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UniProtKB - O75022 (LIRB3_HUMAN)

Entry version 164 (13 Feb 2019)
Sequence version 3 (30 Nov 2010)
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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 3

Gene

LILRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).By similarity

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 3
Short name:
LIR-3
Short name:
Leukocyte immunoglobulin-like receptor 3
Alternative name(s):
CD85 antigen-like family member A
Immunoglobulin-like transcript 5
Short name:
ILT-5
Monocyte inhibitory receptor HL9
CD_antigen: CD85a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LILRB3
Synonyms:ILT5, LIR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000204577.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:6607 LILRB3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604820 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O75022

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 443ExtracellularSequence analysisAdd BLAST420
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 631CytoplasmicSequence analysisAdd BLAST167

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		102725035
107987462
11025

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30381

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LILRB3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001482224 – 631Leukocyte immunoglobulin-like receptor subfamily B member 3Add BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Disulfide bondi245 ↔ 296PROSITE-ProRule annotation
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi345 ↔ 396PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei595Phosphotyrosine; by LYNBy similarity1
Modified residuei625Phosphotyrosine; by LYNBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O75022

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O75022

PeptideAtlas

More...PeptideAtlasi		O75022

PRoteomics IDEntifications database

More...PRIDEi		O75022

ProteomicsDB human proteome resource

More...ProteomicsDBi		49696
49697 [O75022-2]
49698 [O75022-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O75022

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O75022

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in monocytes and B-cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204577 Expressed in 225 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O75022 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O75022 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		O75022, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000245620

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O75022

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O75022

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 100Ig-like C2-type 1Add BLAST59
Domaini111 – 229Ig-like C2-type 2Add BLAST119
Domaini225 – 314Ig-like C2-type 3Add BLAST90
Domaini338 – 419Ig-like C2-type 4Add BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi512 – 517ITIM motif 16
Motifi593 – 598ITIM motif 26
Motifi623 – 628ITIM motif 36

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK.By similarity

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IKJD Eukaryota
ENOG41116BR LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234395

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG074353

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O75022

KEGG Orthology (KO)

More...KOi		K06512

Database of Orthologous Groups

More...OrthoDBi		1000446at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O75022

TreeFam database of animal gene trees

More...TreeFami		TF336644

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13895 Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75022-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ 
        60         70         80         90        100
GSQEAQEYRL HKEGSPEPLD RNNPLEPKNK ARFSIPSMTE HHAGRYRCHY 
       110        120        130        140        150
YSSAGWSEPS DPLEMVMTGA YSKPTLSALP SPVVASGGNM TLRCGSQKGY 
       160        170        180        190        200
HHFVLMKEGE HQLPRTLDSQ QLHSRGFQAL FPVGPVTPSH RWRFTCYYYY 
       210        220        230        240        250
TNTPWVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS LTLQCGSDVG 
       260        270        280        290        300
YNRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSPSN GGQYRCYGAH 
       310        320        330        340        350
NLSSEWSAPS DPLNILMAGQ IYDTVSLSAQ PGPTVASGEN VTLLCQSWWQ 
       360        370        380        390        400
FDTFLLTKEG AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSY 
       410        420        430        440        450
SSNPHLLSHP SEPLELVVSG HSGGSSLPPT GPPSTPGLGR YLEVLIGVSV 
       460        470        480        490        500
AFVLLLFLLL FLLLRRQRHS KHRTSDQRKT DFQRPAGAAE TEPKDRGLLR 
       510        520        530        540        550
RSSPAADVQE ENLYAAVKDT QSEDRVELDS QSPHDEDPQA VTYAPVKHSS 
       560        570        580        590        600
PRREMASPPS SLSGEFLDTK DRQVEEDRQM DTEAAASEAS QDVTYAQLHS 
       610        620        630 
LTLRRKATEP PPSQEGEPPA EPSIYATLAI H
Length:631
Mass (Da):69,386
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i595B1BD5283A7E3E
GO
Isoform 2 (identifier: O75022-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-437: G → GGPEDQPLNPPGSGPQNG

Note: No experimental confirmation available.
Show »
Length:648
Mass (Da):71,029
Checksum:i3FAEB2EEC21105BD
GO
Isoform 3 (identifier: O75022-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     530-530: S → SQ

