UniProtKB - O75112 (LDB3_HUMAN)
LIM domain-binding protein 3
LDB3
Functioni
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
CuratedGO - Molecular functioni
- actin binding Source: GO_Central
- cytoskeletal protein binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- muscle alpha-actinin binding Source: GO_Central
- protein kinase C binding Source: Ensembl
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- heart development Source: GO_Central
- muscle structure development Source: GO_Central
- sarcomere organization Source: Ensembl
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O75112 |
SignaLinki | O75112 |
Names & Taxonomyi
Protein namesi | Recommended name: LIM domain-binding protein 3Alternative name(s): Protein cypher Z-band alternatively spliced PDZ-motif protein |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15710, LDB3 |
MIMi | 605906, gene+phenotype |
neXtProti | NX_O75112 |
VEuPathDBi | HostDB:ENSG00000122367 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- perinuclear region 1 Publication
- pseudopodium 1 Publication
- Z line 1 Publication
Note: Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
Cytoskeleton
- cytoskeleton Source: UniProtKB
- filamentous actin Source: GO_Central
- stress fiber Source: GO_Central
Other locations
- adherens junction Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- pseudopodium Source: UniProtKB-SubCell
- Z disc Source: MGI
Keywords - Cellular componenti
Cell projection, Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Cardiomyopathy, dilated 1C, with or without left ventricular non-compaction (CMD1C)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024009 | 189 | S → L in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs45487699EnsemblClinVar. | 1 | |
Natural variantiVAR_024010 | 206 | T → I in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs121908337EnsemblClinVar. | 1 | |
Natural variantiVAR_024011 | 345 | I → M in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs121908336EnsemblClinVar. | 1 | |
Natural variantiVAR_024013 | 673 | D → N in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs45514002EnsemblClinVar. | 1 |
Left ventricular non-compaction 3 (LVNC3)
Myopathy, myofibrillar, 4 (MFM4)
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 21 Publication (identifier: O75112-2) | |||||
Natural variantiVAR_082848 | 147 | A → T in MFM4. CuratedCorresponds to variant dbSNP:rs121908333Ensembl. | 1 | ||
Natural variantiVAR_082849 | 165 | A → V in MFM4. CuratedCorresponds to variant dbSNP:rs121908334Ensembl. | 1 | ||
Isoform 61 Publication (identifier: O75112-6) | |||||
Natural variantiVAR_082856 | 147 | A → T in MFM4. CuratedCorresponds to variant dbSNP:rs121908333Ensembl. | 1 | ||
Natural variantiVAR_082857 | 165 | A → V in MFM4. CuratedCorresponds to variant dbSNP:rs121908334Ensembl. | 1 | ||
Natural variantiVAR_082858 | 268 | R → C in MFM4. CuratedCorresponds to variant dbSNP:rs121908335Ensembl. | 1 | ||
Isoform 41 Publication (identifier: O75112-4) | |||||
Natural variantiVAR_082852 | 262 | A → T in MFM4. CuratedCorresponds to variant dbSNP:rs121908333Ensembl. | 1 | ||
Natural variantiVAR_082853 | 280 | A → V in MFM4. CuratedCorresponds to variant dbSNP:rs121908334Ensembl. | 1 | ||
Natural variantiVAR_082854 | 383 | R → C in MFM4. CuratedCorresponds to variant dbSNP:rs121908335Ensembl. | 1 |
Keywords - Diseasei
Cardiomyopathy, Disease variant, Myofibrillar myopathyOrganism-specific databases
DisGeNETi | 11155 |
GeneReviewsi | LDB3 |
