Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable tRNA-splicing endonuclease subunit sen54

Gene

sen54

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. May be required to embody the molecular ruler of the complex (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA-splicing endonuclease subunit sen54
Alternative name(s):
tRNA-intron endonuclease sen54
Gene namesi
Name:sen54
ORF Names:SPCC613.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC613.09
PomBaseiSPCC613.09 sen54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001940331 – 384Probable tRNA-splicing endonuclease subunit sen54Add BLAST384

Proteomic databases

MaxQBiO74908
PaxDbiO74908
PRIDEiO74908

Interactioni

Subunit structurei

tRNA splicing endonuclease is a heterotetramer composed of sen2, sen15, sen34 and sen54. Interacts directly with sen2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi4896.SPCC613.09.1

Structurei

3D structure databases

ProteinModelPortaliO74908
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEN54 family.Curated

Phylogenomic databases

HOGENOMiHOG000216526
InParanoidiO74908
KOiK15326
OMAiWERYQAY
OrthoDBiEOG092C3DBL
PhylomeDBiO74908

Family and domain databases

InterProiView protein in InterPro
IPR024337 tRNA_splic_suSen54
IPR024336 tRNA_splic_suSen54_N
PANTHERiPTHR21027 PTHR21027, 1 hit
PfamiView protein in Pfam
PF12928 tRNA_int_end_N2, 1 hit

Sequencei

Sequence statusi: Complete.

O74908-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAQDEDNPF TNLETTVDVT EEIQDWRFLS NVEKDQGTYT IPKRGQKDFE
60 70 80 90 100
PDGTNKQHSA LDLSRKAMFD ALSVERLISA KHAIIATWNA QNGMSCVEKA
110 120 130 140 150
HGPLFKTMGT ADSQNRMWLL PEETLYLVER GSMECWSEEG LPMSLQAVYS
160 170 180 190 200
ASIPLCGSLE NYLVYAHLRR CGFSVIRSNL VPVKEDEYRC DSKIMNFKDL
210 220 230 240 250
LFLGLGKASQ ILQTFNFRKL AFPFSKRRRQ SILLHDTFYT YEEVYHDLQI
260 270 280 290 300
VRGYVPIACN LITSSDSLFQ ITFHAYKPSA SFKKSALSEP DFRICVVSSQ
310 320 330 340 350
DTLLPTIFEI DALFSSTPLR QNMPQHMFQR LKEGYRNIII AIVDYGVISY
360 370 380
IRLSDVCFEE KVYTDFSKKG SKRKRVSKKF QQLV
Length:384
Mass (Da):44,151
Last modified:November 1, 1998 - v1
Checksum:i69AA96FD3AF30636
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA21061.1
PIRiT41475
RefSeqiNP_587697.1, NM_001022692.2

Genome annotation databases

EnsemblFungiiSPCC613.09.1; SPCC613.09.1:pep; SPCC613.09
GeneIDi2538979
KEGGispo:SPCC613.09

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA21061.1
PIRiT41475
RefSeqiNP_587697.1, NM_001022692.2

3D structure databases

ProteinModelPortaliO74908
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4896.SPCC613.09.1

Proteomic databases

MaxQBiO74908
PaxDbiO74908
PRIDEiO74908

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC613.09.1; SPCC613.09.1:pep; SPCC613.09
GeneIDi2538979
KEGGispo:SPCC613.09

Organism-specific databases

EuPathDBiFungiDB:SPCC613.09
PomBaseiSPCC613.09 sen54

Phylogenomic databases

HOGENOMiHOG000216526
InParanoidiO74908
KOiK15326
OMAiWERYQAY
OrthoDBiEOG092C3DBL
PhylomeDBiO74908

Miscellaneous databases

PROiPR:O74908

Family and domain databases

InterProiView protein in InterPro
IPR024337 tRNA_splic_suSen54
IPR024336 tRNA_splic_suSen54_N
PANTHERiPTHR21027 PTHR21027, 1 hit
PfamiView protein in Pfam
PF12928 tRNA_int_end_N2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEN54_SCHPO
AccessioniPrimary (citable) accession number: O74908
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1998
Last modified: February 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again