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Protein

Frizzled-7

Gene

FZD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei569Essential for SDCBP-mediated plasma membrane phosphatidylinositol-4,5-bisphosphate recognition1 Publication1

GO - Molecular functioni

  • frizzled binding Source: UniProtKB
  • G-protein coupled receptor activity Source: GO_Central
  • PDZ domain binding Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
  • Wnt-activated receptor activity Source: WormBase
  • Wnt-protein binding Source: BHF-UCL

GO - Biological processi

  • canonical Wnt signaling pathway Source: UniProtKB
  • cellular response to retinoic acid Source: UniProtKB
  • mesenchymal to epithelial transition Source: BHF-UCL
  • negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
  • negative regulation of cell-substrate adhesion Source: BHF-UCL
  • negative regulation of ectodermal cell fate specification Source: BHF-UCL
  • neuron differentiation Source: UniProtKB
  • non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
  • positive regulation of epithelial cell proliferation involved in wound healing Source: BHF-UCL
  • positive regulation of JNK cascade Source: BHF-UCL
  • positive regulation of phosphorylation Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: BHF-UCL
  • regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • regulation of transcription, DNA-templated Source: BHF-UCL
  • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: Ensembl
  • somatic stem cell division Source: Ensembl
  • stem cell population maintenance Source: BHF-UCL
  • substrate adhesion-dependent cell spreading Source: Ensembl
  • T cell differentiation in thymus Source: Ensembl
  • Wnt signaling pathway, planar cell polarity pathway Source: Reactome

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-4086400 PCP/CE pathway
R-HSA-4608870 Asymmetric localization of PCP proteins
SignaLinkiO75084
SIGNORiO75084

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-7
Short name:
Fz-7
Short name:
hFz7
Alternative name(s):
FzE3
Gene namesi
Name:FZD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000155760.2
HGNCiHGNC:4045 FZD7
MIMi603410 gene
neXtProtiNX_O75084

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 256ExtracellularSequence analysisAdd BLAST224
Transmembranei257 – 277Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini278 – 288CytoplasmicSequence analysisAdd BLAST11
Transmembranei289 – 309Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini310 – 336ExtracellularSequence analysisAdd BLAST27
Transmembranei337 – 357Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini358 – 379CytoplasmicSequence analysisAdd BLAST22
Transmembranei380 – 400Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini401 – 423ExtracellularSequence analysisAdd BLAST23
Transmembranei424 – 444Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini445 – 470CytoplasmicSequence analysisAdd BLAST26
Transmembranei471 – 491Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini492 – 528ExtracellularSequence analysisAdd BLAST37
Transmembranei529 – 549Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini550 – 574CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi569K → A: Impaired SDCBP-mediated interaction with phosphatidylinositol-4,5-bisphosphate. 1 Publication1

Organism-specific databases

DisGeNETi8324
OpenTargetsiENSG00000155760
PharmGKBiPA28462

Chemistry databases

ChEMBLiCHEMBL3559688

Polymorphism and mutation databases

BioMutaiFZD7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001299633 – 574Frizzled-7Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 110PROSITE-ProRule annotation
Disulfide bondi57 ↔ 103PROSITE-ProRule annotation
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 131PROSITE-ProRule annotation
Disulfide bondi120 ↔ 160PROSITE-ProRule annotation
Disulfide bondi124 ↔ 148PROSITE-ProRule annotation
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiO75084
MaxQBiO75084
PaxDbiO75084
PeptideAtlasiO75084
PRIDEiO75084
ProteomicsDBi49751

PTM databases

iPTMnetiO75084
PhosphoSitePlusiO75084

Expressioni

Tissue specificityi

High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.

Gene expression databases

BgeeiENSG00000155760
CleanExiHS_FZD7
GenevisibleiO75084 HS

Organism-specific databases

HPAiHPA069165

Interactioni

Subunit structurei

Interacts with MAGI3 and DVL1 (By similarity). Interacts with MYOC. Binds to SDCBP; this interaction is increased by inositol trisphosphate (IP3) (PubMed:27386966).By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • frizzled binding Source: UniProtKB
  • PDZ domain binding Source: UniProtKB
  • Wnt-protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi113920, 18 interactors
IntActiO75084, 20 interactors
MINTiO75084
STRINGi9606.ENSP00000286201

Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi49 – 51Combined sources3
Helixi55 – 57Combined sources3
Beta strandi58 – 61Combined sources4
Beta strandi64 – 68Combined sources5
Helixi76 – 83Combined sources8
Helixi84 – 86Combined sources3
Helixi87 – 91Combined sources5
Helixi98 – 106Combined sources9
Beta strandi112 – 115Combined sources4
Helixi121 – 136Combined sources16
Turni137 – 139Combined sources3
Helixi144 – 146Combined sources3
Helixi148 – 150Combined sources3
Beta strandi156 – 158Combined sources3
Beta strandi572 – 574Combined sources3

3D structure databases

ProteinModelPortaliO75084
SMRiO75084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 163FZPROSITE-ProRule annotationAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi552 – 557Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi572 – 574PDZ-binding3

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00760000118864
HOGENOMiHOG000233237
HOVERGENiHBG006977
InParanoidiO75084
KOiK02432
OMAiCVERFSE
OrthoDBiEOG091G0N5M
PhylomeDBiO75084
TreeFamiTF317907

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR026552 FZD7
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF31 PTHR11309:SF31, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDPGAAAPL SSLGLCALVL ALLGALSAGA GAQPYHGEKG ISVPDHGFCQ
60 70 80 90 100
PISIPLCTDI AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF
110 120 130 140 150
FLCSMYAPVC TVLDQAIPPC RSLCERARQG CEALMNKFGF QWPERLRCEN
160 170 180 190 200
FPVHGAGEIC VGQNTSDGSG GPGGGPTAYP TAPYLPDLPF TALPPGASDG
210 220 230 240 250
RGRPAFPFSC PRQLKVPPYL GYRFLGERDC GAPCEPGRAN GLMYFKEEER
260 270 280 290 300
RFARLWVGVW SVLCCASTLF TVLTYLVDMR RFSYPERPII FLSGCYFMVA
310 320 330 340 350
VAHVAGFLLE DRAVCVERFS DDGYRTVAQG TKKEGCTILF MVLYFFGMAS
360 370 380 390 400
SIWWVILSLT WFLAAGMKWG HEAIEANSQY FHLAAWAVPA VKTITILAMG
410 420 430 440 450
QVDGDLLSGV CYVGLSSVDA LRGFVLAPLF VYLFIGTSFL LAGFVSLFRI
460 470 480 490 500
RTIMKHDGTK TEKLEKLMVR IGVFSVLYTV PATIVLACYF YEQAFREHWE
510 520 530 540 550
RTWLLQTCKS YAVPCPPGHF PPMSPDFTVF MIKYLMTMIV GITTGFWIWS
560 570
GKTLQSWRRF YHRLSHSSKG ETAV
Length:574
Mass (Da):63,620
Last modified:September 27, 2004 - v2
Checksum:i801934246B426DF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8A → V in BAA32424 (PubMed:9707618).Curated1
Sequence conflicti15L → F in BAA32424 (PubMed:9707618).Curated1
Sequence conflicti201R → K in BAA32424 (PubMed:9707618).Curated1
Sequence conflicti308L → F in BAA32424 (PubMed:9707618).Curated1
Sequence conflicti408S → N in BAA32424 (PubMed:9707618).Curated1
Sequence conflicti415L → F in BAA32424 (PubMed:9707618).Curated1
Sequence conflicti433L → F in BAA32424 (PubMed:9707618).Curated1
Sequence conflicti447L → F in BAA32424 (PubMed:9707618).Curated1
Sequence conflicti534Y → C in BAA32424 (PubMed:9707618).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04929224G → D. Corresponds to variant dbSNP:rs35111363Ensembl.1
Natural variantiVAR_03302424G → S1 PublicationCorresponds to variant dbSNP:rs755615030Ensembl.1
Natural variantiVAR_033941196G → E. Corresponds to variant dbSNP:rs34908164Ensembl.1
Natural variantiVAR_033942487A → V. Corresponds to variant dbSNP:rs35600847Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010881 mRNA Translation: BAA32424.1
AB017365 mRNA Translation: BAA34668.1
AC069148 Genomic DNA Translation: AAX93250.1
CH471063 Genomic DNA Translation: EAW70298.1
BC015915 mRNA Translation: AAH15915.1
CCDSiCCDS2351.1
PIRiJE0339
RefSeqiNP_003498.1, NM_003507.1
UniGeneiHs.173859

Genome annotation databases

EnsembliENST00000286201; ENSP00000286201; ENSG00000155760
GeneIDi8324
KEGGihsa:8324
UCSCiuc002uyw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFZD7_HUMAN
AccessioniPrimary (citable) accession number: O75084
Secondary accession number(s): O94816, Q53S59, Q96B74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: September 27, 2004
Last modified: July 18, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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