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Protein

Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

Gene

NOS1AP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).By similarity

GO - Molecular functioni

  • nitric-oxide synthase binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
Alternative name(s):
C-terminal PDZ ligand of neuronal nitric oxide synthase protein
Nitric oxide synthase 1 adaptor protein
Gene namesi
Name:NOS1AP
Synonyms:CAPON, KIAA0464
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198929.12
HGNCiHGNC:16859 NOS1AP
MIMi605551 gene
neXtProtiNX_O75052

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9722
MalaCardsiNOS1AP
MIMi610141 phenotype
OpenTargetsiENSG00000198929
Orphaneti101016 Romano-Ward syndrome
PharmGKBiPA142671259

Polymorphism and mutation databases

BioMutaiNOS1AP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000893161 – 506Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase proteinAdd BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphoserineBy similarity1
Modified residuei192PhosphoserineBy similarity1
Modified residuei195PhosphoserineBy similarity1
Modified residuei266PhosphoserineCombined sources1
Modified residuei371PhosphoserineBy similarity1
Modified residuei374PhosphoserineBy similarity1
Modified residuei401PhosphoserineBy similarity1
Modified residuei417PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO75052
PaxDbiO75052
PeptideAtlasiO75052
PRIDEiO75052
ProteomicsDBi49725
49726 [O75052-2]
49727 [O75052-3]

PTM databases

iPTMnetiO75052
PhosphoSitePlusiO75052

Expressioni

Gene expression databases

BgeeiENSG00000198929 Expressed in 180 organ(s), highest expression level in frontal cortex
CleanExiHS_NOS1AP
ExpressionAtlasiO75052 baseline and differential
GenevisibleiO75052 HS

Organism-specific databases

HPAiCAB018582
HPA030066
HPA055561

Interactioni

Subunit structurei

Interacts with the PDZ domain of NOS1 or the second PDZ domain of DLG4 through its C-terminus. Interacts with RASD1 and SYN1, SYN2 and SYN3 via its PID domain. Forms a ternary complex with NOS1 and RASD1. Forms a ternary complex with NOS1 and SYN1 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115071, 58 interactors
CORUMiO75052
IntActiO75052, 26 interactors
STRINGi9606.ENSP00000355133

Structurei

3D structure databases

ProteinModelPortaliO75052
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 196PIDPROSITE-ProRule annotationAdd BLAST171

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni494 – 506Interaction with NOS1By similarityAdd BLAST13

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili322 – 363Sequence analysisAdd BLAST42

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi504 – 506PDZ-bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi301 – 308Poly-Gln8

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4458 Eukaryota
KOG4815 Eukaryota
ENOG410ZTVD LUCA
GeneTreeiENSGT00510000046975
HOGENOMiHOG000111298
HOVERGENiHBG050788
InParanoidiO75052
KOiK16513
OMAiXIFYVSH
OrthoDBiEOG091G183F
PhylomeDBiO75052
TreeFamiTF317226

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PfamiView protein in Pfam
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75052-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSKTKYNLV DDGHDLRIPL HNEDAFQHGI CFEAKYVGSL DVPRPNSRVE
60 70 80 90 100
IVAAMRRIRY EFKAKNIKKK KVSIMVSVDG VKVILKKKKK LLLLQKKEWT
110 120 130 140 150
WDESKMLVMQ DPIYRIFYVS HDSQDLKIFS YIARDGASNI FRCNVFKSKK
160 170 180 190 200
KSQAMRIVRT VGQAFEVCHK LSLQHTQQNA DGQEDGESER NSNSSGDPGR
210 220 230 240 250
QLTGAERAST ATAEETDIDA VEVPLPGNDV LEFSRGVTDL DAVGKEGGSH
260 270 280 290 300
TGSKVSHPQE PMLTASPRML LPSSSSKPPG LGTETPLSTH HQMQLLQQLL
310 320 330 340 350
QQQQQQTQVA VAQVHLLKDQ LAAEAAARLE AQARVHQLLL QNKDMLQHIS
360 370 380 390 400
LLVKQVQELE LKLSGQNAMG SQDSLLEITF RSGALPVLCD PTTPKPEDLH
410 420 430 440 450
SPPLGAGLAD FAHPAGSPLG RRDCLVKLEC FRFLPPEDTP PPAQGEALLG
460 470 480 490 500
GLELIKFRES GIASEYESNT DESEERDSWS QEELPRLLNV LQRQELGDGL

DDEIAV
Length:506
Mass (Da):56,150
Last modified:January 4, 2005 - v3
Checksum:iD969C65E87684A7C
GO
Isoform 2 (identifier: O75052-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MPSKTKYNLVDDGHDLR → MSLSSLCPVFSAAASSL
     18-312: Missing.

Show »
Length:211
Mass (Da):22,955
Checksum:iE92ED7BE06D43943
GO
Isoform 3 (identifier: O75052-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-95: Missing.

