LDB3

Functionⁱ

May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.Curated

GO - Molecular functionⁱ

cytoskeletal protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17987659
metal ion binding Source: UniProtKB-KW
muscle alpha-actinin binding Source: Ensembl
protein kinase C binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

sarcomere organization Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: LIM domain-binding protein 3 Alternative name(s): Protein cypher Z-band alternatively spliced PDZ-motif protein
Gene namesⁱ	Name:LDB3Imported Synonyms:KIAA0613Imported, ZASPImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122367.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15710 LDB3
MIMⁱ	605906 gene+phenotype
neXtProtⁱ	NX_O75112

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cardiomyopathy, dilated 1C, with or without left ventricular non-compaction (CMD1C)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Cardiomyopathy dilated type 1C is associated with left ventricular non-compaction in some patients. Left ventricular non-compaction is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024009	189	S → L in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs45487699Ensembl.	1
Natural variantⁱVAR_024010	206	T → I in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs121908337EnsemblClinVar.	1
Natural variantⁱVAR_024011	345	I → M in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs121908336EnsemblClinVar.	1
Natural variantⁱVAR_024013	673	D → N in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs45514002EnsemblClinVar.	1

Left ventricular non-compaction 3 (LVNC3)

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of left ventricular non-compaction, a cardiomyopathy due to myocardial morphogenesis arrest and characterized by a hypertrophic left ventricle, a severely thickened 2-layered myocardium, numerous prominent trabeculations, deep intertrabecular recesses, and poor systolic function. Clinical manifestations are variable. Some affected individuals experience no symptoms at all, others develop heart failure. In some cases, left ventricular non-compaction is associated with other congenital heart anomalies. LVNC3 is an autosomal dominant condition.

Myopathy, myofibrillar, 4 (MFM4)

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disk and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFM4 is characterized by distal and proximal muscle weakness with signs of cardiomyopathy and neuropathy.

Feature key	Position(s)	DescriptionActions	Length
Isoform 21 Publication (identifier: O75112-2)
Natural variantⁱ	147	A → T in MFM4.	1
Natural variantⁱ	165	A → V in MFM4.	1
Isoform 61 Publication (identifier: O75112-6)
Natural variantⁱ	147	A → T in MFM4. Curated1 Publication	1
Natural variantⁱ	165	A → V in MFM4. Curated1 Publication	1
Natural variantⁱ	268	R → C in MFM4. Curated1 Publication	1
Isoform 41 Publication (identifier: O75112-4)
Natural variantⁱ	262	A → T in MFM4.	1
Natural variantⁱ	280	A → V in MFM4.	1
Natural variantⁱ	383	R → C in MFM4.	1

Keywords - Diseaseⁱ

Cardiomyopathy, Disease mutation, Myofibrillar myopathy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11155
GeneReviewsⁱ	LDB3
MalaCards human disease database More...MalaCardsⁱ	LDB3
MIMⁱ	601493 phenotype 605906 gene+phenotype 609452 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000122367
Orphanetⁱ	293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 154 Familial isolated dilated cardiomyopathy 98912 Late-onset distal myopathy, Markesbery-Griggs type 54260 Left ventricular noncompaction 155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
PharmGKBⁱ	PA30318

Polymorphism and mutation databases

BioMutaⁱ	LDB3

BioMutaⁱ

LDB3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000075767	1 – 727	LIM domain-binding protein 3Add BLAST		727

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	44	PhosphoserineBy similarity	1
Modified residueⁱ	121	PhosphoserineBy similarity	1
Modified residueⁱ	123	PhosphoserineBy similarity	1
Modified residueⁱ	217	PhosphoserineBy similarity	1
Modified residueⁱ	219	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	223	PhosphoserineBy similarity	1
Modified residueⁱ	516	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	533	Omega-N-methylarginineBy similarity	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75112
PeptideAtlas More...PeptideAtlasⁱ	O75112
PRIDEⁱ	O75112
ProteomicsDBⁱ	49765 49766 [O75112-2] 49767 [O75112-3] 49768 [O75112-4] 49769 [O75112-5] 49770 [O75112-6] 49771 [O75112-7]

2D gel databases

UCD-2DPAGEⁱ	O75112

UCD-2DPAGEⁱ

O75112

PTM databases

iPTMnetⁱ	O75112
PhosphoSitePlusⁱ	O75112

Expressionⁱ

Tissue specificityⁱ

Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000122367 Expressed in 213 organ(s), highest expression level in cardiac ventricle
ExpressionAtlasⁱ	O75112 baseline and differential
Genevisibleⁱ	O75112 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048955

HPAⁱ

HPA048955

Interactionⁱ

Subunit structureⁱ

Interacts via its LIM domains with various PKC isoforms (By similarity). Interacts via its PDZ domain with the ACTN2 C-terminal region. Interacts with MYOZ1, MYOZ2 and MYOZ3.By similarity2 Publications

GO - Molecular functionⁱ

cytoskeletal protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17987659
muscle alpha-actinin binding Source: Ensembl
protein kinase C binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116326, 6 interactors
IntActⁱ	O75112, 1 interactor

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	2 – 7	Combined sources	6
Beta strandⁱ	9 – 11	Combined sources	3
Beta strandⁱ	14 – 20	Combined sources	7
Helixⁱ	21 – 23	Combined sources	3
Beta strandⁱ	25 – 32	Combined sources	8
Helixⁱ	37 – 40	Combined sources	4
Beta strandⁱ	48 – 52	Combined sources	5
Helixⁱ	62 – 70	Combined sources	9
Beta strandⁱ	73 – 81	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	O75112
SMRⁱ	O75112
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O75112

EvolutionaryTraceⁱ

O75112

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 84	PDZPROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	549 – 607	LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST	59
Domainⁱ	608 – 667	LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	668 – 727	LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST	60

Keywords - Domainⁱ

LIM domain, Repeat

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000220936
HOVERGENⁱ	HBG051478
InParanoidⁱ	O75112
KEGG Orthology (KO) More...KOⁱ	K19867
OMAⁱ	CTSQATT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A45
PhylomeDBⁱ	O75112
TreeFamⁱ	TF106408

Family and domain databases

InterProⁱ	View protein in InterPro IPR031847 DUF4749 IPR001478 PDZ IPR036034 PDZ_sf IPR006643 Zasp-like_motif IPR001781 Znf_LIM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15936 DUF4749, 1 hit PF00412 LIM, 3 hits PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 3 hits SM00228 PDZ, 1 hit SM00735 ZM, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 2 hits PS50023 LIM_DOMAIN_2, 3 hits PS50106 PDZ, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1Curated (identifier: O75112-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV 
        60         70         80         90        100
AIDGVNTDTM THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL 
       110        120        130        140        150
PVIPHQKDPA LDTNGSLVAP SPSPEARASP GTPGTPELRP TFSPAFSRPS 
       160        170        180        190        200
AFSSLAEASD PGPPRASLRA KTSPEGARDL LGPKALPGSS QPRQYNNPIG 
       210        220        230        240        250
LYSAETLREM AQMYQMSLRG KASGVGLPGG SLPIKDLAVD SASPVYQAVI 
       260        270        280        290        300
KSQNKPEDEA DEWARRSSNL QSRSFRILAQ MTGTEFMQDP DEEALRRSST 
       310        320        330        340        350
PIEHAPVCTS QATTPLLPAS AQPPAAASPS AASPPLATAA AHTAIASAST 
       360        370        380        390        400
TAPASSPADS PRPQASSYSP AVAASSAPAT HTSYSEGPAA PAPKPRVVTT 
       410        420        430        440        450
ASIRPSVYQP VPASTYSPSP GANYSPTPYT PSPAPAYTPS PAPAYTPSPV 
       460        470        480        490        500
PTYTPSPAPA YTPSPAPNYN PAPSVAYSGG PAEPASRPPW VTDDSFSQKF 
       510        520        530        540        550
APGKSTTSIS KQTLPRGGPA YTPAGPQVPP LARGTVQRAE RFPASSRTPL 
       560        570        580        590        600
CGHCNNVIRG PFLVAMGRSW HPEEFTCAYC KTSLADVCFV EEQNNVYCER 
       610        620        630        640        650
CYEQFFAPLC AKCNTKIMGE VMHALRQTWH TTCFVCAACK KPFGNSLFHM 
       660        670        680        690        700
EDGEPYCEKD YINLFSTKCH GCDFPVEAGD KFIEALGHTW HDTCFICAVC 
       710        720 
HVNLEGQPFY SKKDRPLCKK HAHTINL

Note: No experimental confirmation available.Curated

Length:727

Mass (Da):77,135

Last modified:December 6, 2005 - v2

Checksum:ⁱ67B5B699D2B2AB68

GO

Isoform 21 Publication (identifier: O75112-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
108-229: DPALDTNGSL...GKASGVGLPG → VVVNSPANAD...QAQAQGSDFS
299-361: Missing.

« Hide

        10         20         30         40         50
MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV 
        60         70         80         90        100
AIDGVNTDTM THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL 
       110        120        130        140        150
PVIPHQKVVV NSPANADYQE RFNPSALKDS ALSTHKPIEV KGLGGKATII 
       160        170        180        190        200
HAQYNTPISM YSQDAIMDAI AGQAQAQGSD FSGSLPIKDL AVDSASPVYQ 
       210        220        230        240        250
AVIKSQNKPE DEADEWARRS SNLQSRSFRI LAQMTGTEFM QDPDEEALRR 
       260        270        280        290        300
SRPQASSYSP AVAASSAPAT HTSYSEGPAA PAPKPRVVTT ASIRPSVYQP 
       310        320        330        340        350
VPASTYSPSP GANYSPTPYT PSPAPAYTPS PAPAYTPSPV PTYTPSPAPA 
       360        370        380        390        400
YTPSPAPNYN PAPSVAYSGG PAEPASRPPW VTDDSFSQKF APGKSTTSIS 
       410        420        430        440        450
KQTLPRGGPA YTPAGPQVPP LARGTVQRAE RFPASSRTPL CGHCNNVIRG 
       460        470        480        490        500
PFLVAMGRSW HPEEFTCAYC KTSLADVCFV EEQNNVYCER CYEQFFAPLC 
       510        520        530        540        550
AKCNTKIMGE VMHALRQTWH TTCFVCAACK KPFGNSLFHM EDGEPYCEKD 
       560        570        580        590        600
YINLFSTKCH GCDFPVEAGD KFIEALGHTW HDTCFICAVC HVNLEGQPFY 
       610 
SKKDRPLCKK HAHTINL

Show »

Length:617

Mass (Da):66,671

Checksum:ⁱF3F1EA54284E4271

GO

Isoform 31 Publication (identifier: O75112-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
108-364: Missing.

« Hide

        10         20         30         40         50
MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV 
        60         70         80         90        100
AIDGVNTDTM THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL 
       110        120        130        140        150
PVIPHQKASS YSPAVAASSA PATHTSYSEG PAAPAPKPRV VTTASIRPSV 
       160        170        180        190        200
YQPVPASTYS PSPGANYSPT PYTPSPAPAY TPSPAPAYTP SPVPTYTPSP 
       210        220        230        240        250
APAYTPSPAP NYNPAPSVAY SGGPAEPASR PPWVTDDSFS QKFAPGKSTT 
       260        270        280        290        300
SISKQTLPRG GPAYTPAGPQ VPPLARGTVQ RAERFPASSR TPLCGHCNNV 
       310        320        330        340        350
IRGPFLVAMG RSWHPEEFTC AYCKTSLADV CFVEEQNNVY CERCYEQFFA 
       360        370        380        390        400
PLCAKCNTKI MGEVMHALRQ TWHTTCFVCA ACKKPFGNSL FHMEDGEPYC 
       410        420        430        440        450
EKDYINLFST KCHGCDFPVE AGDKFIEALG HTWHDTCFIC AVCHVNLEGQ 
       460        470
PFYSKKDRPL CKKHAHTINL

Show »

Length:470

Mass (Da):50,620

Checksum:ⁱEEDF0FA566FF03D5

GO

Isoform 41 Publication (identifier: O75112-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-230: G → GADYQERFNPSALKDSALSTHKPIEVKGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQAQGSDFSG
     299-329: STPIEHAPVCTSQATTPLLPASAQPPAAASP → RERFETERNSPRFAKLRNWHHGLSAQILNVK
     331-727: Missing.

« Hide

        10         20         30         40         50
MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV 
        60         70         80         90        100
AIDGVNTDTM THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL 
       110        120        130        140        150
PVIPHQKDPA LDTNGSLVAP SPSPEARASP GTPGTPELRP TFSPAFSRPS 
       160        170        180        190        200
AFSSLAEASD PGPPRASLRA KTSPEGARDL LGPKALPGSS QPRQYNNPIG 
       210        220        230        240        250
LYSAETLREM AQMYQMSLRG KASGVGLPGG ADYQERFNPS ALKDSALSTH 
       260        270        280        290        300
KPIEVKGLGG KATIIHAQYN TPISMYSQDA IMDAIAGQAQ AQGSDFSGSL 
       310        320        330        340        350
PIKDLAVDSA SPVYQAVIKS QNKPEDEADE WARRSSNLQS RSFRILAQMT 
       360        370        380        390 
GTEFMQDPDE EALRRSRERF ETERNSPRFA KLRNWHHGLS AQILNVKS

Show »

Length:398

Mass (Da):42,832

Checksum:ⁱ9046ADEF699169BE

GO

Isoform 51 Publication (identifier: O75112-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
299-329: STPIEHAPVCTSQATTPLLPASAQPPAAASP → RERFETERNSPRFAKLRNWHHGLSAQILNVK
331-727: Missing.

« Hide

        10         20         30         40         50
MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV 
        60         70         80         90        100
AIDGVNTDTM THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL 
       110        120        130        140        150
PVIPHQKDPA LDTNGSLVAP SPSPEARASP GTPGTPELRP TFSPAFSRPS 
       160        170        180        190        200
AFSSLAEASD PGPPRASLRA KTSPEGARDL LGPKALPGSS QPRQYNNPIG 
       210        220        230        240        250
LYSAETLREM AQMYQMSLRG KASGVGLPGG SLPIKDLAVD SASPVYQAVI 
       260        270        280        290        300
KSQNKPEDEA DEWARRSSNL QSRSFRILAQ MTGTEFMQDP DEEALRRSRE 
       310        320        330
RFETERNSPR FAKLRNWHHG LSAQILNVKS

Show »

Length:330

Mass (Da):35,637

Checksum:ⁱF6B8A00A6EF9B7E0

GO

Isoform 61 Publication (identifier: O75112-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-229: DPALDTNGSL...GKASGVGLPG → VVVNSPANAD...QAQAQGSDFS
     299-329: STPIEHAPVCTSQATTPLLPASAQPPAAASP → RERFETERNSPRFAKLRNWHHGLSAQILNVK
     331-727: Missing.

« Hide

        10         20         30         40         50
MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV 
        60         70         80         90        100
AIDGVNTDTM THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL 
       110        120        130        140        150
PVIPHQKVVV NSPANADYQE RFNPSALKDS ALSTHKPIEV KGLGGKATII 
       160        170        180        190        200
HAQYNTPISM YSQDAIMDAI AGQAQAQGSD FSGSLPIKDL AVDSASPVYQ 
       210        220        230        240        250
AVIKSQNKPE DEADEWARRS SNLQSRSFRI LAQMTGTEFM QDPDEEALRR 
       260        270        280 
SRERFETERN SPRFAKLRNW HHGLSAQILN VKS

Show »

Length:283

Mass (Da):30,999

Checksum:ⁱ099A4472DB4D9258

GO

Isoform 7 (identifier: O75112-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
230-230: G → GADYQERFNPSALKDSALSTHKPIEVKGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQAQGSDFSG
299-361: Missing.

