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Protein

Leukocyte immunoglobulin-like receptor subfamily A member 1

Gene

LILRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as receptor for class I MHC antigens.

GO - Molecular functioni

  • antigen binding Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 1
Alternative name(s):
CD85 antigen-like family member I
Leukocyte immunoglobulin-like receptor 6
Short name:
LIR-6
CD_antigen: CD85i
Gene namesi
Name:LILRA1
Synonyms:LIR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104974.10
HGNCiHGNC:6602 LILRA1
MIMi604810 gene
neXtProtiNX_O75019

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 461ExtracellularSequence analysisAdd BLAST445
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 489CytoplasmicSequence analysis7

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11024
OpenTargetsiENSG00000104974
PharmGKBiPA30376

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001481617 – 489Leukocyte immunoglobulin-like receptor subfamily A member 1Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 197PROSITE-ProRule annotation
Disulfide bondi157 ↔ 167PROSITE-ProRule annotation
Disulfide bondi246 ↔ 297PROSITE-ProRule annotation
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi346 ↔ 397PROSITE-ProRule annotation
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi448N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75019
PeptideAtlasiO75019
PRIDEiO75019
ProteomicsDBi49694
49695 [O75019-2]

PTM databases

iPTMnetiO75019
PhosphoSitePlusiO75019

Expressioni

Tissue specificityi

Detected in monocytes and B-cells.1 Publication

Gene expression databases

BgeeiENSG00000104974 Expressed in 102 organ(s), highest expression level in leukocyte
CleanExiHS_LILRA1
GenevisibleiO75019 HS

Interactioni

Protein-protein interaction databases

BioGridi116214, 1 interactor
STRINGi9606.ENSP00000251372

Structurei

3D structure databases

ProteinModelPortaliO75019
SMRiO75019
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 116Ig-like C2-type 1Add BLAST90
Domaini119 – 224Ig-like C2-type 2Add BLAST106
Domaini226 – 315Ig-like C2-type 3Add BLAST90
Domaini326 – 415Ig-like C2-type 4Add BLAST90

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJD Eukaryota
ENOG41116BR LUCA
GeneTreeiENSGT00760000119033
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiO75019
KOiK06512
OMAiWGRQADF
OrthoDBiEOG091G020P
PhylomeDBiO75019
TreeFamiTF336644

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR016332 A1B_glyco/leuk_Ig-like_rcpt
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PIRSFiPIRSF001979 Alpha_1B_glycoprot_prd, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75019-1) [UniParc]FASTAAdd to basket
Also known as: LIR-6a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ
60 70 80 90 100
GILETQEYRL YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY
110 120 130 140 150
GSHTAGWSEP SDPLELVVTG AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA
160 170 180 190 200
FGSFILCKEG EDEHPQCLNS QPRTHGWSRA IFSVGPVSPS RRWSYRCYAY
210 220 230 240 250
DSNSPHVWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPGE SLTLQCVSDV
260 270 280 290 300
SYDRFVLYKE GERDFLQLPG PQPQAGLSQA NFTLGPVSRS YGGQYRCSGA
310 320 330 340 350
YNLSSEWSAP SDPLDILIAG QFRGRPFISV HPGPTVASGE NVTLLCQSWG
360 370 380 390 400
PFHTFLLTKA GAADAPLRLR SIHEYPKYQA EFPMSPVTSA HSGTYRCYGS
410 420 430 440 450
LSSNPYLLSH PSDSLELMVS GAAETLSPPQ NKSDSKAGAA NTLSPSQNKT
460 470 480
ASHPQDYTVE NLIRMGIAGL VLVVLGILLF EAQHSQRSL
Length:489
Mass (Da):53,275
Last modified:November 1, 1998 - v1
Checksum:i44469FD4884EA068
GO
Isoform 2 (identifier: O75019-2) [UniParc]FASTAAdd to basket
Also known as: LIR-6b

The sequence of this isoform differs from the canonical sequence as follows:
     221-420: Missing.

Show »
Length:289
Mass (Da):31,724
Checksum:iB26E3FE090250FE0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JP96A0A0G2JP96_HUMAN
Leukocyte immunoglobulin-like recep...
LILRA1
506Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5V → L in AAB87663 (PubMed:9548455).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05939612R → G1 PublicationCorresponds to variant dbSNP:rs1974982Ensembl.1
Natural variantiVAR_049886153S → G. Corresponds to variant dbSNP:rs10417589Ensembl.1
Natural variantiVAR_049887220L → P1 PublicationCorresponds to variant dbSNP:rs373854Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008454221 – 420Missing in isoform 2. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025529 mRNA Translation: AAB87663.1
AF025530 mRNA Translation: AAB87664.1
BC101514 mRNA Translation: AAI01515.1
CCDSiCCDS12901.1 [O75019-1]
CCDS62802.1 [O75019-2]
RefSeqiNP_001265247.1, NM_001278318.1 [O75019-2]
NP_001265248.1, NM_001278319.1
NP_006854.1, NM_006863.3 [O75019-1]
UniGeneiHs.710507

Genome annotation databases

EnsembliENST00000251372; ENSP00000251372; ENSG00000104974 [O75019-1]
ENST00000453777; ENSP00000413715; ENSG00000104974 [O75019-2]
ENST00000617170; ENSP00000477637; ENSG00000275525 [O75019-1]
ENST00000620606; ENSP00000478666; ENSG00000275525 [O75019-2]
ENST00000628480; ENSP00000487229; ENSG00000277398 [O75019-2]
ENST00000631007; ENSP00000487011; ENSG00000274935 [O75019-2]
GeneIDi11024
KEGGihsa:11024
UCSCiuc002qgh.4 human [O75019-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025529 mRNA Translation: AAB87663.1
AF025530 mRNA Translation: AAB87664.1
BC101514 mRNA Translation: AAI01515.1
CCDSiCCDS12901.1 [O75019-1]
CCDS62802.1 [O75019-2]
RefSeqiNP_001265247.1, NM_001278318.1 [O75019-2]
NP_001265248.1, NM_001278319.1
NP_006854.1, NM_006863.3 [O75019-1]
UniGeneiHs.710507

3D structure databases

ProteinModelPortaliO75019
SMRiO75019
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116214, 1 interactor
STRINGi9606.ENSP00000251372

PTM databases

iPTMnetiO75019
PhosphoSitePlusiO75019

Proteomic databases

PaxDbiO75019
PeptideAtlasiO75019
PRIDEiO75019
ProteomicsDBi49694
49695 [O75019-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251372; ENSP00000251372; ENSG00000104974 [O75019-1]
ENST00000453777; ENSP00000413715; ENSG00000104974 [O75019-2]
ENST00000617170; ENSP00000477637; ENSG00000275525 [O75019-1]
ENST00000620606; ENSP00000478666; ENSG00000275525 [O75019-2]
ENST00000628480; ENSP00000487229; ENSG00000277398 [O75019-2]
ENST00000631007; ENSP00000487011; ENSG00000274935 [O75019-2]
GeneIDi11024
KEGGihsa:11024
UCSCiuc002qgh.4 human [O75019-1]

Organism-specific databases

CTDi11024
DisGeNETi11024
EuPathDBiHostDB:ENSG00000104974.10
GeneCardsiLILRA1
HGNCiHGNC:6602 LILRA1
MIMi604810 gene
neXtProtiNX_O75019
OpenTargetsiENSG00000104974
PharmGKBiPA30376
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJD Eukaryota
ENOG41116BR LUCA
GeneTreeiENSGT00760000119033
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiO75019
KOiK06512
OMAiWGRQADF
OrthoDBiEOG091G020P
PhylomeDBiO75019
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiLILRA1 human
GenomeRNAii11024
PROiPR:O75019
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104974 Expressed in 102 organ(s), highest expression level in leukocyte
CleanExiHS_LILRA1
GenevisibleiO75019 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR016332 A1B_glyco/leuk_Ig-like_rcpt
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PIRSFiPIRSF001979 Alpha_1B_glycoprot_prd, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIRA1_HUMAN
AccessioniPrimary (citable) accession number: O75019
Secondary accession number(s): O75018, Q3MJA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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