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UniProtKB - O75022 (LIRB3_HUMAN)

Protein

Leukocyte immunoglobulin-like receptor subfamily B member 3

Gene

LILRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).By similarity

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

GO - Molecular functioni

  • signaling receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 3
Short name:
LIR-3
Short name:
Leukocyte immunoglobulin-like receptor 3
Alternative name(s):
CD85 antigen-like family member A
Immunoglobulin-like transcript 5
Short name:
ILT-5
Monocyte inhibitory receptor HL9
CD_antigen: CD85a
Gene namesi
Name:LILRB3
Synonyms:ILT5, LIR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000204577.11
HGNCiHGNC:6607 LILRB3
MIMi604820 gene
neXtProtiNX_O75022

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 443ExtracellularSequence analysisAdd BLAST420
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 631CytoplasmicSequence analysisAdd BLAST167

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi102725035
107987462
11025
PharmGKBiPA30381

Polymorphism and mutation databases

BioMutaiLILRB3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001482224 – 631Leukocyte immunoglobulin-like receptor subfamily B member 3Add BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Disulfide bondi245 ↔ 296PROSITE-ProRule annotation
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi345 ↔ 396PROSITE-ProRule annotation
Modified residuei595Phosphotyrosine; by LYNBy similarity1
Modified residuei625Phosphotyrosine; by LYNBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO75022
PeptideAtlasiO75022
PRIDEiO75022
ProteomicsDBi49696
49697 [O75022-2]
49698 [O75022-3]

PTM databases

iPTMnetiO75022
PhosphoSitePlusiO75022

Expressioni

Tissue specificityi

Detected in monocytes and B-cells.1 Publication

Gene expression databases

BgeeiENSG00000204577 Expressed in 225 organ(s), highest expression level in blood
CleanExiHS_LILRB3
ExpressionAtlasiO75022 baseline and differential
GenevisibleiO75022 HS

Interactioni

Subunit structurei

Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2.By similarity

Binary interactionsi

Protein-protein interaction databases

IntActiO75022, 7 interactors
STRINGi9606.ENSP00000245620

Structurei

3D structure databases

ProteinModelPortaliO75022
SMRiO75022
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 100Ig-like C2-type 1Add BLAST59
Domaini111 – 229Ig-like C2-type 2Add BLAST119
Domaini225 – 314Ig-like C2-type 3Add BLAST90
Domaini338 – 419Ig-like C2-type 4Add BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi512 – 517ITIM motif 16
Motifi593 – 598ITIM motif 26
Motifi623 – 628ITIM motif 36

Domaini

Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK.By similarity

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJD Eukaryota
ENOG41116BR LUCA
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiO75022
KOiK06512
PhylomeDBiO75022
TreeFamiTF336644

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75022-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ 
        60         70         80         90        100
GSQEAQEYRL HKEGSPEPLD RNNPLEPKNK ARFSIPSMTE HHAGRYRCHY 
       110        120        130        140        150
YSSAGWSEPS DPLEMVMTGA YSKPTLSALP SPVVASGGNM TLRCGSQKGY 
       160        170        180        190        200
HHFVLMKEGE HQLPRTLDSQ QLHSRGFQAL FPVGPVTPSH RWRFTCYYYY 
       210        220        230        240        250
TNTPWVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS LTLQCGSDVG 
       260        270        280        290        300
YNRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSPSN GGQYRCYGAH 
       310        320        330        340        350
NLSSEWSAPS DPLNILMAGQ IYDTVSLSAQ PGPTVASGEN VTLLCQSWWQ 
       360        370        380        390        400
FDTFLLTKEG AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSY 
       410        420        430        440        450
SSNPHLLSHP SEPLELVVSG HSGGSSLPPT GPPSTPGLGR YLEVLIGVSV 
       460        470        480        490        500
AFVLLLFLLL FLLLRRQRHS KHRTSDQRKT DFQRPAGAAE TEPKDRGLLR 
       510        520        530        540        550
RSSPAADVQE ENLYAAVKDT QSEDRVELDS QSPHDEDPQA VTYAPVKHSS 
       560        570        580        590        600
PRREMASPPS SLSGEFLDTK DRQVEEDRQM DTEAAASEAS QDVTYAQLHS 
       610        620        630 
LTLRRKATEP PPSQEGEPPA EPSIYATLAI H
Length:631
Mass (Da):69,386
Last modified:November 30, 2010 - v3
Checksum:i595B1BD5283A7E3E
GO
Isoform 2 (identifier: O75022-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-437: G → GGPEDQPLNPPGSGPQNG

Note: No experimental confirmation available.
Show »
Length:648
Mass (Da):71,029
Checksum:i3FAEB2EEC21105BD
GO
Isoform 3 (identifier: O75022-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     530-530: S → SQ