« Hide

        10         20         30         40         50
MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV 
        60         70         80         90        100
AIDGVNTDTM THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL 
       110        120        130        140        150
PVIPHQKDPA LDTNGSLVAP SPSPEARASP GTPGTPELRP TFSPAFSRPS 
       160        170        180        190        200
AFSSLAEASD PGPPRASLRA KTSPEGARDL LGPKALPGSS QPRQYNNPIG 
       210        220        230        240        250
LYSAETLREM AQMYQMSLRG KASGVGLPGG ADYQERFNPS ALKDSALSTH 
       260        270        280        290        300
KPIEVKGLGG KATIIHAQYN TPISMYSQDA IMDAIAGQAQ AQGSDFSGSL 
       310        320        330        340        350
PIKDLAVDSA SPVYQAVIKS QNKPEDEADE WARRSSNLQS RSFRILAQMT 
       360        370        380        390        400
GTEFMQDPDE EALRRSRPQA SSYSPAVAAS SAPATHTSYS EGPAAPAPKP 
       410        420        430        440        450
RVVTTASIRP SVYQPVPAST YSPSPGANYS PTPYTPSPAP AYTPSPAPAY 
       460        470        480        490        500
TPSPVPTYTP SPAPAYTPSP APNYNPAPSV AYSGGPAEPA SRPPWVTDDS 
       510        520        530        540        550
FSQKFAPGKS TTSISKQTLP RGGPAYTPAG PQVPPLARGT VQRAERFPAS 
       560        570        580        590        600
SRTPLCGHCN NVIRGPFLVA MGRSWHPEEF TCAYCKTSLA DVCFVEEQNN 
       610        620        630        640        650
VYCERCYEQF FAPLCAKCNT KIMGEVMHAL RQTWHTTCFV CAACKKPFGN 
       660        670        680        690        700
SLFHMEDGEP YCEKDYINLF STKCHGCDFP VEAGDKFIEA LGHTWHDTCF 
       710        720        730 
ICAVCHVNLE GQPFYSKKDR PLCKKHAHTI NL

Note: No experimental confirmation available.

Show »

Length:732

Mass (Da):78,504

Checksum:ⁱ2820E6271E03DD4C

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A096LPD7	A0A096LPD7_HUMAN	LIM domain-binding protein 3 LIM domain-binding protein 3	LDB3	81	Annotation score:
A0A0C4DGG7	A0A0C4DGG7_HUMAN	LIM domain-binding protein 3 LIM domain-binding protein 3	LDB3	231	Annotation score:

Sequence cautionⁱ

Isoform 6 : The sequence AAQ14317 differs from that shown. Reason: Frameshift at positions 231 and 258.Curated1 Publication

The sequence BAA31588 differs from that shown. Reason: Erroneous initiation.Curated

Isoform 6 : The sequence CAB46727 differs from that shown. Reason: Frameshift at positions 250 and 258.Curated1 Publication

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	365 – 368	ASSY → VVVN in CAB46729 (PubMed:10427098).Curated		4
Sequence conflictⁱ	372	V → N in CAB46729 (PubMed:10427098).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024008	55	V → I1 PublicationCorresponds to variant dbSNP:rs3740343EnsemblClinVar.	1
Natural variantⁱVAR_050146	101	P → L. Corresponds to variant dbSNP:rs45592139EnsemblClinVar.	1
Natural variantⁱVAR_024009	189	S → L in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs45487699Ensembl.	1
Natural variantⁱVAR_024010	206	T → I in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs121908337EnsemblClinVar.	1
Natural variantⁱVAR_024011	345	I → M in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs121908336EnsemblClinVar.	1
Natural variantⁱVAR_024012	635	V → I1 PublicationCorresponds to variant dbSNP:rs45618633EnsemblClinVar.	1
Natural variantⁱVAR_024013	673	D → N in CMD1C. 1 PublicationCorresponds to variant dbSNP:rs45514002EnsemblClinVar.	1
Isoform 21 Publication (identifier: O75112-2)
Natural variantⁱ	117	D → N in dilated cardiomyopathy with left ventricular non-compaction.	1
Natural variantⁱ	136	K → M in dilated cardiomyopathy with left ventricular non-compaction.	1
Natural variantⁱ	147	A → T in MFM4.	1
Natural variantⁱ	165	A → V in MFM4.	1
Isoform 61 Publication (identifier: O75112-6)
Natural variantⁱ	147	A → T in MFM4. Curated1 Publication	1
Natural variantⁱ	165	A → V in MFM4. Curated1 Publication	1
Natural variantⁱ	268	R → C in MFM4. Curated1 Publication	1
Isoform 41 Publication (identifier: O75112-4)
Natural variantⁱ	232	D → N in dilated cardiomyopathy with left ventricular non-compaction.	1
Natural variantⁱ	251	K → M in dilated cardiomyopathy with left ventricular non-compaction.	1
Natural variantⁱ	262	A → T in MFM4.	1
Natural variantⁱ	280	A → V in MFM4.	1
Natural variantⁱ	383	R → C in MFM4.	1
Isoform 51 Publication (identifier: O75112-5)
Natural variantⁱ	315	R → C in MFM-ZASP.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_051897	108 – 364	Missing in isoform 3. 1 PublicationAdd BLAST	257
Alternative sequenceⁱVSP_051898	108 – 229	DPALD…VGLPG → VVVNSPANADYQERFNPSAL KDSALSTHKPIEVKGLGGKA TIIHAQYNTPISMYSQDAIM DAIAGQAQAQGSDFS in isoform 2 and isoform 6. 3 PublicationsAdd BLAST	122
Alternative sequenceⁱVSP_051899	230	G → GADYQERFNPSALKDSALST HKPIEVKGLGGKATIIHAQY NTPISMYSQDAIMDAIAGQA QAQGSDFSG in isoform 4 and isoform 7. 2 Publications	1
Alternative sequenceⁱVSP_051900	299 – 361	Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST	63
Alternative sequenceⁱVSP_051901	299 – 329	STPIE…AAASP → RERFETERNSPRFAKLRNWH HGLSAQILNVK in isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST	31
Alternative sequenceⁱVSP_051902	331 – 727	Missing in isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST	397

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ133766 mRNA Translation: CAB46727.1 Frameshift. AJ133767 mRNA Translation: CAB46728.1 AJ133768 mRNA Translation: CAB46729.1 AF276807 mRNA Translation: AAQ14316.1 AF276808 mRNA Translation: AAQ14317.1 Frameshift. AF276809 mRNA Translation: AAQ14318.1 AB014513 mRNA Translation: BAA31588.1 Different initiation. AK304760 mRNA Translation: BAG65515.1 EF179181 Genomic DNA Translation: ABN05284.1 AC067750 Genomic DNA No translation available. BC010929 mRNA Translation: AAH10929.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41544.1 [O75112-2] CCDS41545.1 [O75112-6] CCDS44450.1 [O75112-5] CCDS53549.1 [O75112-4] CCDS53550.1 [O75112-7] CCDS7377.1 [O75112-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001073583.1, NM_001080114.1 [O75112-2] NP_001073584.1, NM_001080115.1 [O75112-5] NP_001073585.1, NM_001080116.1 [O75112-6] NP_001165081.1, NM_001171610.1 [O75112-7] NP_001165082.1, NM_001171611.1 [O75112-4] NP_009009.1, NM_007078.2 [O75112-1] XP_005269521.1, XM_005269464.4 [O75112-1] XP_005269525.1, XM_005269468.4 [O75112-5] XP_011537497.1, XM_011539195.2 [O75112-4] XP_016871097.1, XM_017015608.1 [O75112-5] XP_016871098.1, XM_017015609.1 [O75112-6]
UniGeneⁱ	Hs.657271

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75112	LDB3 isoform 4		PANTR		727	UniRef100_O75112
O75112-2	LDB3 isoform 7		PANTR		617	UniRef100_A0A2I3S822
O75112-4	LDB3 isoform 8		PANTR		398	UniRef100_H2Q271
O75112-5	LDB3 isoform 5		PANTR		330	UniRef100_A0A2J8KIR3
LIM domain binding 3 isoform 2 (Fragment)		HUMAN		330
cDNA FLJ52572, highly similar to LIM domain-binding protein 3		HUMAN		271
O75112-6	LDB3 isoform 3		PONAB		283	UniRef100_A0A2J8XW67
LIM domain binding 3 isoform 1 (Fragment)		HUMAN		283
LDB3 isoform 3		PANTR		283
O75112-7	LDB3 isoform 1		PANTR		732	UniRef100_A0A2J8KIR0

Protein	Similar proteins		Species	Score	Length	Source
O75112	LDB3 isoform 4		PANTR		727	UniRef90_O75112
LIM domain binding 3		CERAT		735
Uncharacterized protein		MACMU		735
Uncharacterized protein		MACFA		735
LIM domain binding 3		SAIBB		727
+21
O75112-2	Isoform 4 of LIM domain-binding protein 3		MOUSE		622	UniRef90_Q9JKS4-4
Uncharacterized protein		MACMU		630
Uncharacterized protein		AOTNA		630
Uncharacterized protein		PAPAN		625
LIM domain binding 3		SAIBB		625
+80
O75112-4	LDB3 isoform 8		PANTR		398	UniRef90_H2Q271
Uncharacterized protein		PAPAN		398
Uncharacterized protein		RHIBE		398
LIM domain binding 3		SAIBB		398
Uncharacterized protein		Cebus capucinus imitator		398
+26
O75112-5	LIM domain-binding protein 3 isoform 3		MACMU		330	UniRef90_H9EUW3
Uncharacterized protein		RHIBE		330
LDB3 isoform 5		PANTR		330
LIM domain binding 3 isoform 2 (Fragment)		HUMAN		330
LDB3 isoform 7		PONAB		330
+9
O75112-6	LIM domain-binding 3		RAT		288	UniRef90_A0A0G2JXR0
Isoform 6 of LIM domain-binding protein 3		MOUSE		288
LIM domain-binding protein 3 isoform X4		MESAU		288
LIM domain-binding protein 3		CASCN		288
Uncharacterized protein		PIG		288
+89
O75112-7	LIM domain binding 3		BOVIN		730	UniRef90_G3N3C9
Uncharacterized protein		MACMU		740
Uncharacterized protein		CALJA		732
LIM domain binding 3		SAIBB		732
Uncharacterized protein		RHIRO		732
+50

Protein	Similar proteins		Species	Score	Length	Source
O75112	LIM domain-binding protein 3	)	MOUSE		723	UniRef50_O75112
LDB3 isoform 4		PANTR		727
Uncharacterized protein		MACMU		735
LIM domain binding 3		CERAT		735
Uncharacterized protein		MACFA		735
+490
O75112-3	Uncharacterized protein		ANOCA		525	UniRef50_O75112-3
LIM domain-binding protein 3 isoform X7		URSMA		586
UPI00090741B7		ALLMI		521
UPI0009072D0A		ALLMI		520
O75112-4	Isoform 5 of LIM domain-binding protein 3		MOUSE		327	UniRef50_Q9JKS4-5
LIM domain-binding protein 3 isoform X5		ODORO		332
LIM domain binding 3		BOVIN		330
LIM domain-binding protein 3 isoform X3		DELLE		330
LIM domain-binding protein 3 isoform X8		URSMA		330
+91
O75112-5	Uncharacterized protein		ORENI		326	UniRef50_I3KFU2
LIM domain-binding 3b (Fragment)		DANRE		242
Uncharacterized protein		ORNAN		288
Uncharacterized protein		ONCMY		212
LIM domain-binding protein 3-like isoform X1		SALSA		312
+39
O75112-6	LIM domain-binding 3		RAT		288	UniRef50_A0A0G2JXR0
Isoform 6 of LIM domain-binding protein 3		MOUSE		288
Uncharacterized protein		PIG		288
LIM domain-binding protein 3 isoform X4		MESAU		288
Uncharacterized protein		FELCA		288
+91

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ133766 mRNA Translation: CAB46727.1 Frameshift. AJ133767 mRNA Translation: CAB46728.1 AJ133768 mRNA Translation: CAB46729.1 AF276807 mRNA Translation: AAQ14316.1 AF276808 mRNA Translation: AAQ14317.1 Frameshift. AF276809 mRNA Translation: AAQ14318.1 AB014513 mRNA Translation: BAA31588.1 Different initiation. AK304760 mRNA Translation: BAG65515.1 EF179181 Genomic DNA Translation: ABN05284.1 AC067750 Genomic DNA No translation available. BC010929 mRNA Translation: AAH10929.1
CCDSⁱ	CCDS41544.1 [O75112-2] CCDS41545.1 [O75112-6] CCDS44450.1 [O75112-5] CCDS53549.1 [O75112-4] CCDS53550.1 [O75112-7] CCDS7377.1 [O75112-1]
RefSeqⁱ	NP_001073583.1, NM_001080114.1 [O75112-2] NP_001073584.1, NM_001080115.1 [O75112-5] NP_001073585.1, NM_001080116.1 [O75112-6] NP_001165081.1, NM_001171610.1 [O75112-7] NP_001165082.1, NM_001171611.1 [O75112-4] NP_009009.1, NM_007078.2 [O75112-1] XP_005269521.1, XM_005269464.4 [O75112-1] XP_005269525.1, XM_005269468.4 [O75112-5] XP_011537497.1, XM_011539195.2 [O75112-4] XP_016871097.1, XM_017015608.1 [O75112-5] XP_016871098.1, XM_017015609.1 [O75112-6]
UniGeneⁱ	Hs.657271

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1RGW	NMR	-	A	1-85	[»]
	4YDP	X-ray	1.40	A/B	1-84	[»]
ProteinModelPortalⁱ	O75112
SMRⁱ	O75112
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116326, 6 interactors
IntActⁱ	O75112, 1 interactor

PTM databases

iPTMnetⁱ	O75112
PhosphoSitePlusⁱ	O75112

Polymorphism and mutation databases

BioMutaⁱ	LDB3

BioMutaⁱ

LDB3

2D gel databases

UCD-2DPAGEⁱ	O75112

UCD-2DPAGEⁱ

O75112

Proteomic databases

MaxQBⁱ	O75112
PeptideAtlasⁱ	O75112
PRIDEⁱ	O75112
ProteomicsDBⁱ	49765 49766 [O75112-2] 49767 [O75112-3] 49768 [O75112-4] 49769 [O75112-5] 49770 [O75112-6] 49771 [O75112-7]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11155
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000263066; ENSP00000263066; ENSG00000122367 [O75112-2] ENST00000361373; ENSP00000355296; ENSG00000122367 [O75112-1] ENST00000372056; ENSP00000361126; ENSG00000122367 [O75112-4] ENST00000372066; ENSP00000361136; ENSG00000122367 [O75112-6] ENST00000429277; ENSP00000401437; ENSG00000122367 [O75112-7] ENST00000623007; ENSP00000485389; ENSG00000122367 [O75112-5] ENST00000623056; ENSP00000485500; ENSG00000122367 [O75112-7]
GeneIDⁱ	11155
KEGGⁱ	hsa:11155
UCSCⁱ	uc001kdr.4 human [O75112-1]

Organism-specific databases

CTDⁱ	11155
DisGeNETⁱ	11155
EuPathDBⁱ	HostDB:ENSG00000122367.19
GeneCardsⁱ	LDB3
GeneReviewsⁱ	LDB3
HGNCⁱ	HGNC:15710 LDB3
HPAⁱ	HPA048955
MalaCardsⁱ	LDB3
MIMⁱ	601493 phenotype 605906 gene+phenotype 609452 phenotype
neXtProtⁱ	NX_O75112
OpenTargetsⁱ	ENSG00000122367
Orphanetⁱ	293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form 293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form 293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form 154 Familial isolated dilated cardiomyopathy 98912 Late-onset distal myopathy, Markesbery-Griggs type 54260 Left ventricular noncompaction 155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
PharmGKBⁱ	PA30318
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000220936
HOVERGENⁱ	HBG051478
InParanoidⁱ	O75112
KOⁱ	K19867
OMAⁱ	CTSQATT
OrthoDBⁱ	EOG091G0A45
PhylomeDBⁱ	O75112
TreeFamⁱ	TF106408

Miscellaneous databases

ChiTaRSⁱ	LDB3 human
EvolutionaryTraceⁱ	O75112
GeneWikiⁱ	LDB3
GenomeRNAiⁱ	11155
Protein Ontology More...PROⁱ	PR:O75112
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122367 Expressed in 213 organ(s), highest expression level in cardiac ventricle
ExpressionAtlasⁱ	O75112 baseline and differential
Genevisibleⁱ	O75112 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR031847 DUF4749 IPR001478 PDZ IPR036034 PDZ_sf IPR006643 Zasp-like_motif IPR001781 Znf_LIM
Pfamⁱ	View protein in Pfam PF15936 DUF4749, 1 hit PF00412 LIM, 3 hits PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 3 hits SM00228 PDZ, 1 hit SM00735 ZM, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 2 hits PS50023 LIM_DOMAIN_2, 3 hits PS50106 PDZ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LDB3_HUMAN
Accessionⁱ	O75112Primary (citable) accession number: O75112 Secondary accession number(s): A2TDB7 Q9Y4Z5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	December 6, 2005
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - O75112 (LDB3_HUMAN)

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LIM domain-binding protein 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Left ventricular non-compaction 3 (LVNC3)

Myopathy, myofibrillar, 4 (MFM4)

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