UniProtKB - O75038 (PLCH2_HUMAN)

>sp|O75038|PLCH2_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Homo sapiens OX=9606 GN=PLCH2 PE=2 SV=3
MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRG
GSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNC
CFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDE
ADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMST
RRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLL
GIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYA
WVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIE
NHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISED
AEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFS
VSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGD
EGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAH
QILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLN
RAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGD
RGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDH
DPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLR
GPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVA
DDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPA
AVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRS
QPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHR
DSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKS
KSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDL
TADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTS
LGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPE
GACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL

Entry version 167 (17 Jun 2020)
Sequence version 3 (13 Nov 2007)
Previous versions | rss

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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

Gene

PLCH2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).By similarity

Catalytic activityⁱ

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
1D-myo-inositol 1,4,5-trisphosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
a 1,2-diacyl-sn-glycerol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
EC:
3.1.4.11
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
zoom
+
H₂O
=
1D-myo-inositol 1,4,5-trisphosphate
zoom
+
a 1,2-diacyl-sn-glycerol
zoom
+
H⁺

Cofactorⁱ

Ca²⁺PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	341	PROSITE-ProRule annotation	1
Metal bindingⁱ	342	Calcium 1; catalyticBy similarity	1
Metal bindingⁱ	371	Calcium 1; catalyticBy similarity	1
Metal bindingⁱ	373	Calcium 1; catalyticBy similarity	1
Active siteⁱ	385	PROSITE-ProRule annotation	1
Metal bindingⁱ	420	Calcium 1; catalyticBy similarity	1
Binding siteⁱ	469	SubstrateBy similarity	1
Binding siteⁱ	471	SubstrateBy similarity	1
Binding siteⁱ	653	SubstrateBy similarity	1
Binding siteⁱ	680	SubstrateBy similarity	1
Metal bindingⁱ	784	Calcium 2; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	786	Calcium 2By similarity	1
Metal bindingⁱ	810	Calcium 2By similarity	1
Metal bindingⁱ	839	Calcium 3By similarity	1
Metal bindingⁱ	840	Calcium 3; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	841	Calcium 3By similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	182 – 193	PROSITE-ProRule annotationAdd BLAST		12

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Transducer
Biological process	Lipid degradation, Lipid metabolism
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol

Reactomeⁱ

R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol

Chemistry databases

SwissLipidsⁱ	SLP:000001755

SwissLipidsⁱ

SLP:000001755

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC:3.1.4.11) Alternative name(s): Phosphoinositide phospholipase C-eta-2 Phosphoinositide phospholipase C-like 4 Short name: PLC-L4 Short name: Phospholipase C-like protein 4 Phospholipase C-eta-2 Short name: PLC-eta2
Gene namesⁱ	Name:PLCH2 Synonyms:KIAA0450, PLCL4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149527.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29037 PLCH2
MIMⁱ	612836 gene
neXtProtⁱ	NX_O75038

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9651
Open Targets More...OpenTargetsⁱ	ENSG00000149527
PharmGKBⁱ	PA134914471

Miscellaneous databases

Pharosⁱ	O75038 Tbio

Pharosⁱ

O75038 Tbio

Polymorphism and mutation databases

BioMutaⁱ	PLCH2

BioMutaⁱ

PLCH2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000088507	1 – 1416	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2Add BLAST		1416

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	487	PhosphoserineBy similarity	1
Modified residueⁱ	491	PhosphoserineBy similarity	1
Modified residueⁱ	595	PhosphoserineBy similarity	1
Modified residueⁱ	605	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

jPOSTⁱ	O75038
MassIVEⁱ	O75038
PaxDbⁱ	O75038
PeptideAtlas More...PeptideAtlasⁱ	O75038
PRIDEⁱ	O75038
ProteomicsDBⁱ	49717 [O75038-1] 49718 [O75038-2] 49719 [O75038-3] 49720 [O75038-4] 49721 [O75038-5]
TopDownProteomicsⁱ	O75038-1 [O75038-1]

PTM databases

iPTMnetⁱ	O75038
PhosphoSitePlusⁱ	O75038

Expressionⁱ

Tissue specificityⁱ

Expressed in retina and kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000149527 Expressed in right hemisphere of cerebellum and 127 other tissues
ExpressionAtlasⁱ	O75038 baseline and differential
Genevisibleⁱ	O75038 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000149527 Tissue enhanced (brain, retina, skin)

HPAⁱ

ENSG00000149527 Tissue enhanced (brain, retina, skin)

Interactionⁱ

Protein-protein interaction databases

BioGRIDⁱ	115009, 2 interactors
IntActⁱ	O75038, 2 interactors
Molecular INTeraction database More...MINTⁱ	O75038
STRINGⁱ	9606.ENSP00000367747

