Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syndecan-3

Gene

SDC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.By similarity1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928 HS-GAG biosynthesis
R-HSA-2024096 HS-GAG degradation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-3000170 Syndecan interactions
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3656237 Defective EXT2 causes exostoses 2
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-975634 Retinoid metabolism and transport
SIGNORiO75056

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-3
Short name:
SYND3
Gene namesi
Name:SDC3
Synonyms:KIAA0468
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162512.15
HGNCiHGNC:10660 SDC3
MIMi186357 gene
neXtProtiNX_O75056

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 387ExtracellularSequence analysisAdd BLAST387
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 442CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9672
MalaCardsiSDC3
OpenTargetsiENSG00000162512
PharmGKBiPA35590

Polymorphism and mutation databases

BioMutaiSDC3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839891 – 442Syndecan-3Add BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi82O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi84O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi91O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi314O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi367O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Modified residuei409Phosphotyrosine1 Publication1
Modified residuei419Phosphotyrosine1 Publication1
Modified residuei431Phosphotyrosine1 Publication1
Modified residuei441Phosphotyrosine1 Publication1

Post-translational modificationi

O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei383 – 384Cleavage of ectodomainSequence analysis2

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

EPDiO75056
MaxQBiO75056
PaxDbiO75056
PeptideAtlasiO75056
PRIDEiO75056
ProteomicsDBi49730
TopDownProteomicsiO75056

PTM databases

iPTMnetiO75056
PhosphoSitePlusiO75056

Expressioni

Tissue specificityi

Expressed in the nervous system, the adrenal gland, and the spleen.1 Publication

Gene expression databases

BgeeiENSG00000162512 Expressed in 188 organ(s), highest expression level in left adrenal gland
CleanExiHS_SDC3
ExpressionAtlasiO75056 baseline and differential
GenevisibleiO75056 HS

Organism-specific databases

HPAiCAB025786
HPA017087
HPA048085

Interactioni

Subunit structurei

Interacts with TIAM1.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115027, 14 interactors
DIPiDIP-29944N
IntActiO75056, 6 interactors
STRINGi9606.ENSP00000344468

Structurei

3D structure databases

ProteinModelPortaliO75056
SMRiO75056
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi115 – 302Ser/Thr-rich (mucin-like)Add BLAST188

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJZ0 Eukaryota
ENOG410Y2QY LUCA
GeneTreeiENSGT00530000063116
HOGENOMiHOG000049151
HOVERGENiHBG004144
InParanoidiO75056
KOiK16337
OMAiAQRWRNE
OrthoDBiEOG091G0UGA
PhylomeDBiO75056
TreeFamiTF320463

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031194 Syndecan-3
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF7 PTHR10915:SF7, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O75056-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPGPPHRAG AAHGAGAGAG AAAGPGARGL LLPPLLLLLL AGRAAGAQRW
60 70 80 90 100
RSENFERPVD LEGSGDDDSF PDDELDDLYS GSGSGYFEQE SGIETAMRFS
110 120 130 140 150
PDVALAVSTT PAVLPTTNIQ PVGTPFEELP SERPTLEPAT SPLVVTEVPE
160 170 180 190 200
EPSQRATTVS TTMATTAATS TGDPTVATVP ATVATATPST PAAPPFTATT
210 220 230 240 250
AVIRTTGVRR LLPLPLTTVA TARATTPEAP SPPTTAAVLD TEAPTPRLVS
260 270 280 290 300
TATSRPRALP RPATTQEPDI PERSTLPLGT TAPGPTEVAQ TPTPETFLTT
310 320 330 340 350
IRDEPEVPVS GGPSGDFELP EEETTQPDTA NEVVAVGGAA AKASSPPGTL
360 370 380 390 400
PKGARPGPGL LDNAIDSGSS AAQLPQKSIL ERKEVLVAVI VGGVVGALFA
410 420 430 440
AFLVTLLIYR MKKKDEGSYT LEEPKQASVT YQKPDKQEEF YA
Length:442
Mass (Da):45,497
Last modified:September 5, 2006 - v2
Checksum:iD4C284CBC36A92E2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3DPN2D3DPN2_HUMAN
Syndecan
SDC3 hCG_15913
384Annotation score:

Sequence cautioni

The sequence BAA32313 differs from that shown. Intron retention.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027251208V → I. Corresponds to variant dbSNP:rs2491132EnsemblClinVar.1
Natural variantiVAR_027252303D → N1 PublicationCorresponds to variant dbSNP:rs4949184Ensembl.1
Natural variantiVAR_027253329T → I. Corresponds to variant dbSNP:rs2282440EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF248634 mRNA Translation: AAK39969.1
AB007937 mRNA Translation: BAA32313.2 Sequence problems.
AL445235 Genomic DNA No translation available.
BC013974 mRNA No translation available.
CCDSiCCDS30661.1
RefSeqiNP_055469.3, NM_014654.3
UniGeneiHs.158287

Genome annotation databases

EnsembliENST00000339394; ENSP00000344468; ENSG00000162512
GeneIDi9672
KEGGihsa:9672
UCSCiuc001bse.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF248634 mRNA Translation: AAK39969.1
AB007937 mRNA Translation: BAA32313.2 Sequence problems.
AL445235 Genomic DNA No translation available.
BC013974 mRNA No translation available.
CCDSiCCDS30661.1
RefSeqiNP_055469.3, NM_014654.3
UniGeneiHs.158287

3D structure databases

ProteinModelPortaliO75056
SMRiO75056
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115027, 14 interactors
DIPiDIP-29944N
IntActiO75056, 6 interactors
STRINGi9606.ENSP00000344468

PTM databases

iPTMnetiO75056
PhosphoSitePlusiO75056

Polymorphism and mutation databases

BioMutaiSDC3

Proteomic databases

EPDiO75056
MaxQBiO75056
PaxDbiO75056
PeptideAtlasiO75056
PRIDEiO75056
ProteomicsDBi49730
TopDownProteomicsiO75056

Protocols and materials databases

DNASUi9672
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339394; ENSP00000344468; ENSG00000162512
GeneIDi9672
KEGGihsa:9672
UCSCiuc001bse.3 human

Organism-specific databases

CTDi9672
DisGeNETi9672
EuPathDBiHostDB:ENSG00000162512.15
GeneCardsiSDC3
H-InvDBiHIX0000348
HGNCiHGNC:10660 SDC3
HPAiCAB025786
HPA017087
HPA048085
MalaCardsiSDC3
MIMi186357 gene
neXtProtiNX_O75056
OpenTargetsiENSG00000162512
PharmGKBiPA35590
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJZ0 Eukaryota
ENOG410Y2QY LUCA
GeneTreeiENSGT00530000063116
HOGENOMiHOG000049151
HOVERGENiHBG004144
InParanoidiO75056
KOiK16337
OMAiAQRWRNE
OrthoDBiEOG091G0UGA
PhylomeDBiO75056
TreeFamiTF320463

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928 HS-GAG biosynthesis
R-HSA-2024096 HS-GAG degradation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-3000170 Syndecan interactions
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3656237 Defective EXT2 causes exostoses 2
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-975634 Retinoid metabolism and transport
SIGNORiO75056

Miscellaneous databases

ChiTaRSiSDC3 human
GeneWikiiSDC3
GenomeRNAii9672
PROiPR:O75056
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162512 Expressed in 188 organ(s), highest expression level in left adrenal gland
CleanExiHS_SDC3
ExpressionAtlasiO75056 baseline and differential
GenevisibleiO75056 HS

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031194 Syndecan-3
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF7 PTHR10915:SF7, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDC3_HUMAN
AccessioniPrimary (citable) accession number: O75056
Secondary accession number(s): Q5T1Z6
, Q5T1Z7, Q96CT3, Q96PR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again