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Protein

EF-hand calcium-binding domain-containing protein 14

Gene

EFCAB14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi477 – 489PROSITE-ProRule annotationAdd BLAST13

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 14
Gene namesi
Name:EFCAB14
Synonyms:KIAA0494
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159658.10
HGNCiHGNC:29051 EFCAB14
neXtProtiNX_O75071

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159658
PharmGKBiPA142671630

Polymorphism and mutation databases

BioMutaiEFCAB14

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000738821 – 495EF-hand calcium-binding domain-containing protein 14Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75071
MaxQBiO75071
PaxDbiO75071
PeptideAtlasiO75071
PRIDEiO75071
ProteomicsDBi49737

PTM databases

CarbonylDBiO75071
iPTMnetiO75071
PhosphoSitePlusiO75071
SwissPalmiO75071

Expressioni

Gene expression databases

BgeeiENSG00000159658
CleanExiHS_KIAA0494
ExpressionAtlasiO75071 baseline and differential
GenevisibleiO75071 HS

Organism-specific databases

HPAiHPA011224
HPA011938

Interactioni

Protein-protein interaction databases

BioGridi115152, 5 interactors
IntActiO75071, 4 interactors
STRINGi9606.ENSP00000361001

Structurei

3D structure databases

ProteinModelPortaliO75071
SMRiO75071
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini434 – 463EF-hand 1PROSITE-ProRule annotationAdd BLAST30
Domaini464 – 495EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIIA Eukaryota
ENOG4110MGQ LUCA
GeneTreeiENSGT00390000011196
HOGENOMiHOG000231138
HOVERGENiHBG052185
InParanoidiO75071
OMAiYQRQNDL
OrthoDBiEOG091G09JA
PhylomeDBiO75071
TreeFamiTF331353

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

O75071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKRKELNAL IGLAGDSRRK KPKKGPSSHR LLRTEPPDSD SESSSEEEEE
60 70 80 90 100
FGVVGNRSRF AKGDYLRCCK ICYPLCGFVI LAACVVACVG LVWMQVALKE
110 120 130 140 150
DLDALKEKFR TMESNQKSSF QEIPKLNEEL LSKQKQLEKI ESGEMGLNKV
160 170 180 190 200
WINITEMNKQ ISLLTSAVNH LKANVKSAAD LISLPTTVEG LQKSVASIGN
210 220 230 240 250
TLNSVHLAVE ALQKTVDEHK KTMELLQSDM NQHFLKETPG SNQIIPSPSA
260 270 280 290 300
TSELDNKTHS ENLKQDILYL HNSLEEVNSA LVGYQRQNDL KLEGMNETVS
310 320 330 340 350
NLTQRVNLIE SDVVAMSKVE KKANLSFSMM GDRSATLKRQ SLDQVTNRTD
360 370 380 390 400
TVKIQSIKKE DSSNSQVSKL REKLQLISAL TNKPESNRPP ETADEEQVES
410 420 430 440 450
FTSKPSALPK FSQFLGDPVE KAAQLRPISL PGVSSTEDLQ DLFRKTGQDV
460 470 480 490
DGKLTYQEIW TSLGSAMPEP ESLRAFDSDG DGRYSFLELR VALGI
Length:495
Mass (Da):55,031
Last modified:November 1, 1998 - v1
Checksum:i81170A5169D4B46F
GO

Sequence cautioni

The sequence BAA32328 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074176239P → S1 Publication1
Natural variantiVAR_048669337L → P. Corresponds to variant dbSNP:rs6665021Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007963 mRNA Translation: BAA32328.2 Different initiation.
AL593856 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06893.1
CH471059 Genomic DNA Translation: EAX06894.1
BC002525 mRNA Translation: AAH02525.1
CCDSiCCDS30706.1
RefSeqiNP_055589.1, NM_014774.2
UniGeneiHs.707688

Genome annotation databases

EnsembliENST00000371933; ENSP00000361001; ENSG00000159658
GeneIDi9813
KEGGihsa:9813
UCSCiuc001cqk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEFC14_HUMAN
AccessioniPrimary (citable) accession number: O75071
Secondary accession number(s): D3DQ23, Q5SXB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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