ZC3H11A

Functionⁱ

Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	2 – 29	C3H1-type 1PROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	31 – 57	C3H1-type 2PROSITE-ProRule annotationAdd BLAST	27
Zinc fingerⁱ	60 – 86	C3H1-type 3PROSITE-ProRule annotationAdd BLAST	27

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
RNA polymerase II transcription factor activity, sequence-specific DNA binding
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA 3'-end processing Source: Reactome
mRNA export from nucleus Source: Reactome
poly(A)+ mRNA export from nucleus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22928037
RNA export from nucleus Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA transport, Transport
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187 mRNA 3'-end processing

Reactomeⁱ

R-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187 mRNA 3'-end processing

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger CCCH domain-containing protein 11A
Gene namesⁱ	Name:ZC3H11A Synonyms:KIAA0663, ZC3HDC11A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000058673.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29093 ZC3H11A
MIMⁱ	613513 gene
neXtProtⁱ	NX_O75152

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9877
Open Targets More...OpenTargetsⁱ	ENSG00000058673 ENSG00000257315
PharmGKBⁱ	PA142670535

Polymorphism and mutation databases

BioMutaⁱ	ZC3H11A

BioMutaⁱ

ZC3H11A

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000213905	1 – 810	Zinc finger CCCH domain-containing protein 11AAdd BLAST		810

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	108	PhosphoserineCombined sources	1
Cross-linkⁱ	114	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	124	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	132	PhosphoserineCombined sources	1
Cross-linkⁱ	140	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	149	PhosphoserineCombined sources	1
Modified residueⁱ	171	PhosphoserineCombined sources	1
Modified residueⁱ	290	PhosphoserineCombined sources	1
Modified residueⁱ	321	PhosphothreonineCombined sources	1
Modified residueⁱ	370	PhosphoserineCombined sources	1
Cross-linkⁱ	478	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	619	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O75152
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75152
PaxDbⁱ	O75152
PeptideAtlas More...PeptideAtlasⁱ	O75152
PRIDEⁱ	O75152
ProteomicsDBⁱ	49818

PTM databases

iPTMnetⁱ	O75152
PhosphoSitePlusⁱ	O75152

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000058673 Expressed in 245 organ(s), highest expression level in forebrain
CleanExⁱ	HS_ZC3H11A
ExpressionAtlasⁱ	O75152 baseline and differential
Genevisibleⁱ	O75152 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026439 HPA028490 HPA028526

HPAⁱ

HPA026439
HPA028490
HPA028526

Interactionⁱ

Subunit structureⁱ

Interacts with THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent and indicative for an association with the TREX complex.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FOXM1	Q08050	2	EBI-748480,EBI-866480
MLH1	P40692	3	EBI-748480,EBI-744248

Protein-protein interaction databases

BioGridⁱ	115208, 66 interactors
IntActⁱ	O75152, 20 interactors
Molecular INTeraction database More...MINTⁱ	O75152
STRINGⁱ	9606.ENSP00000333253

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75152
SMRⁱ	O75152
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	362 – 423	Sequence analysisAdd BLAST		62

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	161 – 168	Poly-Asp		8

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	2 – 29	C3H1-type 1PROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	31 – 57	C3H1-type 2PROSITE-ProRule annotationAdd BLAST	27
Zinc fingerⁱ	60 – 86	C3H1-type 3PROSITE-ProRule annotationAdd BLAST	27

Keywords - Domainⁱ

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4791 Eukaryota ENOG41101ZI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063354 ENSGT00920000149095
HOVERGENⁱ	HBG082979
InParanoidⁱ	O75152
KEGG Orthology (KO) More...KOⁱ	K22415
OMAⁱ	DVTCIKL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KPN
PhylomeDBⁱ	O75152
TreeFamⁱ	TF335608

