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Protein

Probable phospholipid-transporting ATPase IIA

Gene

ATP9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3914-aspartylphosphate intermediateBy similarity1
Metal bindingi785MagnesiumBy similarity1
Metal bindingi789MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • endocytosis Source: GO_Central
  • phospholipid translocation Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi3.A.3.8.16 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase IIA (EC:3.6.3.1)
Alternative name(s):
ATPase class II type 9A
Gene namesi
Name:ATP9A
Synonyms:ATPIIA, KIAA0611
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000054793.13
HGNCiHGNC:13540 ATP9A
MIMi609126 gene
neXtProtiNX_O75110

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 69CytoplasmicSequence analysisAdd BLAST68
Transmembranei70 – 91HelicalSequence analysisAdd BLAST22
Topological domaini92 – 96ExtracellularSequence analysis5
Transmembranei97 – 119HelicalSequence analysisAdd BLAST23
Topological domaini120 – 303CytoplasmicSequence analysisAdd BLAST184
Transmembranei304 – 325HelicalSequence analysisAdd BLAST22
Topological domaini326 – 332ExtracellularSequence analysis7
Transmembranei333 – 354HelicalSequence analysisAdd BLAST22
Topological domaini355 – 841CytoplasmicSequence analysisAdd BLAST487
Transmembranei842 – 862HelicalSequence analysisAdd BLAST21
Topological domaini863 – 874ExtracellularSequence analysisAdd BLAST12
Transmembranei875 – 893HelicalSequence analysisAdd BLAST19
Topological domaini894 – 923CytoplasmicSequence analysisAdd BLAST30
Transmembranei924 – 942HelicalSequence analysisAdd BLAST19
Topological domaini943 – 949ExtracellularSequence analysis7
Transmembranei950 – 972HelicalSequence analysisAdd BLAST23
Topological domaini973 – 978CytoplasmicSequence analysis6
Transmembranei979 – 999HelicalSequence analysisAdd BLAST21
Topological domaini1000 – 1006ExtracellularSequence analysis7
Transmembranei1007 – 1030HelicalSequence analysisAdd BLAST24
Topological domaini1031 – 1047CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10079
OpenTargetsiENSG00000054793
PharmGKBiPA25171

Polymorphism and mutation databases

BioMutaiATP9A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000463752 – 1047Probable phospholipid-transporting ATPase IIAAdd BLAST1046

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO75110
MaxQBiO75110
PaxDbiO75110
PeptideAtlasiO75110
PRIDEiO75110
ProteomicsDBi49763
49764 [O75110-2]

PTM databases

iPTMnetiO75110
PhosphoSitePlusiO75110
SwissPalmiO75110

Expressioni

Gene expression databases

BgeeiENSG00000054793 Expressed in 234 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_ATP9A
ExpressionAtlasiO75110 baseline and differential
GenevisibleiO75110 HS

Organism-specific databases

HPAiCAB020699
HPA035630

Interactioni

Protein-protein interaction databases

BioGridi115389, 38 interactors
IntActiO75110, 11 interactors
MINTiO75110
STRINGi9606.ENSP00000342481

Structurei

3D structure databases

ProteinModelPortaliO75110
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0210 Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00550000074723
HOVERGENiHBG050617
InParanoidiO75110
KOiK01530
OMAiGHPEKRE
OrthoDBiEOG091G076A
PhylomeDBiO75110
TreeFamiTF300590

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030356 ATP9A
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF49 PTHR24092:SF49, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 2 hits
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform Long (identifier: O75110-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDNIPLQPV RQKKRMDSRP RAGCCEWLRC CGGGEARPRT VWLGHPEKRD
60 70 80 90 100
QRYPRNVINN QKYNFFTFLP GVLFNQFKYF FNLYFLLLAC SQFVPEMRLG
110 120 130 140 150
ALYTYWVPLG FVLAVTVIRE AVEEIRCYVR DKEVNSQVYS RLTARGTVKV
160 170 180 190 200
KSSNIQVGDL IIVEKNQRVP ADMIFLRTSE KNGSCFLRTD QLDGETDWKL
210 220 230 240 250
RLPVACTQRL PTAADLLQIR SYVYAEEPNI DIHNFVGTFT REDSDPPISE
260 270 280 290 300
SLSIENTLWA GTVVASGTVV GVVLYTGREL RSVMNTSNPR SKIGLFDLEV
310 320 330 340 350
NCLTKILFGA LVVVSLVMVA LQHFAGRWYL QIIRFLLLFS NIIPISLRVN
360 370 380 390 400
LDMGKIVYSW VIRRDSKIPG TVVRSSTIPE QLGRISYLLT DKTGTLTQNE
410 420 430 440 450
MIFKRLHLGT VAYGLDSMDE VQSHIFSIYT QQSQDPPAQK GPTLTTKVRR
460 470 480 490 500
TMSSRVHEAV KAIALCHNVT PVYESNGVTD QAEAEKQYED SCRVYQASSP
510 520 530 540 550
DEVALVQWTE SVGLTLVGRD QSSMQLRTPG DQILNFTILQ IFPFTYESKR
560 570 580 590 600
MGIIVRDEST GEITFYMKGA DVVMAGIVQY NDWLEEECGN MAREGLRVLV
610 620 630 640 650
VAKKSLAEEQ YQDFEARYVQ AKLSVHDRSL KVATVIESLE MEMELLCLTG
660 670 680 690 700
VEDQLQADVR PTLETLRNAG IKVWMLTGDK LETATCTAKN AHLVTRNQDI
710 720 730 740 750
HVFRLVTNRG EAHLELNAFR RKHDCALVIS GDSLEVCLKY YEYEFMELAC
760 770 780 790 800
QCPAVVCCRC APTQKAQIVR LLQERTGKLT CAVGDGGNDV SMIQESDCGV
810 820 830 840 850
GVEGKEGKQA SLAADFSITQ FKHLGRLLMV HGRNSYKRSA ALSQFVIHRS
860 870 880 890 900
LCISTMQAVF SSVFYFASVP LYQGFLIIGY STIYTMFPVF SLVLDKDVKS
910 920 930 940 950
EVAMLYPELY KDLLKGRPLS YKTFLIWVLI SIYQGSTIMY GALLLFESEF
960 970 980 990 1000
VHIVAISFTS LILTELLMVA LTIQTWHWLM TVAELLSLAC YIASLVFLHE
1010 1020 1030 1040
FIDVYFIATL SFLWKVSVIT LVSCLPLYVL KYLRRRFSPP SYSKLTS
Length:1,047
Mass (Da):118,583
Last modified:January 24, 2001 - v3
Checksum:i80C307CF5A396755
GO
Isoform Short (identifier: O75110-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-269: Missing.