Miscellaneous databases

RNActⁱ	O75038 protein

RNActⁱ

O75038 protein

Structureⁱ

3D structure databases

SMRⁱ	O75038
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	47 – 155	PHPROSITE-ProRule annotationAdd BLAST	109
Domainⁱ	169 – 204	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	205 – 241	EF-hand 2PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	326 – 471	PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST	146
Domainⁱ	626 – 740	PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST	115
Domainⁱ	740 – 869	C2PROSITE-ProRule annotationAdd BLAST	130

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 155	Necessary for plasma membrane localizationBy similarityAdd BLAST		155

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0169 Eukaryota ENOG410XPSW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158374
HOGENOMⁱ	CLU_002738_0_0_1
InParanoidⁱ	O75038
KEGG Orthology (KO) More...KOⁱ	K19006
OMAⁱ	SMQRSVT
Database of Orthologous Groups More...OrthoDBⁱ	368239at2759
PhylomeDBⁱ	O75038
TreeFamⁱ	TF313216

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR001192 PI-PLC_fam IPR028393 PLC-eta2 IPR017946 PLC-like_Pdiesterase_TIM-brl IPR015359 PLC_EF-hand-like IPR000909 PLipase_C_PInositol-sp_X_dom IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERⁱ	PTHR10336 PTHR10336, 1 hit PTHR10336:SF166 PTHR10336:SF166, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 1 hit PF09279 EF-hand_like, 1 hit PF16457 PH_12, 1 hit PF00388 PI-PLC-X, 1 hit PF00387 PI-PLC-Y, 1 hit
PRINTSⁱ	PR00390 PHPHLIPASEC
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00054 EFh, 2 hits SM00233 PH, 1 hit SM00148 PLCXc, 1 hit SM00149 PLCYc, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit SSF51695 SSF51695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004 C2, 1 hit PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 2 hits PS50003 PH_DOMAIN, 1 hit PS50007 PIPLC_X_DOMAIN, 1 hit PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O75038-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSGPWPSPDS RTKGTVAWLA EVLLWVGGSV VLSSEWQLGP LVERCMGAMQ 
        60         70         80         90        100
EGMQMVKLRG GSKGLVRFYY LDEHRSCIRW RPSRKNEKAK ISIDSIQEVS 
       110        120        130        140        150
EGRQSEVFQR YPDGSFDPNC CFSIYHGSHR ESLDLVSTSS EVARTWVTGL 
       160        170        180        190        200
RYLMAGISDE DSLARRQRTR DQWLKQTFDE ADKNGDGSLS IGEVLQLLHK 
       210        220        230        240        250
LNVNLPRQRV KQMFREADTD DHQGTLGFEE FCAFYKMMST RRDLYLLMLT 
       260        270        280        290        300
YSNHKDHLDA ASLQRFLQVE QKMAGVTLES CQDIIEQFEP CPENKSKGLL 
       310        320        330        340        350
GIDGFTNYTR SPAGDIFNPE HHHVHQDMTQ PLSHYFITSS HNTYLVGDQL 
       360        370        380        390        400
MSQSRVDMYA WVLQAGCRCV EVDCWDGPDG EPIVHHGYTL TSKILFKDVI 
       410        420        430        440        450
ETINKYAFIK NEYPVILSIE NHCSVIQQKK MAQYLTDILG DKLDLSSVSS 
       460        470        480        490        500
EDATTLPSPQ MLKGKILVKG KKLPANISED AEEGEVSDED SADEIDDDCK 
       510        520        530        540        550
LLNGDASTNR KRVENTAKRK LDSLIKESKI RDCEDPNNFS VSTLSPSGKL 
       560        570        580        590        600
GRKSKAEEDV ESGEDAGASR RNGRLVVGSF SRRKKKGSKL KKAASVEEGD 
       610        620        630        640        650
EGQDSPGGQS RGATRQKKTM KLSRALSDLV KYTKSVATHD IEMEAASSWQ 
       660        670        680        690        700
VSSFSETKAH QILQQKPAQY LRFNQQQLSR IYPSSYRVDS SNYNPQPFWN 
       710        720        730        740        750
AGCQMVALNY QSEGRMLQLN RAKFSANGGC GYVLKPGCMC QGVFNPNSED 
       760        770        780        790        800
PLPGQLKKQL VLRIISGQQL PKPRDSMLGD RGEIIDPFVE VEIIGLPVDC 
       810        820        830        840        850
SREQTRVVDD NGFNPTWEET LVFMVHMPEI ALVRFLVWDH DPIGRDFIGQ 
       860        870        880        890        900
RTLAFSSMMP GYRHVYLEGM EEASIFVHVA VSDISGKVKQ ALGLKGLFLR 
       910        920        930        940        950
GPKPGSLDSH AAGRPPARPS VSQRILRRTA SAPTKSQKPG RRGFPELVLG 
       960        970        980        990       1000
TRDTGSKGVA DDVVPPGPGP APEAPAQEGP GSGSPRDTRP LSTQRPLPPL 
      1010       1020       1030       1040       1050
CSLETIAEEP APGPGPPPPA AVPTSSSQGR PPYPTGPGAN VASPLEDTEE 
      1060       1070       1080       1090       1100
PRDSRPRPCN GEGAGGAYER APGSQTDGRS QPRTLGHLPV IRRVKSEGQV 
      1110       1120       1130       1140       1150
PTEPLGGWRP LAAPFPAPAV YSDATGSDPL WQRLEPCGHR DSVSSSSSMS 
      1160       1170       1180       1190       1200
SSDTVIDLSL PSLGLGRSRE NLAGAHMGRL PPRPHSASAA RPDLPPVTKS 
      1210       1220       1230       1240       1250
KSNPNLRATG QRPPIPDELQ PRSLAPRMAG LPFRPPWGCL SLVGVQDCPV 
      1260       1270       1280       1290       1300
AAKSKSLGDL TADDFAPSFE GGSRRLSHSL GLPGGTRRVS GPGVRRDTLT 
      1310       1320       1330       1340       1350
EQLRWLTVFQ QAGDITSPTS LGPAGEGVAG GPGFVRRSSS RSHSRVRAIA 
      1360       1370       1380       1390       1400
SRARQAQERQ QRLQGLGRQG PPEEERGTPE GACSVGHEGS VDAPAPSKGA 
      1410 
LGPASAAAEN LVLLRL

Length:1,416

Mass (Da):154,668

Last modified:November 13, 2007 - v3

Checksum:ⁱ05088ACD9C45AE87

Isoform 2 (identifier: O75038-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPL → MEEPGPPGGLSQDQ
     987-1156: DTRPLSTQRP...SSMSSSDTVI → GKAPAAVAEK...KSPMFSAVRN
     1157-1416: Missing.

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        10         20         30         40         50
MEEPGPPGGL SQDQVERCMG AMQEGMQMVK LRGGSKGLVR FYYLDEHRSC 
        60         70         80         90        100
IRWRPSRKNE KAKISIDSIQ EVSEGRQSEV FQRYPDGSFD PNCCFSIYHG 
       110        120        130        140        150
SHRESLDLVS TSSEVARTWV TGLRYLMAGI SDEDSLARRQ RTRDQWLKQT 
       160        170        180        190        200
FDEADKNGDG SLSIGEVLQL LHKLNVNLPR QRVKQMFREA DTDDHQGTLG 
       210        220        230        240        250
FEEFCAFYKM MSTRRDLYLL MLTYSNHKDH LDAASLQRFL QVEQKMAGVT 
       260        270        280        290        300
LESCQDIIEQ FEPCPENKSK GLLGIDGFTN YTRSPAGDIF NPEHHHVHQD 
       310        320        330        340        350
MTQPLSHYFI TSSHNTYLVG DQLMSQSRVD MYAWVLQAGC RCVEVDCWDG 
       360        370        380        390        400
PDGEPIVHHG YTLTSKILFK DVIETINKYA FIKNEYPVIL SIENHCSVIQ 
       410        420        430        440        450
QKKMAQYLTD ILGDKLDLSS VSSEDATTLP SPQMLKGKIL VKGKKLPANI 
       460        470        480        490        500
SEDAEEGEVS DEDSADEIDD DCKLLNGDAS TNRKRVENTA KRKLDSLIKE 
       510        520        530        540        550
SKIRDCEDPN NFSVSTLSPS GKLGRKSKAE EDVESGEDAG ASRRNGRLVV 
       560        570        580        590        600
GSFSRRKKKG SKLKKAASVE EGDEGQDSPG GQSRGATRQK KTMKLSRALS 
       610        620        630        640        650
DLVKYTKSVA THDIEMEAAS SWQVSSFSET KAHQILQQKP AQYLRFNQQQ 
       660        670        680        690        700
LSRIYPSSYR VDSSNYNPQP FWNAGCQMVA LNYQSEGRML QLNRAKFSAN 
       710        720        730        740        750
GGCGYVLKPG CMCQGVFNPN SEDPLPGQLK KQLVLRIISG QQLPKPRDSM 
       760        770        780        790        800
LGDRGEIIDP FVEVEIIGLP VDCSREQTRV VDDNGFNPTW EETLVFMVHM 
       810        820        830        840        850
PEIALVRFLV WDHDPIGRDF IGQRTLAFSS MMPGYRHVYL EGMEEASIFV 
       860        870        880        890        900
HVAVSDISGK VKQALGLKGL FLRGPKPGSL DSHAAGRPPA RPSVSQRILR 
       910        920        930        940        950
RTASAPTKSQ KPGRRGFPEL VLGTRDTGSK GVADDVVPPG PGPAPEAPAQ 
       960        970        980        990       1000
EGPGSGSPRG KAPAAVAEKS PVRVRPPRVL DGPGPAGMAA TCMKCVVGSC 
      1010       1020       1030       1040       1050
AGVNTGGLQR ERPPSPGPAS RQAAIRQQPR ARADSLGAPC CGLDPHAIPG 
      1060       1070       1080       1090       1100
RSREAPKGPG AWRQGPGGSG SMSSDSSSPD SPGIPERSPR WPEGACRQPG 
      1110       1120 
ALQGEMSALF AQKLEEIRSK SPMFSAVRN

