UniProtKB - O75022 (LIRB3_HUMAN)
Protein
Leukocyte immunoglobulin-like receptor subfamily B member 3
Gene
LILRB3
Organism
Homo sapiens (Human)
Status
Functioni
May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).By similarity
Miscellaneous
Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.
GO - Molecular functioni
- signaling receptor activity Source: ProtInc
- transmembrane signaling receptor activity Source: ProtInc
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cell surface receptor signaling pathway Source: ProtInc
- defense response Source: ProtInc
- negative regulation of osteoclast differentiation Source: UniProtKB
- neutrophil degranulation Source: Reactome
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
Reactomei | R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-6798695 Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte immunoglobulin-like receptor subfamily B member 3Short name: LIR-3 Short name: Leukocyte immunoglobulin-like receptor 3 Alternative name(s): CD85 antigen-like family member A Immunoglobulin-like transcript 5 Short name: ILT-5 Monocyte inhibitory receptor HL9 CD_antigen: CD85a |
Gene namesi | Name:LILRB3 Synonyms:ILT5, LIR3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204577.11 |
HGNCi | HGNC:6607 LILRB3 |
MIMi | 604820 gene |
neXtProti | NX_O75022 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- secretory granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 443 | ExtracellularSequence analysisAdd BLAST | 420 | |
Transmembranei | 444 – 464 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 465 – 631 | CytoplasmicSequence analysisAdd BLAST | 167 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 102725035 107987462 11025 |
PharmGKBi | PA30381 |
Polymorphism and mutation databases
BioMutai | LILRB3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000014822 | 24 – 631 | Leukocyte immunoglobulin-like receptor subfamily B member 3Add BLAST | 608 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 98 | PROSITE-ProRule annotation | ||
Glycosylationi | 139 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 144 ↔ 196 | PROSITE-ProRule annotation | ||
Disulfide bondi | 245 ↔ 296 | PROSITE-ProRule annotation | ||
Glycosylationi | 280 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 301 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 340 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 345 ↔ 396 | PROSITE-ProRule annotation | ||
Modified residuei | 595 | Phosphotyrosine; by LYNBy similarity | 1 | |
Modified residuei | 625 | Phosphotyrosine; by LYNBy similarity | 1 |
Post-translational modificationi
Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | O75022 |
PaxDbi | O75022 |
PeptideAtlasi | O75022 |
PRIDEi | O75022 |
ProteomicsDBi | 49696 49697 [O75022-2] 49698 [O75022-3] |
PTM databases
iPTMneti | O75022 |
PhosphoSitePlusi | O75022 |
Expressioni
Tissue specificityi
Detected in monocytes and B-cells.1 Publication
Gene expression databases
Bgeei | ENSG00000204577 Expressed in 225 organ(s), highest expression level in blood |
ExpressionAtlasi | O75022 baseline and differential |
Genevisiblei | O75022 HS |
Interactioni
Subunit structurei
Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2.By similarity
Binary interactionsi
Protein-protein interaction databases
IntActi | O75022, 7 interactors |
STRINGi | 9606.ENSP00000245620 |
Structurei
3D structure databases
ProteinModelPortali | O75022 |
SMRi | O75022 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 100 | Ig-like C2-type 1Add BLAST | 59 | |
Domaini | 111 – 229 | Ig-like C2-type 2Add BLAST | 119 | |
Domaini | 225 – 314 | Ig-like C2-type 3Add BLAST | 90 | |
Domaini | 338 – 419 | Ig-like C2-type 4Add BLAST | 82 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 512 – 517 | ITIM motif 1 | 6 | |
Motifi | 593 – 598 | ITIM motif 2 | 6 | |
Motifi | 623 – 628 | ITIM motif 3 | 6 |
Domaini
Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK.By similarity
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IKJD Eukaryota ENOG41116BR LUCA |
HOGENOMi | HOG000234395 |
HOVERGENi | HBG074353 |
InParanoidi | O75022 |
KOi | K06512 |
OrthoDBi | 1000446at2759 |
PhylomeDBi | O75022 |
TreeFami | TF336644 |
Family and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 |
Pfami | View protein in Pfam PF13895 Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409 IG, 3 hits SM00408 IGc2, 3 hits |
