AOC2

Functionⁱ

Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina.2 Publications

Catalytic activityⁱ

RCH₂NH₂ + H₂O + O₂ = RCHO + NH₃ + H₂O₂.By similarity

Cofactorⁱ

Protein has several cofactor binding sites:

Cu cation
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P19801 (AOC1_HUMAN)
Note: Binds 1 copper ion per subunit.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P19801 (AOC1_HUMAN)
Ca²⁺
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P19801 (AOC1_HUMAN)
Note: Binds 2 calcium ions per subunit.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P19801 (AOC1_HUMAN)
L-topaquinone
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P19801 (AOC1_HUMAN)
Note: Contains 1 topaquinone per subunit.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P19801 (AOC1_HUMAN)

Kineticsⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	380	Proton acceptorBy similarity	1
Active siteⁱ	465	Schiff-base intermediate with substrate; via topaquinoneBy similarity	1
Metal bindingⁱ	516	Copper; via tele nitrogenBy similarity	1
Metal bindingⁱ	518	Copper; via tele nitrogenBy similarity	1
Metal bindingⁱ	525	Calcium 1By similarity	1
Metal bindingⁱ	526	Calcium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	527	Calcium 1By similarity	1
Metal bindingⁱ	568	Calcium 2By similarity	1
Metal bindingⁱ	659	Calcium 2; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	661	Calcium 2By similarity	1
Metal bindingⁱ	663	Calcium 2By similarity	1
Metal bindingⁱ	669	Calcium 1By similarity	1
Metal bindingⁱ	670	Calcium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	680	Copper; via pros nitrogenBy similarity	1

GO - Molecular functionⁱ

aliphatic-amine oxidase activity Source: UniProtKB-EC
aminoacetone:oxygen oxidoreductase(deaminating) activity Source: UniProtKB-EC
copper ion binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
electron transfer activity
Source: UniProtKB
Traceable author statementⁱ
- 9119395
phenethylamine:oxygen oxidoreductase (deaminating) activity Source: UniProtKB-EC
primary amine oxidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
quinone binding Source: InterPro
tryptamine:oxygen oxidoreductase (deaminating) activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amine metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
catecholamine metabolic process Source: UniProtKB-KW
visual perception
Source: ProtInc
Traceable author statementⁱ
- 9119395
xenobiotic metabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Catecholamine metabolism
Ligand	Calcium, Copper, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	1.4.3.21 2681
Reactomeⁱ	R-HSA-211945 Phase I - Functionalization of compounds
SABIO-RKⁱ	O75106

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Retina-specific copper amine oxidase (EC:1.4.3.21By similarity) Short name: RAO Alternative name(s): Amine oxidase [copper-containing] Semicarbazide-sensitive amine oxidase Short name: SSAO
Gene namesⁱ	Name:AOC2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131480.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:549 AOC2
MIMⁱ	602268 gene
neXtProtⁱ	NX_O75106

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	314
Open Targets More...OpenTargetsⁱ	ENSG00000131480
PharmGKBⁱ	PA24839

Chemistry databases

ChEMBLⁱ	CHEMBL4112

ChEMBLⁱ

CHEMBL4112

Polymorphism and mutation databases

BioMutaⁱ	AOC2

BioMutaⁱ

AOC2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 32	Sequence analysisAdd BLAST		32
ChainⁱPRO_0000035671	33 – 756	Retina-specific copper amine oxidaseAdd BLAST		724

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	133	N-linked (GlcNAc...) asparagineBy similarity	1
Glycosylationⁱ	198	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	226	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	398 ↔ 424	By similarity
Modified residueⁱ	465	2',4',5'-topaquinoneBy similarity	1
Glycosylationⁱ	588	N-linked (GlcNAc...) (complex) asparagineBy similarity	1
Glycosylationⁱ	662	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	730 ↔ 737	By similarity
Disulfide bondⁱ	744	InterchainBy similarity

Post-translational modificationⁱ

Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, TPQ

Proteomic databases

PaxDbⁱ	O75106
PeptideAtlas More...PeptideAtlasⁱ	O75106
PRIDEⁱ	O75106
ProteomicsDBⁱ	49761 49762 [O75106-2]

PTM databases

GlyConnectⁱ	1714
iPTMnetⁱ	O75106
PhosphoSitePlusⁱ	O75106

Expressionⁱ

Tissue specificityⁱ

Expressed in many tissues with much higher expression in retina. Isoform 1 and isoform 2 are expressed in adipose tissue, whereas isoform 1 only seems to be present in thymus, and isoform 2 only in testis.3 Publications

Inductionⁱ

Up-regulated during in vitro adipocyte differentiation.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000131480 Expressed in 97 organ(s), highest expression level in blood
CleanExⁱ	HS_AOC2
Genevisibleⁱ	O75106 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA057779

HPAⁱ

HPA057779

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked (By similarity). Forms a heterodimer with AOC3, in vitro.By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	106811, 6 interactors
IntActⁱ	O75106, 2 interactors
STRINGⁱ	9606.ENSP00000253799

Chemistry databases

BindingDBⁱ

O75106

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75106
SMRⁱ	O75106
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	378 – 388	Substrate bindingBy similarityAdd BLAST	11
Regionⁱ	462 – 467	Substrate bindingBy similarity	6
Regionⁱ	574 – 581	Heparin-bindingBy similarity	8

Sequence similaritiesⁱ

Belongs to the copper/topaquinone oxidase family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1186 Eukaryota COG3733 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046461
HOGENOMⁱ	HOG000233919
HOVERGENⁱ	HBG004164
InParanoidⁱ	O75106
KEGG Orthology (KO) More...KOⁱ	K00276
OMAⁱ	NANWARY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02WY
PhylomeDBⁱ	O75106
TreeFamⁱ	TF314750

Family and domain databases

Gene3Dⁱ	2.70.98.20, 1 hit
InterProⁱ	View protein in InterPro IPR032952 AOC2 IPR000269 Cu_amine_oxidase IPR015798 Cu_amine_oxidase_C IPR036460 Cu_amine_oxidase_C_sf IPR016182 Cu_amine_oxidase_N-reg IPR015800 Cu_amine_oxidase_N2 IPR015802 Cu_amine_oxidase_N3
PANTHERⁱ	PTHR10638 PTHR10638, 1 hit PTHR10638:SF4 PTHR10638:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01179 Cu_amine_oxid, 1 hit PF02727 Cu_amine_oxidN2, 1 hit PF02728 Cu_amine_oxidN3, 1 hit
PRINTSⁱ	PR00766 CUDAOXIDASE
SUPFAMⁱ	SSF49998 SSF49998, 1 hit SSF54416 SSF54416, 2 hits
PROSITEⁱ	View protein in PROSITE PS01164 COPPER_AMINE_OXID_1, 1 hit PS01165 COPPER_AMINE_OXID_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O75106-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHLKIVLAFL ALSLITIFAL AYVLLTSPGG SSQPPHCPSV SHRAQPWPHP 
        60         70         80         90        100
GQSQLFADLS REELTAVMRF LTQRLGPGLV DAAQAQPSDN CIFSVELQLP 
       110        120        130        140        150
PKAAALAHLD RGSPPPAREA LAIVLFGGQP QPNVSELVVG PLPHPSYMRD 
       160        170        180        190        200
VTVERHGGPL PYHRRPVLRA EFTQMWRHLK EVELPKAPIF LSSTFNYNGS 
       210        220        230        240        250
TLAAVHATPR GLRSGDRATW MALYHNISGV GLFLHPVGLE LLLDHRALDP 
       260        270        280        290        300
AHWTVQQVFY LGHYYADLGQ LEREFKSGRL EVVRVPLPPP NGASSLRSRN 
       310        320        330        340        350
SPGPLPPLQF SPQGSQYSVQ GNLVVSSLWS FTFGHGVFSG LRIFDVRFQG 
       360        370        380        390        400
ERIAYEVSVQ ECVSIYGADS PKTMLTRYLD SSFGLGRNSR GLVRGVDCPY 
       410        420        430        440        450
QATMVDIHIL VGKGAVQLLP GAVCVFEEAQ GLPLRRHHNY LQNHFYGGLA 
       460        470        480        490        500
SSALVVRSVS SVGNYDYIWD FVLYPNGALE GRVHATGYIN TAFLKGGEEG 
       510        520        530        540        550
LLFGNRVGER VLGTVHTHAF HFKLDLDVAG LKNWVVAEDV VFKPVAAPWN 
       560        570        580        590        600
PEHWLQRPQL TRQVLGKEDL TAFSLGSPLP RYLYLASNQT NAWGHQRGYR 
       610        620        630        640        650
IQIHSPLGIH IPLESDMERA LSWGRYQLVV TQRKEEESQS SSIYHQNDIW 
       660        670        680        690        700
TPTVTFADFI NNETLLGEDL VAWVTASFLH IPHAEDIPNT VTLGNRVGFL 
       710        720        730        740        750
LRPYNFFDED PSIFSPGSVY FEKGQDAGLC SINPVACLPD LAACVPDLPP 