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Length:1,129

Mass (Da):124,302

Checksum:ⁱAE28DDFBEE739B2A

Isoform 3 (identifier: O75038-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
706-741: Missing.

« Hide

        10         20         30         40         50
MSGPWPSPDS RTKGTVAWLA EVLLWVGGSV VLSSEWQLGP LVERCMGAMQ 
        60         70         80         90        100
EGMQMVKLRG GSKGLVRFYY LDEHRSCIRW RPSRKNEKAK ISIDSIQEVS 
       110        120        130        140        150
EGRQSEVFQR YPDGSFDPNC CFSIYHGSHR ESLDLVSTSS EVARTWVTGL 
       160        170        180        190        200
RYLMAGISDE DSLARRQRTR DQWLKQTFDE ADKNGDGSLS IGEVLQLLHK 
       210        220        230        240        250
LNVNLPRQRV KQMFREADTD DHQGTLGFEE FCAFYKMMST RRDLYLLMLT 
       260        270        280        290        300
YSNHKDHLDA ASLQRFLQVE QKMAGVTLES CQDIIEQFEP CPENKSKGLL 
       310        320        330        340        350
GIDGFTNYTR SPAGDIFNPE HHHVHQDMTQ PLSHYFITSS HNTYLVGDQL 
       360        370        380        390        400
MSQSRVDMYA WVLQAGCRCV EVDCWDGPDG EPIVHHGYTL TSKILFKDVI 
       410        420        430        440        450
ETINKYAFIK NEYPVILSIE NHCSVIQQKK MAQYLTDILG DKLDLSSVSS 
       460        470        480        490        500
EDATTLPSPQ MLKGKILVKG KKLPANISED AEEGEVSDED SADEIDDDCK 
       510        520        530        540        550
LLNGDASTNR KRVENTAKRK LDSLIKESKI RDCEDPNNFS VSTLSPSGKL 
       560        570        580        590        600
GRKSKAEEDV ESGEDAGASR RNGRLVVGSF SRRKKKGSKL KKAASVEEGD 
       610        620        630        640        650
EGQDSPGGQS RGATRQKKTM KLSRALSDLV KYTKSVATHD IEMEAASSWQ 
       660        670        680        690        700
VSSFSETKAH QILQQKPAQY LRFNQQQLSR IYPSSYRVDS SNYNPQPFWN 
       710        720        730        740        750
AGCQMGVFNP NSEDPLPGQL KKQLVLRIIS GQQLPKPRDS MLGDRGEIID 
       760        770        780        790        800
PFVEVEIIGL PVDCSREQTR VVDDNGFNPT WEETLVFMVH MPEIALVRFL 
       810        820        830        840        850
VWDHDPIGRD FIGQRTLAFS SMMPGYRHVY LEGMEEASIF VHVAVSDISG 
       860        870        880        890        900
KVKQALGLKG LFLRGPKPGS LDSHAAGRPP ARPSVSQRIL RRTASAPTKS 
       910        920        930        940        950
QKPGRRGFPE LVLGTRDTGS KGVADDVVPP GPGPAPEAPA QEGPGSGSPR 
       960        970        980        990       1000
DTRPLSTQRP LPPLCSLETI AEEPAPGPGP PPPAAVPTSS SQGRPPYPTG 
      1010       1020       1030       1040       1050
PGANVASPLE DTEEPRDSRP RPCNGEGAGG AYERAPGSQT DGRSQPRTLG 
      1060       1070       1080       1090       1100
HLPVIRRVKS EGQVPTEPLG GWRPLAAPFP APAVYSDATG SDPLWQRLEP 
      1110       1120       1130       1140       1150
CGHRDSVSSS SSMSSSDTVI DLSLPSLGLG RSRENLAGAH MGRLPPRPHS 
      1160       1170       1180       1190       1200
ASAARPDLPP VTKSKSNPNL RATGQRPPIP DELQPRSLAP RMAGLPFRPP 
      1210       1220       1230       1240       1250
WGCLSLVGVQ DCPVAAKSKS LGDLTADDFA PSFEGGSRRL SHSLGLPGGT 
      1260       1270       1280       1290       1300
RRVSGPGVRR DTLTEQLRWL TVFQQAGDIT SPTSLGPAGE GVAGGPGFVR 
      1310       1320       1330       1340       1350
RSSSRSHSRV RAIASRARQA QERQQRLQGL GRQGPPEEER GTPEGACSVG 
      1360       1370       1380
HEGSVDAPAP SKGALGPASA AAENLVLLRL

Show »

Length:1,380

Mass (Da):150,778

Checksum:ⁱ7828287338AF8201

Isoform 4 (identifier: O75038-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
987-1211: DTRPLSTQRP...SNPNLRATGQ → GKAPAAVAEK...TLLPWLACGP
1212-1416: Missing.

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        10         20         30         40         50
MSGPWPSPDS RTKGTVAWLA EVLLWVGGSV VLSSEWQLGP LVERCMGAMQ 
        60         70         80         90        100
EGMQMVKLRG GSKGLVRFYY LDEHRSCIRW RPSRKNEKAK ISIDSIQEVS 
       110        120        130        140        150
EGRQSEVFQR YPDGSFDPNC CFSIYHGSHR ESLDLVSTSS EVARTWVTGL 
       160        170        180        190        200
RYLMAGISDE DSLARRQRTR DQWLKQTFDE ADKNGDGSLS IGEVLQLLHK 
       210        220        230        240        250
LNVNLPRQRV KQMFREADTD DHQGTLGFEE FCAFYKMMST RRDLYLLMLT 
       260        270        280        290        300
YSNHKDHLDA ASLQRFLQVE QKMAGVTLES CQDIIEQFEP CPENKSKGLL 
       310        320        330        340        350
GIDGFTNYTR SPAGDIFNPE HHHVHQDMTQ PLSHYFITSS HNTYLVGDQL 
       360        370        380        390        400
MSQSRVDMYA WVLQAGCRCV EVDCWDGPDG EPIVHHGYTL TSKILFKDVI 
       410        420        430        440        450
ETINKYAFIK NEYPVILSIE NHCSVIQQKK MAQYLTDILG DKLDLSSVSS 
       460        470        480        490        500
EDATTLPSPQ MLKGKILVKG KKLPANISED AEEGEVSDED SADEIDDDCK 
       510        520        530        540        550
LLNGDASTNR KRVENTAKRK LDSLIKESKI RDCEDPNNFS VSTLSPSGKL 
       560        570        580        590        600
GRKSKAEEDV ESGEDAGASR RNGRLVVGSF SRRKKKGSKL KKAASVEEGD 
       610        620        630        640        650
EGQDSPGGQS RGATRQKKTM KLSRALSDLV KYTKSVATHD IEMEAASSWQ 
       660        670        680        690        700
VSSFSETKAH QILQQKPAQY LRFNQQQLSR IYPSSYRVDS SNYNPQPFWN 
       710        720        730        740        750
AGCQMVALNY QSEGRMLQLN RAKFSANGGC GYVLKPGCMC QGVFNPNSED 
       760        770        780        790        800
PLPGQLKKQL VLRIISGQQL PKPRDSMLGD RGEIIDPFVE VEIIGLPVDC 
       810        820        830        840        850
SREQTRVVDD NGFNPTWEET LVFMVHMPEI ALVRFLVWDH DPIGRDFIGQ 
       860        870        880        890        900
RTLAFSSMMP GYRHVYLEGM EEASIFVHVA VSDISGKVKQ ALGLKGLFLR 
       910        920        930        940        950
GPKPGSLDSH AAGRPPARPS VSQRILRRTA SAPTKSQKPG RRGFPELVLG 
       960        970        980        990       1000
TRDTGSKGVA DDVVPPGPGP APEAPAQEGP GSGSPRGKAP AAVAEKSPVR 
      1010       1020       1030       1040       1050
VRPPRVLDGP GPAGMAATCM KCVVGSCAGV NTGGLQRERP PSPGPASRQA 
      1060       1070       1080       1090       1100
AIRQQPRARA DSLGAPCCGL DPHAIPGRSR EAPKGPGAWR QGPGGSGSMS 
      1110       1120       1130       1140       1150
SDSSSPDSPG IPERSPRWPE GACRQPGALQ GEMSALFAQK LEEIRSKSPM 
      1160       1170       1180       1190       1200
FSAGKPLLPC VVLPHAPGMA GPGSPAAASA WTVSPRVLVL VALYPWHCLR 
      1210 
GTLLPWLACG P

Show »

Length:1,211

Mass (Da):132,836

Checksum:ⁱ1472D389D2CF4707

Isoform 5 (identifier: O75038-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.
     117-785: Missing.
     987-1211: DTRPLSTQRP...SNPNLRATGQ → GKAPAAVAEK...TLLPWLACGP
     1212-1416: Missing.

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        10         20         30         40         50
MGAMQEGMQM VKLRGGSKGL VRFYYLDEHR SCIRWRPSRK NEKAKISIDS 
        60         70         80         90        100
IQEVSEGRQS EVFQRYPDGS FDPFVEVEII GLPVDCSREQ TRVVDDNGFN 
       110        120        130        140        150
PTWEETLVFM VHMPEIALVR FLVWDHDPIG RDFIGQRTLA FSSMMPGYRH 
       160        170        180        190        200
VYLEGMEEAS IFVHVAVSDI SGKVKQALGL KGLFLRGPKP GSLDSHAAGR 
       210        220        230        240        250
PPARPSVSQR ILRRTASAPT KSQKPGRRGF PELVLGTRDT GSKGVADDVV 
       260        270        280        290        300
PPGPGPAPEA PAQEGPGSGS PRGKAPAAVA EKSPVRVRPP RVLDGPGPAG 
       310        320        330        340        350
MAATCMKCVV GSCAGVNTGG LQRERPPSPG PASRQAAIRQ QPRARADSLG 
       360        370        380        390        400
APCCGLDPHA IPGRSREAPK GPGAWRQGPG GSGSMSSDSS SPDSPGIPER 
       410        420        430        440        450
SPRWPEGACR QPGALQGEMS ALFAQKLEEI RSKSPMFSAG KPLLPCVVLP 
       460        470        480        490 
HAPGMAGPGS PAAASAWTVS PRVLVLVALY PWHCLRGTLL PWLACGP

Show »

Length:497

Mass (Da):52,942

Checksum:ⁱ843420D08D2C3A9F

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B9DI82	B9DI82_HUMAN	Phosphoinositide phospholipase C Phosphoinositide phospholipase C, EC 3.1.4.11	PLCH2	1,239	Annotation score:
V9GY64	V9GY64_HUMAN	1-phosphatidylinositol 4,5-bisphosp... 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2	PLCH2	111	Annotation score:

Sequence cautionⁱ

The sequence AAH43358 differs from that shown. Reason: Frameshift.Curated

The sequence BAA32295 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

The sequence BAC56932 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	559	D → E in BAB84975 (Ref. 2) Curated	1
Sequence conflictⁱ	560	V → M in BAB84975 (Ref. 2) Curated	1
Isoform 5 (identifier: O75038-5)
Sequence conflictⁱ	209	Q → L in BAC56932 (Ref. 2) Curated	1
Isoform 4 (identifier: O75038-4)
Sequence conflictⁱ	1004	P → L in BAB84975 (Ref. 2) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_029067	1 – 45	Missing in isoform 5. 1 PublicationAdd BLAST	45
Alternative sequenceⁱVSP_029068	1 – 41	MSGPW…QLGPL → MEEPGPPGGLSQDQ in isoform 2. 1 PublicationAdd BLAST	41
Alternative sequenceⁱVSP_029069	117 – 785	Missing in isoform 5. 1 PublicationAdd BLAST	669
Alternative sequenceⁱVSP_029070	706 – 741	Missing in isoform 3. 1 PublicationAdd BLAST	36
Alternative sequenceⁱVSP_029071	987 – 1211	DTRPL…RATGQ → GKAPAAVAEKSPVRVRPPRV LDGPGPAGMAATCMKCVVGS CAGVNTGGLQRERPPSPGPA SRQAAIRQQPRARADSLGAP CCGLDPHAIPGRSREAPKGP GAWRQGPGGSGSMSSDSSSP DSPGIPERSPRWPEGACRQP GALQGEMSALFAQKLEEIRS KSPMFSAGKPLLPCVVLPHA PGMAGPGSPAAASAWTVSPR VLVLVALYPWHCLRGTLLPW LACGP in isoform 4 and isoform 5. 1 PublicationAdd BLAST	225
Alternative sequenceⁱVSP_029072	987 – 1156	DTRPL…SDTVI → GKAPAAVAEKSPVRVRPPRV LDGPGPAGMAATCMKCVVGS CAGVNTGGLQRERPPSPGPA SRQAAIRQQPRARADSLGAP CCGLDPHAIPGRSREAPKGP GAWRQGPGGSGSMSSDSSSP DSPGIPERSPRWPEGACRQP GALQGEMSALFAQKLEEIRS KSPMFSAVRN in isoform 2. 1 PublicationAdd BLAST	170
Alternative sequenceⁱVSP_029073	1157 – 1416	Missing in isoform 2. 1 PublicationAdd BLAST	260
Alternative sequenceⁱVSP_029074	1212 – 1416	Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST	205

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ176850 mRNA Translation: ABA12209.1 AK074149 mRNA Translation: BAB84975.1 AK122591 mRNA Translation: BAC56932.2 Different initiation. AB007919 mRNA Translation: BAA32295.3 Different initiation. AL139246 Genomic DNA No translation available. BC019679 mRNA Translation: AAH19679.1 BC043358 mRNA Translation: AAH43358.1 Frameshift. BC050037 mRNA Translation: AAH50037.1 BC128207 mRNA Translation: AAI28208.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS59959.1 [O75038-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001289941.1, NM_001303012.1 [O75038-2] NP_001289942.1, NM_001303013.1 NP_055453.2, NM_014638.3 [O75038-1]

Genome annotation databases

Ensemblⁱ	ENST00000378486; ENSP00000367747; ENSG00000149527 [O75038-1] ENST00000419816; ENSP00000389803; ENSG00000149527 [O75038-1] ENST00000449969; ENSP00000397289; ENSG00000149527 [O75038-2] ENST00000620687; ENSP00000481938; ENSG00000276429 [O75038-1] ENST00000626246; ENSP00000486186; ENSG00000276429 [O75038-1] ENST00000627854; ENSP00000487140; ENSG00000276429 [O75038-2]
GeneIDⁱ	9651
KEGGⁱ	hsa:9651
UCSC genome browser More...UCSCⁱ	uc001ajj.2 human [O75038-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O75038	PLCH2 isoform 4		PANTR		1416	UniRef90_O75038
Phosphoinositide phospholipase C		GORGO		1416
Isoform 3 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2		HUMAN		1380
UPI0006C97BDE		PANPA		1389
Phosphoinositide phospholipase C		PANTR		1416
+9
O75038-2	Phosphoinositide phospholipase C		PANTR		1129	UniRef90_O75038-2
Phosphoinositide phospholipase C		GORGO		1128
UPI00024D184A		HUMAN		1019
PLCH2 isoform 2		PANTR		1129
Phosphoinositide phospholipase C		PANTR		1126
+1
O75038-4	Phosphoinositide phospholipase C (Fragment)		HUMAN		1129	UniRef90_O75038-4

Protein	Similar proteins		Species	Score	Length	Source
O75038	PLCH2 isoform 4		PANTR		1416	UniRef50_O75038
Phosphoinositide phospholipase C		GORGO		1416
Isoform 3 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2		HUMAN		1380
Phosphoinositide phospholipase C		VULVU		1379
Phosphoinositide phospholipase C		URSAM		1457
+182
O75038-2	Phosphoinositide phospholipase C		PANTR		1129	UniRef50_O75038-2
Phosphoinositide phospholipase C		GORGO		1128
Phosphoinositide phospholipase C		zig-zag eel		1104
Phosphoinositide phospholipase C		HORSE		1120
Phosphoinositide phospholipase C		CALMI		1151
+46
O75038-4	Phosphoinositide phospholipase C (Fragment)		HUMAN		1129	UniRef50_O75038-4
Phosphoinositide phospholipase C		FELCA		1127
Phosphoinositide phospholipase C		ORYLA		1188
Phosphoinositide phospholipase C		AOTNA		1131
Phosphoinositide phospholipase C		CALJA		1126
+24
O75038-5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2		MOUSE		493	UniRef50_O75038-5

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ176850 mRNA Translation: ABA12209.1 AK074149 mRNA Translation: BAB84975.1 AK122591 mRNA Translation: BAC56932.2 Different initiation. AB007919 mRNA Translation: BAA32295.3 Different initiation. AL139246 Genomic DNA No translation available. BC019679 mRNA Translation: AAH19679.1 BC043358 mRNA Translation: AAH43358.1 Frameshift. BC050037 mRNA Translation: AAH50037.1 BC128207 mRNA Translation: AAI28208.1
CCDSⁱ	CCDS59959.1 [O75038-1]
RefSeqⁱ	NP_001289941.1, NM_001303012.1 [O75038-2] NP_001289942.1, NM_001303013.1 NP_055453.2, NM_014638.3 [O75038-1]

3D structure databases

SMRⁱ	O75038
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	115009, 2 interactors
IntActⁱ	O75038, 2 interactors
MINTⁱ	O75038
STRINGⁱ	9606.ENSP00000367747

Chemistry databases

SwissLipidsⁱ	SLP:000001755

SwissLipidsⁱ

SLP:000001755

PTM databases

iPTMnetⁱ	O75038
PhosphoSitePlusⁱ	O75038

Polymorphism and mutation databases

BioMutaⁱ	PLCH2

BioMutaⁱ

PLCH2

Proteomic databases

jPOSTⁱ	O75038
MassIVEⁱ	O75038
PaxDbⁱ	O75038
PeptideAtlasⁱ	O75038
PRIDEⁱ	O75038
ProteomicsDBⁱ	49717 [O75038-1] 49718 [O75038-2] 49719 [O75038-3] 49720 [O75038-4] 49721 [O75038-5]
TopDownProteomicsⁱ	O75038-1 [O75038-1]

Protocols and materials databases

Antibodypediaⁱ	1163 21 antibodies

Antibodypediaⁱ

1163 21 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000378486; ENSP00000367747; ENSG00000149527 [O75038-1] ENST00000419816; ENSP00000389803; ENSG00000149527 [O75038-1] ENST00000449969; ENSP00000397289; ENSG00000149527 [O75038-2] ENST00000620687; ENSP00000481938; ENSG00000276429 [O75038-1] ENST00000626246; ENSP00000486186; ENSG00000276429 [O75038-1] ENST00000627854; ENSP00000487140; ENSG00000276429 [O75038-2]
GeneIDⁱ	9651
KEGGⁱ	hsa:9651
UCSCⁱ	uc001ajj.2 human [O75038-1]

Organism-specific databases

CTDⁱ	9651
DisGeNETⁱ	9651
EuPathDBⁱ	HostDB:ENSG00000149527.17
GeneCardsⁱ	PLCH2
HGNCⁱ	HGNC:29037 PLCH2
HPAⁱ	ENSG00000149527 Tissue enhanced (brain, retina, skin)
MIMⁱ	612836 gene
neXtProtⁱ	NX_O75038
OpenTargetsⁱ	ENSG00000149527
PharmGKBⁱ	PA134914471
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0169 Eukaryota ENOG410XPSW LUCA
GeneTreeⁱ	ENSGT00940000158374
HOGENOMⁱ	CLU_002738_0_0_1
InParanoidⁱ	O75038
KOⁱ	K19006
OMAⁱ	SMQRSVT
OrthoDBⁱ	368239at2759
PhylomeDBⁱ	O75038
TreeFamⁱ	TF313216

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol

Reactomeⁱ

R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol

Miscellaneous databases

BioGRID-ORCSⁱ	9651 0 hits in 771 CRISPR screens
ChiTaRSⁱ	PLCH2 human
GenomeRNAiⁱ	9651
Pharosⁱ	O75038 Tbio
Protein Ontology More...PROⁱ	PR:O75038
RNActⁱ	O75038 protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149527 Expressed in right hemisphere of cerebellum and 127 other tissues
ExpressionAtlasⁱ	O75038 baseline and differential
Genevisibleⁱ	O75038 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR001192 PI-PLC_fam IPR028393 PLC-eta2 IPR017946 PLC-like_Pdiesterase_TIM-brl IPR015359 PLC_EF-hand-like IPR000909 PLipase_C_PInositol-sp_X_dom IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERⁱ	PTHR10336 PTHR10336, 1 hit PTHR10336:SF166 PTHR10336:SF166, 1 hit
Pfamⁱ	View protein in Pfam PF00168 C2, 1 hit PF09279 EF-hand_like, 1 hit PF16457 PH_12, 1 hit PF00388 PI-PLC-X, 1 hit PF00387 PI-PLC-Y, 1 hit
PRINTSⁱ	PR00390 PHPHLIPASEC
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00054 EFh, 2 hits SM00233 PH, 1 hit SM00148 PLCXc, 1 hit SM00149 PLCYc, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit SSF51695 SSF51695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004 C2, 1 hit PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 2 hits PS50003 PH_DOMAIN, 1 hit PS50007 PIPLC_X_DOMAIN, 1 hit PS50008 PIPLC_Y_DOMAIN, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLCH2_HUMAN
Accessionⁱ	O75038Primary (citable) accession number: O75038 Secondary accession number(s): A2VCM3 Q8WUS6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	November 13, 2007
	Last modified:	June 17, 2020
	This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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Help

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Supporting data

UniProtKB - O75038 (PLCH2_HUMAN)

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

PLCH2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