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Entry version 153 (13 Feb 2019)
Sequence version 3 (19 Jul 2004)
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Protein

Microfibrillar-associated protein 3-like

Gene

MFAP3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.1 Publication

Caution

Protein kinase activity is reported (PubMed:24735981). However, no protein kinase domain is detected by any prediction method (PROSITE, Pfam). Its enzyme activity is therefore unsure.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microfibrillar-associated protein 3-like
Alternative name(s):
Testis development protein NYD-SP91 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MFAP3L
Synonyms:KIAA0626
ORF Names:HSD-39, HSD39
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198948.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29083 MFAP3L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75121

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 149ExtracellularSequence analysisAdd BLAST121
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei150 – 172HelicalSequence analysisAdd BLAST23
Topological domaini173 – 409CytoplasmicSequence analysisAdd BLAST237

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9848

Open Targets

More...
OpenTargetsi
ENSG00000198948

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134974574

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MFAP3L

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001486929 – 409Microfibrillar-associated protein 3-likeAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi68 ↔ 125PROSITE-ProRule annotation
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei287Phosphotyrosine; by EGFR1 Publication1
Modified residuei298PhosphoserineBy similarity1
Modified residuei303PhosphoserineBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75121

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75121

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75121

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75121

PeptideAtlas

More...
PeptideAtlasi
O75121

PRoteomics IDEntifications database

More...
PRIDEi
O75121

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49774
49775 [O75121-2]
49776 [O75121-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75121

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75121

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198948 Expressed in 210 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75121 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75121 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017986

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75121

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 141Ig-like C2-typeAdd BLAST95

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE5Z Eukaryota
ENOG410XPPH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011576

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052463

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75121

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWYNSVG

Database of Orthologous Groups

More...
OrthoDBi
1154642at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75121

TreeFam database of animal gene trees

More...
TreeFami
TF333205

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR039696 MFAP3-like

The PANTHER Classification System

More...
PANTHERi
PTHR14340 PTHR14340, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRLKSHLTV CFLPSVPFLI LVSTLATAKS VTNSTLNGTN VVLGSVPVII
60 70 80 90 100
ARTDHIIVKE GNSALINCSV YGIPDPQFKW YNSIGKLLKE EEDEKERGGG
110 120 130 140 150
KWQMHDSGLL NITKVSFSDR GKYTCVASNI YGTVNNTVTL RVIFTSGDMG
160 170 180 190 200
VYYMVVCLVA FTIVMVLNIT RLCMMSSHLK KTEKAINEFF RTEGAEKLQK
210 220 230 240 250
AFEIAKRIPI ITSAKTLELA KVTQFKTMEF ARYIEELARS VPLPPLIMNC
260 270 280 290 300
RTIMEEIMEV VGLEEQGQNF VRHTPEGQEA ADRDEVYTIP NSLKRSDSPA
310 320 330 340 350
ADSDASSLHE QPQQIAIKVS VHPQSKKEHA DDQEGGQFEV KDVEETELSA
360 370 380 390 400
EHSPETAEPS TDVTSTELTS EEPTPVEVPD KVLPPAYLEA TEPAVTHDKN

TCIIYESHV
Length:409
Mass (Da):45,380
Last modified:July 19, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47965B61C0F8A3AA
GO
Isoform 2 (identifier: O75121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:306
Mass (Da):34,099
Checksum:iBAB22A47F60B44B3
GO
Isoform 3 (identifier: O75121-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-102: KW → RL
     103-409: Missing.

Show »
Length:102
Mass (Da):11,126
Checksum:i2E451CF8734B849F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAB5D6RAB5_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCF0D6RCF0_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDM6D6RDM6_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGZ8D6RGZ8_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9L7D6R9L7_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCC0D6RCC0_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31601 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti362D → N in AAS55434 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0111001 – 103Missing in isoform 2. 2 PublicationsAdd BLAST103
Alternative sequenceiVSP_014094101 – 102KW → RL in isoform 3. 1 Publication2
Alternative sequenceiVSP_014095103 – 409Missing in isoform 3. 1 PublicationAdd BLAST307

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF327560 mRNA Translation: AAK15700.1
AY391838 mRNA Translation: AAS55434.1
AB014526 mRNA Translation: BAA31601.2 Different initiation.
AK290041 mRNA Translation: BAF82730.1
AC084866 Genomic DNA Translation: AAY41028.1
AC084866 Genomic DNA Translation: AAY41029.1
CH471056 Genomic DNA Translation: EAX04773.1
CH471056 Genomic DNA Translation: EAX04774.1
CH471056 Genomic DNA Translation: EAX04775.1
BC001279 mRNA Translation: AAH01279.1
BC066912 mRNA Translation: AAH66912.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34103.1 [O75121-1]
CCDS43281.1 [O75121-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001009554.1, NM_001009554.3 [O75121-2]
NP_001288576.1, NM_001301647.1 [O75121-2]
NP_001288577.1, NM_001301648.1 [O75121-2]
NP_067679.6, NM_021647.7 [O75121-1]
XP_005263425.1, XM_005263368.3 [O75121-2]
XP_016864357.1, XM_017008868.1 [O75121-1]
XP_016864358.1, XM_017008869.1 [O75121-1]
XP_016864359.1, XM_017008870.1 [O75121-1]
XP_016864360.1, XM_017008871.1 [O75121-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.593942
Hs.733667

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361618; ENSP00000354583; ENSG00000198948 [O75121-1]
ENST00000393702; ENSP00000377305; ENSG00000198948 [O75121-3]
ENST00000393704; ENSP00000377307; ENSG00000198948 [O75121-2]
ENST00000506110; ENSP00000422571; ENSG00000198948 [O75121-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9848

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9848

UCSC genome browser

More...
UCSCi
uc003isn.4 human [O75121-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327560 mRNA Translation: AAK15700.1
AY391838 mRNA Translation: AAS55434.1
AB014526 mRNA Translation: BAA31601.2 Different initiation.
AK290041 mRNA Translation: BAF82730.1
AC084866 Genomic DNA Translation: AAY41028.1
AC084866 Genomic DNA Translation: AAY41029.1
CH471056 Genomic DNA Translation: EAX04773.1
CH471056 Genomic DNA Translation: EAX04774.1
CH471056 Genomic DNA Translation: EAX04775.1
BC001279 mRNA Translation: AAH01279.1
BC066912 mRNA Translation: AAH66912.1
CCDSiCCDS34103.1 [O75121-1]
CCDS43281.1 [O75121-2]
RefSeqiNP_001009554.1, NM_001009554.3 [O75121-2]
NP_001288576.1, NM_001301647.1 [O75121-2]
NP_001288577.1, NM_001301648.1 [O75121-2]
NP_067679.6, NM_021647.7 [O75121-1]
XP_005263425.1, XM_005263368.3 [O75121-2]
XP_016864357.1, XM_017008868.1 [O75121-1]
XP_016864358.1, XM_017008869.1 [O75121-1]
XP_016864359.1, XM_017008870.1 [O75121-1]
XP_016864360.1, XM_017008871.1 [O75121-1]
UniGeneiHs.593942
Hs.733667

3D structure databases

ProteinModelPortaliO75121
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiO75121
PhosphoSitePlusiO75121

Polymorphism and mutation databases

BioMutaiMFAP3L

Proteomic databases

EPDiO75121
jPOSTiO75121
MaxQBiO75121
PaxDbiO75121
PeptideAtlasiO75121
PRIDEiO75121
ProteomicsDBi49774
49775 [O75121-2]
49776 [O75121-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361618; ENSP00000354583; ENSG00000198948 [O75121-1]
ENST00000393702; ENSP00000377305; ENSG00000198948 [O75121-3]
ENST00000393704; ENSP00000377307; ENSG00000198948 [O75121-2]
ENST00000506110; ENSP00000422571; ENSG00000198948 [O75121-3]
GeneIDi9848
KEGGihsa:9848
UCSCiuc003isn.4 human [O75121-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9848
DisGeNETi9848
EuPathDBiHostDB:ENSG00000198948.11

GeneCards: human genes, protein and diseases

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GeneCardsi
MFAP3L

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0004635
HGNCiHGNC:29083 MFAP3L
HPAiHPA017986
neXtProtiNX_O75121
OpenTargetsiENSG00000198948
PharmGKBiPA134974574

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE5Z Eukaryota
ENOG410XPPH LUCA
GeneTreeiENSGT00390000011576
HOVERGENiHBG052463
InParanoidiO75121
OMAiKWYNSVG
OrthoDBi1154642at2759
PhylomeDBiO75121
TreeFamiTF333205

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MFAP3L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9848

Protein Ontology

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PROi
PR:O75121

Gene expression databases

BgeeiENSG00000198948 Expressed in 210 organ(s), highest expression level in sperm
ExpressionAtlasiO75121 baseline and differential
GenevisibleiO75121 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR039696 MFAP3-like
PANTHERiPTHR14340 PTHR14340, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMFA3L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75121
Secondary accession number(s): A8K1X6
, D3DP35, Q4W5N7, Q4W5N9, Q6TNA8, Q9BVE1, Q9BXK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: February 13, 2019
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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