FSYHGF

Length:756

Mass (Da):83,673

Last modified:January 24, 2006 - v2

Checksum:ⁱ10263D8D56D3BD25

GO

Isoform 2 (identifier: O75106-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
599-625: Missing.

« Hide

        10         20         30         40         50
MHLKIVLAFL ALSLITIFAL AYVLLTSPGG SSQPPHCPSV SHRAQPWPHP 
        60         70         80         90        100
GQSQLFADLS REELTAVMRF LTQRLGPGLV DAAQAQPSDN CIFSVELQLP 
       110        120        130        140        150
PKAAALAHLD RGSPPPAREA LAIVLFGGQP QPNVSELVVG PLPHPSYMRD 
       160        170        180        190        200
VTVERHGGPL PYHRRPVLRA EFTQMWRHLK EVELPKAPIF LSSTFNYNGS 
       210        220        230        240        250
TLAAVHATPR GLRSGDRATW MALYHNISGV GLFLHPVGLE LLLDHRALDP 
       260        270        280        290        300
AHWTVQQVFY LGHYYADLGQ LEREFKSGRL EVVRVPLPPP NGASSLRSRN 
       310        320        330        340        350
SPGPLPPLQF SPQGSQYSVQ GNLVVSSLWS FTFGHGVFSG LRIFDVRFQG 
       360        370        380        390        400
ERIAYEVSVQ ECVSIYGADS PKTMLTRYLD SSFGLGRNSR GLVRGVDCPY 
       410        420        430        440        450
QATMVDIHIL VGKGAVQLLP GAVCVFEEAQ GLPLRRHHNY LQNHFYGGLA 
       460        470        480        490        500
SSALVVRSVS SVGNYDYIWD FVLYPNGALE GRVHATGYIN TAFLKGGEEG 
       510        520        530        540        550
LLFGNRVGER VLGTVHTHAF HFKLDLDVAG LKNWVVAEDV VFKPVAAPWN 
       560        570        580        590        600
PEHWLQRPQL TRQVLGKEDL TAFSLGSPLP RYLYLASNQT NAWGHQRGYQ 
       610        620        630        640        650
LVVTQRKEEE SQSSSIYHQN DIWTPTVTFA DFINNETLLG EDLVAWVTAS 
       660        670        680        690        700
FLHIPHAEDI PNTVTLGNRV GFLLRPYNFF DEDPSIFSPG SVYFEKGQDA 
       710        720 
GLCSINPVAC LPDLAACVPD LPPFSYHGF

Show »

