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Protein

DENN domain-containing protein 4B

Gene

DENND4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DENN domain-containing protein 4B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DENND4B
Synonyms:KIAA0476
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198837.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29044 DENND4B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75064

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000198837

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671629

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DENND4B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003046781 – 1496DENN domain-containing protein 4BAdd BLAST1496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei953PhosphoserineCombined sources1
Modified residuei1092PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75064

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75064

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75064

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75064

PeptideAtlas

More...
PeptideAtlasi
O75064

PRoteomics IDEntifications database

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PRIDEi
O75064

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49735

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75064

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75064

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198837 Expressed in 230 organ(s), highest expression level in lymph node

CleanEx database of gene expression profiles

More...
CleanExi
HS_DENND4B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75064 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75064 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040188
HPA071133

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115238, 2 interactors

Protein interaction database and analysis system

More...
IntActi
O75064, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354597

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O75064

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75064

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 203MABPPROSITE-ProRule annotationAdd BLAST160
Domaini195 – 369uDENNPROSITE-ProRule annotationAdd BLAST175
Domaini390 – 526cDENNPROSITE-ProRule annotationAdd BLAST137
Domaini528 – 644dDENNPROSITE-ProRule annotationAdd BLAST117
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati775 – 811PPR 1Add BLAST37
Repeati812 – 846PPR 2Add BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi886 – 923Gln-richAdd BLAST38
Compositional biasi1106 – 1158Ser-richAdd BLAST53

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQM7 Eukaryota
ENOG410XRZT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160472

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231590

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058313

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75064

KEGG Orthology (KO)

More...
KOi
K20163

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSILPCL

Database of Orthologous Groups

More...
OrthoDBi
75304at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75064

TreeFam database of animal gene trees

More...
TreeFami
TF313237

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR023341 MABP
IPR002885 Pentatricopeptide_repeat
IPR011990 TPR-like_helical_dom_sf
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit
PS51498 MABP, 1 hit
PS51375 PPR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O75064-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEERPPRLV DYFVVAGLAG NGAPIPEETW VPEPSGPLRP PRPAEPITDV
60 70 80 90 100
AVIARALGEE VPQGYTCIQA SAGGHPLELS AGLLGGTQPV ICYRRGRDKP
110 120 130 140 150
PLVELGVLYE GKERPKPGFQ VLDTTPYSHS ANLAPPGPGH PRTYLTYRRA
160 170 180 190 200
AEGAGLHALG ITDLCLVLPS KGEGTPHTYC RLPRNLNPGM WGPAVYLCYK
210 220 230 240 250
VGLAKANTLV YEAELLGRYP EEDNEAFPLP ESVPVFCLPM GATIECWPAQ
260 270 280 290 300
TKYPVPVFST FVLTGAAGDK VYGAALQFYE AFPRARLSER QARALGLLSA
310 320 330 340 350
VERGRALGGR AVRSRRAIAV LSRWPAFPAF RAFLTFLYRY SVSGPHRLPL
360 370 380 390 400
EAHISHFIHN VPFPSPQRPR ILVQMSPYDN LLLCQPVSSP LPLSGASFLQ
410 420 430 440 450
LLQSLGPELA ITLLLAVLTE HKLLVHSLRP DLLTSVCEAL VSMIFPLHWQ
460 470 480 490 500
CPYIPLCPLV LADVLSAPVP FIVGIHSSYF DLHDPPADVI CVDLDTNTLF
510 520 530 540 550
QTEEKKLLSP RTLPRRPYKV LLATLTNLYQ QLDQTYTGPE EEASLEFLLT
560 570 580 590 600
DYEAVCGRRA RLEREVQGAF LRFMACLLKG YRVFLRPLTQ APSEGARDVD
610 620 630 640 650
NLFFLQGFLK SRERSSHKLY SQLLHTQMFS QFIEECSFGS ARHAALEFFD
660 670 680 690 700
SCVEKVHPEQ EKPEPTPLVE LEELSGSELT VFITPPEEPA LPEGSESTPQ
710 720 730 740 750
YCYDGFPELR AELFESLQEQ PGALPVPGPS RSAPSSPAPR RTKQEMKVAQ
760 770 780 790 800
RMAQKSAAVP ELWARCLLGH CYGLWFLCLP AYVRSAPSRV QALHTAYHVL
810 820 830 840 850
RQMESGKVVL PDEVCYRVLM QLCSHYGQPV LSVRVMLEMR QAGIVPNTIT
860 870 880 890 900
YGYYNKAVLE SKWPSGTPGG RLRWAKLRNV VLGAAQFRQP LRERQQQQQQ
910 920 930 940 950
QQQQQQQQQQ EQVSAHQEAG SSQAEPYLER PSPTRPLQRQ TTWAGRSLRD
960 970 980 990 1000
PASPPGRLVK SGSLGSARGA QPTVEAGVAH MIEALGVLEP RGSPVPWHDG
1010 1020 1030 1040 1050
SLSDLSLTGE EPLPGGSPGG SGSALSAQST EALEGLSGRG PKAGGRQDEA
1060 1070 1080 1090 1100
GTPRRGLGAR LQQLLTPSRH SPASRIPPPE LPPDLPPPAR RSPMDSLLHP
1110 1120 1130 1140 1150
RERPGSTASE SSASLGSEWD LSESSLSNLS LRRSSERLSD TPGSFQSPSL
1160 1170 1180 1190 1200
EILLSSCSLC RACDSLVYDE EIMAGWAPDD SNLNTTCPFC ACPFVPLLSV
1210 1220 1230 1240 1250
QTLDSRPSVP SPKSAGASGS KDAPVPGGPG PVLSDRRLCL ALDEPQLCNG
1260 1270 1280 1290 1300
HMGGASRRVE SGAWAYLSPL VLRKELESLV ENEGSEVLAL PELPSAHPII
1310 1320 1330 1340 1350
FWNLLWYFQR LRLPSILPGL VLASCDGPSH SQAPSPWLTP DPASVQVRLL
1360 1370 1380 1390 1400
WDVLTPDPNS CPPLYVLWRV HSQIPQRVVW PGPVPASLSL ALLESVLRHV
1410 1420 1430 1440 1450
GLNEVHKAVG LLLETLGPPP TGLHLQRGIY REILFLTMAA LGKDHVDIVA
1460 1470 1480 1490
FDKKYKSAFN KLASSMGKEE LRHRRAQMPT PKAIDCRKCF GAPPEC
Length:1,496
Mass (Da):163,847
Last modified:September 11, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA852570682E7C62A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PAK5E9PAK5_HUMAN
DENN domain-containing protein 4B
DENND4B
1,218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEF0H0YEF0_HUMAN
DENN domain-containing protein 4B
DENND4B
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA32321 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW53268 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007945 mRNA Translation: BAA32321.3 Different initiation.
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53268.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44228.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T00257

NCBI Reference Sequences

More...
RefSeqi
NP_055671.2, NM_014856.2
XP_005245736.1, XM_005245679.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.744878

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361217; ENSP00000354597; ENSG00000198837

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9909

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9909

UCSC genome browser

More...
UCSCi
uc001fdd.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007945 mRNA Translation: BAA32321.3 Different initiation.
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53268.1 Sequence problems.
CCDSiCCDS44228.1
PIRiT00257
RefSeqiNP_055671.2, NM_014856.2
XP_005245736.1, XM_005245679.2
UniGeneiHs.744878

3D structure databases

ProteinModelPortaliO75064
SMRiO75064
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115238, 2 interactors
IntActiO75064, 4 interactors
STRINGi9606.ENSP00000354597

PTM databases

iPTMnetiO75064
PhosphoSitePlusiO75064

Polymorphism and mutation databases

BioMutaiDENND4B

Proteomic databases

EPDiO75064
jPOSTiO75064
MaxQBiO75064
PaxDbiO75064
PeptideAtlasiO75064
PRIDEiO75064
ProteomicsDBi49735

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9909
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361217; ENSP00000354597; ENSG00000198837
GeneIDi9909
KEGGihsa:9909
UCSCiuc001fdd.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9909
EuPathDBiHostDB:ENSG00000198837.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DENND4B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0029487
HGNCiHGNC:29044 DENND4B
HPAiHPA040188
HPA071133
neXtProtiNX_O75064
OpenTargetsiENSG00000198837
PharmGKBiPA142671629

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQM7 Eukaryota
ENOG410XRZT LUCA
GeneTreeiENSGT00940000160472
HOGENOMiHOG000231590
HOVERGENiHBG058313
InParanoidiO75064
KOiK20163
OMAiPSILPCL
OrthoDBi75304at2759
PhylomeDBiO75064
TreeFamiTF313237

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DENND4B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9909

Protein Ontology

More...
PROi
PR:O75064

Gene expression databases

BgeeiENSG00000198837 Expressed in 230 organ(s), highest expression level in lymph node
CleanExiHS_DENND4B
ExpressionAtlasiO75064 baseline and differential
GenevisibleiO75064 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR023341 MABP
IPR002885 Pentatricopeptide_repeat
IPR011990 TPR-like_helical_dom_sf
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PfamiView protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
PS51498 MABP, 1 hit
PS51375 PPR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEN4B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75064
Secondary accession number(s): Q5T4K0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: January 16, 2019
This is version 130 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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