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UniProtKB - O75023 (LIRB5_HUMAN)

Entry version 155 (02 Dec 2020)
Sequence version 1 (01 Nov 1998)
Previous versions | rss
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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 5

Gene

LILRB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as receptor for class I MHC antigens.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O75023

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 5
Alternative name(s):
CD85 antigen-like family member C
Leukocyte immunoglobulin-like receptor 8
Short name:
LIR-8
CD_antigen: CD85c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LILRB5
Synonyms:LIR8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000105609.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:6609, LILRB5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604814, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75023

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 458ExtracellularSequence analysisAdd BLAST435
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei459 – 479HelicalSequence analysisAdd BLAST21
Topological domaini480 – 590CytoplasmicSequence analysisAdd BLAST111

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10990

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30383

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O75023, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LILRB5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001482524 – 590Leukocyte immunoglobulin-like receptor subfamily B member 5Add BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 195PROSITE-ProRule annotation
Disulfide bondi244 ↔ 295PROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi344 ↔ 395PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei514PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75023

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O75023

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75023

PeptideAtlas

More...PeptideAtlasi		O75023

PRoteomics IDEntifications database

More...PRIDEi		O75023

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49699 [O75023-1]
49700 [O75023-2]
49701 [O75023-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O75023, 6 sites, 1 O-linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75023

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75023

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in a natural killer (NK) cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105609, Expressed in tendon and 132 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75023, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105609, Tissue enhanced (breast, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116186, 1 interactor

Protein interaction database and analysis system

More...IntActi		O75023, 1 interactor

Molecular INTeraction database

More...MINTi		O75023

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000406478

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O75023, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75023

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 116Ig-like C2-type 1Add BLAST90
Domaini111 – 228Ig-like C2-type 2Add BLAST118
Domaini224 – 313Ig-like C2-type 3Add BLAST90
Domaini337 – 418Ig-like C2-type 4Add BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi552 – 557ITIM motif 16
Motifi582 – 587ITIM motif 26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RYEX, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021100_2_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75023

Database of Orthologous Groups

More...OrthoDBi		1000446at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75023

TreeFam database of animal gene trees

More...TreeFami		TF336644

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00047, ig, 2 hits
PF13895, Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75023-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ 
        60         70         80         90        100
GPLETEEYRL DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY 
       110        120        130        140        150
ETPAGWSEPS DPLELVATGF YAEPTLLALP SPVVASGGNV TLQCDTLDGL 
       160        170        180        190        200
LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF PVGPVTPSCR WRFRCYYYYR 
       210        220        230        240        250
KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL TLQCRSDVGY 
       260        270        280        290        300
DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN 
       310        320        330        340        350
LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI 
       360        370        380        390        400
DTFFLTKEGA AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR 
       410        420        430        440        450
SYPYLLSSPS YPQELVVSGP SGDPSLSPTG STPTPGPEDQ PLTPTGLDPQ 
       460        470        480        490        500
SGLGRHLGVV TGVSVAFVLL LFLLLFLLLR HRHQSKHRTS AHFYRPAGAA 
       510        520        530        540        550
GPEPKDQGLQ KRASPVADIQ EEILNAAVKD TQPKDGVEMD ARAAASEAPQ 
       560        570        580        590
DVTYAQLHSL TLRREATEPP PSQEREPPAE PSIYAPLAIH
Length:590
Mass (Da):64,126
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E7AB249F12E44CD
GO
Isoform 2 (identifier: O75023-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-218: Missing.
     435-435: P → PA

Show »
Length:491
Mass (Da):52,969
Checksum:iBDE0FEC49A5CD587
GO
Isoform 3 (identifier: O75023-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-435: P → PA

Show »
Length:591
Mass (Da):64,197
Checksum:i201FDB50AB43ACF7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JMX5A0A0G2JMX5_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB5
622Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPM8A0A0G2JPM8_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB5
643Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNP3A0A0G2JNP3_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB5
643Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNY7A0A0G2JNY7_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB5
490Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMR1A0A0G2JMR1_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB5
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNF6A0A0G2JNF6_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB5
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNR0A0A0G2JNR0_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB5
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12G → W in AK223296 (PubMed:14702039).Curated1
Sequence conflicti255L → R in AK223296 (PubMed:14702039).Curated1
Sequence conflicti355L → S in BAB71361 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061316247D → G. Corresponds to variant dbSNP:rs12975366Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008461119 – 218Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_008462435P → PA in isoform 2 and isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF025534 mRNA Translation: AAB87668.1
AK057072 mRNA Translation: BAB71361.1
AK223296 mRNA No translation available.
AC010492 Genomic DNA No translation available.
BC025704 mRNA Translation: AAH25704.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12885.1 [O75023-1]
CCDS42611.1 [O75023-2]
CCDS46176.1 [O75023-3]

NCBI Reference Sequences

More...RefSeqi		NP_001074911.1, NM_001081442.2
NP_001074912.1, NM_001081443.2
NP_001291386.1, NM_001304457.1
NP_006831.1, NM_006840.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000316219; ENSP00000320390; ENSG00000105609
ENST00000345866; ENSP00000263430; ENSG00000105609
ENST00000449561; ENSP00000406478; ENSG00000105609
ENST00000610764; ENSP00000479022; ENSG00000277414 [O75023-2]
ENST00000614318; ENSP00000483649; ENSG00000278437 [O75023-3]
ENST00000615429; ENSP00000482404; ENSG00000274311 [O75023-2]
ENST00000615837; ENSP00000478835; ENSG00000277414 [O75023-1]
ENST00000616618; ENSP00000478912; ENSG00000274311 [O75023-3]
ENST00000616805; ENSP00000483502; ENSG00000273991 [O75023-1]
ENST00000617355; ENSP00000483481; ENSG00000274311 [O75023-1]
ENST00000619608; ENSP00000479413; ENSG00000277414 [O75023-3]
ENST00000620714; ENSP00000480909; ENSG00000273991 [O75023-2]
ENST00000621193; ENSP00000482062; ENSG00000278437 [O75023-1]
ENST00000621867; ENSP00000481263; ENSG00000273991 [O75023-3]
ENST00000622596; ENSP00000482535; ENSG00000278437 [O75023-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10990

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10990

UCSC genome browser

More...UCSCi		uc002qex.4, human [O75023-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025534 mRNA Translation: AAB87668.1
AK057072 mRNA Translation: BAB71361.1
AK223296 mRNA No translation available.
AC010492 Genomic DNA No translation available.
BC025704 mRNA Translation: AAH25704.1
CCDSiCCDS12885.1 [O75023-1]
CCDS42611.1 [O75023-2]
CCDS46176.1 [O75023-3]
RefSeqiNP_001074911.1, NM_001081442.2
NP_001074912.1, NM_001081443.2
NP_001291386.1, NM_001304457.1
NP_006831.1, NM_006840.4

3D structure databases

SMRiO75023
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116186, 1 interactor
IntActiO75023, 1 interactor
MINTiO75023
STRINGi9606.ENSP00000406478

PTM databases

GlyGeniO75023, 6 sites, 1 O-linked glycan (3 sites)
iPTMnetiO75023
PhosphoSitePlusiO75023

Polymorphism and mutation databases

BioMutaiLILRB5

Proteomic databases

jPOSTiO75023
MassIVEiO75023
PaxDbiO75023
PeptideAtlasiO75023
PRIDEiO75023
ProteomicsDBi49699 [O75023-1]
49700 [O75023-2]
49701 [O75023-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2302, 129 antibodies

The DNASU plasmid repository

More...DNASUi		10990

Genome annotation databases

EnsembliENST00000316219; ENSP00000320390; ENSG00000105609
ENST00000345866; ENSP00000263430; ENSG00000105609
ENST00000449561; ENSP00000406478; ENSG00000105609
ENST00000610764; ENSP00000479022; ENSG00000277414 [O75023-2]
ENST00000614318; ENSP00000483649; ENSG00000278437 [O75023-3]
ENST00000615429; ENSP00000482404; ENSG00000274311 [O75023-2]
ENST00000615837; ENSP00000478835; ENSG00000277414 [O75023-1]
ENST00000616618; ENSP00000478912; ENSG00000274311 [O75023-3]
ENST00000616805; ENSP00000483502; ENSG00000273991 [O75023-1]
ENST00000617355; ENSP00000483481; ENSG00000274311 [O75023-1]
ENST00000619608; ENSP00000479413; ENSG00000277414 [O75023-3]
ENST00000620714; ENSP00000480909; ENSG00000273991 [O75023-2]
ENST00000621193; ENSP00000482062; ENSG00000278437 [O75023-1]
ENST00000621867; ENSP00000481263; ENSG00000273991 [O75023-3]
ENST00000622596; ENSP00000482535; ENSG00000278437 [O75023-2]
GeneIDi10990
KEGGihsa:10990
UCSCiuc002qex.4, human [O75023-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10990
DisGeNETi10990
EuPathDBiHostDB:ENSG00000105609.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		LILRB5
HGNCiHGNC:6609, LILRB5
HPAiENSG00000105609, Tissue enhanced (breast, lymphoid tissue)
MIMi604814, gene
neXtProtiNX_O75023
PharmGKBiPA30383

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RYEX, Eukaryota
HOGENOMiCLU_021100_2_3_1
InParanoidiO75023
OrthoDBi1000446at2759
PhylomeDBiO75023
TreeFamiTF336644

Enzyme and pathway databases

PathwayCommonsiO75023
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10990, 8 hits in 840 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LILRB5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10990
PharosiO75023, Tbio

Protein Ontology

More...PROi		PR:O75023
RNActiO75023, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105609, Expressed in tendon and 132 other tissues
GenevisibleiO75023, HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin
PfamiView protein in Pfam
PF00047, ig, 2 hits
PF13895, Ig_2, 1 hit
SMARTiView protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 3 hits
SUPFAMiSSF48726, SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIRB5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75023
Secondary accession number(s): Q8N760
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1998
Last modified: December 2, 2020
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
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