UniProtKB - O75077 (ADA23_HUMAN)
Disintegrin and metalloproteinase domain-containing protein 23
ADAM23
Functioni
May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
GO - Molecular functioni
- integrin binding Source: ProtInc
- metalloendopeptidase activity Source: InterPro
- metallopeptidase activity Source: ProtInc
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- cellular response to leukemia inhibitory factor Source: Ensembl
- central nervous system development Source: ProtInc
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | O75077 |
Reactomei | R-HSA-5682910, LGI-ADAM interactions |
SignaLinki | O75077 |
Protein family/group databases
MEROPSi | M12.979 |
Names & Taxonomyi
Protein namesi | Recommended name: Disintegrin and metalloproteinase domain-containing protein 23Short name: ADAM 23 Alternative name(s): Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3 Short name: MDC-3 |
Gene namesi | Name:ADAM23 Synonyms:MDC3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:202, ADAM23 |
MIMi | 603710, gene |
neXtProti | NX_O75077 |
VEuPathDBi | HostDB:ENSG00000114948 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- integral component of presynaptic membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- glutamatergic synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 287 – 792 | ExtracellularSequence analysisAdd BLAST | 506 | |
Transmembranei | 793 – 813 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 814 – 832 | CytoplasmicSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 566 | E → A: Significantly lower of adhesion-promoting activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8745 |
OpenTargetsi | ENSG00000114948 |
PharmGKBi | PA24519 |
Miscellaneous databases
Pharosi | O75077, Tbio |
Genetic variation databases
BioMutai | ADAM23 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 59 | Sequence analysisAdd BLAST | 59 | |
PropeptideiPRO_0000029118 | 60 – 286 | Sequence analysisAdd BLAST | 227 | |
ChainiPRO_0000029119 | 287 – 832 | Disintegrin and metalloproteinase domain-containing protein 23Add BLAST | 546 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 76 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 96 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 263 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 408 ↔ 491 | By similarity | ||
Disulfide bondi | 450 ↔ 475 | By similarity | ||
Disulfide bondi | 452 ↔ 459 | By similarity | ||
Glycosylationi | 547 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 548 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 560 ↔ 580 | By similarity | ||
Glycosylationi | 664 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 732 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 736 ↔ 751 | By similarity | ||
Disulfide bondi | 745 ↔ 757 | By similarity | ||
Disulfide bondi | 759 ↔ 768 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
MassIVEi | O75077 |
PaxDbi | O75077 |
PeptideAtlasi | O75077 |
PRIDEi | O75077 |
ProteomicsDBi | 49740 [O75077-1] 49741 [O75077-2] 49742 [O75077-3] |
PTM databases
GlyGeni | O75077, 8 sites |
iPTMneti | O75077 |
PhosphoSitePlusi | O75077 |
SwissPalmi | O75077 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000114948, Expressed in middle temporal gyrus and 187 other tissues |
ExpressionAtlasi | O75077, baseline and differential |
Genevisiblei | O75077, HS |
Organism-specific databases
HPAi | ENSG00000114948, Tissue enhanced (brain, parathyroid gland) |
Interactioni
Subunit structurei
Can bind to LGI1 and LGI4 (By similarity). Ligand for integrin alpha-V/beta-3.
By similarityGO - Molecular functioni
- integrin binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 114282, 3 interactors |
CORUMi | O75077 |
IntActi | O75077, 2 interactors |
MINTi | O75077 |
STRINGi | 9606.ENSP00000264377 |
Miscellaneous databases
RNActi | O75077, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 299 – 496 | Peptidase M12BPROSITE-ProRule annotationAdd BLAST | 198 | |
Domaini | 502 – 588 | DisintegrinPROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 732 – 769 | EGF-likePROSITE-ProRule annotationAdd BLAST | 38 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 37 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 563 – 568 | May bind the integrin receptor | 6 |
Domaini
Keywords - Domaini
EGF-like domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00940000158781 |
HOGENOMi | CLU_012714_5_2_1 |
InParanoidi | O75077 |
OMAi | ECDCTES |
OrthoDBi | 162519at2759 |
PhylomeDBi | O75077 |
TreeFami | TF314733 |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKPPGSSSRQ PPLAGCSLAG ASCGPQRGPA GSVPASAPAR TPPCRLLLVL
60 70 80 90 100
LLLPPLAASS RPRAWGAAAP SAPHWNETAE KNLGVLADED NTLQQNSSSN
110 120 130 140 150
ISYSNAMQKE ITLPSRLIYY INQDSESPYH VLDTKARHQQ KHNKAVHLAQ
160 170 180 190 200
ASFQIEAFGS KFILDLILNN GLLSSDYVEI HYENGKPQYS KGGEHCYYHG
210 220 230 240 250
SIRGVKDSKV ALSTCNGLHG MFEDDTFVYM IEPLELVHDE KSTGRPHIIQ
260 270 280 290 300
KTLAGQYSKQ MKNLTMERGD QWPFLSELQW LKRRKRAVNP SRGIFEEMKY
310 320 330 340 350
LELMIVNDHK TYKKHRSSHA HTNNFAKSVV NLVDSIYKEQ LNTRVVLVAV
360 370 380 390 400
ETWTEKDQID ITTNPVQMLH EFSKYRQRIK QHADAVHLIS RVTFHYKRSS
410 420 430 440 450
LSYFGGVCSR TRGVGVNEYG LPMAVAQVLS QSLAQNLGIQ WEPSSRKPKC
460 470 480 490 500
DCTESWGGCI MEETGVSHSR KFSKCSILEY RDFLQRGGGA CLFNRPTKLF
510 520 530 540 550
EPTECGNGYV EAGEECDCGF HVECYGLCCK KCSLSNGAHC SDGPCCNNTS
560 570 580 590 600
CLFQPRGYEC RDAVNECDIT EYCTGDSGQC PPNLHKQDGY ACNQNQGRCY
610 620 630 640 650
NGECKTRDNQ CQYIWGTKAA GSDKFCYEKL NTEGTEKGNC GKDGDRWIQC
660 670 680 690 700
SKHDVFCGFL LCTNLTRAPR IGQLQGEIIP TSFYHQGRVI DCSGAHVVLD
710 720 730 740 750
DDTDVGYVED GTPCGPSMMC LDRKCLQIQA LNMSSCPLDS KGKVCSGHGV
760 770 780 790 800
CSNEATCICD FTWAGTDCSI RDPVRNLHPP KDEGPKGPSA TNLIIGSIAG
810 820 830
AILVAAIVLG GTGWGFKNVK KRRFDPTQQG PI
The sequence of this isoform differs from the canonical sequence as follows:
787-817: GPSATNLIIGSIAGAILVAAIVLGGTGWGFK → VNMATSRLIGAVAGTLLALGVIFGGTGWGIE
The sequence of this isoform differs from the canonical sequence as follows:
787-832: GPSATNLIIG...RFDPTQQGPI → EMSRREGSIL...AAVLLELLSL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EWD3 | E7EWD3_HUMAN | Disintegrin and metalloproteinase d... | ADAM23 | 832 | Annotation score: | ||
H7C2M6 | H7C2M6_HUMAN | Disintegrin and metalloproteinase d... | ADAM23 | 107 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012045 | 787 – 832 | GPSAT…QQGPI → EMSRREGSILLSKAPSESAA LDGHRLALLDSGYDILAAVL LELLSL in isoform Gamma. 1 PublicationAdd BLAST | 46 | |
Alternative sequenceiVSP_012046 | 787 – 817 | GPSAT…GWGFK → VNMATSRLIGAVAGTLLALG VIFGGTGWGIE in isoform Beta. 1 PublicationAdd BLAST | 31 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009672 mRNA Translation: BAA32351.1 AJ005580 mRNA Translation: CAC20565.1 CH471063 Genomic DNA Translation: EAW70386.1 BC132763 mRNA Translation: AAI32764.1 BC132765 mRNA Translation: AAI32766.1 |
CCDSi | CCDS2369.1 [O75077-1] |
RefSeqi | NP_003803.1, NM_003812.3 [O75077-1] XP_005246989.1, XM_005246932.3 [O75077-3] |
Genome annotation databases
Ensembli | ENST00000264377.8; ENSP00000264377.3; ENSG00000114948.13 |
GeneIDi | 8745 |
KEGGi | hsa:8745 |
MANE-Selecti | ENST00000264377.8; ENSP00000264377.3; NM_003812.4; NP_003803.1 |
UCSCi | uc002vbq.6, human [O75077-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009672 mRNA Translation: BAA32351.1 AJ005580 mRNA Translation: CAC20565.1 CH471063 Genomic DNA Translation: EAW70386.1 BC132763 mRNA Translation: AAI32764.1 BC132765 mRNA Translation: AAI32766.1 |
CCDSi | CCDS2369.1 [O75077-1] |
RefSeqi | NP_003803.1, NM_003812.3 [O75077-1] XP_005246989.1, XM_005246932.3 [O75077-3] |
3D structure databases
AlphaFoldDBi | O75077 |
SMRi | O75077 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114282, 3 interactors |
CORUMi | O75077 |
IntActi | O75077, 2 interactors |
MINTi | O75077 |
STRINGi | 9606.ENSP00000264377 |
Protein family/group databases
MEROPSi | M12.979 |
PTM databases
GlyGeni | O75077, 8 sites |
iPTMneti | O75077 |
PhosphoSitePlusi | O75077 |
SwissPalmi | O75077 |
Genetic variation databases
BioMutai | ADAM23 |
Proteomic databases
MassIVEi | O75077 |
PaxDbi | O75077 |
PeptideAtlasi | O75077 |
PRIDEi | O75077 |
ProteomicsDBi | 49740 [O75077-1] 49741 [O75077-2] 49742 [O75077-3] |
Protocols and materials databases
Antibodypediai | 34180, 245 antibodies from 29 providers |
DNASUi | 8745 |
Genome annotation databases
Ensembli | ENST00000264377.8; ENSP00000264377.3; ENSG00000114948.13 |
GeneIDi | 8745 |
KEGGi | hsa:8745 |
MANE-Selecti | ENST00000264377.8; ENSP00000264377.3; NM_003812.4; NP_003803.1 |
UCSCi | uc002vbq.6, human [O75077-1] |
Organism-specific databases
CTDi | 8745 |
DisGeNETi | 8745 |
GeneCardsi | ADAM23 |
HGNCi | HGNC:202, ADAM23 |
HPAi | ENSG00000114948, Tissue enhanced (brain, parathyroid gland) |
MIMi | 603710, gene |
neXtProti | NX_O75077 |
OpenTargetsi | ENSG00000114948 |
PharmGKBi | PA24519 |
VEuPathDBi | HostDB:ENSG00000114948 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3607, Eukaryota |
GeneTreei | ENSGT00940000158781 |
HOGENOMi | CLU_012714_5_2_1 |
InParanoidi | O75077 |
OMAi | ECDCTES |
OrthoDBi | 162519at2759 |
PhylomeDBi | O75077 |
TreeFami | TF314733 |
Enzyme and pathway databases
PathwayCommonsi | O75077 |
Reactomei | R-HSA-5682910, LGI-ADAM interactions |
SignaLinki | O75077 |
Miscellaneous databases
BioGRID-ORCSi | 8745, 20 hits in 1070 CRISPR screens |
ChiTaRSi | ADAM23, human |
GeneWikii | ADAM23 |
GenomeRNAii | 8745 |
Pharosi | O75077, Tbio |
PROi | PR:O75077 |
RNActi | O75077, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114948, Expressed in middle temporal gyrus and 187 other tissues |
ExpressionAtlasi | O75077, baseline and differential |
Genevisiblei | O75077, HS |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADA23_HUMAN | |
Accessioni | O75077Primary (citable) accession number: O75077 Secondary accession number(s): A2RU59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | November 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot