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Entry version 118 (18 Sep 2019)
Sequence version 1 (01 Nov 1998)
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Protein

BTB/POZ domain-containing protein 1

Gene

btb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BTB/POZ domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:btb1
ORF Names:SPCC330.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPCC330.11

Schizosaccharomyces pombe database

More...
PomBasei
SPCC330.11 btb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002783571 – 1347BTB/POZ domain-containing protein 1Add BLAST1347

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O74881

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O74881

PRoteomics IDEntifications database

More...
PRIDEi
O74881

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O74881

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cul3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
cul3Q097603EBI-3647943,EBI-3647930

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
275298, 28 interactors

Protein interaction database and analysis system

More...
IntActi
O74881, 2 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC330.11.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati51 – 81ANK 1Add BLAST31
Repeati86 – 115ANK 2Add BLAST30
Repeati148 – 198RCC1 1Add BLAST51
Repeati215 – 264RCC1 2Add BLAST50
Repeati265 – 322RCC1 3Add BLAST58
Repeati324 – 372RCC1 4Add BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini619 – 698BTB 1PROSITE-ProRule annotationAdd BLAST80
Domaini758 – 829BTB 2PROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O74881

Identification of Orthologs from Complete Genome Data

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OMAi
CQRCPFF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O74881

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
2.130.10.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR011333 SKP1/BTB/POZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 2 hits
PF00415 RCC1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 2 hits
SM00225 BTB, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF50985 SSF50985, 1 hit
SSF54695 SSF54695, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50097 BTB, 2 hits
PS50012 RCC1_3, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O74881-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHLLFAYYL CNDIRSFQNL LKQDDSKVKE PRKGFSEKSG QKLRINQKDR
60 70 80 90 100
YGRTVLHIAV SENKNSFVRS LLQHKGIDVF VQDEESGYTA LHRAIYVGNL
110 120 130 140 150
EAASLLLSKD PSFRSLRIKD KEGLSPFQFL SRVLSSTIHP VLDLPIIGNE
160 170 180 190 200
LYGFGTNVNN TLGIANGKEP SSPERVFLLK NQTESPTSGQ LFSRDKILDV
210 220 230 240 250
QASKFHSVVL TDEPSQNVYV CGIGAGGRIG FNTDVQYNFI PIPGIIHKVI
260 270 280 290 300
QISVSHTHSL ALTKFGSIYS WGKNGSGELG LSNDELKKDD PIQITPRRIS
310 320 330 340 350
AFKDYQIIGM AAGKSYSVAW TDTDIYSWGL NNGQLGISDH ISVVSTPRRV
360 370 380 390 400
AGLLSPVIHA VCTTRATICL LQNNSIIAFC NYNQVKLPFN VDFGSSLKVT
410 420 430 440 450
KHPLSLTRFN VRKLLASENK LAVLTELGEV YEFDMKLLLD RDSTSSKNST
460 470 480 490 500
RTSFKFTPLW IFESSDLAAL DIAWTADNSL ILCTRNGTCW KRELRSKKRE
510 520 530 540 550
KSSSSPYSRG PYKYNRIENL QMVVGVRASA SGSFFAIRND YLPPPIYKPS
560 570 580 590 600
NMLIDLLRSL LPYDHLLHVR QPRLIPPEDE DGVPIFDEDR AASSNEMQLL
610 620 630 640 650
FEGSIPILTS YENYKQSFSD VTIYCGTSMF HSHKFILCAR SSFLRKLLLQ
660 670 680 690 700
KKKSSVSNII YIEEITQSHS TIRVEDIPPL AVAILLHYLY TDTLLSPWHL
710 720 730 740 750
DSRFSPLKEN LSKLANLLEL PHLAEVLPFS VSRQPLLSLT NDILQLYNNF
760 770 780 790 800
YVLCEETMDT VIKLKDGELK AHGLFLSLRS EYFSSYFQFV SMESNSFDIP
810 820 830 840 850
ITVNLSHLTV EHMSIVLRHV YSDLKVELFD DLKESDFHNW LETMFEILSI
860 870 880 890 900
ADELLFLELK SIAQQSLLRF LNLKTLPTLM DLSLSYHAEE LYSRCIDYAC
910 920 930 940 950
HNIEFFLEAN RISEWDGFHL KKVAQRLTEL LSDQRVHLPS SKIANRLLIR
960 970 980 990 1000
DPVLMEKRNY ELKVLREYLF SQESSQLWDD SPYRSIFEDR RCSTSAVILE
1010 1020 1030 1040 1050
SGIVPSSNQS DSLNKEDAEE KSPKPNVVNV TSITKTAGAS VEIQNNIESA
1060 1070 1080 1090 1100
SSGGDKTQLN GPGADQPVTA TITFDKTSPW RNRENLSHNN NTTRASLREL
1110 1120 1130 1140 1150
LEQEKADAST TTVLSDSRFM KAPTKKSQRE KKKELSKQVP ISKTNVGHID
1160 1170 1180 1190 1200
IELGKSNHSN PWSVATHQRG SFSSSTGVKK SFNGILREAA REEGSSQVIY
1210 1220 1230 1240 1250
QESKKRISNG SPTSWNLLTK PSPRSASLPK NSQPLSISEI MTEQKEEIES
1260 1270 1280 1290 1300
QKRRSSFRKT IEEIQQEEEF QKWWEEESLR VQKELGILKT ERDTSTNRKQ
1310 1320 1330 1340
GQASKQPQRR HRKEKDSKVS ESTAEFKSLP IDIPRTTHKK GKARAVK
Length:1,347
Mass (Da):152,586
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5A3C9FF2E682C3C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA20916.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T41321

NCBI Reference Sequences

More...
RefSeqi
NP_587711.1, NM_001022706.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC330.11.1; SPCC330.11.1:pep; SPCC330.11

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2538714

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC330.11

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA20916.1
PIRiT41321
RefSeqiNP_587711.1, NM_001022706.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi275298, 28 interactors
IntActiO74881, 2 interactors
STRINGi4896.SPCC330.11.1

PTM databases

iPTMnetiO74881

Proteomic databases

MaxQBiO74881
PaxDbiO74881
PRIDEiO74881

Genome annotation databases

EnsemblFungiiSPCC330.11.1; SPCC330.11.1:pep; SPCC330.11
GeneIDi2538714
KEGGispo:SPCC330.11

Organism-specific databases

EuPathDBiFungiDB:SPCC330.11
PomBaseiSPCC330.11 btb1

Phylogenomic databases

InParanoidiO74881
OMAiCQRCPFF
PhylomeDBiO74881

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O74881

Family and domain databases

Gene3Di1.25.40.20, 1 hit
2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF00651 BTB, 2 hits
PF00415 RCC1, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00225 BTB, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50985 SSF50985, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50097 BTB, 2 hits
PS50012 RCC1_3, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBTB1_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O74881
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 1, 1998
Last modified: September 18, 2019
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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