UniProtKB - O75078 (ADA11_HUMAN)

BLAST

>sp|O75078|ADA11_HUMAN Disintegrin and metalloproteinase domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ADAM11 PE=2 SV=3
MRLLRRWAFAALLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGG
EVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSRE
GTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAP
QGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKY
VELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQ
VQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEY
GNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSID
EYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLT
HDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQG
RCYGGRCKTRDRQCQVLWGHAAADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGF
LLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNML
CLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPP
TGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA

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History
Entry version 164 (07 Nov 2018)
Sequence version 3 (03 Oct 2006)
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Protein

Disintegrin and metalloproteinase domain-containing protein 11

Gene

ADAM11

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

GO - Molecular functionⁱ

integrin binding
Source: ProtInc
Traceable author statementⁱ
- 9693107
metalloendopeptidase activity Source: InterPro
metallopeptidase activity
Source: ProtInc
Traceable author statementⁱ
- 9693107

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

integrin-mediated signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8252040

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5682910 LGI-ADAM interactions

Reactomeⁱ

R-HSA-5682910 LGI-ADAM interactions

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M12.976
TCDBⁱ	8.A.77.1.1 the sheddase (sheddase) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Disintegrin and metalloproteinase domain-containing protein 11 Short name: ADAM 11 Alternative name(s): Metalloproteinase-like, disintegrin-like, and cysteine-rich protein Short name: MDC
Gene namesⁱ	Name:ADAM11 Synonyms:MDC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000073670.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:189 ADAM11
MIMⁱ	155120 gene
neXtProtⁱ	NX_O75078

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	226 – 734	ExtracellularSequence analysisAdd BLAST	509
Transmembraneⁱ	735 – 755	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	756 – 769	CytoplasmicSequence analysisAdd BLAST	14

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4185
Open Targets More...OpenTargetsⁱ	ENSG00000073670
PharmGKBⁱ	PA24506

Polymorphism and mutation databases

BioMutaⁱ	ADAM11

BioMutaⁱ

ADAM11

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST	23
PropeptideⁱPRO_0000029074	24 – 225	By similarityAdd BLAST	202
ChainⁱPRO_0000029075	226 – 769	Disintegrin and metalloproteinase domain-containing protein 11Add BLAST	544

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	96	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	163	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	349 ↔ 433	By similarity
Disulfide bondⁱ	392 ↔ 417	By similarity
Disulfide bondⁱ	394 ↔ 401	By similarity
Disulfide bondⁱ	503 ↔ 523	By similarity
Glycosylationⁱ	605	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	673	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	677 ↔ 692	By similarity
Disulfide bondⁱ	686 ↔ 698	By similarity
Disulfide bondⁱ	700 ↔ 709	By similarity

Post-translational modificationⁱ

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O75078
PeptideAtlas More...PeptideAtlasⁱ	O75078
PRIDEⁱ	O75078
ProteomicsDBⁱ	49743 49744 [O75078-2]

PTM databases

iPTMnetⁱ	O75078
PhosphoSitePlusⁱ	O75078

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in brain. Slightly detected or not at all in other tissues.

Gene expression databases

Bgeeⁱ	ENSG00000073670 Expressed in 157 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_ADAM11
ExpressionAtlasⁱ	O75078 baseline and differential
Genevisibleⁱ	O75078 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA074550

HPAⁱ

HPA074550

Interactionⁱ

Subunit structureⁱ

Can bind to LGI1 and LGI4.By similarity

GO - Molecular functionⁱ

integrin binding
Source: ProtInc
Traceable author statementⁱ
- 9693107

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110351, 4 interactors
IntActⁱ	O75078, 1 interactor
STRINGⁱ	9606.ENSP00000200557

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75078
SMRⁱ	O75078
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	239 – 438	Peptidase M12BPROSITE-ProRule annotationAdd BLAST	200
Domainⁱ	444 – 531	DisintegrinPROSITE-ProRule annotationAdd BLAST	88
Domainⁱ	677 – 709	EGF-likePROSITE-ProRule annotationAdd BLAST	33

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	532 – 676	Cys-richAdd BLAST		145

Domainⁱ

A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.

Keywords - Domainⁱ

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3607 Eukaryota ENOG410XX2M LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144014
HOGENOMⁱ	HOG000231962
HOVERGENⁱ	HBG050456
InParanoidⁱ	O75078
KEGG Orthology (KO) More...KOⁱ	K16067
OMAⁱ	DNMGAMA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G010C
PhylomeDBⁱ	O75078
TreeFamⁱ	TF314733

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Dⁱ	3.40.390.10, 1 hit 4.10.70.10, 1 hit
InterProⁱ	View protein in InterPro IPR006586 ADAM_Cys-rich IPR018358 Disintegrin_CS IPR001762 Disintegrin_dom IPR036436 Disintegrin_dom_sf IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR013111 EGF_extracell IPR024079 MetalloPept_cat_dom_sf IPR001590 Peptidase_M12B IPR002870 Peptidase_M12B_N IPR034027 Reprolysin_adamalysin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08516 ADAM_CR, 1 hit PF00200 Disintegrin, 1 hit PF07974 EGF_2, 1 hit PF01562 Pep_M12B_propep, 1 hit PF01421 Reprolysin, 1 hit
PRINTSⁱ	PR00289 DISINTEGRIN
SMARTⁱ	View protein in SMART SM00608 ACR, 1 hit SM00050 DISIN, 1 hit
SUPFAMⁱ	SSF57552 SSF57552, 1 hit
PROSITEⁱ	View protein in PROSITE PS50215 ADAM_MEPRO, 1 hit PS00427 DISINTEGRIN_1, 1 hit PS50214 DISINTEGRIN_2, 1 hit PS00022 EGF_1, 1 hit PS50026 EGF_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform Long (identifier: O75078-1) [UniParc]FASTA Add to basket

Also known as: MDC-769

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLRRWAFA ALLLSLLPTP GLGTQGPAGA LRWGGLPQLG GPGAPEVTEP 
        60         70         80         90        100
SRLVRESSGG EVRKQQLDTR VRQEPPGGPP VHLAQVSFVI PAFNSNFTLD 
       110        120        130        140        150
LELNHHLLSS QYVERHFSRE GTTQHSTGAG DHCYYQGKLR GNPHSFAALS 
       160        170        180        190        200
TCQGLHGVFS DGNLTYIVEP QEVAGPWGAP QGPLPHLIYR TPLLPDPLGC 
       210        220        230        240        250
REPGCLFAVP AQSAPPNRPR LRRKRQVRRG HPTVHSETKY VELIVINDHQ 
       260        270        280        290        300
LFEQMRQSVV LTSNFAKSVV NLADVIYKEQ LNTRIVLVAM ETWADGDKIQ 
       310        320        330        340        350
VQDDLLETLA RLMVYRREGL PEPSDATHLF SGRTFQSTSS GAAYVGGICS 
       360        370        380        390        400
LSHGGGVNEY GNMGAMAVTL AQTLGQNLGM MWNKHRSSAG DCKCPDIWLG 
       410        420        430        440        450
CIMEDTGFYL PRKFSRCSID EYNQFLQEGG GSCLFNKPLK LLDPPECGNG 
       460        470        480        490        500
FVEAGEECDC GSVQECSRAG GNCCKKCTLT HDAMCSDGLC CRRCKYEPRG 
       510        520        530        540        550
VSCREAVNEC DIAETCTGDS SQCPPNLHKL DGYYCDHEQG RCYGGRCKTR 
       560        570        580        590        600
DRQCQVLWGH AAADRFCYEK LNVEGTERGS CGRKGSGWVQ CSKQDVLCGF 
       610        620        630        640        650
LLCVNISGAP RLGDLVGDIS SVTFYHQGKE LDCRGGHVQL ADGSDLSYVE 
       660        670        680        690        700
DGTACGPNML CLDHRCLPAS AFNFSTCPGS GERRICSHHG VCSNEGKCIC 
       710        720        730        740        750
QPDWTGKDCS IHNPLPTSPP TGETERYKGP SGTNIIIGSI AGAVLVAAIV 
       760 
LGGTGWGFKN IRRGRSGGA

Length:769

Mass (Da):83,418

Last modified:October 3, 2006 - v3

Checksum:ⁱEEB091EB6730AC36

Isoform Short (identifier: O75078-2) [UniParc]FASTA Add to basket

Also known as: MDC-524

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     100-104: DLELN → MCWLS
     595-623: DVLCGFLLCVNISGAPRLGDLVGDISSVT → PQQGRAVWLPPLCQHLWSSSARGPGGRHQ
     624-769: Missing.

« Hide

        10         20         30         40         50
MCWLSHHLLS SQYVERHFSR EGTTQHSTGA GDHCYYQGKL RGNPHSFAAL 
        60         70         80         90        100
STCQGLHGVF SDGNLTYIVE PQEVAGPWGA PQGPLPHLIY RTPLLPDPLG 
       110        120        130        140        150
CREPGCLFAV PAQSAPPNRP RLRRKRQVRR GHPTVHSETK YVELIVINDH 
       160        170        180        190        200
QLFEQMRQSV VLTSNFAKSV VNLADVIYKE QLNTRIVLVA METWADGDKI 
       210        220        230        240        250
QVQDDLLETL ARLMVYRREG LPEPSDATHL FSGRTFQSTS SGAAYVGGIC 
       260        270        280        290        300
SLSHGGGVNE YGNMGAMAVT LAQTLGQNLG MMWNKHRSSA GDCKCPDIWL 
       310        320        330        340        350
GCIMEDTGFY LPRKFSRCSI DEYNQFLQEG GGSCLFNKPL KLLDPPECGN 
       360        370        380        390        400
GFVEAGEECD CGSVQECSRA GGNCCKKCTL THDAMCSDGL CCRRCKYEPR 
       410        420        430        440        450
GVSCREAVNE CDIAETCTGD SSQCPPNLHK LDGYYCDHEQ GRCYGGRCKT 
       460        470        480        490        500
RDRQCQVLWG HAAADRFCYE KLNVEGTERG SCGRKGSGWV QCSKQPQQGR 
       510        520 
AVWLPPLCQH LWSSSARGPG GRHQ

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:524

Mass (Da):57,911

Checksum:ⁱCC3756772F1EB346

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B4DKD2	B4DKD2_HUMAN	Disintegrin and metalloproteinase d... Disintegrin and metalloproteinase domain-containing protein 11 (cDNA FLJ60626, highly similar to ADAM 11 (A disintegrin and metalloproteinase domain 11))	ADAM11	569	Annotation score:
K7EKA8	K7EKA8_HUMAN	Disintegrin and metalloproteinase d... Disintegrin and metalloproteinase domain-containing protein 11	ADAM11	517	Annotation score:
H7BY08	H7BY08_HUMAN	Disintegrin and metalloproteinase d... Disintegrin and metalloproteinase domain-containing protein 11	ADAM11	241	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	106	H → Q in BAA06670 (PubMed:8252040).Curated	1
Sequence conflictⁱ	106	H → Q in BAA06671 (PubMed:7956356).Curated	1
Sequence conflictⁱ	325	D → N in BAA04213 (PubMed:8252040).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_062669	693	S → R in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_005472	1 – 99	Missing in isoform Short. 1 PublicationAdd BLAST	99
Alternative sequenceⁱVSP_005473	100 – 104	DLELN → MCWLS in isoform Short. 1 Publication	5
Alternative sequenceⁱVSP_005474	595 – 623	DVLCG…ISSVT → PQQGRAVWLPPLCQHLWSSS ARGPGGRHQ in isoform Short. 1 PublicationAdd BLAST	29
Alternative sequenceⁱVSP_005475	624 – 769	Missing in isoform Short. 1 PublicationAdd BLAST	146

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB009675 mRNA Translation: BAA32352.1 D17390 mRNA Translation: BAA04213.1 D31872 Genomic DNA Translation: BAA06670.1 D31872 Genomic DNA Translation: BAA06671.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11486.1 [O75078-1]
PIRⁱ	I65967 S38539
NCBI Reference Sequences More...RefSeqⁱ	NP_002381.2, NM_002390.5 [O75078-1]
UniGeneⁱ	Hs.6088

Genome annotation databases

Ensemblⁱ	ENST00000200557; ENSP00000200557; ENSG00000073670 [O75078-1]
GeneIDⁱ	4185
KEGGⁱ	hsa:4185
UCSC genome browser More...UCSCⁱ	uc002ihh.4 human [O75078-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75078	Disintegrin and metalloproteinase domain-containing protein 11		MOUSE		773	UniRef90_O75078
disintegrin and metalloproteinase domain-containing protein 11 isoform X1		Enhydra lutris kenyoni		780
Uncharacterized protein		PANPA		780
disintegrin and metalloproteinase domain-containing protein 11		URSMA		780
disintegrin and metalloproteinase domain-containing protein 11 isoform X1		MESAU		778
+153
O75078-2	Disintegrin and metalloproteinase domain-containing protein 11 (Fragment)		HUMAN		517	UniRef90_O75078-2
ADAM11 isoform 4 (Fragment)		PONAB		517
ADAM11 isoform 3 (Fragment)		PANTR		517

Protein	Similar proteins		Species	Score	Length	Source
O75078	Disintegrin and metalloproteinase domain-containing protein 11		MOUSE		773	UniRef50_O75078
disintegrin and metalloproteinase domain-containing protein 11		URSMA		780
disintegrin and metalloproteinase domain-containing protein 11 isoform X1		Enhydra lutris kenyoni		780
Uncharacterized protein		PANPA		780
ADAM metallopeptidase domain 11		RAT		778
+169
O75078-2	Disintegrin and metalloproteinase domain-containing protein 11 (Fragment)		HUMAN		517	UniRef50_O75078-2
ADAM11 isoform 3 (Fragment)		PANTR		517
ADAM11 isoform 4 (Fragment)		PONAB		517
disintegrin and metalloproteinase domain-containing protein 11		ICTPU		521
ADAM metallopeptidase domain 11		ASTMX		498
+4

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB009675 mRNA Translation: BAA32352.1 D17390 mRNA Translation: BAA04213.1 D31872 Genomic DNA Translation: BAA06670.1 D31872 Genomic DNA Translation: BAA06671.1
CCDSⁱ	CCDS11486.1 [O75078-1]
PIRⁱ	I65967 S38539
RefSeqⁱ	NP_002381.2, NM_002390.5 [O75078-1]
UniGeneⁱ	Hs.6088

3D structure databases

ProteinModelPortalⁱ	O75078
SMRⁱ	O75078
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110351, 4 interactors
IntActⁱ	O75078, 1 interactor
STRINGⁱ	9606.ENSP00000200557

Protein family/group databases

MEROPSⁱ	M12.976
TCDBⁱ	8.A.77.1.1 the sheddase (sheddase) family

PTM databases

iPTMnetⁱ	O75078
PhosphoSitePlusⁱ	O75078

Polymorphism and mutation databases

BioMutaⁱ	ADAM11

BioMutaⁱ

ADAM11

Proteomic databases

PaxDbⁱ	O75078
PeptideAtlasⁱ	O75078
PRIDEⁱ	O75078
ProteomicsDBⁱ	49743 49744 [O75078-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4185
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000200557; ENSP00000200557; ENSG00000073670 [O75078-1]
GeneIDⁱ	4185
KEGGⁱ	hsa:4185
UCSCⁱ	uc002ihh.4 human [O75078-1]

Organism-specific databases

CTDⁱ	4185
DisGeNETⁱ	4185
EuPathDBⁱ	HostDB:ENSG00000073670.13
GeneCardsⁱ	ADAM11
HGNCⁱ	HGNC:189 ADAM11
HPAⁱ	HPA074550
MIMⁱ	155120 gene
neXtProtⁱ	NX_O75078
OpenTargetsⁱ	ENSG00000073670
PharmGKBⁱ	PA24506
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3607 Eukaryota ENOG410XX2M LUCA
GeneTreeⁱ	ENSGT00910000144014
HOGENOMⁱ	HOG000231962
HOVERGENⁱ	HBG050456
InParanoidⁱ	O75078
KOⁱ	K16067
OMAⁱ	DNMGAMA
OrthoDBⁱ	EOG091G010C
PhylomeDBⁱ	O75078
TreeFamⁱ	TF314733

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5682910 LGI-ADAM interactions

Reactomeⁱ

R-HSA-5682910 LGI-ADAM interactions

Miscellaneous databases

ChiTaRSⁱ	ADAM11 human
GeneWikiⁱ	ADAM11
GenomeRNAiⁱ	4185
Protein Ontology More...PROⁱ	PR:O75078
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000073670 Expressed in 157 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_ADAM11
ExpressionAtlasⁱ	O75078 baseline and differential
Genevisibleⁱ	O75078 HS

Family and domain databases

CDDⁱ	cd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Dⁱ	3.40.390.10, 1 hit 4.10.70.10, 1 hit
InterProⁱ	View protein in InterPro IPR006586 ADAM_Cys-rich IPR018358 Disintegrin_CS IPR001762 Disintegrin_dom IPR036436 Disintegrin_dom_sf IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR013111 EGF_extracell IPR024079 MetalloPept_cat_dom_sf IPR001590 Peptidase_M12B IPR002870 Peptidase_M12B_N IPR034027 Reprolysin_adamalysin
Pfamⁱ	View protein in Pfam PF08516 ADAM_CR, 1 hit PF00200 Disintegrin, 1 hit PF07974 EGF_2, 1 hit PF01562 Pep_M12B_propep, 1 hit PF01421 Reprolysin, 1 hit
PRINTSⁱ	PR00289 DISINTEGRIN
SMARTⁱ	View protein in SMART SM00608 ACR, 1 hit SM00050 DISIN, 1 hit
SUPFAMⁱ	SSF57552 SSF57552, 1 hit
PROSITEⁱ	View protein in PROSITE PS50215 ADAM_MEPRO, 1 hit PS00427 DISINTEGRIN_1, 1 hit PS50214 DISINTEGRIN_2, 1 hit PS00022 EGF_1, 1 hit PS50026 EGF_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADA11_HUMAN
Accessionⁱ	O75078Primary (citable) accession number: O75078 Secondary accession number(s): Q14808, Q14809, Q14810
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
	Last sequence update:	October 3, 2006
	Last modified:	November 7, 2018
	This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - O75078 (ADA11_HUMAN)

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Disintegrin and metalloproteinase domain-containing protein 11

ADAM11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