Length:729

Mass (Da):80,516

Checksum:ⁱ5F28CCC8EE353415

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	181	E → D (PubMed:9119395).Curated	1
Sequence conflictⁱ	181	E → D (PubMed:9722954).Curated	1
Sequence conflictⁱ	215 – 218	GDRA → RERT (PubMed:9119395).Curated	4
Sequence conflictⁱ	215 – 218	GDRA → RERT (PubMed:9722954).Curated	4
Sequence conflictⁱ	221 – 222	MA → IG (PubMed:9119395).Curated	2
Sequence conflictⁱ	610	H → Q (PubMed:9119395).Curated	1
Sequence conflictⁱ	610	H → Q (PubMed:9722954).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_025022	5	I → V1 PublicationCorresponds to variant dbSNP:rs34230945Ensembl.	1
Natural variantⁱVAR_025023	22	Y → C1 PublicationCorresponds to variant dbSNP:rs34435306Ensembl.	1
Natural variantⁱVAR_025024	141	P → L1 PublicationCorresponds to variant dbSNP:rs35833794Ensembl.	1
Natural variantⁱVAR_025025	273	R → Q1 PublicationCorresponds to variant dbSNP:rs35508987Ensembl.	1
Natural variantⁱVAR_025026	427	E → D1 PublicationCorresponds to variant dbSNP:rs34351794Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006549	599 – 625	Missing in isoform 2. 1 PublicationAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D88213 mRNA Translation: BAA19001.1 AB012943 Genomic DNA Translation: BAA32590.1 AB012943 Genomic DNA Translation: BAA32589.1 AF081363 mRNA Translation: AAD39345.1 DQ060035 Genomic DNA Translation: AAY43129.1 AC016889 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60895.1 BC142641 mRNA Translation: AAI42642.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11443.1 [O75106-1] CCDS45690.1 [O75106-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001149.2, NM_001158.4 [O75106-2] NP_033720.2, NM_009590.3 [O75106-1]
UniGeneⁱ	Hs.143102

Genome annotation databases

Ensemblⁱ	ENST00000253799; ENSP00000253799; ENSG00000131480 [O75106-1] ENST00000452774; ENSP00000406134; ENSG00000131480 [O75106-2]
GeneIDⁱ	314
KEGGⁱ	hsa:314
UCSC genome browser More...UCSCⁱ	uc002ibt.5 human [O75106-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75106	Amine oxidase		MACFA		756	UniRef90_O75106
Amine oxidase		PROCO		756
Amine oxidase		MACMU		756
Amine oxidase		Cebus capucinus imitator		756
Amine oxidase		COLAP		756
+19
O75106-2	Amine oxidase		MACMU		729	UniRef90_O75106-2
Amine oxidase		PONAB		729
Amine oxidase		PANTR		729
UPI0003ABAB6D		MACFA		729
UPI00045E2B22		CHLSB		729
+8

Protein	Similar proteins		Species	Score	Length	Source
O75106	Isoform 3 of Membrane primary amine oxidase		HUMAN		220	UniRef50_Q16853-3
Membrane primary amine oxidase		BOVIN		763
Retina-specific copper amine oxidase		MOUSE		757
Membrane primary amine oxidase		PONAB		763
Amine oxidase		MUSPF		771
+523

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D88213 mRNA Translation: BAA19001.1 AB012943 Genomic DNA Translation: BAA32590.1 AB012943 Genomic DNA Translation: BAA32589.1 AF081363 mRNA Translation: AAD39345.1 DQ060035 Genomic DNA Translation: AAY43129.1 AC016889 Genomic DNA No translation available. CH471152 Genomic DNA Translation: EAW60895.1 BC142641 mRNA Translation: AAI42642.1
CCDSⁱ	CCDS11443.1 [O75106-1] CCDS45690.1 [O75106-2]
RefSeqⁱ	NP_001149.2, NM_001158.4 [O75106-2] NP_033720.2, NM_009590.3 [O75106-1]
UniGeneⁱ	Hs.143102