MalaCardsi | LDB3 |
MIMi | 601493, phenotype 605906, gene+phenotype 609452, phenotype |
OpenTargetsi | ENSG00000122367 |
Orphaneti | 293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 154, Familial isolated dilated cardiomyopathy 98912, Late-onset distal myopathy, Markesbery-Griggs type 54260, Left ventricular noncompaction 155, NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy |
PharmGKBi | PA30318 |
Miscellaneous databases
Pharosi | O75112, Tbio |
Genetic variation databases
BioMutai | LDB3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075767 | 1 – 727 | LIM domain-binding protein 3Add BLAST | 727 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 44 | PhosphoserineBy similarity | 1 | |
Modified residuei | 121 | PhosphoserineBy similarity | 1 | |
Modified residuei | 123 | PhosphoserineBy similarity | 1 | |
Modified residuei | 217 | PhosphoserineBy similarity | 1 | |
Modified residuei | 219 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 223 | PhosphoserineBy similarity | 1 | |
Modified residuei | 516 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 533 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
jPOSTi | O75112 |
MassIVEi | O75112 |
MaxQBi | O75112 |
PeptideAtlasi | O75112 |
PRIDEi | O75112 |
ProteomicsDBi | 49765 [O75112-1] 49766 [O75112-2] 49767 [O75112-3] 49768 [O75112-4] 49769 [O75112-5] 49770 [O75112-6] 49771 [O75112-7] |
2D gel databases
UCD-2DPAGEi | O75112 |
PTM databases
GlyGeni | O75112, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O75112 |
PhosphoSitePlusi | O75112 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000122367, Expressed in cardiac ventricle and 224 other tissues |
ExpressionAtlasi | O75112, baseline and differential |
Genevisiblei | O75112, HS |
Organism-specific databases
HPAi | ENSG00000122367, Group enriched (heart muscle, skeletal muscle, tongue) |
Interactioni
Subunit structurei
Interacts via its LIM domains with various PKC isoforms (By similarity).
Interacts via its PDZ domain with the ACTN2 C-terminal region.
Interacts with MYOZ1, MYOZ2 and MYOZ3.
By similarity2 PublicationsGO - Molecular functioni
- actin binding Source: GO_Central
- cytoskeletal protein binding Source: UniProtKB
- muscle alpha-actinin binding Source: GO_Central
- protein kinase C binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 116326, 12 interactors |
IntActi | O75112, 5 interactors |
Miscellaneous databases
RNActi | O75112, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | O75112 |
SMRi | O75112 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O75112 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 84 | PDZPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 549 – 607 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 608 – 667 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 668 – 727 | LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 86 – 197 | DisorderedSequence analysisAdd BLAST | 112 | |
Regioni | 284 – 440 | DisorderedSequence analysisAdd BLAST | 157 | |
Regioni | 472 – 529 | DisorderedSequence analysisAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 303 – 318 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 343 – 383 | Polar residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 402 – 423 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 424 – 440 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 498 – 515 | Polar residuesSequence analysisAdd BLAST | 18 |
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
GeneTreei | ENSGT00940000154877 |
HOGENOMi | CLU_038114_0_1_1 |
InParanoidi | O75112 |
OMAi | SNVYCER |
OrthoDBi | 1013114at2759 |
PhylomeDBi | O75112 |
TreeFami | TF106408 |
Family and domain databases
DisProti | DP01781 [O75112-6] |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR031847, DUF4749 IPR001478, PDZ IPR036034, PDZ_sf IPR006643, Zasp-like_motif IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF15936, DUF4749, 1 hit PF00412, LIM, 3 hits PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00132, LIM, 3 hits SM00228, PDZ, 1 hit SM00735, ZM, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 3 hits PS50106, PDZ, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV
60 70 80 90 100
AIDGVNTDTM THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL
110 120 130 140 150
PVIPHQKDPA LDTNGSLVAP SPSPEARASP GTPGTPELRP TFSPAFSRPS
160 170 180 190 200
AFSSLAEASD PGPPRASLRA KTSPEGARDL LGPKALPGSS QPRQYNNPIG
210 220 230 240 250
LYSAETLREM AQMYQMSLRG KASGVGLPGG SLPIKDLAVD SASPVYQAVI
260 270 280 290 300
KSQNKPEDEA DEWARRSSNL QSRSFRILAQ MTGTEFMQDP DEEALRRSST
310 320 330 340 350
PIEHAPVCTS QATTPLLPAS AQPPAAASPS AASPPLATAA AHTAIASAST
360 370 380 390 400
TAPASSPADS PRPQASSYSP AVAASSAPAT HTSYSEGPAA PAPKPRVVTT
410 420 430 440 450
ASIRPSVYQP VPASTYSPSP GANYSPTPYT PSPAPAYTPS PAPAYTPSPV
460 470 480 490 500
PTYTPSPAPA YTPSPAPNYN PAPSVAYSGG PAEPASRPPW VTDDSFSQKF
510 520 530 540 550
APGKSTTSIS KQTLPRGGPA YTPAGPQVPP LARGTVQRAE RFPASSRTPL
560 570 580 590 600
CGHCNNVIRG PFLVAMGRSW HPEEFTCAYC KTSLADVCFV EEQNNVYCER
610 620 630 640 650
CYEQFFAPLC AKCNTKIMGE VMHALRQTWH TTCFVCAACK KPFGNSLFHM
660 670 680 690 700
EDGEPYCEKD YINLFSTKCH GCDFPVEAGD KFIEALGHTW HDTCFICAVC
710 720
HVNLEGQPFY SKKDRPLCKK HAHTINL
The sequence of this isoform differs from the canonical sequence as follows:
230-230: G → GADYQERFNPSALKDSALSTHKPIEVKGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQAQGSDFSG
299-329: STPIEHAPVCTSQATTPLLPASAQPPAAASP → RERFETERNSPRFAKLRNWHHGLSAQILNVK
331-727: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
108-229: DPALDTNGSL...GKASGVGLPG → VVVNSPANAD...QAQAQGSDFS
299-329: STPIEHAPVCTSQATTPLLPASAQPPAAASP → RERFETERNSPRFAKLRNWHHGLSAQILNVK
331-727: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DGG7 | A0A0C4DGG7_HUMAN | LIM domain-binding protein 3 | LDB3 | 231 | Annotation score: | ||
A0A096LPD7 | A0A096LPD7_HUMAN | LIM domain-binding protein 3 | LDB3 | 81 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 365 – 368 | ASSY → VVVN in CAB46729 (PubMed:10427098).Curated | 4 | |
Sequence conflicti | 372 | V → N in CAB46729 (PubMed:10427098).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_024008 | 55 | V → I1 PublicationCorresponds to variant dbSNP:rs3740343EnsemblClinVar. | 1 | ||
Natural variantiVAR_050146 | 101 | P → L. Corresponds to variant dbSNP:rs45592139EnsemblClinVar. | 1 | ||
Natural variantiVAR_024009 | 189 | S → L in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs45487699EnsemblClinVar. | 1 | ||
Natural variantiVAR_024010 | 206 | T → I in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs121908337EnsemblClinVar. | 1 | ||
Natural variantiVAR_024011 | 345 | I → M in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs121908336EnsemblClinVar. | 1 | ||
Natural variantiVAR_024012 | 635 | V → I1 PublicationCorresponds to variant dbSNP:rs45618633EnsemblClinVar. | 1 | ||
Natural variantiVAR_024013 | 673 | D → N in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs45514002EnsemblClinVar. | 1 | ||
Isoform 21 Publication (identifier: O75112-2) | |||||