Show »
Length:632
Mass (Da):69,514
Checksum:iFF29920A9E55897D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JPK5A0A0G2JPK5_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JN08A0A0G2JN08_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W6G6F8W6G6_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
643Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLT7A0A0G2JLT7_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
631Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNB3A0A0G2JNB3_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
632Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM46A0A0G2JM46_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
632Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMM1A0A0G2JMM1_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
648Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JN67A0A0G2JN67_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
648Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMZ3A0A0G2JMZ3_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
649Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPG2A0A0G2JPG2_HUMAN
Leukocyte immunoglobulin-like recep...
LILRB3
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53Q → L in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti53Q → L in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti61H → D in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti61H → D in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti115M → L in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti115M → L in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti120A → F in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti149G → R in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti175R → G in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti175R → G in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti187T → N in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti187T → N in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti187T → N in AAP30716 (Ref. 3) Curated1
Sequence conflicti201T → M in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti201T → M in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti205W → R in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti252N → D in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti252N → D in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti263D → A in AAP30716 (Ref. 3) Curated1
Sequence conflicti268P → S in AAP30716 (Ref. 3) Curated1
Sequence conflicti290N → H in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti409H → F in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti417V → M in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti525R → G in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti561S → P in AAB87667 (PubMed:9548455).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01700121V → M. Corresponds to variant dbSNP:rs1132588Ensembl.1
Natural variantiVAR_01700259R → Q1 PublicationCorresponds to variant dbSNP:rs678876Ensembl.1
Natural variantiVAR_01700369L → W. Corresponds to variant dbSNP:rs80077296Ensembl.1
Natural variantiVAR_01700490E → Q1 PublicationCorresponds to variant dbSNP:rs1052963Ensembl.1
Natural variantiVAR_017005122S → N1 PublicationCorresponds to variant dbSNP:rs200783306Ensembl.1
Natural variantiVAR_079582171Q → H1 PublicationCorresponds to variant dbSNP:rs557014003Ensembl.1
Natural variantiVAR_017006205W → Q Requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs1063805Ensembl.1
Natural variantiVAR_017009400Y → F. Corresponds to variant dbSNP:rs8105096Ensembl.1
Natural variantiVAR_017008400Y → H. Corresponds to variant dbSNP:rs1052992Ensembl.1
Natural variantiVAR_017007400Y → R Requires 2 nucleotide substitutions. 2 Publications1
Natural variantiVAR_017010405H → Y1 PublicationCorresponds to variant dbSNP:rs1132604Ensembl.1
Natural variantiVAR_017012539Q → H1 PublicationCorresponds to variant dbSNP:rs1053002Ensembl.1
Natural variantiVAR_017013574V → A1 PublicationCorresponds to variant dbSNP:rs1053008Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008459437G → GGPEDQPLNPPGSGPQNG in isoform 2. Curated1
Alternative sequenceiVSP_040126530S → SQ in isoform 3. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U91928 mRNA Translation: AAB68668.1
AF025533 mRNA Translation: AAB87667.1
AF256195 Genomic DNA Translation: AAP30716.1
AC010492 Genomic DNA No translation available.
AC012314 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33105.1 [O75022-1]
CCDS46175.1 [O75022-3]

NCBI Reference Sequences

More...RefSeqi		XP_006726377.1, XM_006726314.3
XP_016885785.1, XM_017030296.1 [O75022-3]
XP_016885786.1, XM_017030297.1 [O75022-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.631592
Hs.688335

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000245620; ENSP00000245620; ENSG00000204577
ENST00000391750; ENSP00000375630; ENSG00000204577
ENST00000611086; ENSP00000483625; ENSG00000274587 [O75022-1]
ENST00000613698; ENSP00000479234; ENSG00000275019
ENST00000621210; ENSP00000484925; ENSG00000275019

Database of genes from NCBI RefSeq genomes

More...GeneIDi		102725035
107987462

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:102725035
hsa:107987462

UCSC genome browser

More...UCSCi		uc032icw.2 human [O75022-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91928 mRNA Translation: AAB68668.1
AF025533 mRNA Translation: AAB87667.1
AF256195 Genomic DNA Translation: AAP30716.1
AC010492 Genomic DNA No translation available.
AC012314 Genomic DNA No translation available.
CCDSiCCDS33105.1 [O75022-1]
CCDS46175.1 [O75022-3]
RefSeqiXP_006726377.1, XM_006726314.3
XP_016885785.1, XM_017030296.1 [O75022-3]
XP_016885786.1, XM_017030297.1 [O75022-1]
UniGeneiHs.631592
Hs.688335

3D structure databases

ProteinModelPortaliO75022
SMRiO75022
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO75022, 7 interactors
STRINGi9606.ENSP00000245620

PTM databases

iPTMnetiO75022
PhosphoSitePlusiO75022

Polymorphism and mutation databases

BioMutaiLILRB3

Proteomic databases

jPOSTiO75022
PaxDbiO75022
PeptideAtlasiO75022
PRIDEiO75022
ProteomicsDBi49696
49697 [O75022-2]
49698 [O75022-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245620; ENSP00000245620; ENSG00000204577
ENST00000391750; ENSP00000375630; ENSG00000204577
ENST00000611086; ENSP00000483625; ENSG00000274587 [O75022-1]
ENST00000613698; ENSP00000479234; ENSG00000275019
ENST00000621210; ENSP00000484925; ENSG00000275019
GeneIDi102725035
107987462
KEGGihsa:102725035
hsa:107987462
UCSCiuc032icw.2 human [O75022-1]

Organism-specific databases

DisGeNETi102725035
107987462
11025
EuPathDBiHostDB:ENSG00000204577.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		LILRB3

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0015438
HGNCiHGNC:6607 LILRB3
MIMi604820 gene
neXtProtiNX_O75022
PharmGKBiPA30381

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IKJD Eukaryota
ENOG41116BR LUCA
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiO75022
KOiK06512
OrthoDBi1000446at2759
PhylomeDBiO75022
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LILRB3 human

Protein Ontology

More...PROi		PR:O75022

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204577 Expressed in 225 organ(s), highest expression level in blood
ExpressionAtlasiO75022 baseline and differential
GenevisibleiO75022 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIRB3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75022
Secondary accession number(s): C9J1P3
, C9JIP1, O15471, Q86U49
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 30, 2010
Last modified: February 13, 2019
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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