Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (12 Aug 2020)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Heat shock factor 2-binding protein

Gene

HSF2BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • spermatogenesis Source: ProtInc
  • transcription by RNA polymerase II Source: ProtInc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O75031

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heat shock factor 2-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSF2BP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160207.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5226, HSF2BP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604554, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75031

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11077

Open Targets

More...
OpenTargetsi
ENSG00000160207

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29495

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75031, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HSF2BP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000840771 – 334Heat shock factor 2-binding proteinAdd BLAST334

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated by UBE2I in response to MEKK1-mediated stimuli.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75031

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O75031

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75031

PeptideAtlas

More...
PeptideAtlasi
O75031

PRoteomics IDEntifications database

More...
PRIDEi
O75031

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49714 [O75031-1]
5404

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75031

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75031

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160207, Expressed in testis and 101 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O75031, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75031, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000160207, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with HSF2 (PubMed:9651507). The interaction seems to occur between the trimerization domain of HSF2 and the N-terminal hydrophilic region of HSF2BP (PubMed:9651507).

Interacts (via C-terminus) with BNC1 (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O75031
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-7116203,EBI-11096309
ABLIM1 - isoform 4 [O14639-4]3EBI-7116203,EBI-11030084
ACTN3 [Q08043]3EBI-7116203,EBI-2880652
ADD1 [Q96D30]3EBI-7116203,EBI-9089447
ANAPC16 [Q96DE5]3EBI-7116203,EBI-2555937
ANKRD55 [Q3KP44]3EBI-7116203,EBI-14493093
ANKS1B - isoform 3 [Q7Z6G8-3]3EBI-7116203,EBI-17714371
ARHGAP45 [Q92619]3EBI-7116203,EBI-2825900
ARHGEF3 [Q9NR81]3EBI-7116203,EBI-10312733
ARHGEF4 [Q9NR80]3EBI-7116203,EBI-3389984
ARHGEF5 [Q12774]3EBI-7116203,EBI-602199
ARHGEF6 [Q15052]3EBI-7116203,EBI-1642523
BARD1 [Q99728]3EBI-7116203,EBI-473181
BAX [Q07812]3EBI-7116203,EBI-516580
BAZ2B [A0A0A0MR97]3EBI-7116203,EBI-11985607
BCAS2 [O75934]3EBI-7116203,EBI-1050106
BEND7 - isoform 2 [Q8N7W2-2]5EBI-7116203,EBI-10181188
BEX2 [Q9BXY8]3EBI-7116203,EBI-745073
BLK [P51451]3EBI-7116203,EBI-2105445
BMI1 [P35226]3EBI-7116203,EBI-2341576
BYSL [Q13895]3EBI-7116203,EBI-358049
C1orf94 [Q6P1W5]3EBI-7116203,EBI-946029
C2CD6 [Q53TS8]3EBI-7116203,EBI-739879
C4orf46 [Q504U0]3EBI-7116203,EBI-6657981
C5orf49 [A4QMS7]3EBI-7116203,EBI-12039847
C7orf31 [Q8N865]3EBI-7116203,EBI-10174456
CAMSAP3 - isoform 2 [Q9P1Y5-2]3EBI-7116203,EBI-18121830
CARD9 - isoform 2 [Q9H257-2]3EBI-7116203,EBI-11530605
CASS4 - isoform 2 [Q9NQ75-2]3EBI-7116203,EBI-12270182
CBX8 [Q9HC52]3EBI-7116203,EBI-712912
CBY2 - isoform 2 [Q8NA61-2]3EBI-7116203,EBI-11524851
CCDC113 [Q9H0I3]3EBI-7116203,EBI-715690
CCDC116 [Q8IYX3]3EBI-7116203,EBI-744311
CCDC120 [Q96HB5]3EBI-7116203,EBI-744556
CCDC13 [Q8IYE1]3EBI-7116203,EBI-10961312
CCDC130 [P13994]3EBI-7116203,EBI-716093
CCDC146 [Q8IYE0]3EBI-7116203,EBI-10749669
CCDC185 [Q8N715]3EBI-7116203,EBI-740814
CCDC198 [E9PSE9]3EBI-7116203,EBI-11748295
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-7116203,EBI-10175300
CCSER1 - isoform 2 [Q9C0I3-2]3EBI-7116203,EBI-17793327
CDC37 [Q16543]3EBI-7116203,EBI-295634
CDC73 [Q6P1J9]4EBI-7116203,EBI-930143
CDCA7L [Q96GN5]3EBI-7116203,EBI-5278764
CDR2L [Q86X02]3EBI-7116203,EBI-11063830
CDYL2 [Q8N8U2]3EBI-7116203,EBI-8467076
CEP55 [Q53EZ4]3EBI-7116203,EBI-747776
CEP57 - isoform 3 [Q86XR8-3]6EBI-7116203,EBI-11752486
CKS1B [P61024]3EBI-7116203,EBI-456371
CLIP4 [Q8N3C7]3EBI-7116203,EBI-5655540
CNNM1 [Q9NRU3]6EBI-7116203,EBI-11986439
CNNM3 [Q8NE01]3EBI-7116203,EBI-741032
CNOT2 [Q9NZN8]3EBI-7116203,EBI-743033
COIL [P38432]3EBI-7116203,EBI-945751
CTSZ [Q9UBR2]3EBI-7116203,EBI-8636823
CTTNBP2 [Q8WZ74]3EBI-7116203,EBI-1774260
CTTNBP2NL [Q9P2B4]3EBI-7116203,EBI-1774273
CWF19L2 [Q2TBE0]3EBI-7116203,EBI-5453285
DALRD3 - isoform 2 [Q5D0E6-2]3EBI-7116203,EBI-9090939
DCDC2B [A2VCK2]3EBI-7116203,EBI-10173222
DEFB112 [Q30KQ8]3EBI-7116203,EBI-17470374
DMAP1 [Q9NPF5]3EBI-7116203,EBI-399105
DMRT3 [Q9NQL9]3EBI-7116203,EBI-9679045
DOCK8 - isoform 4 [Q8NF50-4]3EBI-7116203,EBI-12021848
DPF2 [Q92785]6EBI-7116203,EBI-359932
DUSP13 [Q9UII6]3EBI-7116203,EBI-749800
EAF1 [Q96JC9]3EBI-7116203,EBI-769261
EIF3D [O15371]3EBI-7116203,EBI-353818
ELOA2 [Q8IYF1]5EBI-7116203,EBI-741705
EMD [P50402]3EBI-7116203,EBI-489887
ENKD1 [Q9H0I2]3EBI-7116203,EBI-744099
EPHB3 [P54753]3EBI-7116203,EBI-968308
EPM2AIP1 [Q7L775]3EBI-7116203,EBI-6255981
FAM107A - isoform 4 [O95990-4]3EBI-7116203,EBI-11977223
FAM110A [Q9BQ89]3EBI-7116203,EBI-1752811
FAM110B [Q8TC76]3EBI-7116203,EBI-2558383
FAM124B - isoform 2 [Q9H5Z6-2]3EBI-7116203,EBI-11986315
FAM161B [Q96MY7]3EBI-7116203,EBI-7225287
FAM214B [Q7L5A3]3EBI-7116203,EBI-745689
FAM228A [Q86W67]3EBI-7116203,EBI-12958227
FAM90A1 [Q86YD7]3EBI-7116203,EBI-6658203
FBXO44 - isoform 2 [Q9H4M3-2]3EBI-7116203,EBI-12104696
FHL2 [Q14192]3EBI-7116203,EBI-701903
FHL3 [Q13643]3EBI-7116203,EBI-741101
FLYWCH1 [Q4VC44]3EBI-7116203,EBI-719415
FUT9 [Q9Y231]3EBI-7116203,EBI-3922408
GAS2L2 [Q8NHY3]3EBI-7116203,EBI-7960826
GAS8 [O95995]3EBI-7116203,EBI-1052570
GCM2 [O75603]3EBI-7116203,EBI-10188645
GEM [P55040]3EBI-7116203,EBI-744104
GGN [Q86UU5]6EBI-7116203,EBI-10259069
GNL3L [Q9NVN8]3EBI-7116203,EBI-746682
GOLGA1 [Q92805]3EBI-7116203,EBI-6164177
GPANK1 [O95872]3EBI-7116203,EBI-751540
GPATCH2L - isoform 2 [Q9NWQ4-1]3EBI-7116203,EBI-11959863
GPBP1 [Q86WP2]3EBI-7116203,EBI-2349758
GPKOW [Q92917]3EBI-7116203,EBI-746309
GPSM3 [Q9Y4H4]3EBI-7116203,EBI-347538
H2AW [Q7L7L0]3EBI-7116203,EBI-5325551
HASPIN [Q8TF76]3EBI-7116203,EBI-1237328
HCK - isoform 2 [P08631-2]3EBI-7116203,EBI-9834454
HDAC4 - isoform 2 [P56524-2]3EBI-7116203,EBI-11953488
HEXIM2 [Q96MH2]3EBI-7116203,EBI-5460660
HEY2 [Q9UBP5]3EBI-7116203,EBI-750630
HNRNPH2 [P55795]3EBI-7116203,EBI-352823
HOXB5 [P09067]3EBI-7116203,EBI-3893317
HOXC8 [P31273]3EBI-7116203,EBI-1752118
HSF2 [Q03933]3EBI-7116203,EBI-2556750
IER2 [Q9BTL4]3EBI-7116203,EBI-2806011
IL16 - isoform 2 [Q14005-2]3EBI-7116203,EBI-17178971
INO80B [Q9C086]3EBI-7116203,EBI-715611
INPP5J [Q15735]3EBI-7116203,EBI-10236940
INSYN2A [Q6ZSG2]3EBI-7116203,EBI-12146621
IPMK [Q8NFU5]3EBI-7116203,EBI-11347579
IQCC [Q4KMZ1]3EBI-7116203,EBI-12206419
ITGB3BP [Q13352]3EBI-7116203,EBI-712105
JRK - isoform 2 [O75564-2]3EBI-7116203,EBI-17181882
KANK2 [Q63ZY3]3EBI-7116203,EBI-2556193
KAT5 [Q92993]3EBI-7116203,EBI-399080
KIAA0408 [Q6ZU52]5EBI-7116203,EBI-739493
KIF24 - isoform 2 [Q5T7B8-2]3EBI-7116203,EBI-10213781
KIF5B [P33176]3EBI-7116203,EBI-355878
KIF9 [Q9HAQ2]3EBI-7116203,EBI-8472129
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-7116203,EBI-14069005
KLF4 [O43474]3EBI-7116203,EBI-7232405
L3MBTL2 [Q969R5]3EBI-7116203,EBI-739909
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-7116203,EBI-11985629
L3MBTL4 - isoform 2 [Q8NA19-2]3EBI-7116203,EBI-12778187
LAGE3 [Q14657]3EBI-7116203,EBI-1052105
LAS2 [Q8IYD9]3EBI-7116203,EBI-749878
LEP [P41159]3EBI-7116203,EBI-12994693
LGALS4 [P56470]3EBI-7116203,EBI-720805
LMO4 [P61968]3EBI-7116203,EBI-2798728
LNX1 [Q8TBB1]3EBI-7116203,EBI-739832
LRRC29 [Q8WV35]3EBI-7116203,EBI-10276755
LRRC56 [Q8IYG6]3EBI-7116203,EBI-14752528
LRRN4 [Q8WUT4]3EBI-7116203,EBI-745046
LUZP4 [Q9P127]3EBI-7116203,EBI-10198848
MAGED1 [Q9Y5V3]3EBI-7116203,EBI-716006
MAGOHB [Q96A72]3EBI-7116203,EBI-746778
MARCHF7 [Q9H992]3EBI-7116203,EBI-949983
MEF2A - isoform 5 [Q02078-5]3EBI-7116203,EBI-12232917
MFAP1 [P55081]3EBI-7116203,EBI-1048159
MGC50722 [Q8IVT4]3EBI-7116203,EBI-14086479
MISP [Q8IVT2]3EBI-7116203,EBI-2555085
MKRN3 [Q13064]3EBI-7116203,EBI-2340269
MMTAG2 [Q9BU76]3EBI-7116203,EBI-742459
MVB12A [Q96EY5]3EBI-7116203,EBI-4290865
MYOZ3 [Q8TDC0]3EBI-7116203,EBI-5662487
NAB2 [Q15742]3EBI-7116203,EBI-8641936
NCK2 [O43639]3EBI-7116203,EBI-713635
NFIL3 [Q16649]3EBI-7116203,EBI-3951858
NHSL2 [Q5HYW2]3EBI-7116203,EBI-2859639
NME4 [O00746]3EBI-7116203,EBI-744871
NPPA [P01160]3EBI-7116203,EBI-953859
NSMF - isoform 2 [Q6X4W1-2]3EBI-7116203,EBI-12028784
NUDT10 [Q8NFP7]3EBI-7116203,EBI-726826
NXF1 [Q9UBU9]3EBI-7116203,EBI-398874
ODF3B [A8MYP8]3EBI-7116203,EBI-12010090
ODF3L2 [Q3SX64]3EBI-7116203,EBI-6660184
OPTN [Q96CV9]3EBI-7116203,EBI-748974
P2RX7 [Q99572]3EBI-7116203,EBI-1753251
PAAT [Q9H8K7]3EBI-7116203,EBI-714785
PAK6 [Q9NQU5]3EBI-7116203,EBI-1053685
PAPSS2 [O95340]3EBI-7116203,EBI-1053912
PARD6B [Q9BYG5]3EBI-7116203,EBI-295391
PDLIM7 [Q9NR12]3EBI-7116203,EBI-350517
PICK1 [Q9NRD5]3EBI-7116203,EBI-79165
PKD2 [Q13563]3EBI-7116203,EBI-7813714
PKN1 [Q16512]3EBI-7116203,EBI-602382
PKP1 - isoform 1 [Q13835-2]3EBI-7116203,EBI-9087684
PLB1 - isoform 2 [Q6P1J6-2]3EBI-7116203,EBI-10694821
PLEKHA2 [Q9HB19]3EBI-7116203,EBI-4401947
PLEKHA7 - isoform 2 [Q6IQ23-2]3EBI-7116203,EBI-12069346
PNMA5 [Q96PV4]3EBI-7116203,EBI-10171633
POGZ [Q7Z3K3]3EBI-7116203,EBI-1389308
POLDIP3 [Q8WUT1]3EBI-7116203,EBI-10276663
POMC [P01189]6EBI-7116203,EBI-12219503
PPM1K [Q8N3J5]3EBI-7116203,EBI-3923368
PPP1R18 [Q6NYC8]3EBI-7116203,EBI-2557469
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-7116203,EBI-12000762
PRPF18 [Q99633]3EBI-7116203,EBI-2798416
PRPF3 [O43395]3EBI-7116203,EBI-744322
PRPF31 [Q8WWY3]3EBI-7116203,EBI-1567797
PRR5L [Q6MZQ0]3EBI-7116203,EBI-1567866
PSMA1 [P25786]3EBI-7116203,EBI-359352
PSTPIP1 [O43586]3EBI-7116203,EBI-1050964
RAB11FIP2 [Q7L804]3EBI-7116203,EBI-1049676
RAB36 [O95755]3EBI-7116203,EBI-12404625
RAB3IL1 [Q8TBN0]3EBI-7116203,EBI-743796
RAD51D [O75771]3EBI-7116203,EBI-1055693
RALY [Q53GL6]3EBI-7116203,EBI-9512693
RBM17 [Q96I25]3EBI-7116203,EBI-740272
RBM41 [Q96IZ5]3EBI-7116203,EBI-740773
RBM48 [Q5RL73]3EBI-7116203,EBI-473821
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-7116203,EBI-1504830
REXO4 [Q9GZR2]3EBI-7116203,EBI-2856313
RIBC1 [Q8N443]3EBI-7116203,EBI-10265323
RIN1 [Q13671]3EBI-7116203,EBI-366017
RNF135 [Q8IUD6]3EBI-7116203,EBI-9916363
RNF169 [Q8NCN4]3EBI-7116203,EBI-6380946
ROBO3 [Q96HH0]3EBI-7116203,EBI-10288358
RPS28 [P62857]3EBI-7116203,EBI-353027
RTP5 [Q14D33]3EBI-7116203,EBI-10217913
SAMD4A - isoform 3 [Q9UPU9-3]3EBI-7116203,EBI-11986417
SAPCD1 - isoform 2 [Q5SSQ6-2]3EBI-7116203,EBI-13072754
SART1 [O43290]6EBI-7116203,EBI-607761
SAXO1 [Q8IYX7]3EBI-7116203,EBI-3957636
SCNM1 [Q9BWG6]3EBI-7116203,EBI-748391
SDCBP [O00560]3EBI-7116203,EBI-727004
SELENOV [P59797]3EBI-7116203,EBI-10216195
SEMA3B - isoform 2 [Q13214-2]3EBI-7116203,EBI-11017428
SEMA4C [Q9C0C4]3EBI-7116203,EBI-10303490
SEPTIN1 [Q8WYJ6]3EBI-7116203,EBI-693002
SEPTIN9 - isoform 2 [Q9UHD8-2]3EBI-7116203,EBI-851564
SETDB1 - isoform 3 [Q15047-3]3EBI-7116203,EBI-11149962
SH2D4A [Q9H788]3EBI-7116203,EBI-747035
SHFL - isoform 4 [Q9NUL5-4]3EBI-7116203,EBI-11955083
SHISA6 [Q6ZSJ9]3EBI-7116203,EBI-12037847
SLAIN1 [Q8ND83]3EBI-7116203,EBI-10269374
SLC6A1 [P30531]3EBI-7116203,EBI-9071694
SMARCB1 - isoform B [Q12824-2]3EBI-7116203,EBI-358436
SMARCD1 [Q96GM5]3EBI-7116203,EBI-358489
SMG9 [Q9H0W8]3EBI-7116203,EBI-2872322
SMRP1 [Q8NCR6]3EBI-7116203,EBI-10269322
SNAPC1 [Q16533]3EBI-7116203,EBI-11915024
SNW1 [Q13573]3EBI-7116203,EBI-632715
SNX18 [Q96RF0]3EBI-7116203,EBI-298169
SNX21 - isoform 2 [Q969T3-2]3EBI-7116203,EBI-12142321
