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Protein

Zinc finger CCCH domain-containing protein 11A

Gene

ZC3H11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 29C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri31 – 57C3H1-type 2PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri60 – 86C3H1-type 3PROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

  • mRNA 3'-end processing Source: Reactome
  • mRNA export from nucleus Source: Reactome
  • poly(A)+ mRNA export from nucleus Source: UniProtKB
  • RNA export from nucleus Source: Reactome

Keywordsi

Biological processmRNA transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 11A
Gene namesi
Name:ZC3H11A
Synonyms:KIAA0663, ZC3HDC11A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000058673.15
HGNCiHGNC:29093 ZC3H11A
MIMi613513 gene
neXtProtiNX_O75152

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9877
OpenTargetsiENSG00000058673
ENSG00000257315
PharmGKBiPA142670535

Polymorphism and mutation databases

BioMutaiZC3H11A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139051 – 810Zinc finger CCCH domain-containing protein 11AAdd BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphoserineCombined sources1
Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei132PhosphoserineCombined sources1
Cross-linki140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei149PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei321PhosphothreonineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki619Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO75152
MaxQBiO75152
PaxDbiO75152
PeptideAtlasiO75152
PRIDEiO75152
ProteomicsDBi49818

PTM databases

iPTMnetiO75152
PhosphoSitePlusiO75152

Expressioni

Gene expression databases

BgeeiENSG00000058673 Expressed in 245 organ(s), highest expression level in forebrain
CleanExiHS_ZC3H11A
ExpressionAtlasiO75152 baseline and differential
GenevisibleiO75152 HS

Organism-specific databases

HPAiHPA026439
HPA028490
HPA028526

Interactioni

Subunit structurei

Interacts with THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent and indicative for an association with the TREX complex.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi115208, 66 interactors
IntActiO75152, 20 interactors
MINTiO75152
STRINGi9606.ENSP00000333253

Structurei

3D structure databases

ProteinModelPortaliO75152
SMRiO75152
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili362 – 423Sequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi161 – 168Poly-Asp8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 29C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri31 – 57C3H1-type 2PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri60 – 86C3H1-type 3PROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4791 Eukaryota
ENOG41101ZI LUCA
GeneTreeiENSGT00530000063354
ENSGT00920000149095
HOVERGENiHBG082979
InParanoidiO75152
KOiK22415
OMAiDVTCIKL
OrthoDBiEOG091G0KPN
PhylomeDBiO75152
TreeFamiTF335608

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 3 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

O75152-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNQGEDCYF FFYSTCTKGD SCPFRHCEAA IGNETVCTLW QEGRCFRQVC
60 70 80 90 100
RFRHMEIDKK RSEIPCYWEN QPTGCQKLNC AFHHNRGRYV DGLFLPPSKT
110 120 130 140 150
VLPTVPESPE EEVKASQLSV QQNKLSVQSN PSPQLRSVMK VESSENVPSP
160 170 180 190 200
THPPVVINAA DDDEDDDDQF SEEGDETKTP TLQPTPEVHN GLRVTSVRKP
210 220 230 240 250
AVNIKQGECL NFGIKTLEEI KSKKMKEKSK KQGEGSSGVS SLLLHPEPVP
260 270 280 290 300
GPEKENVRTV VRTVTLSTKQ GEEPLVRLSL TERLGKRKFS AGGDSDPPLK
310 320 330 340 350
RSLAQRLGKK VEAPETNIDK TPKKAQVSKS LKERLGMSAD PDNEDATDKV
360 370 380 390 400
NKVGEIHVKT LEEILLERAS QKRGELQTKL KTEGPSKTDD STSGARSSST
410 420 430 440 450
IRIKTFSEVL AEKKHRQQEA ERQKSKKDTT CIKLKIDSEI KKTVVLPPIV
460 470 480 490 500
ASRGQSEEPA GKTKSMQEVH IKTLEEIKLE KALRVQQSSE SSTSSPSQHE
510 520 530 540 550
ATPGARRLLR ITKRTGMKEE KNLQEGNEVD SQSSIRTEAK EASGETTGVD
560 570 580 590 600
ITKIQVKRCE TMREKHMQKQ QEREKSVLTP LRGDVASCNT QVAEKPVLTA
610 620 630 640 650
VPGITRHLTK RLPTKSSQKV EVETSGIGDS LLNVKCAAQT LEKRGKAKPK
660 670 680 690 700
VNVKPSVVKV VSSPKLAPKR KAVEMHAAVI AAVKPLSSSS VLQEPPAKKA
710 720 730 740 750
AVAVVPLVSE DKSVTVPEAE NPRDSLVLPP TQSSSDSSPP EVSGPSSSQM
760 770 780 790 800
SMKTRRLSSA STGKPPLSVE DDFEKLIWEI SGGKLEAEID LDPGKDEDDL
810
LLELSEMIDS
Length:810
Mass (Da):89,131
Last modified:August 16, 2005 - v3
Checksum:i9048ABC7F4A372FB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBY7E9PBY7_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H11A
515Annotation score:
E9PQ61E9PQ61_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H11A
652Annotation score:
C9J0L0C9J0L0_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H11A
50Annotation score:
A0A1W2PPR9A0A1W2PPR9_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H11A
301Annotation score:

Sequence cautioni

The sequence BAA31638 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH10553 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80C → Y in CAH10553 (PubMed:17974005).Curated1
Sequence conflicti246P → L in CAH10530 (PubMed:17974005).Curated1
Sequence conflicti266L → P in CAH10525 (PubMed:17974005).Curated1
Sequence conflicti277R → G in CAH10530 (PubMed:17974005).Curated1
Sequence conflicti409V → G in CAH10525 (PubMed:17974005).Curated1
Sequence conflicti412E → K in CAH10525 (PubMed:17974005).Curated1
Sequence conflicti616S → P in CAH10566 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052967640T → N. Corresponds to variant dbSNP:rs11240604Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014563 mRNA Translation: BAA31638.2 Different initiation.
CR627439 mRNA Translation: CAH10525.1
CR627446 mRNA Translation: CAH10530.1
BX648271 mRNA Translation: CAH10553.1 Sequence problems.
BX649148 mRNA Translation: CAH10566.1
BC014268 mRNA Translation: AAH14268.1
CCDSiCCDS30978.1
PIRiT00368
RefSeqiNP_001306167.1, NM_001319238.1
NP_001306168.1, NM_001319239.1
NP_055642.3, NM_014827.5
XP_005245700.1, XM_005245643.2
XP_005245701.1, XM_005245644.3
XP_006711736.1, XM_006711673.2
XP_011508501.1, XM_011510199.1
XP_011508502.1, XM_011510200.1
XP_011508503.1, XM_011510201.1
XP_011508504.1, XM_011510202.1
XP_016858445.1, XM_017002956.1
XP_016858446.1, XM_017002957.1
XP_016858447.1, XM_017002958.1
XP_016858448.1, XM_017002959.1
UniGeneiHs.532399
Hs.732801

Genome annotation databases

EnsembliENST00000332127; ENSP00000333253; ENSG00000058673
ENST00000367210; ENSP00000356179; ENSG00000058673
ENST00000367212; ENSP00000356181; ENSG00000058673
ENST00000367214; ENSP00000356183; ENSG00000058673
ENST00000639812; ENSP00000491830; ENSG00000058673
GeneIDi9877
KEGGihsa:9877
UCSCiuc001hac.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZC11A_HUMAN
AccessioniPrimary (citable) accession number: O75152
Secondary accession number(s): Q6AHY4
, Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: September 12, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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