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Protein

Low affinity immunoglobulin gamma Fc region receptor III-B

Gene

FCGR3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Miscellaneous

Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The 'Phe-203' in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring.

GO - Molecular functioni

GO - Biological processi

  • immune response Source: ProtInc
  • neutrophil degranulation Source: Reactome

Keywordsi

Molecular functionIgG-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor III-B
Alternative name(s):
Fc-gamma RIII-beta
Short name:
Fc-gamma RIII
Short name:
Fc-gamma RIIIb
Short name:
FcRIII
Short name:
FcRIIIb
FcR-10
IgG Fc receptor III-1
CD_antigen: CD16b
Gene namesi
Name:FCGR3B
Synonyms:CD16B, FCG3, FCGR3, IGFR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162747.9
HGNCiHGNC:3620 FCGR3B
MIMi610665 gene
neXtProtiNX_O75015

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2215
MalaCardsiFCGR3B
Orphaneti855 Hashimoto struma
536 Systemic lupus erythematosus
PharmGKBiPA28066

Chemistry databases

ChEMBLiCHEMBL5842
DrugBankiDB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00028 Immune Globulin Human
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

Polymorphism and mutation databases

BioMutaiFCGR3B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001515117 – 200Low affinity immunoglobulin gamma Fc region receptor III-BAdd BLAST184
PropeptideiPRO_0000015152201 – 233Removed in mature formSequence analysisAdd BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 89Combined sources2 Publications
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 172Combined sources2 Publications
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi200GPI-anchor amidated serineSequence analysis1

Post-translational modificationi

Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.
The soluble form is produced by a proteolytic cleavage.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO75015
PeptideAtlasiO75015
PRIDEiO75015
ProteomicsDBi49693

PTM databases

GlyConnecti1463
iPTMnetiO75015
PhosphoSitePlusiO75015

Expressioni

Tissue specificityi

Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.

Gene expression databases

BgeeiENSG00000162747 Expressed in 169 organ(s), highest expression level in blood
CleanExiHS_FCGR3B
ExpressionAtlasiO75015 baseline and differential
GenevisibleiO75015 HS

Interactioni

Subunit structurei

Monomer. Interacts with INPP5D/SHIP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi108509, 22 interactors
IntActiO75015, 2 interactors
STRINGi9606.ENSP00000294800

Chemistry databases

BindingDBiO75015

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO75015
SMRiO75015
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75015

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 96Ig-like C2-type 1Add BLAST57
Domaini121 – 179Ig-like C2-type 2Add BLAST59

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IKYD Eukaryota
ENOG41114N1 LUCA
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiO75015
KOiK06463
PhylomeDBiO75015
TreeFamiTF335097

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O75015-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWQLLLPTAL LLLVSAGMRT EDLPKAVVFL EPQWYSVLEK DSVTLKCQGA
60 70 80 90 100
YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VNDSGEYRCQ TNLSTLSDPV
110 120 130 140 150
QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKDRKY
160 170 180 190 200
FHHNSDFHIP KATLKDSGSY FCRGLVGSKN VSSETVNITI TQGLAVSTIS
210 220 230
SFSPPGYQVS FCLVMVLLFA VDTGLYFSVK TNI
Length:233
Mass (Da):26,216
Last modified:November 1, 1999 - v2
Checksum:i7AB5159432761726
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9MML6M9MML6_HUMAN
Low affinity immunoglobulin gamma F...
FCGR3B
269Annotation score:
A0A087WZR4A0A087WZR4_HUMAN
Low affinity immunoglobulin gamma F...
FCGR3B
216Annotation score:
A0A087WU90A0A087WU90_HUMAN
Low affinity immunoglobulin gamma F...
FCGR3B
130Annotation score:
H0Y4U3H0Y4U3_HUMAN
Low affinity immunoglobulin gamma F...
FCGR3B
254Annotation score:
E9PNY5E9PNY5_HUMAN
Low affinity immunoglobulin gamma F...
FCGR3B
104Annotation score:

Polymorphismi

There are three allelic forms of FCGR3B: FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA. The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides.6 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00395636S → R in allele FCGR3B*01. 1
Natural variantiVAR_00396365S → N in allele FCGR3B*01. 1 PublicationCorresponds to variant dbSNP:rs448740Ensembl.1
Natural variantiVAR_00880278A → D in allele SH. 1 PublicationCorresponds to variant dbSNP:rs5030738Ensembl.1
Natural variantiVAR_00395782N → D in allele FCGR3B*01. 1
Natural variantiVAR_003964106I → V in allele FCGR3B*01. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16863 mRNA Translation: CAA34753.1
X07934 mRNA Translation: CAA30758.1
J04162 mRNA Translation: AAA35881.1
M24854 mRNA Translation: AAA53507.1
AJ581669 mRNA Translation: CAE46408.1
AL451067 Genomic DNA No translation available.
Z46223 Genomic DNA Translation: CAA86296.1
CCDSiCCDS41433.1
CCDS58040.1
PIRiJU0284
RefSeqiNP_000561.3, NM_000570.4
NP_001231682.1, NM_001244753.1
NP_001257964.1, NM_001271035.1
NP_001257965.1, NM_001271036.1
NP_001257966.1, NM_001271037.1
UniGeneiHs.372679
Hs.694258
Hs.736230

Genome annotation databases

EnsembliENST00000294800; ENSP00000294800; ENSG00000162747
ENST00000367964; ENSP00000356941; ENSG00000162747
GeneIDi2215
KEGGihsa:2215
UCSCiuc021pdo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16863 mRNA Translation: CAA34753.1
X07934 mRNA Translation: CAA30758.1
J04162 mRNA Translation: AAA35881.1
M24854 mRNA Translation: AAA53507.1
AJ581669 mRNA Translation: CAE46408.1
AL451067 Genomic DNA No translation available.
Z46223 Genomic DNA Translation: CAA86296.1
CCDSiCCDS41433.1
CCDS58040.1
PIRiJU0284
RefSeqiNP_000561.3, NM_000570.4
NP_001231682.1, NM_001244753.1
NP_001257964.1, NM_001271035.1
NP_001257965.1, NM_001271036.1
NP_001257966.1, NM_001271037.1
UniGeneiHs.372679
Hs.694258
Hs.736230

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E4JX-ray2.50A18-193[»]
1E4KX-ray3.20C18-193[»]
1FNLX-ray1.80A19-192[»]
1T83X-ray3.00C19-194[»]
1T89X-ray3.50C19-194[»]
ProteinModelPortaliO75015
SMRiO75015
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108509, 22 interactors
IntActiO75015, 2 interactors
STRINGi9606.ENSP00000294800

Chemistry databases

BindingDBiO75015
ChEMBLiCHEMBL5842
DrugBankiDB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00028 Immune Globulin Human
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

PTM databases

GlyConnecti1463
iPTMnetiO75015
PhosphoSitePlusiO75015

Polymorphism and mutation databases

BioMutaiFCGR3B

Proteomic databases

PaxDbiO75015
PeptideAtlasiO75015
PRIDEiO75015
ProteomicsDBi49693

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294800; ENSP00000294800; ENSG00000162747
ENST00000367964; ENSP00000356941; ENSG00000162747
GeneIDi2215
KEGGihsa:2215
UCSCiuc021pdo.2 human

Organism-specific databases

CTDi2215
DisGeNETi2215
EuPathDBiHostDB:ENSG00000162747.9
GeneCardsiFCGR3B
H-InvDBiHIX0056770
HGNCiHGNC:3620 FCGR3B
MalaCardsiFCGR3B
MIMi610665 gene
neXtProtiNX_O75015
Orphaneti855 Hashimoto struma
536 Systemic lupus erythematosus
PharmGKBiPA28066
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKYD Eukaryota
ENOG41114N1 LUCA
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiO75015
KOiK06463
PhylomeDBiO75015
TreeFamiTF335097

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceiO75015
GeneWikiiFCGR3B
GenomeRNAii2215
PROiPR:O75015
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162747 Expressed in 169 organ(s), highest expression level in blood
CleanExiHS_FCGR3B
ExpressionAtlasiO75015 baseline and differential
GenevisibleiO75015 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCG3B_HUMAN
AccessioniPrimary (citable) accession number: O75015
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 10, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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