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UniProtKB - O75064 (DEN4B_HUMAN)
Protein
DENN domain-containing protein 4B
Gene
DENND4B
Organism
Homo sapiens (Human)
Status
Functioni
Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
1 PublicationGO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB
GO - Biological processi
- regulation of Rab protein signal transduction Source: FlyBase
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Enzyme and pathway databases
PathwayCommonsi | O75064 |
Reactomei | R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
SignaLinki | O75064 |
Names & Taxonomyi
Protein namesi | Recommended name: DENN domain-containing protein 4B |
Gene namesi | Name:DENND4B Synonyms:KIAA0476 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29044, DENND4B |
neXtProti | NX_O75064 |
VEuPathDBi | HostDB:ENSG00000198837 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus 1 Publication
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Other locations
- cytoplasmic vesicle Source: GO_Central
Keywords - Cellular componenti
Golgi apparatusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9909 |
OpenTargetsi | ENSG00000198837 |
PharmGKBi | PA142671629 |
Miscellaneous databases
Pharosi | O75064, Tbio |
Genetic variation databases
BioMutai | DENND4B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304678 | 1 – 1496 | DENN domain-containing protein 4BAdd BLAST | 1496 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 953 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1092 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O75064 |
jPOSTi | O75064 |
MassIVEi | O75064 |
MaxQBi | O75064 |
PaxDbi | O75064 |
PeptideAtlasi | O75064 |
PRIDEi | O75064 |
ProteomicsDBi | 49735 |
PTM databases
iPTMneti | O75064 |
PhosphoSitePlusi | O75064 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198837, Expressed in granulocyte and 244 other tissues |
ExpressionAtlasi | O75064, baseline and differential |
Genevisiblei | O75064, HS |
Organism-specific databases
HPAi | ENSG00000198837, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 115238, 13 interactors |
IntActi | O75064, 5 interactors |
STRINGi | 9606.ENSP00000354597 |
Miscellaneous databases
RNActi | O75064, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 203 | MABPPROSITE-ProRule annotationAdd BLAST | 160 | |
Domaini | 195 – 369 | uDENNPROSITE-ProRule annotationAdd BLAST | 175 | |
Domaini | 390 – 526 | cDENNPROSITE-ProRule annotationAdd BLAST | 137 | |
Domaini | 528 – 644 | dDENNPROSITE-ProRule annotationAdd BLAST | 117 | |
Repeati | 775 – 811 | PPR 1Add BLAST | 37 | |
Repeati | 812 – 846 | PPR 2Add BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 720 – 744 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 891 – 970 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 995 – 1055 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 1067 – 1119 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 1205 – 1227 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 891 – 921 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1072 – 1090 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1105 – 1119 | Polar residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2127, Eukaryota |
GeneTreei | ENSGT00940000160472 |
InParanoidi | O75064 |
OMAi | LECKWPS |
OrthoDBi | 75304at2759 |
PhylomeDBi | O75064 |
TreeFami | TF313237 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 3.40.50.11500, 1 hit |
InterProi | View protein in InterPro IPR001194, cDENN_dom IPR005112, dDENN_dom IPR043153, DENN_C IPR023341, MABP IPR002885, Pentatricopeptide_repeat IPR011990, TPR-like_helical_dom_sf IPR037516, Tripartite_DENN IPR005113, uDENN_dom |
Pfami | View protein in Pfam PF03455, dDENN, 1 hit PF02141, DENN, 1 hit PF03456, uDENN, 1 hit |
SMARTi | View protein in SMART SM00801, dDENN, 1 hit SM00799, DENN, 1 hit SM00800, uDENN, 1 hit |
PROSITEi | View protein in PROSITE PS50211, DENN, 1 hit PS51498, MABP, 1 hit PS51375, PPR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
O75064-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEERPPRLV DYFVVAGLAG NGAPIPEETW VPEPSGPLRP PRPAEPITDV
60 70 80 90 100
AVIARALGEE VPQGYTCIQA SAGGHPLELS AGLLGGTQPV ICYRRGRDKP
110 120 130 140 150
PLVELGVLYE GKERPKPGFQ VLDTTPYSHS ANLAPPGPGH PRTYLTYRRA
160 170 180 190 200
AEGAGLHALG ITDLCLVLPS KGEGTPHTYC RLPRNLNPGM WGPAVYLCYK
210 220 230 240 250
VGLAKANTLV YEAELLGRYP EEDNEAFPLP ESVPVFCLPM GATIECWPAQ
260 270 280 290 300
TKYPVPVFST FVLTGAAGDK VYGAALQFYE AFPRARLSER QARALGLLSA
310 320 330 340 350
VERGRALGGR AVRSRRAIAV LSRWPAFPAF RAFLTFLYRY SVSGPHRLPL
360 370 380 390 400
EAHISHFIHN VPFPSPQRPR ILVQMSPYDN LLLCQPVSSP LPLSGASFLQ
410 420 430 440 450
LLQSLGPELA ITLLLAVLTE HKLLVHSLRP DLLTSVCEAL VSMIFPLHWQ
460 470 480 490 500
CPYIPLCPLV LADVLSAPVP FIVGIHSSYF DLHDPPADVI CVDLDTNTLF
510 520 530 540 550
QTEEKKLLSP RTLPRRPYKV LLATLTNLYQ QLDQTYTGPE EEASLEFLLT
560 570 580 590 600
DYEAVCGRRA RLEREVQGAF LRFMACLLKG YRVFLRPLTQ APSEGARDVD
610 620 630 640 650
NLFFLQGFLK SRERSSHKLY SQLLHTQMFS QFIEECSFGS ARHAALEFFD
660 670 680 690 700
SCVEKVHPEQ EKPEPTPLVE LEELSGSELT VFITPPEEPA LPEGSESTPQ
710 720 730 740 750
YCYDGFPELR AELFESLQEQ PGALPVPGPS RSAPSSPAPR RTKQEMKVAQ
760 770 780 790 800
RMAQKSAAVP ELWARCLLGH CYGLWFLCLP AYVRSAPSRV QALHTAYHVL
810 820 830 840 850
RQMESGKVVL PDEVCYRVLM QLCSHYGQPV LSVRVMLEMR QAGIVPNTIT
860 870 880 890 900
YGYYNKAVLE SKWPSGTPGG RLRWAKLRNV VLGAAQFRQP LRERQQQQQQ
910 920 930 940 950
QQQQQQQQQQ EQVSAHQEAG SSQAEPYLER PSPTRPLQRQ TTWAGRSLRD
960 970 980 990 1000
PASPPGRLVK SGSLGSARGA QPTVEAGVAH MIEALGVLEP RGSPVPWHDG
1010 1020 1030 1040 1050
SLSDLSLTGE EPLPGGSPGG SGSALSAQST EALEGLSGRG PKAGGRQDEA
1060 1070 1080 1090 1100
GTPRRGLGAR LQQLLTPSRH SPASRIPPPE LPPDLPPPAR RSPMDSLLHP
1110 1120 1130 1140 1150
RERPGSTASE SSASLGSEWD LSESSLSNLS LRRSSERLSD TPGSFQSPSL
1160 1170 1180 1190 1200
EILLSSCSLC RACDSLVYDE EIMAGWAPDD SNLNTTCPFC ACPFVPLLSV
1210 1220 1230 1240 1250
QTLDSRPSVP SPKSAGASGS KDAPVPGGPG PVLSDRRLCL ALDEPQLCNG
1260 1270 1280 1290 1300
HMGGASRRVE SGAWAYLSPL VLRKELESLV ENEGSEVLAL PELPSAHPII
1310 1320 1330 1340 1350
FWNLLWYFQR LRLPSILPGL VLASCDGPSH SQAPSPWLTP DPASVQVRLL
1360 1370 1380 1390 1400
WDVLTPDPNS CPPLYVLWRV HSQIPQRVVW PGPVPASLSL ALLESVLRHV
1410 1420 1430 1440 1450
GLNEVHKAVG LLLETLGPPP TGLHLQRGIY REILFLTMAA LGKDHVDIVA
1460 1470 1480 1490
FDKKYKSAFN KLASSMGKEE LRHRRAQMPT PKAIDCRKCF GAPPEC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PAK5 | E9PAK5_HUMAN | DENN domain-containing protein 4B | DENND4B | 1,218 | Annotation score: | ||
H0YEF0 | H0YEF0_HUMAN | DENN domain-containing protein 4B | DENND4B | 181 | Annotation score: |
Sequence cautioni
The sequence BAA32321 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW53268 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007945 mRNA Translation: BAA32321.3 Different initiation. AL358472 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53268.1 Sequence problems. |
CCDSi | CCDS44228.1 |
PIRi | T00257 |
RefSeqi | NP_055671.2, NM_014856.2 XP_005245736.1, XM_005245679.2 |
Genome annotation databases
Ensembli | ENST00000361217; ENSP00000354597; ENSG00000198837 |
GeneIDi | 9909 |
KEGGi | hsa:9909 |
MANE-Selecti | ENST00000361217.9; ENSP00000354597.4; NM_014856.3; NP_055671.2 |
UCSCi | uc001fdd.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007945 mRNA Translation: BAA32321.3 Different initiation. AL358472 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53268.1 Sequence problems. |
CCDSi | CCDS44228.1 |
PIRi | T00257 |
RefSeqi | NP_055671.2, NM_014856.2 XP_005245736.1, XM_005245679.2 |
3D structure databases
SMRi | O75064 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115238, 13 interactors |
IntActi | O75064, 5 interactors |
STRINGi | 9606.ENSP00000354597 |
PTM databases
iPTMneti | O75064 |
PhosphoSitePlusi | O75064 |
Genetic variation databases
BioMutai | DENND4B |
Proteomic databases
EPDi | O75064 |
jPOSTi | O75064 |
MassIVEi | O75064 |
MaxQBi | O75064 |
PaxDbi | O75064 |
PeptideAtlasi | O75064 |
PRIDEi | O75064 |
ProteomicsDBi | 49735 |
Protocols and materials databases
Antibodypediai | 50670, 27 antibodies from 8 providers |
DNASUi | 9909 |
Genome annotation databases
Ensembli | ENST00000361217; ENSP00000354597; ENSG00000198837 |
GeneIDi | 9909 |
KEGGi | hsa:9909 |
MANE-Selecti | ENST00000361217.9; ENSP00000354597.4; NM_014856.3; NP_055671.2 |
UCSCi | uc001fdd.2, human |
Organism-specific databases
CTDi | 9909 |
DisGeNETi | 9909 |
GeneCardsi | DENND4B |
HGNCi | HGNC:29044, DENND4B |
HPAi | ENSG00000198837, Low tissue specificity |
neXtProti | NX_O75064 |
OpenTargetsi | ENSG00000198837 |
PharmGKBi | PA142671629 |
VEuPathDBi | HostDB:ENSG00000198837 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2127, Eukaryota |
GeneTreei | ENSGT00940000160472 |
InParanoidi | O75064 |
OMAi | LECKWPS |
OrthoDBi | 75304at2759 |
PhylomeDBi | O75064 |
TreeFami | TF313237 |
Enzyme and pathway databases
PathwayCommonsi | O75064 |
Reactomei | R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
SignaLinki | O75064 |
Miscellaneous databases
BioGRID-ORCSi | 9909, 6 hits in 1047 CRISPR screens |
ChiTaRSi | DENND4B, human |
GenomeRNAii | 9909 |
Pharosi | O75064, Tbio |
PROi | PR:O75064 |
RNActi | O75064, protein |
Gene expression databases
Bgeei | ENSG00000198837, Expressed in granulocyte and 244 other tissues |
ExpressionAtlasi | O75064, baseline and differential |
Genevisiblei | O75064, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 3.40.50.11500, 1 hit |
InterProi | View protein in InterPro IPR001194, cDENN_dom IPR005112, dDENN_dom IPR043153, DENN_C IPR023341, MABP IPR002885, Pentatricopeptide_repeat IPR011990, TPR-like_helical_dom_sf IPR037516, Tripartite_DENN IPR005113, uDENN_dom |
Pfami | View protein in Pfam PF03455, dDENN, 1 hit PF02141, DENN, 1 hit PF03456, uDENN, 1 hit |
SMARTi | View protein in SMART SM00801, dDENN, 1 hit SM00799, DENN, 1 hit SM00800, uDENN, 1 hit |
PROSITEi | View protein in PROSITE PS50211, DENN, 1 hit PS51498, MABP, 1 hit PS51375, PPR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DEN4B_HUMAN | |
Accessioni | O75064Primary (citable) accession number: O75064 Secondary accession number(s): Q5T4K0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | September 11, 2007 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM