UniProtKB - O75038 (PLCH2_HUMAN)
Protein
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
Gene
PLCH2
Organism
Homo sapiens (Human)
Status
Functioni
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:18361507). This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).By similarity1 Publication
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+1 PublicationEC:3.1.4.111 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
Ca2+PROSITE-ProRule annotation
Activity regulationi
Activity is stimulated by GNB1:GNG2.1 Publication
Kineticsi
- KM=14.4 µM for 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)1 Publication
- Vmax=12.6 µmol/min/mg enzyme1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 341 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 342 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 371 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 373 | Calcium 1; catalyticBy similarity | 1 | |
Active sitei | 385 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 420 | Calcium 1; catalyticBy similarity | 1 | |
Binding sitei | 469 | SubstrateBy similarity | 1 | |
Binding sitei | 471 | SubstrateBy similarity | 1 | |
Binding sitei | 653 | SubstrateBy similarity | 1 | |
Binding sitei | 680 | SubstrateBy similarity | 1 | |
Metal bindingi | 784 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 786 | Calcium 2By similarity | 1 | |
Metal bindingi | 810 | Calcium 2By similarity | 1 | |
Metal bindingi | 839 | Calcium 3By similarity | 1 | |
Metal bindingi | 840 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 841 | Calcium 3By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 182 – 193 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phosphatidylinositol phospholipase C activity Source: GO_Central
GO - Biological processi
- inositol phosphate metabolic process Source: Reactome
- lipid catabolic process Source: UniProtKB-KW
- phosphatidylinositol-mediated signaling Source: GO_Central
- phosphatidylinositol metabolic process Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Transducer |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | O75038 |
Reactomei | R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol |
Chemistry databases
SwissLipidsi | SLP:000001755 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2Curated (EC:3.1.4.111 Publication)Alternative name(s): Phosphoinositide phospholipase C-eta-2 Phosphoinositide phospholipase C-like 4 Short name: PLC-L4 Short name: Phospholipase C-like protein 4 Phospholipase C-eta-2 Short name: PLC-eta2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000149527.17 |
HGNCi | HGNC:29037, PLCH2 |
MIMi | 612836, gene |
neXtProti | NX_O75038 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Other locations
- Cytoplasm By similarity
Note: Localized predominantly at the plasma membrane.By similarity
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9651 |
OpenTargetsi | ENSG00000149527 |
PharmGKBi | PA134914471 |
Miscellaneous databases
Pharosi | O75038, Tbio |
Polymorphism and mutation databases
BioMutai | PLCH2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088507 | 1 – 1416 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2Add BLAST | 1416 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 487 | PhosphoserineBy similarity | 1 | |
Modified residuei | 491 | PhosphoserineBy similarity | 1 | |
Modified residuei | 595 | PhosphoserineBy similarity | 1 | |
Modified residuei | 605 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O75038 |
MassIVEi | O75038 |
PaxDbi | O75038 |
PeptideAtlasi | O75038 |
PRIDEi | O75038 |
ProteomicsDBi | 49717 [O75038-1] 49718 [O75038-2] 49719 [O75038-3] 49720 [O75038-4] 49721 [O75038-5] |
TopDownProteomicsi | O75038-1 [O75038-1] |
PTM databases
iPTMneti | O75038 |
PhosphoSitePlusi | O75038 |
Expressioni
Tissue specificityi
Expressed in retina and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000149527, Expressed in right hemisphere of cerebellum and 151 other tissues |
ExpressionAtlasi | O75038, baseline and differential |
Genevisiblei | O75038, HS |
Organism-specific databases
HPAi | ENSG00000149527, Tissue enhanced (brain, retina, skin) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 115009, 2 interactors |
IntActi | O75038, 2 interactors |
MINTi | O75038 |
STRINGi | 9606.ENSP00000367747 |
Miscellaneous databases
RNActi | O75038, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 155 | PHPROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 169 – 204 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 205 – 241 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 326 – 471 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 146 | |
Domaini | 626 – 740 | PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 740 – 869 | C2PROSITE-ProRule annotationAdd BLAST | 130 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 155 | Necessary for plasma membrane localizationBy similarityAdd BLAST | 155 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0169, Eukaryota |
GeneTreei | ENSGT00940000158374 |
HOGENOMi | CLU_002738_0_0_1 |
InParanoidi | O75038 |
OMAi | SMQRSVT |
OrthoDBi | 368239at2759 |
PhylomeDBi | O75038 |
TreeFami | TF313216 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR028393, PLC-eta2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF166, PTHR10336:SF166, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF16457, PH_12, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00233, PH, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS50003, PH_DOMAIN, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O75038-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGPWPSPDS RTKGTVAWLA EVLLWVGGSV VLSSEWQLGP LVERCMGAMQ
60 70 80 90 100
EGMQMVKLRG GSKGLVRFYY LDEHRSCIRW RPSRKNEKAK ISIDSIQEVS
110 120 130 140 150
EGRQSEVFQR YPDGSFDPNC CFSIYHGSHR ESLDLVSTSS EVARTWVTGL
160 170 180 190 200
RYLMAGISDE DSLARRQRTR DQWLKQTFDE ADKNGDGSLS IGEVLQLLHK
210 220 230 240 250
LNVNLPRQRV KQMFREADTD DHQGTLGFEE FCAFYKMMST RRDLYLLMLT
260 270 280 290 300
YSNHKDHLDA ASLQRFLQVE QKMAGVTLES CQDIIEQFEP CPENKSKGLL
310 320 330 340 350
GIDGFTNYTR SPAGDIFNPE HHHVHQDMTQ PLSHYFITSS HNTYLVGDQL
360 370 380 390 400
MSQSRVDMYA WVLQAGCRCV EVDCWDGPDG EPIVHHGYTL TSKILFKDVI
410 420 430 440 450
ETINKYAFIK NEYPVILSIE NHCSVIQQKK MAQYLTDILG DKLDLSSVSS
460 470 480 490 500
EDATTLPSPQ MLKGKILVKG KKLPANISED AEEGEVSDED SADEIDDDCK
510 520 530 540 550
LLNGDASTNR KRVENTAKRK LDSLIKESKI RDCEDPNNFS VSTLSPSGKL
560 570 580 590 600
GRKSKAEEDV ESGEDAGASR RNGRLVVGSF SRRKKKGSKL KKAASVEEGD
610 620 630 640 650
EGQDSPGGQS RGATRQKKTM KLSRALSDLV KYTKSVATHD IEMEAASSWQ
660 670 680 690 700
VSSFSETKAH QILQQKPAQY LRFNQQQLSR IYPSSYRVDS SNYNPQPFWN
710 720 730 740 750
AGCQMVALNY QSEGRMLQLN RAKFSANGGC GYVLKPGCMC QGVFNPNSED
760 770 780 790 800
PLPGQLKKQL VLRIISGQQL PKPRDSMLGD RGEIIDPFVE VEIIGLPVDC
810 820 830 840 850
SREQTRVVDD NGFNPTWEET LVFMVHMPEI ALVRFLVWDH DPIGRDFIGQ
860 870 880 890 900
RTLAFSSMMP GYRHVYLEGM EEASIFVHVA VSDISGKVKQ ALGLKGLFLR
910 920 930 940 950
GPKPGSLDSH AAGRPPARPS VSQRILRRTA SAPTKSQKPG RRGFPELVLG
960 970 980 990 1000
TRDTGSKGVA DDVVPPGPGP APEAPAQEGP GSGSPRDTRP LSTQRPLPPL
1010 1020 1030 1040 1050
CSLETIAEEP APGPGPPPPA AVPTSSSQGR PPYPTGPGAN VASPLEDTEE
1060 1070 1080 1090 1100
