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Protein

Low-density lipoprotein receptor-related protein 3

Gene

LRP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.

GO - Biological processi

  • receptor-mediated endocytosis Source: ProtInc

Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 3
Short name:
LRP-3
Alternative name(s):
105 kDa low-density lipoprotein receptor-related protein
Short name:
hLRp105
Gene namesi
Name:LRP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130881.13
HGNCiHGNC:6695 LRP3
MIMi603159 gene
neXtProtiNX_O75074

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini37 – 496ExtracellularSequence analysisAdd BLAST460
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Topological domaini518 – 770CytoplasmicSequence analysisAdd BLAST253

Keywords - Cellular componenti

Coated pit, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130881
PharmGKBiPA30453

Polymorphism and mutation databases

BioMutaiLRP3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_000001732337 – 770Low-density lipoprotein receptor-related protein 3Add BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 72By similarity
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 120By similarity
Disulfide bondi166 ↔ 178By similarity
Disulfide bondi173 ↔ 191By similarity
Disulfide bondi185 ↔ 200By similarity
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi212 ↔ 227By similarity
Disulfide bondi219 ↔ 240By similarity
Disulfide bondi234 ↔ 249By similarity
Disulfide bondi254 ↔ 282By similarity
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi416 ↔ 430By similarity
Disulfide bondi423 ↔ 443By similarity
Disulfide bondi437 ↔ 452By similarity
Disulfide bondi455 ↔ 467By similarity
Disulfide bondi462 ↔ 480By similarity
Disulfide bondi474 ↔ 489By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75074
PeptideAtlasiO75074
PRIDEiO75074
ProteomicsDBi49739

PTM databases

iPTMnetiO75074
PhosphoSitePlusiO75074

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.1 Publication

Gene expression databases

BgeeiENSG00000130881 Expressed in 92 organ(s), highest expression level in putamen
CleanExiHS_LRP3
ExpressionAtlasiO75074 baseline and differential
GenevisibleiO75074 HS

Interactioni

Subunit structurei

Binds GGA1 and GGA2.By similarity

Protein-protein interaction databases

BioGridi110217, 2 interactors
ELMiO75074
IntActiO75074, 3 interactors
MINTiO75074
STRINGi9606.ENSP00000253193

Structurei

3D structure databases

ProteinModelPortaliO75074
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 159CUB 1PROSITE-ProRule annotationAdd BLAST117
Domaini165 – 201LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini211 – 250LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST40
Domaini254 – 365CUB 2PROSITE-ProRule annotationAdd BLAST112
Domaini415 – 453LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST39
Domaini454 – 490LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi751 – 754Poly-Pro4

Sequence similaritiesi

Belongs to the LDLR family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1215 Eukaryota
ENOG410XP34 LUCA
GeneTreeiENSGT00810000125405
HOGENOMiHOG000013017
HOVERGENiHBG049162
InParanoidiO75074
KOiK20050
OMAiSLDWLML
OrthoDBiEOG091G0I9Q
PhylomeDBiO75074
TreeFamiTF332149

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00112 LDLa, 4 hits
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00057 Ldl_recept_a, 3 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00192 LDLa, 5 hits
SUPFAMiSSF49854 SSF49854, 2 hits
SSF57424 SSF57424, 4 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01209 LDLRA_1, 3 hits
PS50068 LDLRA_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O75074-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH
60 70 80 90 100
TERRGVIYSP AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS
110 120 130 140 150
LDWLLLGPAA PPRQEAFRLC GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ
160 170 180 190 200
GFRLSYIRGK LGQASCQADE FRCDNGKCLP GPWQCNTVDE CGDGSDEGNC
210 220 230 240 250
SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC GDGSDEAGCP
260 270 280 290 300
DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL
310 320 330 340 350
RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR
360 370 380 390 400
ARSAGHGFNA TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG
410 420 430 440 450
WWHCASGRDE QGCPACPPDQ YPCEGGSGLC YTPADRCNNQ KSCPDGADEK
460 470 480 490 500
NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC QDGSDEHGCL AAVPRKVITA
510 520 530 540 550
ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL EAEFVRREAP
560 570 580 590 600
PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS
610 620 630 640 650
RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP
660 670 680 690 700
PAPLMDTGST RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR
710 720 730 740 750
KVCREPLVDG PAPADAPREP CSAQDPHPQV STASSTLGPH SPEPLGVCRN
760 770
PPPPCSPMLE ASDDEALLVC
Length:770
Mass (Da):82,884
Last modified:December 20, 2005 - v2
Checksum:i5175EDCB7A7D22EE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYG8V9GYG8_HUMAN
Low-density lipoprotein receptor-re...
LRP3
91Annotation score:

Sequence cautioni

The sequence BAG51998 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG59164 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85T → I in BAG51998 (PubMed:16303743).Curated1
Sequence conflicti458G → D in BAG51998 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049764213P → L. Corresponds to variant dbSNP:rs3745978Ensembl.1
Natural variantiVAR_018171708V → A4 PublicationsCorresponds to variant dbSNP:rs3745974Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009462 mRNA Translation: BAA32330.1
BC007408 mRNA Translation: AAH07408.1
AK074751 mRNA Translation: BAG51998.1 Different initiation.
AK296536 mRNA Translation: BAG59164.1 Different initiation.
CCDSiCCDS12430.1
PIRiT00204
RefSeqiNP_002324.2, NM_002333.3
UniGeneiHs.515340

Genome annotation databases

EnsembliENST00000253193; ENSP00000253193; ENSG00000130881
GeneIDi4037
KEGGihsa:4037
UCSCiuc010edh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009462 mRNA Translation: BAA32330.1
BC007408 mRNA Translation: AAH07408.1
AK074751 mRNA Translation: BAG51998.1 Different initiation.
AK296536 mRNA Translation: BAG59164.1 Different initiation.
CCDSiCCDS12430.1
PIRiT00204
RefSeqiNP_002324.2, NM_002333.3
UniGeneiHs.515340

3D structure databases

ProteinModelPortaliO75074
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110217, 2 interactors
ELMiO75074
IntActiO75074, 3 interactors
MINTiO75074
STRINGi9606.ENSP00000253193

PTM databases

iPTMnetiO75074
PhosphoSitePlusiO75074

Polymorphism and mutation databases

BioMutaiLRP3

Proteomic databases

PaxDbiO75074
PeptideAtlasiO75074
PRIDEiO75074
ProteomicsDBi49739

Protocols and materials databases

DNASUi4037
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253193; ENSP00000253193; ENSG00000130881
GeneIDi4037
KEGGihsa:4037
UCSCiuc010edh.4 human

Organism-specific databases

CTDi4037
EuPathDBiHostDB:ENSG00000130881.13
GeneCardsiLRP3
H-InvDBiHIX0014999
HGNCiHGNC:6695 LRP3
MIMi603159 gene
neXtProtiNX_O75074
OpenTargetsiENSG00000130881
PharmGKBiPA30453
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1215 Eukaryota
ENOG410XP34 LUCA
GeneTreeiENSGT00810000125405
HOGENOMiHOG000013017
HOVERGENiHBG049162
InParanoidiO75074
KOiK20050
OMAiSLDWLML
OrthoDBiEOG091G0I9Q
PhylomeDBiO75074
TreeFamiTF332149

Miscellaneous databases

ChiTaRSiLRP3 human
GeneWikiiLRP3
GenomeRNAii4037
PROiPR:O75074
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130881 Expressed in 92 organ(s), highest expression level in putamen
CleanExiHS_LRP3
ExpressionAtlasiO75074 baseline and differential
GenevisibleiO75074 HS

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00112 LDLa, 4 hits
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00057 Ldl_recept_a, 3 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00192 LDLa, 5 hits
SUPFAMiSSF49854 SSF49854, 2 hits
SSF57424 SSF57424, 4 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01209 LDLRA_1, 3 hits
PS50068 LDLRA_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRP3_HUMAN
AccessioniPrimary (citable) accession number: O75074
Secondary accession number(s): B3KQD6, B4DKF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 20, 2005
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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