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Protein

DNA polymerase kappa

Gene

mug40

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Has a role in meiosis.2 Publications

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi136MagnesiumBy similarity1
Metal bindingi226MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: PomBase
  • DNA replication Source: UniProtKB-KW
  • error-free translesion synthesis Source: PomBase
  • meiotic cell cycle Source: UniProtKB-KW
  • response to intra-S DNA damage checkpoint signaling Source: PomBase
  • translesion synthesis Source: PomBase

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication, DNA synthesis, Meiosis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-5655862 Translesion synthesis by POLK
R-SPO-5656169 Termination of translesion DNA synthesis
R-SPO-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-SPO-5696400 Dual Incision in GG-NER
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase kappa (EC:2.7.7.7)
Alternative name(s):
Meiotically up-regulated gene 40 protein
Gene namesi
Name:mug40
ORF Names:SPCC553.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC553.07c
PomBaseiSPCC553.07c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002785221 – 547DNA polymerase kappaAdd BLAST547

Proteomic databases

MaxQBiO74944
PaxDbiO74944
PRIDEiO74944

Interactioni

Subunit structurei

Interacts with hus1 and rad17.1 Publication

Protein-protein interaction databases

BioGridi276108, 10 interactors
STRINGi4896.SPCC553.07c.1

Structurei

3D structure databases

ProteinModelPortaliO74944
SMRiO74944
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 316UmuCAdd BLAST185

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 28Poly-Ser4

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiO74944
KOiK03511
OMAiLRCTHLV
OrthoDBiEOG092C4SHK
PhylomeDBiO74944

Family and domain databases

CDDicd03586 PolY_Pol_IV_kappa, 1 hit
Gene3Di3.30.1490.100, 1 hit
HAMAPiMF_01113 DNApol_IV, 1 hit
InterProiView protein in InterPro
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR022880 DNApol_IV
IPR001126 UmuC
PfamiView protein in Pfam
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit
SUPFAMiSSF100879 SSF100879, 1 hit
PROSITEiView protein in PROSITE
PS50173 UMUC, 1 hit

Sequencei

Sequence statusi: Complete.

O74944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENAKDFIGE TIKENGLLTI EDDGSSSSDE EATLKRRLAG PSVLKSGQEN
60 70 80 90 100
VNQKKINEII YEASKGSKFF EAEQKRDREL RLRIEKVQVE VEKYQSKLRF
110 120 130 140 150
DKAFQREWTI RQESVDTTVE DFRAKRDLTQ IIVHVDCDAF YASIEELKNP
160 170 180 190 200
KLKSLPMAVG KSVLCTANYV ARKFGVRSAM PEFIARKICP DLVVIPLNLS
210 220 230 240 250
EYAIKSKEIQ NVLAQYDSNL CPASIDEFYM NLTSHLRLQE LAFTVENITM
260 270 280 290 300
VVEKIRKQVH EETGVTVSCG IAANKLLAKI ASNKRKPNNQ FFIPFDEIGI
310 320 330 340 350
SKFMNDLPVR EVSGIGRVLE QQLLGLEIKT CGDIQRNLVI LSYIFLPKSF
360 370 380 390 400
QNLLRCSYGF GTTILDEYGE SKRKTIGSEA TFSSNLSSPS IIEYKLRLLV
410 420 430 440 450
QNVSENLQKR GLVTNSIAIK YKTSEFQVHT KQKSIGQFIH SESDLLKPAL
460 470 480 490 500
QLLRQSYPMT IRLLGVRATK LVSKSRCLAM QLKFQSQNTV PCPVCQKNIE
510 520 530 540
NELGILNQHV DLCLNVETVK SLINTDHTAN PTIKKRKSNT LDTYFLE
Length:547
Mass (Da):62,055
Last modified:October 11, 2004 - v3
Checksum:iC18B08BF11336C71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA19259.2
PIRiT41397
RefSeqiNP_587767.2, NM_001022760.2

Genome annotation databases

EnsemblFungiiSPCC553.07c.1; SPCC553.07c.1:pep; SPCC553.07c
GeneIDi2539547
KEGGispo:SPCC553.07c

Similar proteinsi

Entry informationi

Entry nameiPOLK_SCHPO
AccessioniPrimary (citable) accession number: O74944
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2004
Last modified: June 20, 2018
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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