We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - O74976 (FAT2_SCHPO)
Protein
Oxalate--CoA ligase
Gene
pcs60
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalyzes the first step in a degradation pathway of oxalate to CO2 to protect the cell against the harmful effects of oxalate derived from endogenous processes or an environmental sources.
By similarityCatalytic activityi
- EC:6.2.1.8By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 168 – 179 | ATPBy similarityAdd BLAST | 12 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- medium-chain fatty acid-CoA ligase activity Source: GO_Central
- oxalate-CoA ligase activity Source: UniProtKB-EC
GO - Biological processi
- acetyl-CoA metabolic process Source: PomBase
- fatty acid metabolic process Source: GO_Central
Keywordsi
Molecular function | Ligase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Oxalate--CoA ligaseCurated (EC:6.2.1.8By similarity)Alternative name(s): Oxalyl-CoA synthetase Peroxisomal-coenzyme A synthetase |
Gene namesi | Name:pcs60 ORF Names:SPCC1827.03c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPCC1827.03c, pcs60 |
VEuPathDBi | FungiDB:SPCC1827.03c |
Subcellular locationi
Peroxisome
- Peroxisome matrix By similarity
- Peroxisome membrane By similarity; Peripheral membrane protein By similarity
Cytosol
- cytosol Source: PomBase
Peroxisome
- peroxisomal matrix Source: UniProtKB-SubCell
- peroxisomal membrane Source: PomBase
Keywords - Cellular componenti
Membrane, PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193183 | 1 – 512 | Oxalate--CoA ligaseAdd BLAST | 512 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 283 | Phosphoserine1 Publication | 1 | |
Modified residuei | 284 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | O74976 |
PaxDbi | O74976 |
PTM databases
iPTMneti | O74976 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 275823, 27 interactors |
STRINGi | 4896.SPCC1827.03c.1 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 381 – 429 | FACSBy similarityAdd BLAST | 49 | |
Motifi | 510 – 512 | Microbody targeting signalSequence analysis | 3 |
Domaini
The FACS motif is required for catalytic activity and substrate specificity.By similarity
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Phylogenomic databases
eggNOGi | KOG1176, Eukaryota |
HOGENOMi | CLU_000022_59_0_1 |
InParanoidi | O74976 |
OMAi | PNIRFIR |
PhylomeDBi | O74976 |
Family and domain databases
CDDi | cd05926, FACL_fum10p_like, 1 hit |
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR045310, Pcs60-like |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
O74976-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFTTLYSAI QGDASARALV APSLNAELSF SELRIAIMDL QRQIASLGIK
60 70 80 90 100
VGDPVNIAIP NGLEFVVAFY AVSWQRAICG PLNSNYKQSE FEFYIDDLKS
110 120 130 140 150
KLVIVPEGSV AANTPAVRAA KKLSVAVAEL AWCPKSRLVR IVHFEGAKIN
160 170 180 190 200
APQPLGLPQP DDVMLVLHTS GTTGRPKVVP LTHKNLCRSI HNITTSYRLD
210 220 230 240 250
PRDTSYVVMP LFHVHGLLCG LLSTLASGGC AVVPPKFSAH SFWKEFIQYG
260 270 280 290 300
ATWYTAVPTI HQILLRTPPP KPLPRIRFIR SCSSPLAPPV LSKLEATFRA
310 320 330 340 350
PVLEAYAMTE ASHQMTTNPL PPLVHKPHSV GKPFGVELKI LDQKGNEMPQ
360 370 380 390 400
GKEGEICVRG INVTKGYLNN PAANKSSFTK DRFFRTGDEG KLDKDGYVFI
410 420 430 440 450
TGRIKELVNR GGEKISPAEI DAVLMQHPDV SEAVCFAVPD EKYGQDIQAA
460 470 480 490 500
INPVAGKTVT PKQLHDYLEQ KVAAFKIPKK FYFTDRIPKT ATGKVQRRLV
510
CDAFFNHSKA KL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 218 | Missing in BAA13768 (PubMed:9501991).Curated | 1 | |
Sequence conflicti | 288 | P → T in BAA13768 (PubMed:9501991).Curated | 1 | |
Sequence conflicti | 305 | A → G in BAA13768 (PubMed:9501991).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA19311.1 D89105 mRNA Translation: BAA13768.1 |
PIRi | T41164 |
RefSeqi | NP_588549.1, NM_001023536.2 |
Genome annotation databases
EnsemblFungii | SPCC1827.03c.1; SPCC1827.03c.1:pep; SPCC1827.03c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA19311.1 D89105 mRNA Translation: BAA13768.1 |
PIRi | T41164 |
RefSeqi | NP_588549.1, NM_001023536.2 |
3D structure databases
SMRi | O74976 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 275823, 27 interactors |
STRINGi | 4896.SPCC1827.03c.1 |
PTM databases
iPTMneti | O74976 |
Proteomic databases
MaxQBi | O74976 |
PaxDbi | O74976 |
Genome annotation databases
EnsemblFungii | SPCC1827.03c.1; SPCC1827.03c.1:pep; SPCC1827.03c |
Organism-specific databases
PomBasei | SPCC1827.03c, pcs60 |
VEuPathDBi | FungiDB:SPCC1827.03c |
Phylogenomic databases
eggNOGi | KOG1176, Eukaryota |
HOGENOMi | CLU_000022_59_0_1 |
InParanoidi | O74976 |
OMAi | PNIRFIR |
PhylomeDBi | O74976 |
Miscellaneous databases
PROi | PR:O74976 |
Family and domain databases
CDDi | cd05926, FACL_fum10p_like, 1 hit |
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR045310, Pcs60-like |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FAT2_SCHPO | |
Accessioni | O74976Primary (citable) accession number: O74976 Secondary accession number(s): P78757 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families