SUPFAMi | SSF48726 SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O75022-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ
60 70 80 90 100
GSQEAQEYRL HKEGSPEPLD RNNPLEPKNK ARFSIPSMTE HHAGRYRCHY
110 120 130 140 150
YSSAGWSEPS DPLEMVMTGA YSKPTLSALP SPVVASGGNM TLRCGSQKGY
160 170 180 190 200
HHFVLMKEGE HQLPRTLDSQ QLHSRGFQAL FPVGPVTPSH RWRFTCYYYY
210 220 230 240 250
TNTPWVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS LTLQCGSDVG
260 270 280 290 300
YNRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSPSN GGQYRCYGAH
310 320 330 340 350
NLSSEWSAPS DPLNILMAGQ IYDTVSLSAQ PGPTVASGEN VTLLCQSWWQ
360 370 380 390 400
FDTFLLTKEG AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSY
410 420 430 440 450
SSNPHLLSHP SEPLELVVSG HSGGSSLPPT GPPSTPGLGR YLEVLIGVSV
460 470 480 490 500
AFVLLLFLLL FLLLRRQRHS KHRTSDQRKT DFQRPAGAAE TEPKDRGLLR
510 520 530 540 550
RSSPAADVQE ENLYAAVKDT QSEDRVELDS QSPHDEDPQA VTYAPVKHSS
560 570 580 590 600
PRREMASPPS SLSGEFLDTK DRQVEEDRQM DTEAAASEAS QDVTYAQLHS
610 620 630
LTLRRKATEP PPSQEGEPPA EPSIYATLAI H
Computationally mapped potential isoform sequencesi
There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JPK5 | A0A0G2JPK5_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB3 | 489 | Annotation score: | ||
A0A0G2JN08 | A0A0G2JN08_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB3 | 489 | Annotation score: | ||
F8W6G6 | F8W6G6_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB3 | 643 | Annotation score: | ||
A0A0G2JLT7 | A0A0G2JLT7_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB3 | 631 | Annotation score: | ||
A0A0G2JNB3 | A0A0G2JNB3_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB3 | 632 | Annotation score: | ||
A0A0G2JM46 | A0A0G2JM46_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB3 | 632 | Annotation score: | ||
A0A0G2JMM1 | A0A0G2JMM1_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB3 | 648 | Annotation score: | ||
A0A0G2JN67 | A0A0G2JN67_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB3 | 648 | Annotation score: | ||
A0A0G2JMZ3 | A0A0G2JMZ3_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB3 | 649 | Annotation score: | ||
A0A0G2JPG2 | A0A0G2JPG2_HUMAN | Leukocyte immunoglobulin-like recep... | LILRB3 | 455 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 53 | Q → L in AAB68668 (PubMed:9278324).Curated | 1 | |
Sequence conflicti | 53 | Q → L in AAB87667 (PubMed:9548455).Curated | 1 | |
Sequence conflicti | 61 | H → D in AAB68668 (PubMed:9278324).Curated | 1 | |
Sequence conflicti | 61 | H → D in AAB87667 (PubMed:9548455).Curated | 1 | |
Sequence conflicti | 115 | M → L in AAB68668 (PubMed:9278324).Curated | 1 | |
Sequence conflicti | 115 | M → L in AAB87667 (PubMed:9548455).Curated | 1 | |
Sequence conflicti | 120 | A → F in AAB68668 (PubMed:9278324).Curated | 1 | |
Sequence conflicti | 149 | G → R in AAB87667 (PubMed:9548455).Curated | 1 | |
Sequence conflicti | 175 | R → G in AAB68668 (PubMed:9278324).Curated | 1 | |
Sequence conflicti | 175 | R → G in AAB87667 (PubMed:9548455).Curated | 1 | |
Sequence conflicti | 187 | T → N in AAB68668 (PubMed:9278324).Curated | 1 | |
Sequence conflicti | 187 | T → N in AAB87667 (PubMed:9548455).Curated | 1 | |
Sequence conflicti | 187 | T → N in AAP30716 (Ref. 3) Curated | 1 | |
Sequence conflicti | 201 | T → M in AAB68668 (PubMed:9278324).Curated | 1 | |
Sequence conflicti | 201 | T → M in AAB87667 (PubMed:9548455).Curated | 1 | |
Sequence conflicti | 205 | W → R in AAB87667 (PubMed:9548455).Curated | 1 | |
Sequence conflicti | 252 | N → D in AAB68668 (PubMed:9278324).Curated | 1 | |
Sequence conflicti | 252 | N → D in AAB87667 (PubMed:9548455).Curated | 1 | |
Sequence conflicti | 263 | D → A in AAP30716 (Ref. 3) Curated | 1 | |
Sequence conflicti | 268 | P → S in AAP30716 (Ref. 3) Curated | 1 | |
Sequence conflicti | 290 | N → H in AAB68668 (PubMed:9278324).Curated | 1 | |
Sequence conflicti | 409 | H → F in AAB68668 (PubMed:9278324).Curated | 1 | |
Sequence conflicti | 417 | V → M in AAB68668 (PubMed:9278324).Curated | 1 | |
Sequence conflicti | 525 | R → G in AAB87667 (PubMed:9548455).Curated | 1 | |
Sequence conflicti | 561 | S → P in AAB87667 (PubMed:9548455).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_017001 | 21 | V → M. Corresponds to variant dbSNP:rs1132588Ensembl. | 1 | |
Natural variantiVAR_017002 | 59 | R → Q1 PublicationCorresponds to variant dbSNP:rs678876Ensembl. | 1 | |
Natural variantiVAR_017003 | 69 | L → W. Corresponds to variant dbSNP:rs80077296Ensembl. | 1 | |
Natural variantiVAR_017004 | 90 | E → Q1 PublicationCorresponds to variant dbSNP:rs1052963Ensembl. | 1 | |
Natural variantiVAR_017005 | 122 | S → N1 PublicationCorresponds to variant dbSNP:rs200783306Ensembl. | 1 | |
Natural variantiVAR_079582 | 171 | Q → H1 PublicationCorresponds to variant dbSNP:rs557014003Ensembl. | 1 | |
Natural variantiVAR_017006 | 205 | W → Q Requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs1063805Ensembl. | 1 | |
Natural variantiVAR_017009 | 400 | Y → F. Corresponds to variant dbSNP:rs8105096Ensembl. | 1 | |
Natural variantiVAR_017008 | 400 | Y → H. Corresponds to variant dbSNP:rs1052992Ensembl. | 1 | |
Natural variantiVAR_017007 | 400 | Y → R Requires 2 nucleotide substitutions. 2 Publications | 1 | |
Natural variantiVAR_017010 | 405 | H → Y1 PublicationCorresponds to variant dbSNP:rs1132604Ensembl. | 1 | |
Natural variantiVAR_017012 | 539 | Q → H1 PublicationCorresponds to variant dbSNP:rs1053002Ensembl. | 1 | |
Natural variantiVAR_017013 | 574 | V → A1 PublicationCorresponds to variant dbSNP:rs1053008Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008459 | 437 | G → GGPEDQPLNPPGSGPQNG in isoform 2. Curated | 1 | |
Alternative sequenceiVSP_040126 | 530 | S → SQ in isoform 3. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91928 mRNA Translation: AAB68668.1 AF025533 mRNA Translation: AAB87667.1 AF256195 Genomic DNA Translation: AAP30716.1 AC010492 Genomic DNA No translation available. AC012314 Genomic DNA No translation available. |
CCDSi | CCDS33105.1 [O75022-1] CCDS46175.1 [O75022-3] |
RefSeqi | XP_006726377.1, XM_006726314.3 XP_016885785.1, XM_017030296.1 [O75022-3] XP_016885786.1, XM_017030297.1 [O75022-1] |
UniGenei | Hs.631592 Hs.688335 |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91928 mRNA Translation: AAB68668.1 AF025533 mRNA Translation: AAB87667.1 AF256195 Genomic DNA Translation: AAP30716.1 AC010492 Genomic DNA No translation available. AC012314 Genomic DNA No translation available. |
CCDSi | CCDS33105.1 [O75022-1] CCDS46175.1 [O75022-3] |
RefSeqi | XP_006726377.1, XM_006726314.3 XP_016885785.1, XM_017030296.1 [O75022-3] XP_016885786.1, XM_017030297.1 [O75022-1] |
UniGenei | Hs.631592 Hs.688335 |
3D structure databases
ProteinModelPortali | O75022 |
SMRi | O75022 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | O75022, 7 interactors |
STRINGi | 9606.ENSP00000245620 |
PTM databases
iPTMneti | O75022 |
PhosphoSitePlusi | O75022 |
Polymorphism and mutation databases
BioMutai | LILRB3 |
Proteomic databases
jPOSTi | O75022 |
PaxDbi | O75022 |
PeptideAtlasi | O75022 |
PRIDEi | O75022 |
ProteomicsDBi | 49696 49697 [O75022-2] 49698 [O75022-3] |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Organism-specific databases
DisGeNETi | 102725035 107987462 11025 |
EuPathDBi | HostDB:ENSG00000204577.11 |
GeneCardsi | LILRB3 |
H-InvDBi | HIX0015438 |
HGNCi | HGNC:6607 LILRB3 |
MIMi | 604820 gene |
neXtProti | NX_O75022 |
PharmGKBi | PA30381 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IKJD Eukaryota ENOG41116BR LUCA |
HOGENOMi | HOG000234395 |
HOVERGENi | HBG074353 |
InParanoidi | O75022 |
KOi | K06512 |
OrthoDBi | 1000446at2759 |
PhylomeDBi | O75022 |
TreeFami | TF336644 |
Enzyme and pathway databases
Reactomei | R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-6798695 Neutrophil degranulation |
Miscellaneous databases
ChiTaRSi | LILRB3 human |
PROi | PR:O75022 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204577 Expressed in 225 organ(s), highest expression level in blood |
ExpressionAtlasi | O75022 baseline and differential |
Genevisiblei | O75022 HS |
Family and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 |
Pfami | View protein in Pfam PF13895 Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409 IG, 3 hits SM00408 IGc2, 3 hits |
SUPFAMi | SSF48726 SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | LIRB3_HUMAN | |
Accessioni | O75022Primary (citable) accession number: O75022 Secondary accession number(s): C9J1P3 Q86U49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2003 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 13, 2019 | |
This is version 164 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations