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Protein

Microfibrillar-associated protein 3-like

Gene

MFAP3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.1 Publication

Caution

Protein kinase activity is reported (PubMed:24735981). However, no protein kinase domain is detected by any prediction method (PROSITE, Pfam). Its enzyme activity is therefore unsure.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 3-like
Alternative name(s):
Testis development protein NYD-SP91 Publication
Gene namesi
Name:MFAP3L
Synonyms:KIAA0626
ORF Names:HSD-39, HSD39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000198948.11
HGNCiHGNC:29083 MFAP3L
neXtProtiNX_O75121

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 149ExtracellularSequence analysisAdd BLAST121
Transmembranei150 – 172HelicalSequence analysisAdd BLAST23
Topological domaini173 – 409CytoplasmicSequence analysisAdd BLAST237

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9848
OpenTargetsiENSG00000198948
PharmGKBiPA134974574

Polymorphism and mutation databases

BioMutaiMFAP3L

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001486929 – 409Microfibrillar-associated protein 3-likeAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi68 ↔ 125PROSITE-ProRule annotation
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei287Phosphotyrosine; by EGFR1 Publication1
Modified residuei298PhosphoserineBy similarity1
Modified residuei303PhosphoserineBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO75121
MaxQBiO75121
PaxDbiO75121
PeptideAtlasiO75121
PRIDEiO75121
ProteomicsDBi49774
49775 [O75121-2]
49776 [O75121-3]

PTM databases

iPTMnetiO75121
PhosphoSitePlusiO75121

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000198948 Expressed in 210 organ(s), highest expression level in sperm
CleanExiHS_MFAP3L
ExpressionAtlasiO75121 baseline and differential
GenevisibleiO75121 HS

Organism-specific databases

HPAiHPA017986

Structurei

3D structure databases

ProteinModelPortaliO75121
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 141Ig-like C2-typeAdd BLAST95

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE5Z Eukaryota
ENOG410XPPH LUCA
GeneTreeiENSGT00390000011576
HOVERGENiHBG052463
InParanoidiO75121
OMAiKWYNSVG
OrthoDBiEOG091G0BD8
PhylomeDBiO75121
TreeFamiTF333205

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR039696 MFAP3-like
PANTHERiPTHR14340 PTHR14340, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRLKSHLTV CFLPSVPFLI LVSTLATAKS VTNSTLNGTN VVLGSVPVII
60 70 80 90 100
ARTDHIIVKE GNSALINCSV YGIPDPQFKW YNSIGKLLKE EEDEKERGGG
110 120 130 140 150
KWQMHDSGLL NITKVSFSDR GKYTCVASNI YGTVNNTVTL RVIFTSGDMG
160 170 180 190 200
VYYMVVCLVA FTIVMVLNIT RLCMMSSHLK KTEKAINEFF RTEGAEKLQK
210 220 230 240 250
AFEIAKRIPI ITSAKTLELA KVTQFKTMEF ARYIEELARS VPLPPLIMNC
260 270 280 290 300
RTIMEEIMEV VGLEEQGQNF VRHTPEGQEA ADRDEVYTIP NSLKRSDSPA
310 320 330 340 350
ADSDASSLHE QPQQIAIKVS VHPQSKKEHA DDQEGGQFEV KDVEETELSA
360 370 380 390 400
EHSPETAEPS TDVTSTELTS EEPTPVEVPD KVLPPAYLEA TEPAVTHDKN

TCIIYESHV
Length:409
Mass (Da):45,380
Last modified:July 19, 2004 - v3
Checksum:i47965B61C0F8A3AA
GO
Isoform 2 (identifier: O75121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:306
Mass (Da):34,099
Checksum:iBAB22A47F60B44B3
GO
Isoform 3 (identifier: O75121-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-102: KW → RL
     103-409: Missing.

Show »
Length:102
Mass (Da):11,126
Checksum:i2E451CF8734B849F
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAB5D6RAB5_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
156Annotation score:
D6RCF0D6RCF0_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
63Annotation score:
D6RDM6D6RDM6_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
98Annotation score:
D6RGZ8D6RGZ8_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
90Annotation score:
D6R9L7D6R9L7_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
73Annotation score:
D6RCC0D6RCC0_HUMAN
Microfibrillar-associated protein 3...
MFAP3L
44Annotation score:

Sequence cautioni

The sequence BAA31601 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti362D → N in AAS55434 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0111001 – 103Missing in isoform 2. 2 PublicationsAdd BLAST103
Alternative sequenceiVSP_014094101 – 102KW → RL in isoform 3. 1 Publication2
Alternative sequenceiVSP_014095103 – 409Missing in isoform 3. 1 PublicationAdd BLAST307

