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UniProtKB - O74969 (GHT2_SCHPO)
Protein
High-affinity glucose transporter ght2
Gene
ght2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
High-affinity glucose transporter.
GO - Molecular functioni
- carbohydrate:proton symporter activity Source: GO_Central
- galactose transmembrane transporter activity Source: PomBase
GO - Biological processi
- carbohydrate transport Source: GO_Central
- galactose import across plasma membrane Source: PomBase
Keywordsi
Biological process | Sugar transport, Transport |
Protein family/group databases
TCDBi | 2.A.1.1.21, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: High-affinity glucose transporter ght2Alternative name(s): Hexose transporter 2 |
Gene namesi | Name:ght2 ORF Names:SPBC4B4.08 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC4B4.08, ght2 |
VEuPathDBi | FungiDB:SPBC4B4.08 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: PomBase
- plasma membrane Source: PomBase
Other locations
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 5 – 13 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 14 – 34 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 35 – 62 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 63 – 83 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 84 – 91 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 92 – 112 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 113 – 116 | ExtracellularSequence analysis | 4 | |
Transmembranei | 117 – 137 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 148 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 149 – 169 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 183 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 184 – 204 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 205 – 270 | CytoplasmicSequence analysisAdd BLAST | 66 | |
Transmembranei | 271 – 289 | Helical; Name=7Sequence analysisAdd BLAST | 19 | |
Topological domaini | 290 – 305 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 306 – 326 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 327 – 332 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 333 – 353 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 354 – 367 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 368 – 388 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 389 – 408 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 409 – 429 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 430 – 436 | ExtracellularSequence analysis | 7 | |
Transmembranei | 437 – 457 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 458 – 531 | CytoplasmicSequence analysisAdd BLAST | 74 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050410 | 1 – 531 | High-affinity glucose transporter ght2Add BLAST | 531 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 361 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 507 | Phosphoserine1 Publication | 1 | |
Modified residuei | 515 | Phosphoserine1 Publication | 1 | |
Modified residuei | 519 | Phosphoserine1 Publication | 1 | |
Modified residuei | 520 | Phosphoserine1 Publication | 1 | |
Modified residuei | 523 | Phosphotyrosine1 Publication | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | O74969 |
PaxDbi | O74969 |
PTM databases
iPTMneti | O74969 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 276521, 4 interactors |
STRINGi | 4896.SPBC4B4.08.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 491 – 531 | DisorderedSequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 491 – 507 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 512 – 531 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0254, Eukaryota |
HOGENOMi | CLU_001265_30_1_1 |
InParanoidi | O74969 |
OMAi | FWNIIFC |
PhylomeDBi | O74969 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit |
i Sequence
Sequence statusi: Complete.
O74969-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGFKRGKNFT LVMLIFVSMA GWMFGADTGS IGGVTSMRDF RERYADRYDP
60 70 80 90 100
ITDQYSLSSA RQGLLTGMVN VGSLFGCIIS SPIADRFGKR LSIIGFCAVY
110 120 130 140 150
IIGIIVQVTA VPSWVQIMVA KIWTGIGIGA LSVLAPGYQS ETAPPSIRGT
160 170 180 190 200
VVVTYQLFVT GGIFIAACIN MGTHKLHKTA QWRVSIGINL LWGIITMIGI
210 220 230 240 250
LFLPESPRYL IQVGKDEEAV RVLSESAELF PDSEEVQNEY HRLKSSIDEE
260 270 280 290 300
FAGGPCSWAS IFGKDIRYRT FLGMFVMSLQ QLTGNNYFFY YGFSVMQGAG
310 320 330 340 350
INSPYLSAMI LDAVNFGCTF GGMYVLERFG RRNPLIIGGI WQSICFFIYS
360 370 380 390 400
AVGSRALYHK NGTSNTRAGA VMIVMACLFI FGFAQTWAPA AYVIVGESYP
410 420 430 440 450
VRYRSKCAAV ATASNWLWNF LISFFTPFIQ ASIGFKYGYV FASCNLTGAI
460 470 480 490 500
VIFLFAKETK GLTLEEINEL YMSVIKPWES GNFKLNYSEQ KKVEKEKSRK
510 520 530
GGARGESVEY VERASNTDSS PQYSSHEEDY A
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 – 12 | Missing in AAB70519 (PubMed:10735857).CuratedAdd BLAST | 12 | |
Sequence conflicti | 29 | G → R in AAB70519 (PubMed:10735857).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF017180 mRNA Translation: AAB70519.1 CU329671 Genomic DNA Translation: CAA19288.1 |
PIRi | T40480 T43533 |
RefSeqi | NP_596425.1, NM_001022344.2 |
Genome annotation databases
EnsemblFungii | SPBC4B4.08.1; SPBC4B4.08.1:pep; SPBC4B4.08 |
GeneIDi | 2539977 |
KEGGi | spo:SPBC4B4.08 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF017180 mRNA Translation: AAB70519.1 CU329671 Genomic DNA Translation: CAA19288.1 |
PIRi | T40480 T43533 |
RefSeqi | NP_596425.1, NM_001022344.2 |
3D structure databases
AlphaFoldDBi | O74969 |
SMRi | O74969 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 276521, 4 interactors |
STRINGi | 4896.SPBC4B4.08.1 |
Protein family/group databases
TCDBi | 2.A.1.1.21, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | O74969 |
Proteomic databases
MaxQBi | O74969 |
PaxDbi | O74969 |
Genome annotation databases
EnsemblFungii | SPBC4B4.08.1; SPBC4B4.08.1:pep; SPBC4B4.08 |
GeneIDi | 2539977 |
KEGGi | spo:SPBC4B4.08 |
Organism-specific databases
PomBasei | SPBC4B4.08, ght2 |
VEuPathDBi | FungiDB:SPBC4B4.08 |
Phylogenomic databases
eggNOGi | KOG0254, Eukaryota |
HOGENOMi | CLU_001265_30_1_1 |
InParanoidi | O74969 |
OMAi | FWNIIFC |
PhylomeDBi | O74969 |
Miscellaneous databases
PROi | PR:O74969 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GHT2_SCHPO | |
Accessioni | O74969Primary (citable) accession number: O74969 Secondary accession number(s): O13346 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | November 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families