Natural variantiVAR_082846 | 117 | D → N in dilated cardiomyopathy with left ventricular non-compaction. CuratedCorresponds to variant dbSNP:rs121908338Ensembl. | 1 | ||
Natural variantiVAR_082847 | 136 | K → M in dilated cardiomyopathy with left ventricular non-compaction. Curated | 1 | ||
Natural variantiVAR_082848 | 147 | A → T in MFM4. CuratedCorresponds to variant dbSNP:rs121908333Ensembl. | 1 | ||
Natural variantiVAR_082849 | 165 | A → V in MFM4. CuratedCorresponds to variant dbSNP:rs121908334Ensembl. | 1 | ||
Isoform 61 Publication (identifier: O75112-6) | |||||
Natural variantiVAR_082856 | 147 | A → T in MFM4. CuratedCorresponds to variant dbSNP:rs121908333Ensembl. | 1 | ||
Natural variantiVAR_082857 | 165 | A → V in MFM4. CuratedCorresponds to variant dbSNP:rs121908334Ensembl. | 1 | ||
Natural variantiVAR_082858 | 268 | R → C in MFM4. CuratedCorresponds to variant dbSNP:rs121908335Ensembl. | 1 | ||
Isoform 41 Publication (identifier: O75112-4) | |||||
Natural variantiVAR_082850 | 232 | D → N in dilated cardiomyopathy with left ventricular non-compaction. CuratedCorresponds to variant dbSNP:rs121908338Ensembl. | 1 | ||
Natural variantiVAR_082851 | 251 | K → M in dilated cardiomyopathy with left ventricular non-compaction. Curated | 1 | ||
Natural variantiVAR_082852 | 262 | A → T in MFM4. CuratedCorresponds to variant dbSNP:rs121908333Ensembl. | 1 | ||
Natural variantiVAR_082853 | 280 | A → V in MFM4. CuratedCorresponds to variant dbSNP:rs121908334Ensembl. | 1 | ||
Natural variantiVAR_082854 | 383 | R → C in MFM4. CuratedCorresponds to variant dbSNP:rs121908335Ensembl. | 1 | ||
Isoform 51 Publication (identifier: O75112-5) | |||||
Natural variantiVAR_082855 | 315 | R → C in MFM-ZASP. CuratedCorresponds to variant dbSNP:rs121908335Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_051897 | 108 – 364 | Missing in isoform 3. 1 PublicationAdd BLAST | 257 | |
Alternative sequenceiVSP_051898 | 108 – 229 | DPALD…VGLPG → VVVNSPANADYQERFNPSAL KDSALSTHKPIEVKGLGGKA TIIHAQYNTPISMYSQDAIM DAIAGQAQAQGSDFS in isoform 2 and isoform 6. 3 PublicationsAdd BLAST | 122 | |
Alternative sequenceiVSP_051899 | 230 | G → GADYQERFNPSALKDSALST HKPIEVKGLGGKATIIHAQY NTPISMYSQDAIMDAIAGQA QAQGSDFSG in isoform 4 and isoform 7. 2 Publications | 1 | |
Alternative sequenceiVSP_051900 | 299 – 361 | Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST | 63 | |
Alternative sequenceiVSP_051901 | 299 – 329 | STPIE…AAASP → RERFETERNSPRFAKLRNWH HGLSAQILNVK in isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST | 31 | |
Alternative sequenceiVSP_051902 | 331 – 727 | Missing in isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST | 397 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000263066; ENSP00000263066; ENSG00000122367 [O75112-6] ENST00000361373; ENSP00000355296; ENSG00000122367 ENST00000372056; ENSP00000361126; ENSG00000122367 [O75112-4] ENST00000372066; ENSP00000361136; ENSG00000122367 [O75112-6] ENST00000429277; ENSP00000401437; ENSG00000122367 [O75112-2] ENST00000623007; ENSP00000485389; ENSG00000122367 [O75112-5] ENST00000623056; ENSP00000485500; ENSG00000122367 [O75112-7] |
GeneIDi | 11155 |
KEGGi | hsa:11155 |
MANE-Selecti | ENST00000361373.9; ENSP00000355296.3; NM_007078.3; NP_009009.1 |
UCSCi | uc001kdr.4, human [O75112-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RGW | NMR | - | A | 1-85 | [»] | |
4YDP | X-ray | 1.40 | A/B | 1-84 | [»] | |
BMRBi | O75112 | |||||
SMRi | O75112 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116326, 12 interactors |
IntActi | O75112, 5 interactors |
PTM databases
GlyGeni | O75112, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O75112 |
PhosphoSitePlusi | O75112 |
Genetic variation databases
BioMutai | LDB3 |
2D gel databases
UCD-2DPAGEi | O75112 |
Proteomic databases
jPOSTi | O75112 |
MassIVEi | O75112 |
MaxQBi | O75112 |
PeptideAtlasi | O75112 |
PRIDEi | O75112 |
ProteomicsDBi | 49765 [O75112-1] 49766 [O75112-2] 49767 [O75112-3] 49768 [O75112-4] 49769 [O75112-5] 49770 [O75112-6] 49771 [O75112-7] |
Protocols and materials databases
Antibodypediai | 15974, 260 antibodies from 36 providers |
DNASUi | 11155 |
Genome annotation databases
Ensembli | ENST00000263066; ENSP00000263066; ENSG00000122367 [O75112-6] ENST00000361373; ENSP00000355296; ENSG00000122367 ENST00000372056; ENSP00000361126; ENSG00000122367 [O75112-4] ENST00000372066; ENSP00000361136; ENSG00000122367 [O75112-6] ENST00000429277; ENSP00000401437; ENSG00000122367 [O75112-2] ENST00000623007; ENSP00000485389; ENSG00000122367 [O75112-5] ENST00000623056; ENSP00000485500; ENSG00000122367 [O75112-7] |
GeneIDi | 11155 |
KEGGi | hsa:11155 |
MANE-Selecti | ENST00000361373.9; ENSP00000355296.3; NM_007078.3; NP_009009.1 |
UCSCi | uc001kdr.4, human [O75112-1] |
Organism-specific databases
CTDi | 11155 |
DisGeNETi | 11155 |
GeneCardsi | LDB3 |
GeneReviewsi | LDB3 |
HGNCi | HGNC:15710, LDB3 |
HPAi | ENSG00000122367, Group enriched (heart muscle, skeletal muscle, tongue) |
MalaCardsi | LDB3 |
MIMi | 601493, phenotype 605906, gene+phenotype 609452, phenotype |
neXtProti | NX_O75112 |
OpenTargetsi | ENSG00000122367 |
Orphaneti | 293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 154, Familial isolated dilated cardiomyopathy 98912, Late-onset distal myopathy, Markesbery-Griggs type 54260, Left ventricular noncompaction 155, NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy |
PharmGKBi | PA30318 |
VEuPathDBi | HostDB:ENSG00000122367 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154877 |
HOGENOMi | CLU_038114_0_1_1 |
InParanoidi | O75112 |
OMAi | SNVYCER |
OrthoDBi | 1013114at2759 |
PhylomeDBi | O75112 |
TreeFami | TF106408 |
Enzyme and pathway databases
PathwayCommonsi | O75112 |
SignaLinki | O75112 |
Miscellaneous databases
BioGRID-ORCSi | 11155, 10 hits in 1034 CRISPR screens |
ChiTaRSi | LDB3, human |
EvolutionaryTracei | O75112 |
GeneWikii | LDB3 |
GenomeRNAii | 11155 |
Pharosi | O75112, Tbio |
PROi | PR:O75112 |
RNActi | O75112, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122367, Expressed in cardiac ventricle and 224 other tissues |
ExpressionAtlasi | O75112, baseline and differential |
Genevisiblei | O75112, HS |
Family and domain databases
DisProti | DP01781 [O75112-6] |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR031847, DUF4749 IPR001478, PDZ IPR036034, PDZ_sf IPR006643, Zasp-like_motif IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF15936, DUF4749, 1 hit PF00412, LIM, 3 hits PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00132, LIM, 3 hits SM00228, PDZ, 1 hit SM00735, ZM, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 3 hits PS50106, PDZ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LDB3_HUMAN | |
Accessioni | O75112Primary (citable) accession number: O75112 Secondary accession number(s): A2TDB7 Q9Y4Z5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 6, 2005 | |
Last modified: | February 23, 2022 | |
This is version 188 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references