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):55,569
Checksum:i365A1A9B987EE0F3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PSG0E9PSG0_HUMAN
Carboxyl-terminal PDZ ligand of neu...
NOS1AP
349Annotation score:
E9PIP8E9PIP8_HUMAN
Carboxyl-terminal PDZ ligand of neu...
NOS1AP
81Annotation score:

Sequence cautioni

The sequence BAA32309 differs from that shown. Reason: Erroneous initiation.Curated

Polymorphismi

Genetic variation in NOS1AP influences the electrocardiographic QT interval [MIMi:610141]. The QT interval is defined as the time from the beginning of the Q wave to the end of the T wave, representing the duration of ventricular electrical activity. The QT interval, a measure of cardiac repolarization, is a genetically influenced quantitative trait with considerable medical relevance: both high and low values are associated with increased risk of cardiovascular morbidity and mortality.1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0427511 – 17MPSKT…GHDLR → MSLSSLCPVFSAAASSL in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_04275218 – 312Missing in isoform 2. 1 PublicationAdd BLAST295
Alternative sequenceiVSP_04335091 – 95Missing in isoform 3. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007933 mRNA Translation: BAA32309.2 Different initiation.
AY841899 mRNA Translation: AAW57298.1
AL590408 Genomic DNA No translation available.
AL450163 Genomic DNA No translation available.
AL512785 Genomic DNA No translation available.
BC112295 mRNA Translation: AAI12296.1
BC143771 mRNA Translation: AAI43772.1
AF037070 mRNA Translation: AAC39656.1
CCDSiCCDS1237.1 [O75052-1]
CCDS44267.1 [O75052-2]
CCDS53421.1 [O75052-3]
RefSeqiNP_001119532.2, NM_001126060.1 [O75052-2]
NP_001158229.1, NM_001164757.1 [O75052-3]
NP_055512.1, NM_014697.2 [O75052-1]
UniGeneiHs.731942

Genome annotation databases

EnsembliENST00000361897; ENSP00000355133; ENSG00000198929 [O75052-1]
ENST00000493151; ENSP00000434988; ENSG00000198929 [O75052-2]
ENST00000530878; ENSP00000431586; ENSG00000198929 [O75052-3]
GeneIDi9722
KEGGihsa:9722
UCSCiuc001gbv.3 human [O75052-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007933 mRNA Translation: BAA32309.2 Different initiation.
AY841899 mRNA Translation: AAW57298.1
AL590408 Genomic DNA No translation available.
AL450163 Genomic DNA No translation available.
AL512785 Genomic DNA No translation available.
BC112295 mRNA Translation: AAI12296.1
BC143771 mRNA Translation: AAI43772.1
AF037070 mRNA Translation: AAC39656.1
CCDSiCCDS1237.1 [O75052-1]
CCDS44267.1 [O75052-2]
CCDS53421.1 [O75052-3]
RefSeqiNP_001119532.2, NM_001126060.1 [O75052-2]
NP_001158229.1, NM_001164757.1 [O75052-3]
NP_055512.1, NM_014697.2 [O75052-1]
UniGeneiHs.731942

3D structure databases

ProteinModelPortaliO75052
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115071, 58 interactors
CORUMiO75052
IntActiO75052, 26 interactors
STRINGi9606.ENSP00000355133

PTM databases

iPTMnetiO75052
PhosphoSitePlusiO75052

Polymorphism and mutation databases

BioMutaiNOS1AP

Proteomic databases

MaxQBiO75052
PaxDbiO75052
PeptideAtlasiO75052
PRIDEiO75052
ProteomicsDBi49725
49726 [O75052-2]
49727 [O75052-3]

Protocols and materials databases

DNASUi9722
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361897; ENSP00000355133; ENSG00000198929 [O75052-1]
ENST00000493151; ENSP00000434988; ENSG00000198929 [O75052-2]
ENST00000530878; ENSP00000431586; ENSG00000198929 [O75052-3]
GeneIDi9722
KEGGihsa:9722
UCSCiuc001gbv.3 human [O75052-1]

Organism-specific databases

CTDi9722
DisGeNETi9722
EuPathDBiHostDB:ENSG00000198929.12
GeneCardsiNOS1AP
HGNCiHGNC:16859 NOS1AP
HPAiCAB018582
HPA030066
HPA055561
MalaCardsiNOS1AP
MIMi605551 gene
610141 phenotype
neXtProtiNX_O75052
OpenTargetsiENSG00000198929
Orphaneti101016 Romano-Ward syndrome
PharmGKBiPA142671259
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4458 Eukaryota
KOG4815 Eukaryota
ENOG410ZTVD LUCA
GeneTreeiENSGT00510000046975
HOGENOMiHOG000111298
HOVERGENiHBG050788
InParanoidiO75052
KOiK16513
OMAiXIFYVSH
OrthoDBiEOG091G183F
PhylomeDBiO75052
TreeFamiTF317226

Miscellaneous databases

ChiTaRSiNOS1AP human
GeneWikiiNOS1AP
GenomeRNAii9722
PROiPR:O75052
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198929 Expressed in 180 organ(s), highest expression level in frontal cortex
CleanExiHS_NOS1AP
ExpressionAtlasiO75052 baseline and differential
GenevisibleiO75052 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PfamiView protein in Pfam
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAPON_HUMAN
AccessioniPrimary (citable) accession number: O75052
Secondary accession number(s): B7ZLF5
, O43564, Q3T551, Q5VU95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: October 10, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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