3D structure databases

ProteinModelPortalⁱ	O75106
SMRⁱ	O75106
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106811, 6 interactors
IntActⁱ	O75106, 2 interactors
STRINGⁱ	9606.ENSP00000253799

Chemistry databases

BindingDBⁱ	O75106
ChEMBLⁱ	CHEMBL4112

PTM databases

GlyConnectⁱ	1714
iPTMnetⁱ	O75106
PhosphoSitePlusⁱ	O75106

Polymorphism and mutation databases

BioMutaⁱ	AOC2

BioMutaⁱ

AOC2

Proteomic databases

PaxDbⁱ	O75106
PeptideAtlasⁱ	O75106
PRIDEⁱ	O75106
ProteomicsDBⁱ	49761 49762 [O75106-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000253799; ENSP00000253799; ENSG00000131480 [O75106-1] ENST00000452774; ENSP00000406134; ENSG00000131480 [O75106-2]
GeneIDⁱ	314
KEGGⁱ	hsa:314
UCSCⁱ	uc002ibt.5 human [O75106-1]

Organism-specific databases

CTDⁱ	314
DisGeNETⁱ	314
EuPathDBⁱ	HostDB:ENSG00000131480.8
GeneCardsⁱ	AOC2
HGNCⁱ	HGNC:549 AOC2
HPAⁱ	HPA057779
MIMⁱ	602268 gene
neXtProtⁱ	NX_O75106
OpenTargetsⁱ	ENSG00000131480
PharmGKBⁱ	PA24839
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1186 Eukaryota COG3733 LUCA
GeneTreeⁱ	ENSGT00510000046461
HOGENOMⁱ	HOG000233919
HOVERGENⁱ	HBG004164
InParanoidⁱ	O75106
KOⁱ	K00276
OMAⁱ	NANWARY
OrthoDBⁱ	EOG091G02WY
PhylomeDBⁱ	O75106
TreeFamⁱ	TF314750

Enzyme and pathway databases

BRENDAⁱ	1.4.3.21 2681
Reactomeⁱ	R-HSA-211945 Phase I - Functionalization of compounds
SABIO-RKⁱ	O75106

Miscellaneous databases

GenomeRNAiⁱ	314
Protein Ontology More...PROⁱ	PR:O75106
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131480 Expressed in 97 organ(s), highest expression level in blood
CleanExⁱ	HS_AOC2
Genevisibleⁱ	O75106 HS

Family and domain databases

Gene3Dⁱ	2.70.98.20, 1 hit
InterProⁱ	View protein in InterPro IPR032952 AOC2 IPR000269 Cu_amine_oxidase IPR015798 Cu_amine_oxidase_C IPR036460 Cu_amine_oxidase_C_sf IPR016182 Cu_amine_oxidase_N-reg IPR015800 Cu_amine_oxidase_N2 IPR015802 Cu_amine_oxidase_N3
PANTHERⁱ	PTHR10638 PTHR10638, 1 hit PTHR10638:SF4 PTHR10638:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF01179 Cu_amine_oxid, 1 hit PF02727 Cu_amine_oxidN2, 1 hit PF02728 Cu_amine_oxidN3, 1 hit
PRINTSⁱ	PR00766 CUDAOXIDASE
SUPFAMⁱ	SSF49998 SSF49998, 1 hit SSF54416 SSF54416, 2 hits
PROSITEⁱ	View protein in PROSITE PS01164 COPPER_AMINE_OXID_1, 1 hit PS01165 COPPER_AMINE_OXID_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AOC2_HUMAN
Accessionⁱ	O75106Primary (citable) accession number: O75106 Secondary accession number(s): A5PKW2 , O00120, O75105, Q4TTW5, Q9UNY0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	January 24, 2006
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O75106 (AOC2_HUMAN)

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Retina-specific copper amine oxidase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