EFCAB14

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	477 – 489	PROSITE-ProRule annotationAdd BLAST		13

GO - Molecular functionⁱ

calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Metal-binding

Ligand

Calcium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: EF-hand calcium-binding domain-containing protein 14
Gene namesⁱ	Name:EFCAB14 Synonyms:KIAA0494
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000159658.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29051 EFCAB14
neXtProtⁱ	NX_O75071

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000159658
PharmGKBⁱ	PA142671630

Polymorphism and mutation databases

BioMutaⁱ	EFCAB14

BioMutaⁱ

EFCAB14

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000073882	1 – 495	EF-hand calcium-binding domain-containing protein 14Add BLAST		495

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	17	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O75071
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O75071
PaxDbⁱ	O75071
PeptideAtlas More...PeptideAtlasⁱ	O75071
PRIDEⁱ	O75071
ProteomicsDBⁱ	49737

PTM databases

CarbonylDBⁱ	O75071
GlyConnectⁱ	1198
iPTMnetⁱ	O75071
PhosphoSitePlusⁱ	O75071
SwissPalmⁱ	O75071

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000159658 Expressed in 255 organ(s), highest expression level in globus pallidus
CleanExⁱ	HS_KIAA0494
ExpressionAtlasⁱ	O75071 baseline and differential
Genevisibleⁱ	O75071 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA011224 HPA011938

HPAⁱ

HPA011224
HPA011938

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115152, 5 interactors
IntActⁱ	O75071, 4 interactors
STRINGⁱ	9606.ENSP00000361001

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O75071
SMRⁱ	O75071
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	434 – 463	EF-hand 1PROSITE-ProRule annotationAdd BLAST		30
Domainⁱ	464 – 495	EF-hand 2PROSITE-ProRule annotationAdd BLAST		32

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IIIA Eukaryota ENOG4110MGQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011196
HOGENOMⁱ	HOG000231138
HOVERGENⁱ	HBG052185
InParanoidⁱ	O75071
OMAⁱ	GYQRQND
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09JA
PhylomeDBⁱ	O75071
TreeFamⁱ	TF331353

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR002048 EF_hand_dom
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS50222 EF_HAND_2, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

O75071-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKKRKELNAL IGLAGDSRRK KPKKGPSSHR LLRTEPPDSD SESSSEEEEE 
        60         70         80         90        100
FGVVGNRSRF AKGDYLRCCK ICYPLCGFVI LAACVVACVG LVWMQVALKE 
       110        120        130        140        150
DLDALKEKFR TMESNQKSSF QEIPKLNEEL LSKQKQLEKI ESGEMGLNKV 
       160        170        180        190        200
WINITEMNKQ ISLLTSAVNH LKANVKSAAD LISLPTTVEG LQKSVASIGN 
       210        220        230        240        250
TLNSVHLAVE ALQKTVDEHK KTMELLQSDM NQHFLKETPG SNQIIPSPSA 
       260        270        280        290        300
TSELDNKTHS ENLKQDILYL HNSLEEVNSA LVGYQRQNDL KLEGMNETVS 
       310        320        330        340        350
NLTQRVNLIE SDVVAMSKVE KKANLSFSMM GDRSATLKRQ SLDQVTNRTD 
       360        370        380        390        400
TVKIQSIKKE DSSNSQVSKL REKLQLISAL TNKPESNRPP ETADEEQVES 
       410        420        430        440        450
FTSKPSALPK FSQFLGDPVE KAAQLRPISL PGVSSTEDLQ DLFRKTGQDV 
       460        470        480        490 
DGKLTYQEIW TSLGSAMPEP ESLRAFDSDG DGRYSFLELR VALGI

Length:495

Mass (Da):55,031

Last modified:November 1, 1998 - v1

Checksum:ⁱ81170A5169D4B46F

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	S4R3Q1	S4R3Q1_HUMAN		EF-hand calcium-binding domain-cont... EF-hand calcium-binding domain-containing protein 14	EFCAB14	66	Annotation score:

Sequence cautionⁱ

The sequence BAA32328 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_074176	239	P → S1 Publication		1
Natural variantⁱVAR_048669	337	L → P. Corresponds to variant dbSNP:rs6665021Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB007963 mRNA Translation: BAA32328.2 Different initiation. AL593856 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06893.1 CH471059 Genomic DNA Translation: EAX06894.1 BC002525 mRNA Translation: AAH02525.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30706.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055589.1, NM_014774.2
UniGeneⁱ	Hs.707688

Genome annotation databases

Ensemblⁱ	ENST00000371933; ENSP00000361001; ENSG00000159658
GeneIDⁱ	9813
KEGGⁱ	hsa:9813
UCSC genome browser More...UCSCⁱ	uc001cqk.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O75071	EF-hand domain-containing protein KIAA0494		CALJA		496	UniRef90_O75071
EF-hand calcium binding domain 14		SAIBB		496
Uncharacterized protein		AOTNA		496
EF-hand calcium binding domain 14		PANTR		495
EF-hand domain-containing protein KIAA0494		MACMU		495
+30

Protein	Similar proteins		Species	Score	Length	Source
O75071	EF-hand calcium-binding domain-containing protein 14		MOUSE		484	UniRef50_O75071
Uncharacterized protein		AOTNA		496
EF-hand domain-containing protein KIAA0494		CALJA		496
EF-hand calcium binding domain 14		SAIBB		496
EFCAB14 isoform 1		PANTR		495
+182

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB007963 mRNA Translation: BAA32328.2 Different initiation. AL593856 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06893.1 CH471059 Genomic DNA Translation: EAX06894.1 BC002525 mRNA Translation: AAH02525.1
CCDSⁱ	CCDS30706.1
RefSeqⁱ	NP_055589.1, NM_014774.2
UniGeneⁱ	Hs.707688

3D structure databases

ProteinModelPortalⁱ	O75071
SMRⁱ	O75071
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115152, 5 interactors
IntActⁱ	O75071, 4 interactors
STRINGⁱ	9606.ENSP00000361001

PTM databases

CarbonylDBⁱ	O75071
GlyConnectⁱ	1198
iPTMnetⁱ	O75071
PhosphoSitePlusⁱ	O75071
SwissPalmⁱ	O75071

Polymorphism and mutation databases

BioMutaⁱ	EFCAB14

BioMutaⁱ

EFCAB14

Proteomic databases

EPDⁱ	O75071
MaxQBⁱ	O75071
PaxDbⁱ	O75071
PeptideAtlasⁱ	O75071
PRIDEⁱ	O75071
ProteomicsDBⁱ	49737

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000371933; ENSP00000361001; ENSG00000159658
GeneIDⁱ	9813
KEGGⁱ	hsa:9813
UCSCⁱ	uc001cqk.4 human

Organism-specific databases

CTDⁱ	9813
EuPathDBⁱ	HostDB:ENSG00000159658.10
GeneCardsⁱ	EFCAB14
HGNCⁱ	HGNC:29051 EFCAB14
HPAⁱ	HPA011224 HPA011938
neXtProtⁱ	NX_O75071
OpenTargetsⁱ	ENSG00000159658
PharmGKBⁱ	PA142671630
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIIA Eukaryota ENOG4110MGQ LUCA
GeneTreeⁱ	ENSGT00390000011196
HOGENOMⁱ	HOG000231138
HOVERGENⁱ	HBG052185
InParanoidⁱ	O75071
OMAⁱ	GYQRQND
OrthoDBⁱ	EOG091G09JA
PhylomeDBⁱ	O75071
TreeFamⁱ	TF331353

Miscellaneous databases

ChiTaRSⁱ	EFCAB14 human
GenomeRNAiⁱ	9813
Protein Ontology More...PROⁱ	PR:O75071

Gene expression databases

Bgeeⁱ	ENSG00000159658 Expressed in 255 organ(s), highest expression level in globus pallidus
CleanExⁱ	HS_KIAA0494
ExpressionAtlasⁱ	O75071 baseline and differential
Genevisibleⁱ	O75071 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR002048 EF_hand_dom
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS50222 EF_HAND_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EFC14_HUMAN
Accessionⁱ	O75071Primary (citable) accession number: O75071 Secondary accession number(s): D3DQ23, Q5SXB8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - O75071 (EFC14_HUMAN)

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EF-hand calcium-binding domain-containing protein 14

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