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Protein

Disintegrin and metalloproteinase domain-containing protein 11

Gene

ADAM11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  • integrin binding Source: ProtInc
  • metalloendopeptidase activity Source: InterPro
  • metallopeptidase activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5682910 LGI-ADAM interactions

Protein family/group databases

MEROPSiM12.976
TCDBi8.A.77.1.1 the sheddase (sheddase) family

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 11
Short name:
ADAM 11
Alternative name(s):
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein
Short name:
MDC
Gene namesi
Name:ADAM11
Synonyms:MDC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000073670.13
HGNCiHGNC:189 ADAM11
MIMi155120 gene
neXtProtiNX_O75078

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini226 – 734ExtracellularSequence analysisAdd BLAST509
Transmembranei735 – 755HelicalSequence analysisAdd BLAST21
Topological domaini756 – 769CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4185
OpenTargetsiENSG00000073670
PharmGKBiPA24506

Polymorphism and mutation databases

BioMutaiADAM11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000002907424 – 225By similarityAdd BLAST202
ChainiPRO_0000029075226 – 769Disintegrin and metalloproteinase domain-containing protein 11Add BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi349 ↔ 433By similarity
Disulfide bondi392 ↔ 417By similarity
Disulfide bondi394 ↔ 401By similarity
Disulfide bondi503 ↔ 523By similarity
Glycosylationi605N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi677 ↔ 692By similarity
Disulfide bondi686 ↔ 698By similarity
Disulfide bondi700 ↔ 709By similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75078
PeptideAtlasiO75078
PRIDEiO75078
ProteomicsDBi49743
49744 [O75078-2]

PTM databases

iPTMnetiO75078
PhosphoSitePlusiO75078

Expressioni

Tissue specificityi

Expressed predominantly in brain. Slightly detected or not at all in other tissues.

Gene expression databases

BgeeiENSG00000073670 Expressed in 157 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_ADAM11
ExpressionAtlasiO75078 baseline and differential
GenevisibleiO75078 HS

Organism-specific databases

HPAiHPA074550

Interactioni

Subunit structurei

Can bind to LGI1 and LGI4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110351, 4 interactors
IntActiO75078, 1 interactor
STRINGi9606.ENSP00000200557

Structurei

3D structure databases

ProteinModelPortaliO75078
SMRiO75078
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini239 – 438Peptidase M12BPROSITE-ProRule annotationAdd BLAST200
Domaini444 – 531DisintegrinPROSITE-ProRule annotationAdd BLAST88
Domaini677 – 709EGF-likePROSITE-ProRule annotationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi532 – 676Cys-richAdd BLAST145

Domaini

A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
GeneTreeiENSGT00910000144014
HOGENOMiHOG000231962
HOVERGENiHBG050456
InParanoidiO75078
KOiK16067
OMAiDNMGAMA
OrthoDBiEOG091G010C
PhylomeDBiO75078
TreeFamiTF314733

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF07974 EGF_2, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: O75078-1) [UniParc]FASTAAdd to basket
Also known as: MDC-769

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLLRRWAFA ALLLSLLPTP GLGTQGPAGA LRWGGLPQLG GPGAPEVTEP
60 70 80 90 100
SRLVRESSGG EVRKQQLDTR VRQEPPGGPP VHLAQVSFVI PAFNSNFTLD
110 120 130 140 150
LELNHHLLSS QYVERHFSRE GTTQHSTGAG DHCYYQGKLR GNPHSFAALS
160 170 180 190 200
TCQGLHGVFS DGNLTYIVEP QEVAGPWGAP QGPLPHLIYR TPLLPDPLGC
210 220 230 240 250
REPGCLFAVP AQSAPPNRPR LRRKRQVRRG HPTVHSETKY VELIVINDHQ
260 270 280 290 300
LFEQMRQSVV LTSNFAKSVV NLADVIYKEQ LNTRIVLVAM ETWADGDKIQ
310 320 330 340 350
VQDDLLETLA RLMVYRREGL PEPSDATHLF SGRTFQSTSS GAAYVGGICS
360 370 380 390 400
LSHGGGVNEY GNMGAMAVTL AQTLGQNLGM MWNKHRSSAG DCKCPDIWLG
410 420 430 440 450
CIMEDTGFYL PRKFSRCSID EYNQFLQEGG GSCLFNKPLK LLDPPECGNG
460 470 480 490 500
FVEAGEECDC GSVQECSRAG GNCCKKCTLT HDAMCSDGLC CRRCKYEPRG
510 520 530 540 550
VSCREAVNEC DIAETCTGDS SQCPPNLHKL DGYYCDHEQG RCYGGRCKTR
560 570 580 590 600
DRQCQVLWGH AAADRFCYEK LNVEGTERGS CGRKGSGWVQ CSKQDVLCGF
610 620 630 640 650
LLCVNISGAP RLGDLVGDIS SVTFYHQGKE LDCRGGHVQL ADGSDLSYVE
660 670 680 690 700
DGTACGPNML CLDHRCLPAS AFNFSTCPGS GERRICSHHG VCSNEGKCIC
710 720 730 740 750
QPDWTGKDCS IHNPLPTSPP TGETERYKGP SGTNIIIGSI AGAVLVAAIV
760
LGGTGWGFKN IRRGRSGGA
Length:769
Mass (Da):83,418
Last modified:October 3, 2006 - v3
Checksum:iEEB091EB6730AC36
GO
Isoform Short (identifier: O75078-2) [UniParc]FASTAAdd to basket
Also known as: MDC-524

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     100-104: DLELN → MCWLS
     595-623: DVLCGFLLCVNISGAPRLGDLVGDISSVT → PQQGRAVWLPPLCQHLWSSSARGPGGRHQ
     624-769: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:524
Mass (Da):57,911
Checksum:iCC3756772F1EB346
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DKD2B4DKD2_HUMAN
Disintegrin and metalloproteinase d...
ADAM11
569Annotation score:
K7EKA8K7EKA8_HUMAN
Disintegrin and metalloproteinase d...
ADAM11
517Annotation score:
H7BY08H7BY08_HUMAN
Disintegrin and metalloproteinase d...
ADAM11
241Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106H → Q in BAA06670 (PubMed:8252040).Curated1
Sequence conflicti106H → Q in BAA06671 (PubMed:7956356).Curated1
Sequence conflicti325D → N in BAA04213 (PubMed:8252040).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062669693S → R in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0054721 – 99Missing in isoform Short. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_005473100 – 104DLELN → MCWLS in isoform Short. 1 Publication5
Alternative sequenceiVSP_005474595 – 623DVLCG…ISSVT → PQQGRAVWLPPLCQHLWSSS ARGPGGRHQ in isoform Short. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_005475624 – 769Missing in isoform Short. 1 PublicationAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009675 mRNA Translation: BAA32352.1
D17390 mRNA Translation: BAA04213.1
D31872 Genomic DNA Translation: BAA06670.1
D31872 Genomic DNA Translation: BAA06671.1
CCDSiCCDS11486.1 [O75078-1]
PIRiI65967
S38539
RefSeqiNP_002381.2, NM_002390.5 [O75078-1]
UniGeneiHs.6088

Genome annotation databases

EnsembliENST00000200557; ENSP00000200557; ENSG00000073670 [O75078-1]
GeneIDi4185
KEGGihsa:4185
UCSCiuc002ihh.4 human [O75078-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009675 mRNA Translation: BAA32352.1
D17390 mRNA Translation: BAA04213.1
D31872 Genomic DNA Translation: BAA06670.1
D31872 Genomic DNA Translation: BAA06671.1
CCDSiCCDS11486.1 [O75078-1]
PIRiI65967
S38539
RefSeqiNP_002381.2, NM_002390.5 [O75078-1]
UniGeneiHs.6088

3D structure databases

ProteinModelPortaliO75078
SMRiO75078
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110351, 4 interactors
IntActiO75078, 1 interactor
STRINGi9606.ENSP00000200557

Protein family/group databases

MEROPSiM12.976
TCDBi8.A.77.1.1 the sheddase (sheddase) family

PTM databases

iPTMnetiO75078
PhosphoSitePlusiO75078

Polymorphism and mutation databases

BioMutaiADAM11

Proteomic databases

PaxDbiO75078
PeptideAtlasiO75078
PRIDEiO75078
ProteomicsDBi49743
49744 [O75078-2]

Protocols and materials databases

DNASUi4185
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000200557; ENSP00000200557; ENSG00000073670 [O75078-1]
GeneIDi4185
KEGGihsa:4185
UCSCiuc002ihh.4 human [O75078-1]

Organism-specific databases

CTDi4185
DisGeNETi4185
EuPathDBiHostDB:ENSG00000073670.13
GeneCardsiADAM11
HGNCiHGNC:189 ADAM11
HPAiHPA074550
MIMi155120 gene
neXtProtiNX_O75078
OpenTargetsiENSG00000073670
PharmGKBiPA24506
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
GeneTreeiENSGT00910000144014
HOGENOMiHOG000231962
HOVERGENiHBG050456
InParanoidiO75078
KOiK16067
OMAiDNMGAMA
OrthoDBiEOG091G010C
PhylomeDBiO75078
TreeFamiTF314733

Enzyme and pathway databases

ReactomeiR-HSA-5682910 LGI-ADAM interactions

Miscellaneous databases

ChiTaRSiADAM11 human
GeneWikiiADAM11
GenomeRNAii4185
PROiPR:O75078
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000073670 Expressed in 157 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_ADAM11
ExpressionAtlasiO75078 baseline and differential
GenevisibleiO75078 HS

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF07974 EGF_2, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA11_HUMAN
AccessioniPrimary (citable) accession number: O75078
Secondary accession number(s): Q14808, Q14809, Q14810
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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