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Protein

Copine-3

Gene

CPNE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).1 Publication

Caution

Was reported to have a protein kinase activity.1 Publication

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium-dependent protein binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • receptor tyrosine kinase binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • transporter activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-3Curated
Alternative name(s):
Copine III1 PublicationImported
Gene namesi
Name:CPNE3Imported
Synonyms:CPN3, KIAA06361 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000085719.11
HGNCiHGNC:2316 CPNE3
MIMi604207 gene
neXtProtiNX_O75131

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8895
OpenTargetsiENSG00000085719
PharmGKBiPA26833

Polymorphism and mutation databases

BioMutaiCPNE3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448381 – 537Copine-3Add BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei243PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on serine and threonine residues (PubMed:11041869).1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75131
MaxQBiO75131
PaxDbiO75131
PeptideAtlasiO75131
PRIDEiO75131
ProteomicsDBi49793

PTM databases

iPTMnetiO75131
PhosphoSitePlusiO75131
SwissPalmiO75131

Expressioni

Tissue specificityi

Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870).3 Publications

Gene expression databases

BgeeiENSG00000085719 Expressed in 232 organ(s), highest expression level in bone marrow
CleanExiHS_CPNE3
ExpressionAtlasiO75131 baseline and differential
GenevisibleiO75131 HS

Organism-specific databases

HPAiHPA029552

Interactioni

Subunit structurei

Monomer (PubMed:12949241). Interacts with ERBB2 (preferentially with the tyrosine phosphorylated form); this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner (PubMed:20010870). Interacts with SHC1; this interaction may mediate the binding of CPNE3 with ERBB2 (PubMed:20010870). Interacts with RACK1 (PubMed:20010870).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TINF2Q9BSI42EBI-718988,EBI-717399

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114412, 33 interactors
IntActiO75131, 10 interactors
MINTiO75131
STRINGi9606.ENSP00000198765

Structurei

3D structure databases

ProteinModelPortaliO75131
SMRiO75131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 99C2 1PROSITE-ProRule annotationAdd BLAST98
Domaini125 – 230C2 2PROSITE-ProRule annotationAdd BLAST106
Domaini291 – 513VWFAPROSITE-ProRule annotationAdd BLAST223

Sequence similaritiesi

Belongs to the copine family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiO75131
OMAiDYYFELV
OrthoDBiEOG091G05IT
PhylomeDBiO75131
TreeFamiTF316419

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O75131-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQCVTKVA LNVSCANLLD KDIGSKSDPL CVLFLNTSGQ QWYEVERTER
60 70 80 90 100
IKNCLNPQFS KTFIIDYYFE VVQKLKFGVY DIDNKTIELS DDDFLGECEC
110 120 130 140 150
TLGQIVSSKK LTRPLVMKTG RPAGKGSITI SAEEIKDNRV VLFEMEARKL
160 170 180 190 200
DNKDLFGKSD PYLEFHKQTS DGNWLMVHRT EVVKNNLNPV WRPFKISLNS
210 220 230 240 250
LCYGDMDKTI KVECYDYDND GSHDLIGTFQ TTMTKLKEAS RSSPVEFECI
260 270 280 290 300
NEKKRQKKKS YKNSGVISVK QCEITVECTF LDYIMGGCQL NFTVGVDFTG
310 320 330 340 350
SNGDPRSPDS LHYISPNGVN EYLTALWSVG LVIQDYDADK MFPAFGFGAQ
360 370 380 390 400
IPPQWQVSHE FPMNFNPSNP YCNGIQGIVE AYRSCLPQIK LYGPTNFSPI
410 420 430 440 450
INHVARFAAA ATQQQTASQY FVLLIITDGV ITDLDETRQA IVNASRLPMS
460 470 480 490 500
IIIVGVGGAD FSAMEFLDGD GGSLRSPLGE VAIRDIVQFV PFRQFQNAPK
510 520 530
EALAQCVLAE IPQQVVGYFN TYKLLPPKNP ATKQQKQ
Length:537
Mass (Da):60,131
Last modified:November 1, 1998 - v1
Checksum:i91F2C5EAD611B842
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHZ0E5RHZ0_HUMAN
Copine-3
CPNE3
153Annotation score:
A0A087WYQ3A0A087WYQ3_HUMAN
Copine-3
CPNE3
234Annotation score:
E5RFT7E5RFT7_HUMAN
Copine-3
CPNE3
79Annotation score:
A0A087WUS8A0A087WUS8_HUMAN
Copine-3
CPNE3
135Annotation score:
A0A087WXR6A0A087WXR6_HUMAN
Copine-3
CPNE3
139Annotation score:
H0YB26H0YB26_HUMAN
Copine-3
CPNE3
262Annotation score:
A0A0G2JMP5A0A0G2JMP5_HUMAN
Copine-3
CPNE3
8Annotation score:

Sequence cautioni

The sequence BAA31611 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti394P → Q in AAH36242 (PubMed:15489334).Curated1
Sequence conflicti419Q → R in AAH36242 (PubMed:15489334).Curated1
Sequence conflicti475R → H in AAH36242 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048848252E → D. Corresponds to variant dbSNP:rs41333046Ensembl.1
Natural variantiVAR_024424412T → M1 PublicationCorresponds to variant dbSNP:rs2304789Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077226 mRNA Translation: AAD46074.2
AB014536 mRNA Translation: BAA31611.2 Different initiation.
AK292912 mRNA Translation: BAF85601.1
BC036242 mRNA Translation: AAH36242.1
BC066597 mRNA Translation: AAH66597.1
CCDSiCCDS6243.1
RefSeqiNP_003900.1, NM_003909.4
XP_005251150.1, XM_005251093.4
XP_016869434.1, XM_017013945.1
UniGeneiHs.191219

Genome annotation databases

EnsembliENST00000517490; ENSP00000477590; ENSG00000085719
GeneIDi8895
KEGGihsa:8895
UCSCiuc033bsf.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077226 mRNA Translation: AAD46074.2
AB014536 mRNA Translation: BAA31611.2 Different initiation.
AK292912 mRNA Translation: BAF85601.1
BC036242 mRNA Translation: AAH36242.1
BC066597 mRNA Translation: AAH66597.1
CCDSiCCDS6243.1
RefSeqiNP_003900.1, NM_003909.4
XP_005251150.1, XM_005251093.4
XP_016869434.1, XM_017013945.1
UniGeneiHs.191219

3D structure databases

ProteinModelPortaliO75131
SMRiO75131
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114412, 33 interactors
IntActiO75131, 10 interactors
MINTiO75131
STRINGi9606.ENSP00000198765

PTM databases

iPTMnetiO75131
PhosphoSitePlusiO75131
SwissPalmiO75131

Polymorphism and mutation databases

BioMutaiCPNE3

Proteomic databases

EPDiO75131
MaxQBiO75131
PaxDbiO75131
PeptideAtlasiO75131
PRIDEiO75131
ProteomicsDBi49793

Protocols and materials databases

DNASUi8895
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000517490; ENSP00000477590; ENSG00000085719
GeneIDi8895
KEGGihsa:8895
UCSCiuc033bsf.1 human

Organism-specific databases

CTDi8895
DisGeNETi8895
EuPathDBiHostDB:ENSG00000085719.11
GeneCardsiCPNE3
HGNCiHGNC:2316 CPNE3
HPAiHPA029552
MIMi604207 gene
neXtProtiNX_O75131
OpenTargetsiENSG00000085719
PharmGKBiPA26833
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiO75131
OMAiDYYFELV
OrthoDBiEOG091G05IT
PhylomeDBiO75131
TreeFamiTF316419

Enzyme and pathway databases

ReactomeiR-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiCPNE3 human
GenomeRNAii8895
PROiPR:O75131
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000085719 Expressed in 232 organ(s), highest expression level in bone marrow
CleanExiHS_CPNE3
ExpressionAtlasiO75131 baseline and differential
GenevisibleiO75131 HS

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCPNE3_HUMAN
AccessioniPrimary (citable) accession number: O75131
Secondary accession number(s): A8KA47, Q8IYA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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