Show »
Length:632
Mass (Da):69,514
Checksum:iFF29920A9E55897D
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JPK5A0A0G2JPK5_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
489Annotation score:
A0A0G2JN08A0A0G2JN08_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
489Annotation score:
F8W6G6F8W6G6_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
643Annotation score:
A0A0G2JNB3A0A0G2JNB3_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
632Annotation score:
A0A0G2JLT7A0A0G2JLT7_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
631Annotation score:
A0A0G2JN67A0A0G2JN67_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
648Annotation score:
A0A0G2JM46A0A0G2JM46_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
632Annotation score:
A0A0G2JMZ3A0A0G2JMZ3_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
649Annotation score:
A0A0G2JMM1A0A0G2JMM1_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
648Annotation score:
A0A0G2JPG2A0A0G2JPG2_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
455Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53Q → L in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti53Q → L in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti61H → D in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti61H → D in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti115M → L in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti115M → L in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti120A → F in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti149G → R in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti175R → G in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti175R → G in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti187T → N in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti187T → N in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti187T → N in AAP30716 (Ref. 3) Curated1
Sequence conflicti201T → M in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti201T → M in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti205W → R in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti252N → D in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti252N → D in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti263D → A in AAP30716 (Ref. 3) Curated1
Sequence conflicti268P → S in AAP30716 (Ref. 3) Curated1
Sequence conflicti290N → H in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti409H → F in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti417V → M in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti525R → G in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti561S → P in AAB87667 (PubMed:9548455).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01700121V → M. Corresponds to variant dbSNP:rs1132588Ensembl.1
Natural variantiVAR_01700259R → Q1 PublicationCorresponds to variant dbSNP:rs678876Ensembl.1
Natural variantiVAR_01700369L → W. Corresponds to variant dbSNP:rs80077296Ensembl.1
Natural variantiVAR_01700490E → Q1 PublicationCorresponds to variant dbSNP:rs1052963Ensembl.1
Natural variantiVAR_017005122S → N1 PublicationCorresponds to variant dbSNP:rs200783306Ensembl.1
Natural variantiVAR_079582171Q → H1 PublicationCorresponds to variant dbSNP:rs557014003Ensembl.1
Natural variantiVAR_017006205W → Q Requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs1063805Ensembl.1
Natural variantiVAR_017009400Y → F. Corresponds to variant dbSNP:rs8105096Ensembl.1
Natural variantiVAR_017008400Y → H. Corresponds to variant dbSNP:rs1052992Ensembl.1
Natural variantiVAR_017007400Y → R Requires 2 nucleotide substitutions. 2 Publications1
Natural variantiVAR_017010405H → Y1 PublicationCorresponds to variant dbSNP:rs1132604Ensembl.1
Natural variantiVAR_017012539Q → H1 PublicationCorresponds to variant dbSNP:rs1053002Ensembl.1
Natural variantiVAR_017013574V → A1 PublicationCorresponds to variant dbSNP:rs1053008Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008459437G → GGPEDQPLNPPGSGPQNG in isoform 2. Curated1
Alternative sequenceiVSP_040126530S → SQ in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91928 mRNA Translation: AAB68668.1
AF025533 mRNA Translation: AAB87667.1
AF256195 Genomic DNA Translation: AAP30716.1
AC010492 Genomic DNA No translation available.
AC012314 Genomic DNA No translation available.
CCDSiCCDS33105.1 [O75022-1]
CCDS46175.1 [O75022-3]
RefSeqiXP_006726377.1, XM_006726314.3
XP_016885785.1, XM_017030296.1 [O75022-3]
XP_016885786.1, XM_017030297.1 [O75022-1]
UniGeneiHs.631592
Hs.688335

Genome annotation databases

EnsembliENST00000245620; ENSP00000245620; ENSG00000204577
ENST00000391750; ENSP00000375630; ENSG00000204577
ENST00000611086; ENSP00000483625; ENSG00000274587 [O75022-1]
ENST00000613698; ENSP00000479234; ENSG00000275019
ENST00000621210; ENSP00000484925; ENSG00000275019
GeneIDi102725035
107987462
KEGGihsa:102725035
hsa:107987462
UCSCiuc032icw.2 human [O75022-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91928 mRNA Translation: AAB68668.1
AF025533 mRNA Translation: AAB87667.1
AF256195 Genomic DNA Translation: AAP30716.1
AC010492 Genomic DNA No translation available.
AC012314 Genomic DNA No translation available.
CCDSiCCDS33105.1 [O75022-1]
CCDS46175.1 [O75022-3]
RefSeqiXP_006726377.1, XM_006726314.3
XP_016885785.1, XM_017030296.1 [O75022-3]
XP_016885786.1, XM_017030297.1 [O75022-1]
UniGeneiHs.631592
Hs.688335

3D structure databases

ProteinModelPortaliO75022
SMRiO75022
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO75022, 7 interactors
STRINGi9606.ENSP00000245620

PTM databases

iPTMnetiO75022
PhosphoSitePlusiO75022

Polymorphism and mutation databases

BioMutaiLILRB3

Proteomic databases

PaxDbiO75022
PeptideAtlasiO75022
PRIDEiO75022
ProteomicsDBi49696
49697 [O75022-2]
49698 [O75022-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245620; ENSP00000245620; ENSG00000204577
ENST00000391750; ENSP00000375630; ENSG00000204577
ENST00000611086; ENSP00000483625; ENSG00000274587 [O75022-1]
ENST00000613698; ENSP00000479234; ENSG00000275019
ENST00000621210; ENSP00000484925; ENSG00000275019
GeneIDi102725035
107987462
KEGGihsa:102725035
hsa:107987462
UCSCiuc032icw.2 human [O75022-1]

Organism-specific databases

DisGeNETi102725035
107987462
11025
EuPathDBiHostDB:ENSG00000204577.11
GeneCardsiLILRB3
H-InvDBiHIX0015438
HGNCiHGNC:6607 LILRB3
MIMi604820 gene
neXtProtiNX_O75022
PharmGKBiPA30381
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJD Eukaryota
ENOG41116BR LUCA
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiO75022
KOiK06512
PhylomeDBiO75022
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiLILRB3 human
PROiPR:O75022
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204577 Expressed in 225 organ(s), highest expression level in blood
CleanExiHS_LILRB3
ExpressionAtlasiO75022 baseline and differential
GenevisibleiO75022 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIRB3_HUMAN
AccessioniPrimary (citable) accession number: O75022
Secondary accession number(s): C9J1P3
, C9JIP1, O15471, Q86U49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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