

More...IntActi		O75152, 42 interactors

Molecular INTeraction database

More...MINTi		O75152

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000438527

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75152, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75152

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni139 – 194DisorderedSequence analysisAdd BLAST56
Regioni223 – 258DisorderedSequence analysisAdd BLAST36
Regioni285 – 351DisorderedSequence analysisAdd BLAST67
Regioni367 – 432DisorderedSequence analysisAdd BLAST66
Regioni482 – 549DisorderedSequence analysisAdd BLAST68
Regioni715 – 768DisorderedSequence analysisAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili362 – 423Sequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi176 – 190Polar residuesSequence analysisAdd BLAST15
Compositional biasi303 – 319Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi325 – 351Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi367 – 386Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi387 – 405Polar residuesSequence analysisAdd BLAST19
Compositional biasi407 – 432Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi484 – 501Polar residuesSequence analysisAdd BLAST18
Compositional biasi512 – 526Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi527 – 541Polar residuesSequence analysisAdd BLAST15
Compositional biasi726 – 765Polar residuesSequence analysisAdd BLAST40

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 29C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri31 – 57C3H1-type 2PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri60 – 86C3H1-type 3PROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4791, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00920000149095

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019514_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75152

Identification of Orthologs from Complete Genome Data

More...OMAi		CAFFHER

Database of Orthologous Groups

More...OrthoDBi		265128at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75152

TreeFam database of animal gene trees

More...TreeFami		TF335608

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041686, Znf-CCCH_3
IPR000571, Znf_CCCH

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15663, zf-CCCH_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00356, ZnF_C3H1, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50103, ZF_C3H1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O75152-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNQGEDCYF FFYSTCTKGD SCPFRHCEAA IGNETVCTLW QEGRCFRQVC 
        60         70         80         90        100
RFRHMEIDKK RSEIPCYWEN QPTGCQKLNC AFHHNRGRYV DGLFLPPSKT 
       110        120        130        140        150
VLPTVPESPE EEVKASQLSV QQNKLSVQSN PSPQLRSVMK VESSENVPSP 
       160        170        180        190        200
THPPVVINAA DDDEDDDDQF SEEGDETKTP TLQPTPEVHN GLRVTSVRKP 
       210        220        230        240        250
AVNIKQGECL NFGIKTLEEI KSKKMKEKSK KQGEGSSGVS SLLLHPEPVP 
       260        270        280        290        300
GPEKENVRTV VRTVTLSTKQ GEEPLVRLSL TERLGKRKFS AGGDSDPPLK 
       310        320        330        340        350
RSLAQRLGKK VEAPETNIDK TPKKAQVSKS LKERLGMSAD PDNEDATDKV 
       360        370        380        390        400
NKVGEIHVKT LEEILLERAS QKRGELQTKL KTEGPSKTDD STSGARSSST 
       410        420        430        440        450
IRIKTFSEVL AEKKHRQQEA ERQKSKKDTT CIKLKIDSEI KKTVVLPPIV 
       460        470        480        490        500
ASRGQSEEPA GKTKSMQEVH IKTLEEIKLE KALRVQQSSE SSTSSPSQHE 
       510        520        530        540        550
ATPGARRLLR ITKRTGMKEE KNLQEGNEVD SQSSIRTEAK EASGETTGVD 
       560        570        580        590        600
ITKIQVKRCE TMREKHMQKQ QEREKSVLTP LRGDVASCNT QVAEKPVLTA 
       610        620        630        640        650
VPGITRHLTK RLPTKSSQKV EVETSGIGDS LLNVKCAAQT LEKRGKAKPK 
       660        670        680        690        700
VNVKPSVVKV VSSPKLAPKR KAVEMHAAVI AAVKPLSSSS VLQEPPAKKA 
       710        720        730        740        750
AVAVVPLVSE DKSVTVPEAE NPRDSLVLPP TQSSSDSSPP EVSGPSSSQM 
       760        770        780        790        800
SMKTRRLSSA STGKPPLSVE DDFEKLIWEI SGGKLEAEID LDPGKDEDDL 
       810
LLELSEMIDS
Length:810
Mass (Da):89,131
Last modified:August 16, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9048ABC7F4A372FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBY7E9PBY7_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H11A
515Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ61E9PQ61_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H11A
652Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPR9A0A1W2PPR9_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H11A
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0L0C9J0L0_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H11A
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31638 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH10553 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti80C → Y in CAH10553 (PubMed:17974005).Curated1
Sequence conflicti246P → L in CAH10530 (PubMed:17974005).Curated1
Sequence conflicti266L → P in CAH10525 (PubMed:17974005).Curated1
Sequence conflicti277R → G in CAH10530 (PubMed:17974005).Curated1
Sequence conflicti409V → G in CAH10525 (PubMed:17974005).Curated1
Sequence conflicti412E → K in CAH10525 (PubMed:17974005).Curated1
Sequence conflicti616S → P in CAH10566 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052967640T → N. Corresponds to variant dbSNP:rs11240604Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB014563 mRNA Translation: BAA31638.2 Different initiation.
CR627439 mRNA Translation: CAH10525.1
CR627446 mRNA Translation: CAH10530.1
BX648271 mRNA Translation: CAH10553.1 Sequence problems.
BX649148 mRNA Translation: CAH10566.1
BC014268 mRNA Translation: AAH14268.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30978.1

Protein sequence database of the Protein Information Resource

More...PIRi		T00368

NCBI Reference Sequences

More...RefSeqi		NP_001306167.1, NM_001319238.1
NP_001306168.1, NM_001319239.1
NP_055642.3, NM_014827.5
XP_005245700.1, XM_005245643.2
XP_005245701.1, XM_005245644.3
XP_006711736.1, XM_006711673.2
XP_011508501.1, XM_011510199.1
XP_011508502.1, XM_011510200.1
XP_011508503.1, XM_011510201.1
XP_011508504.1, XM_011510202.1
XP_016858445.1, XM_017002956.1
XP_016858446.1, XM_017002957.1
XP_016858447.1, XM_017002958.1
XP_016858448.1, XM_017002959.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000332127; ENSP00000333253; ENSG00000058673
ENST00000367210; ENSP00000356179; ENSG00000058673
ENST00000367212; ENSP00000356181; ENSG00000058673
ENST00000367214; ENSP00000356183; ENSG00000058673
ENST00000639812; ENSP00000491830; ENSG00000058673

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9877

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9877

UCSC genome browser

More...UCSCi		uc001hac.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014563 mRNA Translation: BAA31638.2 Different initiation.
CR627439 mRNA Translation: CAH10525.1
CR627446 mRNA Translation: CAH10530.1
BX648271 mRNA Translation: CAH10553.1 Sequence problems.
BX649148 mRNA Translation: CAH10566.1
BC014268 mRNA Translation: AAH14268.1
CCDSiCCDS30978.1
PIRiT00368
RefSeqiNP_001306167.1, NM_001319238.1
NP_001306168.1, NM_001319239.1
NP_055642.3, NM_014827.5
XP_005245700.1, XM_005245643.2
XP_005245701.1, XM_005245644.3
XP_006711736.1, XM_006711673.2
XP_011508501.1, XM_011510199.1
XP_011508502.1, XM_011510200.1
XP_011508503.1, XM_011510201.1
XP_011508504.1, XM_011510202.1
XP_016858445.1, XM_017002956.1
XP_016858446.1, XM_017002957.1
XP_016858447.1, XM_017002958.1
XP_016858448.1, XM_017002959.1

3D structure databases

SMRiO75152
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115208, 89 interactors
IntActiO75152, 42 interactors
MINTiO75152
STRINGi9606.ENSP00000438527

PTM databases

GlyGeniO75152, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO75152
MetOSiteiO75152
PhosphoSitePlusiO75152

Genetic variation databases

BioMutaiZC3H11A

Proteomic databases

CPTACiCPTAC-1020
EPDiO75152
jPOSTiO75152
MassIVEiO75152
MaxQBiO75152
PaxDbiO75152
PeptideAtlasiO75152
PRIDEiO75152
ProteomicsDBi49818

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34548, 139 antibodies

The DNASU plasmid repository

More...DNASUi		9877

Genome annotation databases

EnsembliENST00000332127; ENSP00000333253; ENSG00000058673
ENST00000367210; ENSP00000356179; ENSG00000058673
ENST00000367212; ENSP00000356181; ENSG00000058673
ENST00000367214; ENSP00000356183; ENSG00000058673
ENST00000639812; ENSP00000491830; ENSG00000058673
GeneIDi9877
KEGGihsa:9877
UCSCiuc001hac.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9877
DisGeNETi9877

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZC3H11A
HGNCiHGNC:29093, ZC3H11A
HPAiENSG00000058673, Low tissue specificity
MIMi613513, gene
neXtProtiNX_O75152
OpenTargetsiENSG00000058673
PharmGKBiPA142670535
VEuPathDBiHostDB:ENSG00000058673

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4791, Eukaryota
GeneTreeiENSGT00920000149095
HOGENOMiCLU_019514_1_0_1
InParanoidiO75152
OMAiCAFFHER
OrthoDBi265128at2759
PhylomeDBiO75152
TreeFamiTF335608

Enzyme and pathway databases

PathwayCommonsiO75152
ReactomeiR-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187, mRNA 3'-end processing
R-HSA-73856, RNA Polymerase II Transcription Termination

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9877, 48 hits in 1021 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZC3H11A, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZC3H11A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9877
PharosiO75152, Tbio

Protein Ontology

More...PROi		PR:O75152
RNActiO75152, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000058673, Expressed in forebrain and 257 other tissues
ExpressionAtlasiO75152, baseline and differential
GenevisibleiO75152, HS

Family and domain databases

InterProiView protein in InterPro
IPR041686, Znf-CCCH_3
IPR000571, Znf_CCCH
PfamiView protein in Pfam
PF15663, zf-CCCH_3, 1 hit
SMARTiView protein in SMART
SM00356, ZnF_C3H1, 3 hits
PROSITEiView protein in PROSITE
PS50103, ZF_C3H1, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZC11A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75152
Secondary accession number(s): Q6AHY4
, Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: September 29, 2021
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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