ght2

Protein namesⁱ	Recommended name: High-affinity glucose transporter ght2 Alternative name(s): Hexose transporter 2
Gene namesⁱ	Name:ght2 ORF Names:SPBC4B4.08
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome II

Organism-specific databases

EuPathDBⁱ	FungiDB:SPBC4B4.08
PomBaseⁱ	SPBC4B4.08 ght2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	5 – 13	CytoplasmicSequence analysis	9
Transmembraneⁱ	14 – 34	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	35 – 62	ExtracellularSequence analysisAdd BLAST	28
Transmembraneⁱ	63 – 83	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	84 – 91	CytoplasmicSequence analysis	8
Transmembraneⁱ	92 – 112	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	113 – 116	ExtracellularSequence analysis	4
Transmembraneⁱ	117 – 137	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	138 – 148	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	149 – 169	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	170 – 183	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	184 – 204	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	205 – 270	CytoplasmicSequence analysisAdd BLAST	66
Transmembraneⁱ	271 – 289	Helical; Name=7Sequence analysisAdd BLAST	19
Topological domainⁱ	290 – 305	ExtracellularSequence analysisAdd BLAST	16
Transmembraneⁱ	306 – 326	Helical; Name=8Sequence analysisAdd BLAST	21
Topological domainⁱ	327 – 332	CytoplasmicSequence analysis	6
Transmembraneⁱ	333 – 353	Helical; Name=9Sequence analysisAdd BLAST	21
Topological domainⁱ	354 – 367	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	368 – 388	Helical; Name=10Sequence analysisAdd BLAST	21
Topological domainⁱ	389 – 408	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	409 – 429	Helical; Name=11Sequence analysisAdd BLAST	21
Topological domainⁱ	430 – 436	ExtracellularSequence analysis	7
Transmembraneⁱ	437 – 457	Helical; Name=12Sequence analysisAdd BLAST	21
Topological domainⁱ	458 – 531	CytoplasmicSequence analysisAdd BLAST	74

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050410	1 – 531	High-affinity glucose transporter ght2Add BLAST		531

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	361	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	507	Phosphoserine1 Publication	1
Modified residueⁱ	515	Phosphoserine1 Publication	1
Modified residueⁱ	519	Phosphoserine1 Publication	1
Modified residueⁱ	520	Phosphoserine1 Publication	1
Modified residueⁱ	523	Phosphotyrosine1 Publication	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O74969
PaxDbⁱ	O74969
PRIDEⁱ	O74969

PTM databases

iPTMnetⁱ	O74969

iPTMnetⁱ

O74969

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	276521, 1 interactor
STRINGⁱ	4896.SPBC4B4.08.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O74969
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMⁱ	HOG000202870
InParanoidⁱ	O74969
KEGG Orthology (KO) More...KOⁱ	K08139
OMAⁱ	VIGWSGP
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C1Q5W
PhylomeDBⁱ	O74969

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O74969-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGFKRGKNFT LVMLIFVSMA GWMFGADTGS IGGVTSMRDF RERYADRYDP 
        60         70         80         90        100
ITDQYSLSSA RQGLLTGMVN VGSLFGCIIS SPIADRFGKR LSIIGFCAVY 
       110        120        130        140        150
IIGIIVQVTA VPSWVQIMVA KIWTGIGIGA LSVLAPGYQS ETAPPSIRGT 
       160        170        180        190        200
VVVTYQLFVT GGIFIAACIN MGTHKLHKTA QWRVSIGINL LWGIITMIGI 
       210        220        230        240        250
LFLPESPRYL IQVGKDEEAV RVLSESAELF PDSEEVQNEY HRLKSSIDEE 
       260        270        280        290        300
FAGGPCSWAS IFGKDIRYRT FLGMFVMSLQ QLTGNNYFFY YGFSVMQGAG 
       310        320        330        340        350
INSPYLSAMI LDAVNFGCTF GGMYVLERFG RRNPLIIGGI WQSICFFIYS 
       360        370        380        390        400
AVGSRALYHK NGTSNTRAGA VMIVMACLFI FGFAQTWAPA AYVIVGESYP 
       410        420        430        440        450
VRYRSKCAAV ATASNWLWNF LISFFTPFIQ ASIGFKYGYV FASCNLTGAI 
       460        470        480        490        500
VIFLFAKETK GLTLEEINEL YMSVIKPWES GNFKLNYSEQ KKVEKEKSRK 
       510        520        530 
GGARGESVEY VERASNTDSS PQYSSHEEDY A

Length:531

Mass (Da):58,846

Last modified:November 1, 1998 - v1

Checksum:ⁱ6446BAAAC7FF698E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1 – 12	Missing in AAB70519 (PubMed:10735857).CuratedAdd BLAST		12
Sequence conflictⁱ	29	G → R in AAB70519 (PubMed:10735857).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF017180 mRNA Translation: AAB70519.1 CU329671 Genomic DNA Translation: CAA19288.1
PIRⁱ	T40480 T43533
NCBI Reference Sequences More...RefSeqⁱ	NP_596425.1, NM_001022344.2

Genome annotation databases

EnsemblFungiⁱ	SPBC4B4.08.1; SPBC4B4.08.1:pep; SPBC4B4.08
GeneIDⁱ	2539977
KEGGⁱ	spo:SPBC4B4.08

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O74969	High-affinity glucose transporter ght5		SCHPO		546	UniRef50_P78831
Hexose transporter Ght2		SCHJY		524
Hexose transporter Ght5		SCHOY		530
Hexose transporter Ght6		SCHCR		534
Probable high-affinity hexose transporter ght8, mitochondrial		SCHPO		547
+19

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF017180 mRNA Translation: AAB70519.1 CU329671 Genomic DNA Translation: CAA19288.1
PIRⁱ	T40480 T43533
RefSeqⁱ	NP_596425.1, NM_001022344.2

3D structure databases

ProteinModelPortalⁱ	O74969
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	276521, 1 interactor
STRINGⁱ	4896.SPBC4B4.08.1

Protein family/group databases

TCDBⁱ	2.A.1.1.21 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.1.21 the major facilitator superfamily (mfs)

PTM databases

iPTMnetⁱ	O74969

iPTMnetⁱ

O74969

Proteomic databases

MaxQBⁱ	O74969
PaxDbⁱ	O74969
PRIDEⁱ	O74969

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPBC4B4.08.1; SPBC4B4.08.1:pep; SPBC4B4.08
GeneIDⁱ	2539977
KEGGⁱ	spo:SPBC4B4.08

Organism-specific databases

EuPathDBⁱ	FungiDB:SPBC4B4.08
PomBaseⁱ	SPBC4B4.08 ght2

Phylogenomic databases

HOGENOMⁱ	HOG000202870
InParanoidⁱ	O74969
KOⁱ	K08139
OMAⁱ	VIGWSGP
OrthoDBⁱ	EOG092C1Q5W
PhylomeDBⁱ	O74969

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O74969

PROⁱ

PR:O74969

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GHT2_SCHPO
Accessionⁱ	O74969Primary (citable) accession number: O74969 Secondary accession number(s): O13346
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

UniProtKB

UniParc

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Proteomes

Annotation systems

Supporting data

UniProtKB - O74969 (GHT2_SCHPO)

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High-affinity glucose transporter ght2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Golgi apparatus

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