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UniProtKB - O75074 (LRP3_HUMAN)
Protein
Low-density lipoprotein receptor-related protein 3
Gene
LRP3
Organism
Homo sapiens (Human)
Status
Functioni
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.
GO - Biological processi
- negative regulation of fat cell differentiation Source: ARUK-UCL
- negative regulation of gene expression Source: ARUK-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of osteoblast differentiation Source: ARUK-UCL
- receptor-mediated endocytosis Source: ProtInc
- transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Molecular function | Receptor |
Biological process | Endocytosis |
Enzyme and pathway databases
PathwayCommonsi | O75074 |
SignaLinki | O75074 |
Names & Taxonomyi
Protein namesi | Recommended name: Low-density lipoprotein receptor-related protein 3Short name: LRP-3 Alternative name(s): 105 kDa low-density lipoprotein receptor-related protein Short name: hLRp105 |
Gene namesi | Name:LRP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6695, LRP3 |
MIMi | 603159, gene |
neXtProti | NX_O75074 |
VEuPathDBi | HostDB:ENSG00000130881 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
- coated pit By similarity
Plasma Membrane
- clathrin-coated pit Source: UniProtKB-KW
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 37 – 496 | ExtracellularSequence analysisAdd BLAST | 460 | |
Transmembranei | 497 – 517 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 518 – 770 | CytoplasmicSequence analysisAdd BLAST | 253 |
Keywords - Cellular componenti
Coated pit, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4037 |
OpenTargetsi | ENSG00000130881 |
PharmGKBi | PA30453 |
Miscellaneous databases
Pharosi | O75074, Tbio |
Genetic variation databases
BioMutai | LRP3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 36 | Sequence analysisAdd BLAST | 36 | |
ChainiPRO_0000017323 | 37 – 770 | Low-density lipoprotein receptor-related protein 3Add BLAST | 734 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 43 ↔ 72 | By similarity | ||
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 99 ↔ 120 | By similarity | ||
Disulfide bondi | 166 ↔ 178 | By similarity | ||
Disulfide bondi | 173 ↔ 191 | By similarity | ||
Disulfide bondi | 185 ↔ 200 | By similarity | ||
Glycosylationi | 199 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 212 ↔ 227 | By similarity | ||
Disulfide bondi | 219 ↔ 240 | By similarity | ||
Disulfide bondi | 234 ↔ 249 | By similarity | ||
Disulfide bondi | 254 ↔ 282 | By similarity | ||
Glycosylationi | 359 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 416 ↔ 430 | By similarity | ||
Disulfide bondi | 423 ↔ 443 | By similarity | ||
Disulfide bondi | 437 ↔ 452 | By similarity | ||
Disulfide bondi | 455 ↔ 467 | By similarity | ||
Disulfide bondi | 462 ↔ 480 | By similarity | ||
Disulfide bondi | 474 ↔ 489 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | O75074 |
MassIVEi | O75074 |
PaxDbi | O75074 |
PeptideAtlasi | O75074 |
PRIDEi | O75074 |
ProteomicsDBi | 49739 |
PTM databases
GlyGeni | O75074, 3 sites |
iPTMneti | O75074 |
PhosphoSitePlusi | O75074 |
Expressioni
Tissue specificityi
Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.1 Publication
Gene expression databases
Bgeei | ENSG00000130881, Expressed in putamen and 117 other tissues |
ExpressionAtlasi | O75074, baseline and differential |
Genevisiblei | O75074, HS |
Organism-specific databases
HPAi | ENSG00000130881, Low tissue specificity |
Interactioni
Subunit structurei
Binds GGA1 and GGA2.
By similarityProtein-protein interaction databases
BioGRIDi | 110217, 48 interactors |
ELMi | O75074 |
IntActi | O75074, 3 interactors |
MINTi | O75074 |
STRINGi | 9606.ENSP00000253193 |
Miscellaneous databases
RNActi | O75074, protein |
Structurei
3D structure databases
AlphaFoldDBi | O75074 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 159 | CUB 1PROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 165 – 201 | LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 211 – 250 | LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 254 – 365 | CUB 2PROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 415 – 453 | LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 454 – 490 | LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST | 37 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 635 – 770 | DisorderedSequence analysisAdd BLAST | 136 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 672 – 689 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 691 – 706 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 725 – 739 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the LDLR family.Curated
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000160021 |
HOGENOMi | CLU_013747_1_0_1 |
InParanoidi | O75074 |
OMAi | KACREPL |
OrthoDBi | 135036at2759 |
PhylomeDBi | O75074 |
TreeFami | TF332149 |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00112, LDLa, 4 hits |
Gene3Di | 2.60.120.290, 2 hits 4.10.400.10, 4 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF00057, Ldl_recept_a, 3 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00192, LDLa, 5 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF57424, SSF57424, 4 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS01209, LDLRA_1, 3 hits PS50068, LDLRA_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O75074-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH
60 70 80 90 100
TERRGVIYSP AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS
110 120 130 140 150
LDWLLLGPAA PPRQEAFRLC GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ
160 170 180 190 200
GFRLSYIRGK LGQASCQADE FRCDNGKCLP GPWQCNTVDE CGDGSDEGNC
210 220 230 240 250
SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC GDGSDEAGCP
260 270 280 290 300
DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL
310 320 330 340 350
RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR
360 370 380 390 400
ARSAGHGFNA TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG
410 420 430 440 450
WWHCASGRDE QGCPACPPDQ YPCEGGSGLC YTPADRCNNQ KSCPDGADEK
460 470 480 490 500
NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC QDGSDEHGCL AAVPRKVITA
510 520 530 540 550
ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL EAEFVRREAP
560 570 580 590 600
PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS
610 620 630 640 650
RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP
660 670 680 690 700
PAPLMDTGST RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR
710 720 730 740 750
KVCREPLVDG PAPADAPREP CSAQDPHPQV STASSTLGPH SPEPLGVCRN
760 770
PPPPCSPMLE ASDDEALLVC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketV9GYG8 | V9GYG8_HUMAN | Low-density lipoprotein receptor-re... | LRP3 | 91 | Annotation score: |
Sequence cautioni
The sequence BAG51998 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG59164 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 85 | T → I in BAG51998 (PubMed:16303743).Curated | 1 | |
Sequence conflicti | 458 | G → D in BAG51998 (PubMed:16303743).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049764 | 213 | P → L. Corresponds to variant dbSNP:rs3745978Ensembl. | 1 | |
Natural variantiVAR_018171 | 708 | V → A4 PublicationsCorresponds to variant dbSNP:rs3745974Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009462 mRNA Translation: BAA32330.1 BC007408 mRNA Translation: AAH07408.1 AK074751 mRNA Translation: BAG51998.1 Different initiation. AK296536 mRNA Translation: BAG59164.1 Different initiation. |
CCDSi | CCDS12430.1 |
PIRi | T00204 |
RefSeqi | NP_002324.2, NM_002333.3 |
Genome annotation databases
Ensembli | ENST00000253193.9; ENSP00000253193.6; ENSG00000130881.14 |
GeneIDi | 4037 |
KEGGi | hsa:4037 |
MANE-Selecti | ENST00000253193.9; ENSP00000253193.6; NM_002333.4; NP_002324.2 |
UCSCi | uc010edh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009462 mRNA Translation: BAA32330.1 BC007408 mRNA Translation: AAH07408.1 AK074751 mRNA Translation: BAG51998.1 Different initiation. AK296536 mRNA Translation: BAG59164.1 Different initiation. |
CCDSi | CCDS12430.1 |
PIRi | T00204 |
RefSeqi | NP_002324.2, NM_002333.3 |
3D structure databases
AlphaFoldDBi | O75074 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 110217, 48 interactors |
ELMi | O75074 |
IntActi | O75074, 3 interactors |
MINTi | O75074 |
STRINGi | 9606.ENSP00000253193 |
PTM databases
GlyGeni | O75074, 3 sites |
iPTMneti | O75074 |
PhosphoSitePlusi | O75074 |
Genetic variation databases
BioMutai | LRP3 |
Proteomic databases
jPOSTi | O75074 |
MassIVEi | O75074 |
PaxDbi | O75074 |
PeptideAtlasi | O75074 |
PRIDEi | O75074 |
ProteomicsDBi | 49739 |
Protocols and materials databases
Antibodypediai | 29007, 168 antibodies from 27 providers |
DNASUi | 4037 |
Genome annotation databases
Ensembli | ENST00000253193.9; ENSP00000253193.6; ENSG00000130881.14 |
GeneIDi | 4037 |
KEGGi | hsa:4037 |
MANE-Selecti | ENST00000253193.9; ENSP00000253193.6; NM_002333.4; NP_002324.2 |
UCSCi | uc010edh.4, human |
Organism-specific databases
CTDi | 4037 |
DisGeNETi | 4037 |
GeneCardsi | LRP3 |
HGNCi | HGNC:6695, LRP3 |
HPAi | ENSG00000130881, Low tissue specificity |
MIMi | 603159, gene |
neXtProti | NX_O75074 |
OpenTargetsi | ENSG00000130881 |
PharmGKBi | PA30453 |
VEuPathDBi | HostDB:ENSG00000130881 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000160021 |
HOGENOMi | CLU_013747_1_0_1 |
InParanoidi | O75074 |
OMAi | KACREPL |
OrthoDBi | 135036at2759 |
PhylomeDBi | O75074 |
TreeFami | TF332149 |
Enzyme and pathway databases
PathwayCommonsi | O75074 |
SignaLinki | O75074 |
Miscellaneous databases
BioGRID-ORCSi | 4037, 24 hits in 1073 CRISPR screens |
ChiTaRSi | LRP3, human |
GeneWikii | LRP3 |
GenomeRNAii | 4037 |
Pharosi | O75074, Tbio |
PROi | PR:O75074 |
RNActi | O75074, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130881, Expressed in putamen and 117 other tissues |
ExpressionAtlasi | O75074, baseline and differential |
Genevisiblei | O75074, HS |
Family and domain databases
CDDi | cd00041, CUB, 2 hits cd00112, LDLa, 4 hits |
Gene3Di | 2.60.120.290, 2 hits 4.10.400.10, 4 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF00057, Ldl_recept_a, 3 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00042, CUB, 2 hits SM00192, LDLa, 5 hits |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF57424, SSF57424, 4 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 2 hits PS01209, LDLRA_1, 3 hits PS50068, LDLRA_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LRP3_HUMAN | |
Accessioni | O75074Primary (citable) accession number: O75074 Secondary accession number(s): B3KQD6, B4DKF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | December 20, 2005 | |
Last modified: | May 25, 2022 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families