UniProtKB - O75078 (ADA11_HUMAN)
Disintegrin and metalloproteinase domain-containing protein 11
ADAM11
Functioni
GO - Molecular functioni
- integrin binding Source: ProtInc
- metalloendopeptidase activity Source: InterPro
- metallopeptidase activity Source: ProtInc
GO - Biological processi
- integrin-mediated signaling pathway Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | O75078 |
Reactomei | R-HSA-5682910, LGI-ADAM interactions |
Protein family/group databases
MEROPSi | M12.976 |
TCDBi | 8.A.77.1.1, the sheddase (sheddase) family |
Names & Taxonomyi
Protein namesi | Recommended name: Disintegrin and metalloproteinase domain-containing protein 11Short name: ADAM 11 Alternative name(s): Metalloproteinase-like, disintegrin-like, and cysteine-rich protein Short name: MDC |
Gene namesi | Name:ADAM11 Synonyms:MDC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:189, ADAM11 |
MIMi | 155120, gene |
neXtProti | NX_O75078 |
VEuPathDBi | HostDB:ENSG00000073670.13 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 226 – 734 | ExtracellularSequence analysisAdd BLAST | 509 | |
Transmembranei | 735 – 755 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 756 – 769 | CytoplasmicSequence analysisAdd BLAST | 14 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4185 |
OpenTargetsi | ENSG00000073670 |
PharmGKBi | PA24506 |
Miscellaneous databases
Pharosi | O75078, Tbio |
Genetic variation databases
BioMutai | ADAM11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
PropeptideiPRO_0000029074 | 24 – 225 | By similarityAdd BLAST | 202 | |
ChainiPRO_0000029075 | 226 – 769 | Disintegrin and metalloproteinase domain-containing protein 11Add BLAST | 544 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 96 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 349 ↔ 433 | By similarity | ||
Disulfide bondi | 392 ↔ 417 | By similarity | ||
Disulfide bondi | 394 ↔ 401 | By similarity | ||
Disulfide bondi | 503 ↔ 523 | By similarity | ||
Glycosylationi | 605 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 673 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 677 ↔ 692 | By similarity | ||
Disulfide bondi | 686 ↔ 698 | By similarity | ||
Disulfide bondi | 700 ↔ 709 | By similarity |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
MassIVEi | O75078 |
PaxDbi | O75078 |
PeptideAtlasi | O75078 |
PRIDEi | O75078 |
ProteomicsDBi | 49743 [O75078-1] 49744 [O75078-2] |
PTM databases
GlyGeni | O75078, 4 sites |
iPTMneti | O75078 |
PhosphoSitePlusi | O75078 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000073670, Expressed in right hemisphere of cerebellum and 171 other tissues |
ExpressionAtlasi | O75078, baseline and differential |
Genevisiblei | O75078, HS |
Organism-specific databases
HPAi | ENSG00000073670, Group enriched (brain, heart muscle) |
Interactioni
Subunit structurei
Can bind to LGI1 and LGI4.
By similarityGO - Molecular functioni
- integrin binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 110351, 5 interactors |
IntActi | O75078, 3 interactors |
STRINGi | 9606.ENSP00000200557 |
Miscellaneous databases
RNActi | O75078, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 239 – 438 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | 200 | |
Domaini | 444 – 531 | DisintegrinPROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 677 – 709 | EGF-likePROSITE-ProRule annotationAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 532 – 676 | Cys-richAdd BLAST | 145 |
Domaini
Keywords - Domaini
EGF-like domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00940000159790 |
InParanoidi | O75078 |
OMAi | CPDAWLG |
OrthoDBi | 162519at2759 |
PhylomeDBi | O75078 |
TreeFami | TF314733 |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR013111, EGF_extracell IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF07974, EGF_2, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRLLRRWAFA ALLLSLLPTP GLGTQGPAGA LRWGGLPQLG GPGAPEVTEP
60 70 80 90 100
SRLVRESSGG EVRKQQLDTR VRQEPPGGPP VHLAQVSFVI PAFNSNFTLD
110 120 130 140 150
LELNHHLLSS QYVERHFSRE GTTQHSTGAG DHCYYQGKLR GNPHSFAALS
160 170 180 190 200
TCQGLHGVFS DGNLTYIVEP QEVAGPWGAP QGPLPHLIYR TPLLPDPLGC
210 220 230 240 250
REPGCLFAVP AQSAPPNRPR LRRKRQVRRG HPTVHSETKY VELIVINDHQ
260 270 280 290 300
LFEQMRQSVV LTSNFAKSVV NLADVIYKEQ LNTRIVLVAM ETWADGDKIQ
310 320 330 340 350
VQDDLLETLA RLMVYRREGL PEPSDATHLF SGRTFQSTSS GAAYVGGICS
360 370 380 390 400
LSHGGGVNEY GNMGAMAVTL AQTLGQNLGM MWNKHRSSAG DCKCPDIWLG
410 420 430 440 450
CIMEDTGFYL PRKFSRCSID EYNQFLQEGG GSCLFNKPLK LLDPPECGNG
460 470 480 490 500
FVEAGEECDC GSVQECSRAG GNCCKKCTLT HDAMCSDGLC CRRCKYEPRG
510 520 530 540 550
VSCREAVNEC DIAETCTGDS SQCPPNLHKL DGYYCDHEQG RCYGGRCKTR
560 570 580 590 600
DRQCQVLWGH AAADRFCYEK LNVEGTERGS CGRKGSGWVQ CSKQDVLCGF
610 620 630 640 650
LLCVNISGAP RLGDLVGDIS SVTFYHQGKE LDCRGGHVQL ADGSDLSYVE
660 670 680 690 700
DGTACGPNML CLDHRCLPAS AFNFSTCPGS GERRICSHHG VCSNEGKCIC
710 720 730 740 750
QPDWTGKDCS IHNPLPTSPP TGETERYKGP SGTNIIIGSI AGAVLVAAIV
760
LGGTGWGFKN IRRGRSGGA
The sequence of this isoform differs from the canonical sequence as follows:
1-99: Missing.
100-104: DLELN → MCWLS
595-623: DVLCGFLLCVNISGAPRLGDLVGDISSVT → PQQGRAVWLPPLCQHLWSSSARGPGGRHQ
624-769: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DKD2 | B4DKD2_HUMAN | Disintegrin and metalloproteinase d... | ADAM11 | 569 | Annotation score: | ||
H7BY08 | H7BY08_HUMAN | Disintegrin and metalloproteinase d... | ADAM11 | 241 | Annotation score: | ||
K7EKA8 | K7EKA8_HUMAN | Disintegrin and metalloproteinase d... | ADAM11 | 517 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 106 | H → Q in BAA06670 (PubMed:8252040).Curated | 1 | |
Sequence conflicti | 106 | H → Q in BAA06671 (PubMed:7956356).Curated | 1 | |
Sequence conflicti | 325 | D → N in BAA04213 (PubMed:8252040).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062669 | 693 | S → R in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005472 | 1 – 99 | Missing in isoform Short. 1 PublicationAdd BLAST | 99 | |
Alternative sequenceiVSP_005473 | 100 – 104 | DLELN → MCWLS in isoform Short. 1 Publication | 5 | |
Alternative sequenceiVSP_005474 | 595 – 623 | DVLCG…ISSVT → PQQGRAVWLPPLCQHLWSSS ARGPGGRHQ in isoform Short. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_005475 | 624 – 769 | Missing in isoform Short. 1 PublicationAdd BLAST | 146 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009675 mRNA Translation: BAA32352.1 D17390 mRNA Translation: BAA04213.1 D31872 Genomic DNA Translation: BAA06670.1 D31872 Genomic DNA Translation: BAA06671.1 |
CCDSi | CCDS11486.1 [O75078-1] |
PIRi | I65967 S38539 |
RefSeqi | NP_002381.2, NM_002390.5 [O75078-1] |
Genome annotation databases
Ensembli | ENST00000200557; ENSP00000200557; ENSG00000073670 [O75078-1] |
GeneIDi | 4185 |
KEGGi | hsa:4185 |
UCSCi | uc002ihh.4, human [O75078-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009675 mRNA Translation: BAA32352.1 D17390 mRNA Translation: BAA04213.1 D31872 Genomic DNA Translation: BAA06670.1 D31872 Genomic DNA Translation: BAA06671.1 |
CCDSi | CCDS11486.1 [O75078-1] |
PIRi | I65967 S38539 |
RefSeqi | NP_002381.2, NM_002390.5 [O75078-1] |
3D structure databases
SMRi | O75078 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110351, 5 interactors |
IntActi | O75078, 3 interactors |
STRINGi | 9606.ENSP00000200557 |
Protein family/group databases
MEROPSi | M12.976 |
TCDBi | 8.A.77.1.1, the sheddase (sheddase) family |
PTM databases
GlyGeni | O75078, 4 sites |
iPTMneti | O75078 |
PhosphoSitePlusi | O75078 |
Genetic variation databases
BioMutai | ADAM11 |
Proteomic databases
MassIVEi | O75078 |
PaxDbi | O75078 |
PeptideAtlasi | O75078 |
PRIDEi | O75078 |
ProteomicsDBi | 49743 [O75078-1] 49744 [O75078-2] |
Protocols and materials databases
Antibodypediai | 29870, 134 antibodies |
DNASUi | 4185 |
Genome annotation databases
Ensembli | ENST00000200557; ENSP00000200557; ENSG00000073670 [O75078-1] |
GeneIDi | 4185 |
KEGGi | hsa:4185 |
UCSCi | uc002ihh.4, human [O75078-1] |
Organism-specific databases
CTDi | 4185 |
DisGeNETi | 4185 |
GeneCardsi | ADAM11 |
HGNCi | HGNC:189, ADAM11 |
HPAi | ENSG00000073670, Group enriched (brain, heart muscle) |
MIMi | 155120, gene |
neXtProti | NX_O75078 |
OpenTargetsi | ENSG00000073670 |
PharmGKBi | PA24506 |
VEuPathDBi | HostDB:ENSG00000073670.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00940000159790 |
InParanoidi | O75078 |
OMAi | CPDAWLG |
OrthoDBi | 162519at2759 |
PhylomeDBi | O75078 |
TreeFami | TF314733 |
Enzyme and pathway databases
PathwayCommonsi | O75078 |
Reactomei | R-HSA-5682910, LGI-ADAM interactions |
Miscellaneous databases
BioGRID-ORCSi | 4185, 27 hits in 872 CRISPR screens |
ChiTaRSi | ADAM11, human |
GeneWikii | ADAM11 |
GenomeRNAii | 4185 |
Pharosi | O75078, Tbio |
PROi | PR:O75078 |
RNActi | O75078, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000073670, Expressed in right hemisphere of cerebellum and 171 other tissues |
ExpressionAtlasi | O75078, baseline and differential |
Genevisiblei | O75078, HS |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR013111, EGF_extracell IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF07974, EGF_2, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADA11_HUMAN | |
Accessioni | O75078Primary (citable) accession number: O75078 Secondary accession number(s): Q14808, Q14809, Q14810 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | October 3, 2006 | |
Last modified: | February 10, 2021 | |
This is version 179 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot