LRP3

Functionⁱ

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.

GO - Biological processⁱ

receptor-mediated endocytosis
Source: ProtInc
Traceable author statementⁱ
- 9693042

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Endocytosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Low-density lipoprotein receptor-related protein 3 Short name: LRP-3 Alternative name(s): 105 kDa low-density lipoprotein receptor-related protein Short name: hLRp105
Gene namesⁱ	Name:LRP3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130881.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6695 LRP3
MIMⁱ	603159 gene
neXtProtⁱ	NX_O75074

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	37 – 496	ExtracellularSequence analysisAdd BLAST	460
Transmembraneⁱ	497 – 517	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	518 – 770	CytoplasmicSequence analysisAdd BLAST	253

Keywords - Cellular componentⁱ

Coated pit, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000130881
PharmGKBⁱ	PA30453

Polymorphism and mutation databases

BioMutaⁱ	LRP3

BioMutaⁱ

LRP3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 36	Sequence analysisAdd BLAST		36
ChainⁱPRO_0000017323	37 – 770	Low-density lipoprotein receptor-related protein 3Add BLAST		734

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	43 ↔ 72	By similarity
Glycosylationⁱ	71	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	99 ↔ 120	By similarity
Disulfide bondⁱ	166 ↔ 178	By similarity
Disulfide bondⁱ	173 ↔ 191	By similarity
Disulfide bondⁱ	185 ↔ 200	By similarity
Glycosylationⁱ	199	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	212 ↔ 227	By similarity
Disulfide bondⁱ	219 ↔ 240	By similarity
Disulfide bondⁱ	234 ↔ 249	By similarity
Disulfide bondⁱ	254 ↔ 282	By similarity
Glycosylationⁱ	359	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	416 ↔ 430	By similarity
Disulfide bondⁱ	423 ↔ 443	By similarity
Disulfide bondⁱ	437 ↔ 452	By similarity
Disulfide bondⁱ	455 ↔ 467	By similarity
Disulfide bondⁱ	462 ↔ 480	By similarity
Disulfide bondⁱ	474 ↔ 489	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O75074
PeptideAtlas More...PeptideAtlasⁱ	O75074
PRIDEⁱ	O75074
ProteomicsDBⁱ	49739

PTM databases

iPTMnetⁱ	O75074
PhosphoSitePlusⁱ	O75074

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000130881 Expressed in 92 organ(s), highest expression level in putamen
CleanExⁱ	HS_LRP3
ExpressionAtlasⁱ	O75074 baseline and differential
Genevisibleⁱ	O75074 HS

Interactionⁱ

Subunit structureⁱ

Binds GGA1 and GGA2.By similarity

Protein-protein interaction databases

BioGridⁱ	110217, 2 interactors
ELMⁱ	O75074
IntActⁱ	O75074, 3 interactors
Molecular INTeraction database More...MINTⁱ	O75074
STRINGⁱ	9606.ENSP00000253193

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75074
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	43 – 159	CUB 1PROSITE-ProRule annotationAdd BLAST	117
Domainⁱ	165 – 201	LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	211 – 250	LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	254 – 365	CUB 2PROSITE-ProRule annotationAdd BLAST	112
Domainⁱ	415 – 453	LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST	39
Domainⁱ	454 – 490	LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST	37

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	751 – 754	Poly-Pro		4

Sequence similaritiesⁱ

Belongs to the LDLR family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1215 Eukaryota ENOG410XP34 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125405
HOGENOMⁱ	HOG000013017
HOVERGENⁱ	HBG049162
InParanoidⁱ	O75074
KEGG Orthology (KO) More...KOⁱ	K20050
OMAⁱ	SLDWLML
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I9Q
PhylomeDBⁱ	O75074
TreeFamⁱ	TF332149

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00041 CUB, 2 hits cd00112 LDLa, 4 hits
Gene3Dⁱ	2.60.120.290, 2 hits
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR035914 Sperma_CUB_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00431 CUB, 2 hits PF00057 Ldl_recept_a, 3 hits
PRINTSⁱ	PR00261 LDLRECEPTOR
SMARTⁱ	View protein in SMART SM00042 CUB, 2 hits SM00192 LDLa, 5 hits
SUPFAMⁱ	SSF49854 SSF49854, 2 hits SSF57424 SSF57424, 4 hits
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 2 hits PS01209 LDLRA_1, 3 hits PS50068 LDLRA_2, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O75074-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH 
        60         70         80         90        100
TERRGVIYSP AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS 
       110        120        130        140        150
LDWLLLGPAA PPRQEAFRLC GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ 
       160        170        180        190        200
GFRLSYIRGK LGQASCQADE FRCDNGKCLP GPWQCNTVDE CGDGSDEGNC 
       210        220        230        240        250
SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC GDGSDEAGCP 
       260        270        280        290        300
DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL 
       310        320        330        340        350
RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR 
       360        370        380        390        400
ARSAGHGFNA TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG 
       410        420        430        440        450
WWHCASGRDE QGCPACPPDQ YPCEGGSGLC YTPADRCNNQ KSCPDGADEK 
       460        470        480        490        500
NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC QDGSDEHGCL AAVPRKVITA 
       510        520        530        540        550
ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL EAEFVRREAP 
       560        570        580        590        600
PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS 
       610        620        630        640        650
RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP 
       660        670        680        690        700
PAPLMDTGST RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR 
       710        720        730        740        750
KVCREPLVDG PAPADAPREP CSAQDPHPQV STASSTLGPH SPEPLGVCRN 
       760        770
PPPPCSPMLE ASDDEALLVC

Length:770

Mass (Da):82,884

Last modified:December 20, 2005 - v2

Checksum:ⁱ5175EDCB7A7D22EE

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	V9GYG8	V9GYG8_HUMAN		Low-density lipoprotein receptor-re... Low-density lipoprotein receptor-related protein 3	LRP3	91	Annotation score:

Sequence cautionⁱ

The sequence BAG51998 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAG59164 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	85	T → I in BAG51998 (PubMed:16303743).Curated		1
Sequence conflictⁱ	458	G → D in BAG51998 (PubMed:16303743).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049764	213	P → L. Corresponds to variant dbSNP:rs3745978Ensembl.		1
Natural variantⁱVAR_018171	708	V → A4 PublicationsCorresponds to variant dbSNP:rs3745974Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB009462 mRNA Translation: BAA32330.1 BC007408 mRNA Translation: AAH07408.1 AK074751 mRNA Translation: BAG51998.1 Different initiation. AK296536 mRNA Translation: BAG59164.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12430.1
PIRⁱ	T00204
NCBI Reference Sequences More...RefSeqⁱ	NP_002324.2, NM_002333.3
UniGeneⁱ	Hs.515340

Genome annotation databases

Ensemblⁱ	ENST00000253193; ENSP00000253193; ENSG00000130881
GeneIDⁱ	4037
KEGGⁱ	hsa:4037
UCSC genome browser More...UCSCⁱ	uc010edh.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75074	Low-density lipoprotein receptor-related protein 3		RAT		770	UniRef90_O75074
LDL receptor related protein 3		PANTR		770
LDL receptor related protein 3		CALJA		770
Low-density lipoprotein receptor-related protein 3		MACMU		770
Uncharacterized protein		MACFA		755
+48

Protein	Similar proteins		Species	Score	Length	Source
O75074	Low-density lipoprotein receptor-related protein 3		RAT		770	UniRef50_O75074
Uncharacterized protein		MACNE		770
Uncharacterized protein		AOTNA		770
Low density lipoprotein receptor-related protein 3		PANTR		770
LDL receptor related protein 3		CALJA		770
+325

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB009462 mRNA Translation: BAA32330.1 BC007408 mRNA Translation: AAH07408.1 AK074751 mRNA Translation: BAG51998.1 Different initiation. AK296536 mRNA Translation: BAG59164.1 Different initiation.
CCDSⁱ	CCDS12430.1
PIRⁱ	T00204
RefSeqⁱ	NP_002324.2, NM_002333.3
UniGeneⁱ	Hs.515340

3D structure databases

ProteinModelPortalⁱ	O75074
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110217, 2 interactors
ELMⁱ	O75074
IntActⁱ	O75074, 3 interactors
MINTⁱ	O75074
STRINGⁱ	9606.ENSP00000253193

PTM databases

iPTMnetⁱ	O75074
PhosphoSitePlusⁱ	O75074

Polymorphism and mutation databases

BioMutaⁱ	LRP3

BioMutaⁱ

LRP3

Proteomic databases

PaxDbⁱ	O75074
PeptideAtlasⁱ	O75074
PRIDEⁱ	O75074
ProteomicsDBⁱ	49739

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4037
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000253193; ENSP00000253193; ENSG00000130881
GeneIDⁱ	4037
KEGGⁱ	hsa:4037
UCSCⁱ	uc010edh.4 human

Organism-specific databases

CTDⁱ	4037
EuPathDBⁱ	HostDB:ENSG00000130881.13
GeneCardsⁱ	LRP3
H-InvDBⁱ	HIX0014999
HGNCⁱ	HGNC:6695 LRP3
MIMⁱ	603159 gene
neXtProtⁱ	NX_O75074
OpenTargetsⁱ	ENSG00000130881
PharmGKBⁱ	PA30453
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1215 Eukaryota ENOG410XP34 LUCA
GeneTreeⁱ	ENSGT00810000125405
HOGENOMⁱ	HOG000013017
HOVERGENⁱ	HBG049162
InParanoidⁱ	O75074
KOⁱ	K20050
OMAⁱ	SLDWLML
OrthoDBⁱ	EOG091G0I9Q
PhylomeDBⁱ	O75074
TreeFamⁱ	TF332149

Miscellaneous databases

ChiTaRSⁱ	LRP3 human
GeneWikiⁱ	LRP3
GenomeRNAiⁱ	4037
Protein Ontology More...PROⁱ	PR:O75074
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130881 Expressed in 92 organ(s), highest expression level in putamen
CleanExⁱ	HS_LRP3
ExpressionAtlasⁱ	O75074 baseline and differential
Genevisibleⁱ	O75074 HS

Family and domain databases

CDDⁱ	cd00041 CUB, 2 hits cd00112 LDLa, 4 hits
Gene3Dⁱ	2.60.120.290, 2 hits
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR002172 LDrepeatLR_classA_rpt IPR035914 Sperma_CUB_dom_sf
Pfamⁱ	View protein in Pfam PF00431 CUB, 2 hits PF00057 Ldl_recept_a, 3 hits
PRINTSⁱ	PR00261 LDLRECEPTOR
SMARTⁱ	View protein in SMART SM00042 CUB, 2 hits SM00192 LDLa, 5 hits
SUPFAMⁱ	SSF49854 SSF49854, 2 hits SSF57424 SSF57424, 4 hits
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 2 hits PS01209 LDLRA_1, 3 hits PS50068 LDLRA_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LRP3_HUMAN
Accessionⁱ	O75074Primary (citable) accession number: O75074 Secondary accession number(s): B3KQD6, B4DKF2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
	Last sequence update:	December 20, 2005
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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Help

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Supporting data

UniProtKB - O75074 (LRP3_HUMAN)

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Low-density lipoprotein receptor-related protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