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Entry version 175 (08 May 2019)
Sequence version 3 (02 Nov 2010)
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Protein

Slit homolog 3 protein

Gene

SLIT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • Roundabout binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373752 Netrin-1 signaling
R-HSA-376176 Signaling by ROBO receptors
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Slit homolog 3 protein
Short name:
Slit-3
Alternative name(s):
Multiple epidermal growth factor-like domains protein 5
Short name:
Multiple EGF-like domains protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLIT3
Synonyms:KIAA0814, MEGF5, SLIL2
ORF Names:UNQ691/PRO1336
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11087 SLIT3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603745 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75094

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6586

Open Targets

More...
OpenTargetsi
ENSG00000184347

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35940

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLIT3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000773234 – 1523Slit homolog 3 proteinAdd BLAST1490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi284 ↔ 293By similarity
Disulfide bondi441 ↔ 464By similarity
Disulfide bondi443 ↔ 485By similarity
Disulfide bondi505 ↔ 511By similarity
Disulfide bondi509 ↔ 518By similarity
Glycosylationi563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi622N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi667 ↔ 690By similarity
Disulfide bondi669 ↔ 711By similarity
Glycosylationi784N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi792N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi797N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi920 ↔ 931By similarity
Disulfide bondi925 ↔ 941By similarity
Glycosylationi928N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi943 ↔ 952By similarity
Disulfide bondi959 ↔ 970By similarity
Disulfide bondi964 ↔ 982By similarity
Disulfide bondi984 ↔ 993By similarity
Disulfide bondi1000 ↔ 1011By similarity
Disulfide bondi1005 ↔ 1020By similarity
Glycosylationi1008N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1022 ↔ 1031By similarity
Glycosylationi1025N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1038 ↔ 1051By similarity
Disulfide bondi1045 ↔ 1060By similarity
Disulfide bondi1062 ↔ 1071By similarity
Disulfide bondi1078 ↔ 1089By similarity
Disulfide bondi1083 ↔ 1098By similarity
Disulfide bondi1100 ↔ 1109By similarity
Disulfide bondi1123 ↔ 1134By similarity
Disulfide bondi1128 ↔ 1143By similarity
Disulfide bondi1145 ↔ 1154By similarity
Glycosylationi1181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1305 ↔ 1332By similarity
Disulfide bondi1355 ↔ 1364By similarity
Disulfide bondi1372 ↔ 1382By similarity
Disulfide bondi1377 ↔ 1391By similarity
Disulfide bondi1393 ↔ 1402By similarity
Glycosylationi1406N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1412 ↔ 1422By similarity
Disulfide bondi1417 ↔ 1432By similarity
Disulfide bondi1434 ↔ 1443By similarity
Disulfide bondi1449 ↔ 1487By similarity
Disulfide bondi1467 ↔ 1501By similarity
Disulfide bondi1478 ↔ 1517By similarity
Disulfide bondi1482 ↔ 1519By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75094

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75094

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75094

PeptideAtlas

More...
PeptideAtlasi
O75094

PRoteomics IDEntifications database

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PRIDEi
O75094

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49755
49756 [O75094-2]
49757 [O75094-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1750

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75094

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75094

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in thyroid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184347 Expressed in 221 organ(s), highest expression level in popliteal artery

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75094 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75094 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA051630

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112473, 2 interactors

Protein interaction database and analysis system

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IntActi
O75094, 6 interactors

Molecular INTeraction database

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MINTi
O75094

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332164

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 61LRRNTAdd BLAST28
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati62 – 83LRR 1Add BLAST22
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 131LRR 3Add BLAST22
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 179LRR 5Add BLAST22
Repeati182 – 203LRR 6Add BLAST22
Domaini215 – 265LRRCT 1Add BLAST51
Domaini271 – 307LRRNT 2Add BLAST37
Repeati308 – 329LRR 7Add BLAST22
Repeati332 – 353LRR 8Add BLAST22
Repeati356 – 377LRR 9Add BLAST22
Repeati380 – 401LRR 10Add BLAST22
Repeati404 – 425LRR 11Add BLAST22
Domaini437 – 487LRRCT 2Add BLAST51
Domaini496 – 532LRRNT 3Add BLAST37
Repeati533 – 554LRR 12Add BLAST22
Repeati558 – 579LRR 13Add BLAST22
Repeati582 – 603LRR 14Add BLAST22
Repeati606 – 627LRR 15Add BLAST22
Repeati630 – 651LRR 16Add BLAST22
Domaini663 – 713LRRCT 3Add BLAST51
Domaini716 – 752LRRNT 4Add BLAST37
Repeati753 – 775LRR 17Add BLAST23
Repeati776 – 797LRR 18Add BLAST22
Repeati800 – 821LRR 19Add BLAST22
Repeati824 – 845LRR 20Add BLAST22
Domaini857 – 907LRRCT 4Add BLAST51
Domaini918 – 953EGF-like 1PROSITE-ProRule annotationAdd BLAST36
Domaini955 – 994EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini996 – 1032EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini1034 – 1072EGF-like 4PROSITE-ProRule annotationAdd BLAST39
Domaini1074 – 1110EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini1119 – 1155EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini1158 – 1332Laminin G-likePROSITE-ProRule annotationAdd BLAST175
Domaini1340 – 1365EGF-like 7PROSITE-ProRule annotationAdd BLAST26
Domaini1368 – 1403EGF-like 8PROSITE-ProRule annotationAdd BLAST36
Domaini1408 – 1444EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini1449 – 1523CTCKPROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4237 Eukaryota
COG4886 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159322

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000116120

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75094

KEGG Orthology (KO)

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KOi
K06850

Identification of Orthologs from Complete Genome Data

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OMAi
IQDFTCE

Database of Orthologous Groups

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OrthoDBi
28488at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75094

TreeFam database of animal gene trees

More...
TreeFami
TF332887

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 6 hits
PF02210 Laminin_G_2, 1 hit
PF13855 LRR_8, 5 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 9 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 18 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75094-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPGWAGVGA AVRARLALAL ALASVLSGPP AVACPTKCTC SAASVDCHGL
60 70 80 90 100
GLRAVPRGIP RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSVI
110 120 130 140 150
ERGAFQDLKQ LERLRLNKNK LQVLPELLFQ STPKLTRLDL SENQIQGIPR
160 170 180 190 200
KAFRGITDVK NLQLDNNHIS CIEDGAFRAL RDLEILTLNN NNISRILVTS
210 220 230 240 250
FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTVGQFT LCMAPVHLRG
260 270 280 290 300
FNVADVQKKE YVCPAPHSEP PSCNANSISC PSPCTCSNNI VDCRGKGLME
310 320 330 340 350
IPANLPEGIV EIRLEQNSIK AIPAGAFTQY KKLKRIDISK NQISDIAPDA
360 370 380 390 400
FQGLKSLTSL VLYGNKITEI VKGLFDGLVS LQLLLLNANK INCLRVNTFQ
410 420 430 440 450
DLQNLNLLSL YDNKLQTISK GLFAPLQSIQ TLHLAQNPFV CDCHLKWLAD
460 470 480 490 500
YLQDNPIETS GARCSSPRRL ANKRISQIKS KKFRCSGSED YRSRFSSECF
510 520 530 540 550
MDLVCPEKCR CEGTIVDCSN QKLVRIPSHL PEYVTDLRLN DNEVSVLEAT
560 570 580 590 600
GIFKKLPNLR KINLSNNKIK EVREGAFDGA ASVQELMLTG NQLETVHGRV
610 620 630 640 650
FRGLSGLKTL MLRSNLIGCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT
660 670 680 690 700
TLVSLSTINL LSNPFNCNCH LAWLGKWLRK RRIVSGNPRC QKPFFLKEIP
710 720 730 740 750
IQDVAIQDFT CDGNEESSCQ LSPRCPEQCT CMETVVRCSN KGLRALPRGM
760 770 780 790 800
PKDVTELYLE GNHLTAVPRE LSALRHLTLI DLSNNSISML TNYTFSNMSH
810 820 830 840 850
LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE GSFNDLTSLS
860 870 880 890 900
HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPEPM ADRLLLTTPT
910 920 930 940 950
HRFQCKGPVD INIVAKCNAC LSSPCKNNGT CTQDPVELYR CACPYSYKGK
960 970 980 990 1000
DCTVPINTCI QNPCQHGGTC HLSDSHKDGF SCSCPLGFEG QRCEINPDDC
1010 1020 1030 1040 1050
EDNDCENNAT CVDGINNYVC ICPPNYTGEL CDEVIDHCVP ELNLCQHEAK
1060 1070 1080 1090 1100
CIPLDKGFSC ECVPGYSGKL CETDNDDCVA HKCRHGAQCV DTINGYTCTC
1110 1120 1130 1140 1150
PQGFSGPFCE HPPPMVLLQT SPCDQYECQN GAQCIVVQQE PTCRCPPGFA
1160 1170 1180 1190 1200
GPRCEKLITV NFVGKDSYVE LASAKVRPQA NISLQVATDK DNGILLYKGD
1210 1220 1230 1240 1250
NDPLALELYQ GHVRLVYDSL SSPPTTVYSV ETVNDGQFHS VELVTLNQTL
1260 1270 1280 1290 1300
NLVVDKGTPK SLGKLQKQPA VGINSPLYLG GIPTSTGLSA LRQGTDRPLG
1310 1320 1330 1340 1350
GFHGCIHEVR INNELQDFKA LPPQSLGVSP GCKSCTVCKH GLCRSVEKDS
1360 1370 1380 1390 1400
VVCECRPGWT GPLCDQEARD PCLGHRCHHG KCVATGTSYM CKCAEGYGGD
1410 1420 1430 1440 1450
LCDNKNDSAN ACSAFKCHHG QCHISDQGEP YCLCQPGFSG EHCQQENPCL
1460 1470 1480 1490 1500
GQVVREVIRR QKGYASCATA SKVPIMECRG GCGPQCCQPT RSKRRKYVFQ
1510 1520
CTDGSSFVEE VERHLECGCL ACS
Length:1,523
Mass (Da):167,713
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEB00887F6908554
GO
Isoform 2 (identifier: O75094-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1117-1216: Missing.

Show »
Length:1,423
Mass (Da):156,766
Checksum:i4A5F62D857F47D19
GO
Isoform 3 (identifier: O75094-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1446-1523: ENPCLGQVVR...HLECGCLACS → VFRAQVFQSSLPGNCSWSCWPPRPPMP

Show »
Length:1,472
Mass (Da):162,157
Checksum:i6BF26D278F72D157
GO
Isoform 4 (identifier: O75094-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     906-906: K → KVLWFCCP

Note: No experimental confirmation available.
Show »
Length:1,530
Mass (Da):168,562
Checksum:iC5DBA4B7B0D5221D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSC8A0A0A0MSC8_HUMAN
Slit homolog 3 protein
SLIT3
1,393Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA32466 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB59249 differs from that shown. Intron retention.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049004371V → A5 PublicationsCorresponds to variant dbSNP:rs891921Ensembl.1
Natural variantiVAR_021905395R → Q. Corresponds to variant dbSNP:rs2288792Ensembl.1
Natural variantiVAR_024265618G → S1 PublicationCorresponds to variant dbSNP:rs10036727Ensembl.1
Natural variantiVAR_049005810R → Q. Corresponds to variant dbSNP:rs36052924Ensembl.1
Natural variantiVAR_020168994E → G. Corresponds to variant dbSNP:rs2305993Ensembl.1
Natural variantiVAR_0490061064P → A. Corresponds to variant dbSNP:rs10072243Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054798906K → KVLWFCCP in isoform 4. Curated1
Alternative sequenceiVSP_0097141117 – 1216Missing in isoform 2. 2 PublicationsAdd BLAST100
Alternative sequenceiVSP_0097151446 – 1523ENPCL…CLACS → VFRAQVFQSSLPGNCSWSCW PPRPPMP in isoform 3. 1 PublicationAdd BLAST78

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB017169 mRNA Translation: BAA35186.1
AB011538 mRNA Translation: BAA32466.2 Different initiation.
AY358884 mRNA Translation: AAQ89243.1
AC008409 Genomic DNA No translation available.
AC008479 Genomic DNA No translation available.
AC011365 Genomic DNA No translation available.
AC011389 Genomic DNA No translation available.
AC027311 Genomic DNA No translation available.
AC094081 Genomic DNA No translation available.
AC112165 Genomic DNA No translation available.
BC146759 mRNA Translation: AAI46760.1
AL122074 mRNA Translation: CAB59249.1 Sequence problems.
AF075240 mRNA Translation: AAD19336.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4369.1 [O75094-1]
CCDS64311.1 [O75094-4]

Protein sequence database of the Protein Information Resource

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PIRi
T34555

NCBI Reference Sequences

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RefSeqi
NP_001258875.1, NM_001271946.1
NP_003053.1, NM_003062.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332966; ENSP00000332164; ENSG00000184347 [O75094-4]
ENST00000519560; ENSP00000430333; ENSG00000184347 [O75094-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6586

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6586

UCSC genome browser

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UCSCi
uc003mab.5 human [O75094-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017169 mRNA Translation: BAA35186.1
AB011538 mRNA Translation: BAA32466.2 Different initiation.
AY358884 mRNA Translation: AAQ89243.1
AC008409 Genomic DNA No translation available.
AC008479 Genomic DNA No translation available.
AC011365 Genomic DNA No translation available.
AC011389 Genomic DNA No translation available.
AC027311 Genomic DNA No translation available.
AC094081 Genomic DNA No translation available.
AC112165 Genomic DNA No translation available.
BC146759 mRNA Translation: AAI46760.1
AL122074 mRNA Translation: CAB59249.1 Sequence problems.
AF075240 mRNA Translation: AAD19336.1
CCDSiCCDS4369.1 [O75094-1]
CCDS64311.1 [O75094-4]
PIRiT34555
RefSeqiNP_001258875.1, NM_001271946.1
NP_003053.1, NM_003062.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112473, 2 interactors
IntActiO75094, 6 interactors
MINTiO75094
STRINGi9606.ENSP00000332164

PTM databases

GlyConnecti1750
iPTMnetiO75094
PhosphoSitePlusiO75094

Polymorphism and mutation databases

BioMutaiSLIT3

Proteomic databases

jPOSTiO75094
MaxQBiO75094
PaxDbiO75094
PeptideAtlasiO75094
PRIDEiO75094
ProteomicsDBi49755
49756 [O75094-2]
49757 [O75094-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332966; ENSP00000332164; ENSG00000184347 [O75094-4]
ENST00000519560; ENSP00000430333; ENSG00000184347 [O75094-1]
GeneIDi6586
KEGGihsa:6586
UCSCiuc003mab.5 human [O75094-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6586
DisGeNETi6586

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLIT3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0005394
HGNCiHGNC:11087 SLIT3
HPAiHPA051630
MIMi603745 gene
neXtProtiNX_O75094
OpenTargetsiENSG00000184347
PharmGKBiPA35940

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000159322
HOGENOMiHOG000116120
InParanoidiO75094
KOiK06850
OMAiIQDFTCE
OrthoDBi28488at2759
PhylomeDBiO75094
TreeFamiTF332887

Enzyme and pathway databases

ReactomeiR-HSA-373752 Netrin-1 signaling
R-HSA-376176 Signaling by ROBO receptors
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLIT3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLIT3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6586

Protein Ontology

More...
PROi
PR:O75094

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184347 Expressed in 221 organ(s), highest expression level in popliteal artery
ExpressionAtlasiO75094 baseline and differential
GenevisibleiO75094 HS

Family and domain databases

Gene3Di3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00008 EGF, 6 hits
PF02210 Laminin_G_2, 1 hit
PF13855 LRR_8, 5 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 3 hits
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 9 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 18 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLIT3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75094
Secondary accession number(s): A6H8U9
, J3KNP3, O95804, Q9UFH5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 2, 2010
Last modified: May 8, 2019
This is version 175 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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