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327560 mRNA Translation: AAK15700.1
AY391838 mRNA Translation: AAS55434.1
AB014526 mRNA Translation: BAA31601.2 Different initiation.
AK290041 mRNA Translation: BAF82730.1
AC084866 Genomic DNA Translation: AAY41028.1
AC084866 Genomic DNA Translation: AAY41029.1
CH471056 Genomic DNA Translation: EAX04773.1
CH471056 Genomic DNA Translation: EAX04774.1
CH471056 Genomic DNA Translation: EAX04775.1
BC001279 mRNA Translation: AAH01279.1
BC066912 mRNA Translation: AAH66912.1
CCDSiCCDS34103.1 [O75121-1]
CCDS43281.1 [O75121-2]
RefSeqiNP_001009554.1, NM_001009554.3 [O75121-2]
NP_001288576.1, NM_001301647.1 [O75121-2]
NP_001288577.1, NM_001301648.1 [O75121-2]
NP_067679.6, NM_021647.7 [O75121-1]
XP_005263425.1, XM_005263368.3 [O75121-2]
XP_016864357.1, XM_017008868.1 [O75121-1]
XP_016864358.1, XM_017008869.1 [O75121-1]
XP_016864359.1, XM_017008870.1 [O75121-1]
XP_016864360.1, XM_017008871.1 [O75121-1]
UniGeneiHs.593942
Hs.733667

Genome annotation databases

EnsembliENST00000361618; ENSP00000354583; ENSG00000198948 [O75121-1]
ENST00000393702; ENSP00000377305; ENSG00000198948 [O75121-3]
ENST00000393704; ENSP00000377307; ENSG00000198948 [O75121-2]
ENST00000506110; ENSP00000422571; ENSG00000198948 [O75121-3]
GeneIDi9848
KEGGihsa:9848
UCSCiuc003isn.4 human [O75121-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327560 mRNA Translation: AAK15700.1
AY391838 mRNA Translation: AAS55434.1
AB014526 mRNA Translation: BAA31601.2 Different initiation.
AK290041 mRNA Translation: BAF82730.1
AC084866 Genomic DNA Translation: AAY41028.1
AC084866 Genomic DNA Translation: AAY41029.1
CH471056 Genomic DNA Translation: EAX04773.1
CH471056 Genomic DNA Translation: EAX04774.1
CH471056 Genomic DNA Translation: EAX04775.1
BC001279 mRNA Translation: AAH01279.1
BC066912 mRNA Translation: AAH66912.1
CCDSiCCDS34103.1 [O75121-1]
CCDS43281.1 [O75121-2]
RefSeqiNP_001009554.1, NM_001009554.3 [O75121-2]
NP_001288576.1, NM_001301647.1 [O75121-2]
NP_001288577.1, NM_001301648.1 [O75121-2]
NP_067679.6, NM_021647.7 [O75121-1]
XP_005263425.1, XM_005263368.3 [O75121-2]
XP_016864357.1, XM_017008868.1 [O75121-1]
XP_016864358.1, XM_017008869.1 [O75121-1]
XP_016864359.1, XM_017008870.1 [O75121-1]
XP_016864360.1, XM_017008871.1 [O75121-1]
UniGeneiHs.593942
Hs.733667

3D structure databases

ProteinModelPortaliO75121
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiO75121
PhosphoSitePlusiO75121

Polymorphism and mutation databases

BioMutaiMFAP3L

Proteomic databases

EPDiO75121
MaxQBiO75121
PaxDbiO75121
PeptideAtlasiO75121
PRIDEiO75121
ProteomicsDBi49774
49775 [O75121-2]
49776 [O75121-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361618; ENSP00000354583; ENSG00000198948 [O75121-1]
ENST00000393702; ENSP00000377305; ENSG00000198948 [O75121-3]
ENST00000393704; ENSP00000377307; ENSG00000198948 [O75121-2]
ENST00000506110; ENSP00000422571; ENSG00000198948 [O75121-3]
GeneIDi9848
KEGGihsa:9848
UCSCiuc003isn.4 human [O75121-1]

Organism-specific databases

CTDi9848
DisGeNETi9848
EuPathDBiHostDB:ENSG00000198948.11
GeneCardsiMFAP3L
H-InvDBiHIX0004635
HGNCiHGNC:29083 MFAP3L
HPAiHPA017986
neXtProtiNX_O75121
OpenTargetsiENSG00000198948
PharmGKBiPA134974574
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE5Z Eukaryota
ENOG410XPPH LUCA
GeneTreeiENSGT00390000011576
HOVERGENiHBG052463
InParanoidiO75121
OMAiKWYNSVG
OrthoDBiEOG091G0BD8
PhylomeDBiO75121
TreeFamiTF333205

Miscellaneous databases

ChiTaRSiMFAP3L human
GenomeRNAii9848
PROiPR:O75121

Gene expression databases

BgeeiENSG00000198948 Expressed in 210 organ(s), highest expression level in sperm
CleanExiHS_MFAP3L
ExpressionAtlasiO75121 baseline and differential
GenevisibleiO75121 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR039696 MFAP3-like
PANTHERiPTHR14340 PTHR14340, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMFA3L_HUMAN
AccessioniPrimary (citable) accession number: O75121
Secondary accession number(s): A8K1X6
, D3DP35, Q4W5N7, Q4W5N9, Q6TNA8, Q9BVE1, Q9BXK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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