Show »
Length:926
Mass (Da):105,133
Checksum:iF2F66A97B9000AA4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR22A0A0A0MR22_HUMAN
Phospholipid-transporting ATPase
ATP9A
911Annotation score:

Sequence cautioni

The sequence BAD18775 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186F → S in BAD18775 (PubMed:14702039).Curated1
Sequence conflicti415L → P in BAD18775 (PubMed:14702039).Curated1
Sequence conflicti957S → P in BAD18775 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000432149 – 269Missing in isoform Short. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035684 Genomic DNA No translation available.
AL138807 Genomic DNA No translation available.
AL353799 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75597.1
CH471077 Genomic DNA Translation: EAW75598.1
CH471077 Genomic DNA Translation: EAW75599.1
CH471077 Genomic DNA Translation: EAW75600.1
AB014511 mRNA Translation: BAA31586.1
AK172802 mRNA Translation: BAD18775.1 Different initiation.
CCDSiCCDS33489.1 [O75110-1]
RefSeqiNP_006036.1, NM_006045.2 [O75110-1]
UniGeneiHs.649234

Genome annotation databases

EnsembliENST00000338821; ENSP00000342481; ENSG00000054793 [O75110-1]
GeneIDi10079
KEGGihsa:10079
UCSCiuc002xwg.2 human [O75110-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035684 Genomic DNA No translation available.
AL138807 Genomic DNA No translation available.
AL353799 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75597.1
CH471077 Genomic DNA Translation: EAW75598.1
CH471077 Genomic DNA Translation: EAW75599.1
CH471077 Genomic DNA Translation: EAW75600.1
AB014511 mRNA Translation: BAA31586.1
AK172802 mRNA Translation: BAD18775.1 Different initiation.
CCDSiCCDS33489.1 [O75110-1]
RefSeqiNP_006036.1, NM_006045.2 [O75110-1]
UniGeneiHs.649234

3D structure databases

ProteinModelPortaliO75110
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115389, 38 interactors
IntActiO75110, 11 interactors
MINTiO75110
STRINGi9606.ENSP00000342481

Protein family/group databases

TCDBi3.A.3.8.16 the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiO75110
PhosphoSitePlusiO75110
SwissPalmiO75110

Polymorphism and mutation databases

BioMutaiATP9A

Proteomic databases

EPDiO75110
MaxQBiO75110
PaxDbiO75110
PeptideAtlasiO75110
PRIDEiO75110
ProteomicsDBi49763
49764 [O75110-2]

Protocols and materials databases

DNASUi10079
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338821; ENSP00000342481; ENSG00000054793 [O75110-1]
GeneIDi10079
KEGGihsa:10079
UCSCiuc002xwg.2 human [O75110-1]

Organism-specific databases

CTDi10079
DisGeNETi10079
EuPathDBiHostDB:ENSG00000054793.13
GeneCardsiATP9A
HGNCiHGNC:13540 ATP9A
HPAiCAB020699
HPA035630
MIMi609126 gene
neXtProtiNX_O75110
OpenTargetsiENSG00000054793
PharmGKBiPA25171
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0210 Eukaryota
ENOG410XPYK LUCA
GeneTreeiENSGT00550000074723
HOVERGENiHBG050617
InParanoidiO75110
KOiK01530
OMAiGHPEKRE
OrthoDBiEOG091G076A
PhylomeDBiO75110
TreeFamiTF300590

Enzyme and pathway databases

ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRSiATP9A human
GenomeRNAii10079
PROiPR:O75110
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000054793 Expressed in 234 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_ATP9A
ExpressionAtlasiO75110 baseline and differential
GenevisibleiO75110 HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030356 ATP9A
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF49 PTHR24092:SF49, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 2 hits
SSF81660 SSF81660, 2 hits
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATP9A_HUMAN
AccessioniPrimary (citable) accession number: O75110
Secondary accession number(s): E1P5Y3
, E1P5Y4, Q5TFW5, Q5TFW6, Q5TFW9, Q6ZMF3, Q9NQK6, Q9NQK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 24, 2001
Last modified: September 12, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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