Family and domain databases

InterProⁱ	View protein in InterPro IPR000571 Znf_CCCH
SMARTⁱ	View protein in SMART SM00356 ZnF_C3H1, 3 hits
PROSITEⁱ	View protein in PROSITE PS50103 ZF_C3H1, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.ⁱShow all

O75152-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPNQGEDCYF FFYSTCTKGD SCPFRHCEAA IGNETVCTLW QEGRCFRQVC 
        60         70         80         90        100
RFRHMEIDKK RSEIPCYWEN QPTGCQKLNC AFHHNRGRYV DGLFLPPSKT 
       110        120        130        140        150
VLPTVPESPE EEVKASQLSV QQNKLSVQSN PSPQLRSVMK VESSENVPSP 
       160        170        180        190        200
THPPVVINAA DDDEDDDDQF SEEGDETKTP TLQPTPEVHN GLRVTSVRKP 
       210        220        230        240        250
AVNIKQGECL NFGIKTLEEI KSKKMKEKSK KQGEGSSGVS SLLLHPEPVP 
       260        270        280        290        300
GPEKENVRTV VRTVTLSTKQ GEEPLVRLSL TERLGKRKFS AGGDSDPPLK 
       310        320        330        340        350
RSLAQRLGKK VEAPETNIDK TPKKAQVSKS LKERLGMSAD PDNEDATDKV 
       360        370        380        390        400
NKVGEIHVKT LEEILLERAS QKRGELQTKL KTEGPSKTDD STSGARSSST 
       410        420        430        440        450
IRIKTFSEVL AEKKHRQQEA ERQKSKKDTT CIKLKIDSEI KKTVVLPPIV 
       460        470        480        490        500
ASRGQSEEPA GKTKSMQEVH IKTLEEIKLE KALRVQQSSE SSTSSPSQHE 
       510        520        530        540        550
ATPGARRLLR ITKRTGMKEE KNLQEGNEVD SQSSIRTEAK EASGETTGVD 
       560        570        580        590        600
ITKIQVKRCE TMREKHMQKQ QEREKSVLTP LRGDVASCNT QVAEKPVLTA 
       610        620        630        640        650
VPGITRHLTK RLPTKSSQKV EVETSGIGDS LLNVKCAAQT LEKRGKAKPK 
       660        670        680        690        700
VNVKPSVVKV VSSPKLAPKR KAVEMHAAVI AAVKPLSSSS VLQEPPAKKA 
       710        720        730        740        750
AVAVVPLVSE DKSVTVPEAE NPRDSLVLPP TQSSSDSSPP EVSGPSSSQM 
       760        770        780        790        800
SMKTRRLSSA STGKPPLSVE DDFEKLIWEI SGGKLEAEID LDPGKDEDDL 
       810
LLELSEMIDS

Length:810

Mass (Da):89,131

Last modified:August 16, 2005 - v3

Checksum:ⁱ9048ABC7F4A372FB

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
E9PBY7	E9PBY7_HUMAN	Zinc finger CCCH domain-containing ... Zinc finger CCCH domain-containing protein 11A	ZC3H11A	515	Annotation score:
E9PQ61	E9PQ61_HUMAN	Zinc finger CCCH domain-containing ... Zinc finger CCCH domain-containing protein 11A	ZC3H11A	652	Annotation score:
C9J0L0	C9J0L0_HUMAN	Zinc finger CCCH domain-containing ... Zinc finger CCCH domain-containing protein 11A	ZC3H11A	50	Annotation score:
A0A1W2PPR9	A0A1W2PPR9_HUMAN	Zinc finger CCCH domain-containing ... Zinc finger CCCH domain-containing protein 11A	ZC3H11A	301	Annotation score:

Sequence cautionⁱ

The sequence BAA31638 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAH10553 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	80	C → Y in CAH10553 (PubMed:17974005).Curated	1
Sequence conflictⁱ	246	P → L in CAH10530 (PubMed:17974005).Curated	1
Sequence conflictⁱ	266	L → P in CAH10525 (PubMed:17974005).Curated	1
Sequence conflictⁱ	277	R → G in CAH10530 (PubMed:17974005).Curated	1
Sequence conflictⁱ	409	V → G in CAH10525 (PubMed:17974005).Curated	1
Sequence conflictⁱ	412	E → K in CAH10525 (PubMed:17974005).Curated	1
Sequence conflictⁱ	616	S → P in CAH10566 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052967	640	T → N. Corresponds to variant dbSNP:rs11240604Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB014563 mRNA Translation: BAA31638.2 Different initiation. CR627439 mRNA Translation: CAH10525.1 CR627446 mRNA Translation: CAH10530.1 BX648271 mRNA Translation: CAH10553.1 Sequence problems. BX649148 mRNA Translation: CAH10566.1 BC014268 mRNA Translation: AAH14268.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30978.1
PIRⁱ	T00368
NCBI Reference Sequences More...RefSeqⁱ	NP_001306167.1, NM_001319238.1 NP_001306168.1, NM_001319239.1 NP_055642.3, NM_014827.5 XP_005245700.1, XM_005245643.2 XP_005245701.1, XM_005245644.3 XP_006711736.1, XM_006711673.2 XP_011508501.1, XM_011510199.1 XP_011508502.1, XM_011510200.1 XP_011508503.1, XM_011510201.1 XP_011508504.1, XM_011510202.1 XP_016858445.1, XM_017002956.1 XP_016858446.1, XM_017002957.1 XP_016858447.1, XM_017002958.1 XP_016858448.1, XM_017002959.1
UniGeneⁱ	Hs.532399 Hs.732801

Genome annotation databases

Ensemblⁱ	ENST00000332127; ENSP00000333253; ENSG00000058673 ENST00000367210; ENSP00000356179; ENSG00000058673 ENST00000367212; ENSP00000356181; ENSG00000058673 ENST00000367214; ENSP00000356183; ENSG00000058673 ENST00000639812; ENSP00000491830; ENSG00000058673
GeneIDⁱ	9877
KEGGⁱ	hsa:9877
UCSC genome browser More...UCSCⁱ	uc001hac.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O75152	cDNA FLJ58196, highly similar to Zinc finger CCCH domain-containing protein 11A		HUMAN		756	UniRef100_O75152
Zinc finger CCCH domain-containing protein 11A (Fragment)		HUMAN		50
Zinc finger CCCH domain-containing protein 11A (Fragment)		HUMAN		515

Protein	Similar proteins		Species	Score	Length	Source
O75152	Zinc finger CCCH domain-containing protein 11A		PONAB		811	UniRef90_O75152
cDNA FLJ58196, highly similar to Zinc finger CCCH domain-containing protein 11A		HUMAN		756
Uncharacterized protein		FELCA		816
zinc finger CCCH domain-containing protein 11A isoform X1		ODORO		816
zinc finger CCCH domain-containing protein 11A isoform X1		NEOSC		816
+78

Protein	Similar proteins		Species	Score	Length	Source
O75152	Zinc finger CCCH domain-containing protein 11A		PONAB		811	UniRef50_O75152
Zinc finger CCCH domain-containing protein 11B		HUMAN		805
zinc finger CCCH domain-containing protein 11A isoform X1		Florida manatee		816
zinc finger CCCH domain-containing protein 11A isoform X1		NEOSC		816
zinc finger CCCH domain-containing protein 11A isoform X1		Enhydra lutris kenyoni		816
+100

Entry informationⁱ

Entry nameⁱ	ZC11A_HUMAN
Accessionⁱ	O75152Primary (citable) accession number: O75152 Secondary accession number(s): Q6AHY4 , Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
	Last sequence update:	August 16, 2005
	Last modified:	September 12, 2018
	This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75152 (ZC11A_HUMAN)

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Zinc finger CCCH domain-containing protein 11A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