SPATA22 [Q8NHS9]6EBI-7116203,EBI-7067260
SPEG - isoform 3 [Q15772-4]3EBI-7116203,EBI-12175897
SPG7 [Q9UQ90]3EBI-7116203,EBI-717201
SPRED1 [Q7Z699]3EBI-7116203,EBI-5235340
SPRY1 [O43609]3EBI-7116203,EBI-3866665
SYNGAP1 [Q96PV0]3EBI-7116203,EBI-2682386
TAB2 [Q9NYJ8]3EBI-7116203,EBI-358708
TAGAP [Q8N103]3EBI-7116203,EBI-12136823
TASOR2 [Q5VWN6]3EBI-7116203,EBI-745958
TBC1D1 [Q86TI0]3EBI-7116203,EBI-1644036
TBC1D30 - isoform 2 [Q9Y2I9-2]3EBI-7116203,EBI-17455779
TCEA2 [Q15560]3EBI-7116203,EBI-710310
TCF19 [Q9Y242]3EBI-7116203,EBI-7413767
TEPSIN [Q96N21]3EBI-7116203,EBI-11139477
TFIP11 [Q9UBB9]3EBI-7116203,EBI-1105213
THAP6 [Q8TBB0]3EBI-7116203,EBI-3925505
TMEFF2 [Q9UIK5]3EBI-7116203,EBI-11423693
TMSB4X [P62328]3EBI-7116203,EBI-712598
TNS4 [Q8IZW8]3EBI-7116203,EBI-7543499
TOX2 - isoform 3 [Q96NM4-3]5EBI-7116203,EBI-12815137
TP53BP2 [Q05BL1]3EBI-7116203,EBI-11952721
TRAF5 [O00463]3EBI-7116203,EBI-523498
TSEN15 [Q8WW01]3EBI-7116203,EBI-372432
TSGA10IP [Q3SY00]3EBI-7116203,EBI-10241197
TSHZ3 [Q63HK5]3EBI-7116203,EBI-9053916
TTC23 - isoform 3 [Q5W5X9-3]3EBI-7116203,EBI-9090990
TTC9C [Q8N5M4]3EBI-7116203,EBI-2851213
TULP3 [O75386]3EBI-7116203,EBI-5357290
TUSC5 [A5PKU2]3EBI-7116203,EBI-11988865
UPRT [Q96BW1]3EBI-7116203,EBI-742943
USP20 [A0A024R8A9]3EBI-7116203,EBI-14096082
VEZF1 [Q14119]3EBI-7116203,EBI-11980193
VHL - isoform 2 [P40337-2]6EBI-7116203,EBI-12157263
VPS72 [Q15906]3EBI-7116203,EBI-399189
WASF1 [Q92558]3EBI-7116203,EBI-1548747
WDR25 - isoform 2 [Q64LD2-2]3EBI-7116203,EBI-12032042
WDYHV1 [Q96HA8]3EBI-7116203,EBI-741158
ZBTB16 [Q05516]3EBI-7116203,EBI-711925
ZBTB42 [B2RXF5]3EBI-7116203,EBI-12287587
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-7116203,EBI-14104088
ZCWPW2 [Q504Y3]3EBI-7116203,EBI-12274792
ZFC3H1 [G3V1X1]6EBI-7116203,EBI-6448783
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-7116203,EBI-10183064
ZNF185 [O15231]3EBI-7116203,EBI-6874731
ZNF250 - isoform 3 [P15622-3]3EBI-7116203,EBI-10177272
ZNF417 [Q8TAU3]3EBI-7116203,EBI-740727
ZNF511 [Q8NB15]3EBI-7116203,EBI-10269136
ZNF564 [Q8TBZ8]3EBI-7116203,EBI-10273713
ZNF581 [Q9P0T4]6EBI-7116203,EBI-745520
ZNF587 [Q96SQ5]3EBI-7116203,EBI-6427977
ZNF648 [Q5T619]3EBI-7116203,EBI-11985915
ZNF688 [P0C7X2]3EBI-7116203,EBI-4395732
ZNF774 [Q6NX45]3EBI-7116203,EBI-10251462
ZNF835 [Q9Y2P0]3EBI-7116203,EBI-5667516
ZNF84 [P51523]3EBI-7116203,EBI-2849074
ZNF844 [Q08AG5]3EBI-7116203,EBI-10225757

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116260, 5 interactors

Protein interaction database and analysis system

More...
IntActi
O75031, 285 interactors

Molecular INTeraction database

More...
MINTi
O75031

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291560

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O75031, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili49 – 122Sequence analysisAdd BLAST74

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSZY, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008490

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75031

Identification of Orthologs from Complete Genome Data

More...
OMAi
AEVCLHA

Database of Orthologous Groups

More...
OrthoDBi
1093123at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75031

TreeFam database of animal gene trees

More...
TreeFami
TF331782

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR039584, HSF2BP

The PANTHER Classification System

More...
PANTHERi
PTHR15434, PTHR15434, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75031-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEAGAAEEA CRHMGTKEEF VKVRKKDLER LTTEVMQIRD FLPRILNGEV
60 70 80 90 100
LESFQKLKIV EKNLERKEQE LEQLKMDCEH FKARLETVQA DNIREKKEKL
110 120 130 140 150
ALRQQLNEAK QQLLQQAEYC TEMGAAACTL LWGVSSSEEV VKAILGGDKA
160 170 180 190 200
LKFFSITGQT MESFVKSLDG DVQELDSDES QFVFALAGIV TNVAAIACGR
210 220 230 240 250
EFLVNSSRVL LDTILQLLGD LKPGQCTKLK VLMLMSLYNV SINLKGLKYI
260 270 280 290 300
SESPGFIPLL WWLLSDPDAE VCLHVLRLVQ SVVLEPEVFS KSASEFRSSL
310 320 330
PLQRILAMSK SRNPRLQTAA QELLEDLRTL EHNV
Length:334
Mass (Da):37,645
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF07981999F576E86
GO
Isoform 2 (identifier: O75031-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Show »
Length:259
Mass (Da):28,846
Checksum:iEC2D2F3ECBF6FF2B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JSF2C9JSF2_HUMAN
Heat shock factor 2-binding protein
HSF2BP
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti232 – 233LM → YG in BAA95539 (PubMed:10830953).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0541581 – 75Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007131 mRNA Translation: BAA31967.1
AK301795 mRNA Translation: BAG63248.1
AP001050 Genomic DNA No translation available.
AP001751 Genomic DNA Translation: BAA95537.1
AP001752 Genomic DNA Translation: BAA95539.1
BC000153 mRNA Translation: AAH00153.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13697.1 [O75031-1]

NCBI Reference Sequences

More...
RefSeqi
NP_008962.1, NM_007031.1 [O75031-1]
XP_011527748.1, XM_011529446.2 [O75031-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291560; ENSP00000291560; ENSG00000160207 [O75031-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11077

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11077

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007131 mRNA Translation: BAA31967.1
AK301795 mRNA Translation: BAG63248.1
AP001050 Genomic DNA No translation available.
AP001751 Genomic DNA Translation: BAA95537.1
AP001752 Genomic DNA Translation: BAA95539.1
BC000153 mRNA Translation: AAH00153.1
CCDSiCCDS13697.1 [O75031-1]
RefSeqiNP_008962.1, NM_007031.1 [O75031-1]
XP_011527748.1, XM_011529446.2 [O75031-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116260, 5 interactors
IntActiO75031, 285 interactors
MINTiO75031
STRINGi9606.ENSP00000291560

PTM databases

iPTMnetiO75031
PhosphoSitePlusiO75031

Polymorphism and mutation databases

BioMutaiHSF2BP

Proteomic databases

EPDiO75031
MassIVEiO75031
PaxDbiO75031
PeptideAtlasiO75031
PRIDEiO75031
ProteomicsDBi49714 [O75031-1]
5404

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
9965, 100 antibodies

The DNASU plasmid repository

More...
DNASUi
11077

Genome annotation databases

EnsembliENST00000291560; ENSP00000291560; ENSG00000160207 [O75031-1]
GeneIDi11077
KEGGihsa:11077

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11077
DisGeNETi11077
EuPathDBiHostDB:ENSG00000160207.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HSF2BP
HGNCiHGNC:5226, HSF2BP
HPAiENSG00000160207, Tissue enriched (testis)
MIMi604554, gene
neXtProtiNX_O75031
OpenTargetsiENSG00000160207
PharmGKBiPA29495

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QSZY, Eukaryota
GeneTreeiENSGT00390000008490
InParanoidiO75031
OMAiAEVCLHA
OrthoDBi1093123at2759
PhylomeDBiO75031
TreeFamiTF331782

Enzyme and pathway databases

PathwayCommonsiO75031

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11077, 11 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HSF2BP, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11077
PharosiO75031, Tdark

Protein Ontology

More...
PROi
PR:O75031
RNActiO75031, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160207, Expressed in testis and 101 other tissues
ExpressionAtlasiO75031, baseline and differential
GenevisibleiO75031, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR039584, HSF2BP
PANTHERiPTHR15434, PTHR15434, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHSF2B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75031
Secondary accession number(s): B4DX36
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: August 12, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again