PRDSRPRPCN GEGAGGAYER APGSQTDGRS QPRTLGHLPV IRRVKSEGQV
1110 1120 1130 1140 1150
PTEPLGGWRP LAAPFPAPAV YSDATGSDPL WQRLEPCGHR DSVSSSSSMS
1160 1170 1180 1190 1200
SSDTVIDLSL PSLGLGRSRE NLAGAHMGRL PPRPHSASAA RPDLPPVTKS
1210 1220 1230 1240 1250
KSNPNLRATG QRPPIPDELQ PRSLAPRMAG LPFRPPWGCL SLVGVQDCPV
1260 1270 1280 1290 1300
AAKSKSLGDL TADDFAPSFE GGSRRLSHSL GLPGGTRRVS GPGVRRDTLT
1310 1320 1330 1340 1350
EQLRWLTVFQ QAGDITSPTS LGPAGEGVAG GPGFVRRSSS RSHSRVRAIA
1360 1370 1380 1390 1400
SRARQAQERQ QRLQGLGRQG PPEEERGTPE GACSVGHEGS VDAPAPSKGA
1410
LGPASAAAEN LVLLRL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB9DI82 | B9DI82_HUMAN | Phosphoinositide phospholipase C | PLCH2 | 1,239 | Annotation score: | ||
V9GY64 | V9GY64_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCH2 | 111 | Annotation score: |
Sequence cautioni
The sequence AAH43358 differs from that shown. Reason: Frameshift.Curated
The sequence BAA32295 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC56932 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 559 | D → E in BAB84975 (Ref. 2) Curated | 1 | ||
Sequence conflicti | 560 | V → M in BAB84975 (Ref. 2) Curated | 1 | ||
Isoform 5 (identifier: O75038-5) | |||||
Sequence conflicti | 209 | Q → L in BAC56932 (Ref. 2) Curated | 1 | ||
Isoform 4 (identifier: O75038-4) | |||||
Sequence conflicti | 1004 | P → L in BAB84975 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029067 | 1 – 45 | Missing in isoform 5. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_029068 | 1 – 41 | MSGPW…QLGPL → MEEPGPPGGLSQDQ in isoform 2. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_029069 | 117 – 785 | Missing in isoform 5. 1 PublicationAdd BLAST | 669 | |
Alternative sequenceiVSP_029070 | 706 – 741 | Missing in isoform 3. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_029071 | 987 – 1211 | DTRPL…RATGQ → GKAPAAVAEKSPVRVRPPRV LDGPGPAGMAATCMKCVVGS CAGVNTGGLQRERPPSPGPA SRQAAIRQQPRARADSLGAP CCGLDPHAIPGRSREAPKGP GAWRQGPGGSGSMSSDSSSP DSPGIPERSPRWPEGACRQP GALQGEMSALFAQKLEEIRS KSPMFSAGKPLLPCVVLPHA PGMAGPGSPAAASAWTVSPR VLVLVALYPWHCLRGTLLPW LACGP in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 225 | |
Alternative sequenceiVSP_029072 | 987 – 1156 | DTRPL…SDTVI → GKAPAAVAEKSPVRVRPPRV LDGPGPAGMAATCMKCVVGS CAGVNTGGLQRERPPSPGPA SRQAAIRQQPRARADSLGAP CCGLDPHAIPGRSREAPKGP GAWRQGPGGSGSMSSDSSSP DSPGIPERSPRWPEGACRQP GALQGEMSALFAQKLEEIRS KSPMFSAVRN in isoform 2. 1 PublicationAdd BLAST | 170 | |
Alternative sequenceiVSP_029073 | 1157 – 1416 | Missing in isoform 2. 1 PublicationAdd BLAST | 260 | |
Alternative sequenceiVSP_029074 | 1212 – 1416 | Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 205 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ176850 mRNA Translation: ABA12209.1 AK074149 mRNA Translation: BAB84975.1 AK122591 mRNA Translation: BAC56932.2 Different initiation. AB007919 mRNA Translation: BAA32295.3 Different initiation. AL139246 Genomic DNA No translation available. BC019679 mRNA Translation: AAH19679.1 BC043358 mRNA Translation: AAH43358.1 Frameshift. BC050037 mRNA Translation: AAH50037.1 BC128207 mRNA Translation: AAI28208.1 |
CCDSi | CCDS59959.1 [O75038-1] |
RefSeqi | NP_001289941.1, NM_001303012.1 [O75038-2] NP_001289942.1, NM_001303013.1 NP_055453.2, NM_014638.3 [O75038-1] |
Genome annotation databases
Ensembli | ENST00000378486; ENSP00000367747; ENSG00000149527 [O75038-1] ENST00000419816; ENSP00000389803; ENSG00000149527 [O75038-1] ENST00000449969; ENSP00000397289; ENSG00000149527 [O75038-2] ENST00000620687; ENSP00000481938; ENSG00000276429 [O75038-1] ENST00000626246; ENSP00000486186; ENSG00000276429 [O75038-1] ENST00000627854; ENSP00000487140; ENSG00000276429 [O75038-2] |
GeneIDi | 9651 |
KEGGi | hsa:9651 |
UCSCi | uc001ajj.2, human [O75038-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ176850 mRNA Translation: ABA12209.1 AK074149 mRNA Translation: BAB84975.1 AK122591 mRNA Translation: BAC56932.2 Different initiation. AB007919 mRNA Translation: BAA32295.3 Different initiation. AL139246 Genomic DNA No translation available. BC019679 mRNA Translation: AAH19679.1 BC043358 mRNA Translation: AAH43358.1 Frameshift. BC050037 mRNA Translation: AAH50037.1 BC128207 mRNA Translation: AAI28208.1 |
CCDSi | CCDS59959.1 [O75038-1] |
RefSeqi | NP_001289941.1, NM_001303012.1 [O75038-2] NP_001289942.1, NM_001303013.1 NP_055453.2, NM_014638.3 [O75038-1] |
3D structure databases
SMRi | O75038 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115009, 2 interactors |
IntActi | O75038, 2 interactors |
MINTi | O75038 |
STRINGi | 9606.ENSP00000367747 |
Chemistry databases
SwissLipidsi | SLP:000001755 |
PTM databases
iPTMneti | O75038 |
PhosphoSitePlusi | O75038 |
Polymorphism and mutation databases
BioMutai | PLCH2 |
Proteomic databases
jPOSTi | O75038 |
MassIVEi | O75038 |
PaxDbi | O75038 |
PeptideAtlasi | O75038 |
PRIDEi | O75038 |
ProteomicsDBi | 49717 [O75038-1] 49718 [O75038-2] 49719 [O75038-3] 49720 [O75038-4] 49721 [O75038-5] |
TopDownProteomicsi | O75038-1 [O75038-1] |
Protocols and materials databases
Antibodypediai | 1163, 21 antibodies |
Genome annotation databases
Ensembli | ENST00000378486; ENSP00000367747; ENSG00000149527 [O75038-1] ENST00000419816; ENSP00000389803; ENSG00000149527 [O75038-1] ENST00000449969; ENSP00000397289; ENSG00000149527 [O75038-2] ENST00000620687; ENSP00000481938; ENSG00000276429 [O75038-1] ENST00000626246; ENSP00000486186; ENSG00000276429 [O75038-1] ENST00000627854; ENSP00000487140; ENSG00000276429 [O75038-2] |
GeneIDi | 9651 |
KEGGi | hsa:9651 |
UCSCi | uc001ajj.2, human [O75038-1] |
Organism-specific databases
CTDi | 9651 |
DisGeNETi | 9651 |
EuPathDBi | HostDB:ENSG00000149527.17 |
GeneCardsi | PLCH2 |
HGNCi | HGNC:29037, PLCH2 |
HPAi | ENSG00000149527, Tissue enhanced (brain, retina, skin) |
MIMi | 612836, gene |
neXtProti | NX_O75038 |
OpenTargetsi | ENSG00000149527 |
PharmGKBi | PA134914471 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0169, Eukaryota |
GeneTreei | ENSGT00940000158374 |
HOGENOMi | CLU_002738_0_0_1 |
InParanoidi | O75038 |
OMAi | SMQRSVT |
OrthoDBi | 368239at2759 |
PhylomeDBi | O75038 |
TreeFami | TF313216 |
Enzyme and pathway databases
PathwayCommonsi | O75038 |
Reactomei | R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol |
Miscellaneous databases
BioGRID-ORCSi | 9651, 2 hits in 822 CRISPR screens |
ChiTaRSi | PLCH2, human |
GenomeRNAii | 9651 |
Pharosi | O75038, Tbio |
PROi | PR:O75038 |
RNActi | O75038, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149527, Expressed in right hemisphere of cerebellum and 151 other tissues |
ExpressionAtlasi | O75038, baseline and differential |
Genevisiblei | O75038, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR028393, PLC-eta2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF166, PTHR10336:SF166, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF16457, PH_12, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00233, PH, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS50003, PH_DOMAIN, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCH2_HUMAN | |
Accessioni | O75038Primary (citable) accession number: O75038 Secondary accession number(s): A2VCM3 Q8WUS6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | November 13, 2007 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM