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UniProtKB - O75064 (DEN4B_HUMAN)

Entry version 147 (23 Feb 2022)
Sequence version 4 (11 Sep 2007)
Previous versions | rss
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Protein

DENN domain-containing protein 4B

Gene

DENND4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75064

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O75064

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DENN domain-containing protein 4B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DENND4B
Synonyms:KIAA0476
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29044, DENND4B

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75064

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198837

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9909

Open Targets

More...OpenTargetsi		ENSG00000198837

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671629

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75064, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DENND4B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003046781 – 1496DENN domain-containing protein 4BAdd BLAST1496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei953PhosphoserineCombined sources1
Modified residuei1092PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O75064

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75064

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75064

MaxQB - The MaxQuant DataBase

More...MaxQBi		O75064

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75064

PeptideAtlas

More...PeptideAtlasi		O75064

PRoteomics IDEntifications database

More...PRIDEi		O75064

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49735

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75064

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75064

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198837, Expressed in granulocyte and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75064, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75064, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198837, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115238, 13 interactors

Protein interaction database and analysis system

More...IntActi		O75064, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354597

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75064, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75064

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 203MABPPROSITE-ProRule annotationAdd BLAST160
Domaini195 – 369uDENNPROSITE-ProRule annotationAdd BLAST175
Domaini390 – 526cDENNPROSITE-ProRule annotationAdd BLAST137
Domaini528 – 644dDENNPROSITE-ProRule annotationAdd BLAST117
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati775 – 811PPR 1Add BLAST37
Repeati812 – 846PPR 2Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni720 – 744DisorderedSequence analysisAdd BLAST25
Regioni891 – 970DisorderedSequence analysisAdd BLAST80
Regioni995 – 1055DisorderedSequence analysisAdd BLAST61
Regioni1067 – 1119DisorderedSequence analysisAdd BLAST53
Regioni1205 – 1227DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi891 – 921Polar residuesSequence analysisAdd BLAST31
Compositional biasi1072 – 1090Pro residuesSequence analysisAdd BLAST19
Compositional biasi1105 – 1119Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2127, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160472

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75064

Identification of Orthologs from Complete Genome Data

More...OMAi		LECKWPS

Database of Orthologous Groups

More...OrthoDBi		75304at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75064

TreeFam database of animal gene trees

More...TreeFami		TF313237

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit
3.40.50.11500, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR023341, MABP
IPR002885, Pentatricopeptide_repeat
IPR011990, TPR-like_helical_dom_sf
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03455, dDENN, 1 hit
PF02141, DENN, 1 hit
PF03456, uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00800, uDENN, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50211, DENN, 1 hit
PS51498, MABP, 1 hit
PS51375, PPR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O75064-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEERPPRLV DYFVVAGLAG NGAPIPEETW VPEPSGPLRP PRPAEPITDV 
        60         70         80         90        100
AVIARALGEE VPQGYTCIQA SAGGHPLELS AGLLGGTQPV ICYRRGRDKP 
       110        120        130        140        150
PLVELGVLYE GKERPKPGFQ VLDTTPYSHS ANLAPPGPGH PRTYLTYRRA 
       160        170        180        190        200
AEGAGLHALG ITDLCLVLPS KGEGTPHTYC RLPRNLNPGM WGPAVYLCYK 
       210        220        230        240        250
VGLAKANTLV YEAELLGRYP EEDNEAFPLP ESVPVFCLPM GATIECWPAQ 
       260        270        280        290        300
TKYPVPVFST FVLTGAAGDK VYGAALQFYE AFPRARLSER QARALGLLSA 
       310        320        330        340        350
VERGRALGGR AVRSRRAIAV LSRWPAFPAF RAFLTFLYRY SVSGPHRLPL 
       360        370        380        390        400
EAHISHFIHN VPFPSPQRPR ILVQMSPYDN LLLCQPVSSP LPLSGASFLQ 
       410        420        430        440        450
LLQSLGPELA ITLLLAVLTE HKLLVHSLRP DLLTSVCEAL VSMIFPLHWQ 
       460        470        480        490        500
CPYIPLCPLV LADVLSAPVP FIVGIHSSYF DLHDPPADVI CVDLDTNTLF 
       510        520        530        540        550
QTEEKKLLSP RTLPRRPYKV LLATLTNLYQ QLDQTYTGPE EEASLEFLLT 
       560        570        580        590        600
DYEAVCGRRA RLEREVQGAF LRFMACLLKG YRVFLRPLTQ APSEGARDVD 
       610        620        630        640        650
NLFFLQGFLK SRERSSHKLY SQLLHTQMFS QFIEECSFGS ARHAALEFFD 
       660        670        680        690        700
SCVEKVHPEQ EKPEPTPLVE LEELSGSELT VFITPPEEPA LPEGSESTPQ 
       710        720        730        740        750
YCYDGFPELR AELFESLQEQ PGALPVPGPS RSAPSSPAPR RTKQEMKVAQ 
       760        770        780        790        800
RMAQKSAAVP ELWARCLLGH CYGLWFLCLP AYVRSAPSRV QALHTAYHVL 
       810        820        830        840        850
RQMESGKVVL PDEVCYRVLM QLCSHYGQPV LSVRVMLEMR QAGIVPNTIT 
       860        870        880        890        900
YGYYNKAVLE SKWPSGTPGG RLRWAKLRNV VLGAAQFRQP LRERQQQQQQ 
       910        920        930        940        950
QQQQQQQQQQ EQVSAHQEAG SSQAEPYLER PSPTRPLQRQ TTWAGRSLRD 
       960        970        980        990       1000
PASPPGRLVK SGSLGSARGA QPTVEAGVAH MIEALGVLEP RGSPVPWHDG 
      1010       1020       1030       1040       1050
SLSDLSLTGE EPLPGGSPGG SGSALSAQST EALEGLSGRG PKAGGRQDEA 
      1060       1070       1080       1090       1100
GTPRRGLGAR LQQLLTPSRH SPASRIPPPE LPPDLPPPAR RSPMDSLLHP 
      1110       1120       1130       1140       1150
RERPGSTASE SSASLGSEWD LSESSLSNLS LRRSSERLSD TPGSFQSPSL 
      1160       1170       1180       1190       1200
EILLSSCSLC RACDSLVYDE EIMAGWAPDD SNLNTTCPFC ACPFVPLLSV 
      1210       1220       1230       1240       1250
QTLDSRPSVP SPKSAGASGS KDAPVPGGPG PVLSDRRLCL ALDEPQLCNG 
      1260       1270       1280       1290       1300
HMGGASRRVE SGAWAYLSPL VLRKELESLV ENEGSEVLAL PELPSAHPII 
      1310       1320       1330       1340       1350
FWNLLWYFQR LRLPSILPGL VLASCDGPSH SQAPSPWLTP DPASVQVRLL 
      1360       1370       1380       1390       1400
WDVLTPDPNS CPPLYVLWRV HSQIPQRVVW PGPVPASLSL ALLESVLRHV 
      1410       1420       1430       1440       1450
GLNEVHKAVG LLLETLGPPP TGLHLQRGIY REILFLTMAA LGKDHVDIVA 
      1460       1470       1480       1490 
FDKKYKSAFN KLASSMGKEE LRHRRAQMPT PKAIDCRKCF GAPPEC
Length:1,496
Mass (Da):163,847
Last modified:September 11, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA852570682E7C62A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PAK5E9PAK5_HUMAN
DENN domain-containing protein 4B
DENND4B
1,218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEF0H0YEF0_HUMAN
DENN domain-containing protein 4B
DENND4B
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA32321 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW53268 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB007945 mRNA Translation: BAA32321.3 Different initiation.
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53268.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44228.1

Protein sequence database of the Protein Information Resource

More...PIRi		T00257

NCBI Reference Sequences

More...RefSeqi		NP_055671.2, NM_014856.2
XP_005245736.1, XM_005245679.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361217; ENSP00000354597; ENSG00000198837

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9909

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9909

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000361217.9; ENSP00000354597.4; NM_014856.3; NP_055671.2

UCSC genome browser

More...UCSCi		uc001fdd.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007945 mRNA Translation: BAA32321.3 Different initiation.
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53268.1 Sequence problems.
CCDSiCCDS44228.1
PIRiT00257
RefSeqiNP_055671.2, NM_014856.2
XP_005245736.1, XM_005245679.2

3D structure databases

SMRiO75064
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115238, 13 interactors
IntActiO75064, 5 interactors
STRINGi9606.ENSP00000354597

PTM databases

iPTMnetiO75064
PhosphoSitePlusiO75064

Genetic variation databases

BioMutaiDENND4B

Proteomic databases

EPDiO75064
jPOSTiO75064
MassIVEiO75064
MaxQBiO75064
PaxDbiO75064
PeptideAtlasiO75064
PRIDEiO75064
ProteomicsDBi49735

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		50670, 27 antibodies from 8 providers

The DNASU plasmid repository

More...DNASUi		9909

Genome annotation databases

EnsembliENST00000361217; ENSP00000354597; ENSG00000198837
GeneIDi9909
KEGGihsa:9909
MANE-SelectiENST00000361217.9; ENSP00000354597.4; NM_014856.3; NP_055671.2
UCSCiuc001fdd.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9909
DisGeNETi9909

GeneCards: human genes, protein and diseases

More...GeneCardsi		DENND4B
HGNCiHGNC:29044, DENND4B
HPAiENSG00000198837, Low tissue specificity
neXtProtiNX_O75064
OpenTargetsiENSG00000198837
PharmGKBiPA142671629
VEuPathDBiHostDB:ENSG00000198837

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2127, Eukaryota
GeneTreeiENSGT00940000160472
InParanoidiO75064
OMAiLECKWPS
OrthoDBi75304at2759
PhylomeDBiO75064
TreeFamiTF313237

Enzyme and pathway databases

PathwayCommonsiO75064
ReactomeiR-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs
SignaLinkiO75064

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9909, 6 hits in 1047 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DENND4B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9909
PharosiO75064, Tbio

Protein Ontology

More...PROi		PR:O75064
RNActiO75064, protein

Gene expression databases

BgeeiENSG00000198837, Expressed in granulocyte and 244 other tissues
ExpressionAtlasiO75064, baseline and differential
GenevisibleiO75064, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.40.50.11500, 1 hit
InterProiView protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR023341, MABP
IPR002885, Pentatricopeptide_repeat
IPR011990, TPR-like_helical_dom_sf
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom
PfamiView protein in Pfam
PF03455, dDENN, 1 hit
PF02141, DENN, 1 hit
PF03456, uDENN, 1 hit
SMARTiView protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00800, uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211, DENN, 1 hit
PS51498, MABP, 1 hit
PS51375, PPR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEN4B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75064
Secondary accession number(s): Q5T4K0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: February 23, 2022
This is version 147 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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