UniProtKB - O74831 (FRDA_SCHPO)
Protein
Frataxin homolog, mitochondrial
Gene
SPCC1183.03c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+. May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (By similarity).By similarity
Catalytic activityi
- EC:1.16.3.1
GO - Molecular functioni
- 2 iron, 2 sulfur cluster binding Source: GO_Central
- ferric iron binding Source: GO_Central
- ferrous iron binding Source: GO_Central
- ferroxidase activity Source: GO_Central
- iron chaperone activity Source: PomBase
GO - Biological processi
- [2Fe-2S] cluster assembly Source: PomBase
- cellular iron ion homeostasis Source: GO_Central
- heme biosynthetic process Source: PomBase
- ion transport Source: UniProtKB-KW
- iron incorporation into metallo-sulfur cluster Source: PomBase
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Heme biosynthesis, Ion transport, Iron storage, Iron transport, Transport |
Ligand | Iron |
Enzyme and pathway databases
Reactomei | R-SPO-1268020, Mitochondrial protein import R-SPO-1362409, Mitochondrial iron-sulfur cluster biogenesis |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:SPCC1183.03c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPCC1183.03c |
VEuPathDBi | FungiDB:SPCC1183.03c |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrial matrix Source: PomBase
- mitochondrion Source: PomBase
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | Mitochondrion | ||
ChainiPRO_0000010134 | ? – 158 | Frataxin homolog, mitochondrial |
Proteomic databases
MaxQBi | O74831 |
PaxDbi | O74831 |
Interactioni
Subunit structurei
Monomer. Oligomer (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 275715, 1 interactor |
STRINGi | 4896.SPCC1183.03c.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the frataxin family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3413, Eukaryota |
HOGENOMi | CLU_080880_4_0_1 |
InParanoidi | O74831 |
OMAi | VYAHDGV |
PhylomeDBi | O74831 |
Family and domain databases
Gene3Di | 3.30.920.10, 1 hit |
InterProi | View protein in InterPro IPR017789, Frataxin IPR002908, Frataxin/CyaY IPR036524, Frataxin/CyaY_sf IPR020895, Frataxin_CS |
PANTHERi | PTHR16821, PTHR16821, 1 hit |
Pfami | View protein in Pfam PF01491, Frataxin_Cyay, 1 hit |
PRINTSi | PR00904, FRATAXIN |
SMARTi | View protein in SMART SM01219, Frataxin_Cyay, 1 hit |
SUPFAMi | SSF55387, SSF55387, 1 hit |
TIGRFAMsi | TIGR03421, FeS_CyaY, 1 hit TIGR03422, mito_frataxin, 1 hit |
PROSITEi | View protein in PROSITE PS01344, FRATAXIN_1, 1 hit PS50810, FRATAXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O74831-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSLRAAFRR RTPIFLKPYE FSTNVFGLRC RYYSQVRHNG ALTDLEYHRV
60 70 80 90 100
ADDTLDVLND TFEDLLEEVG KKDYDIQYAN GVITLMLGEK GTYVINKQPP
110 120 130 140 150
AHQIWLSSPV SGPKHYEYSL KSKTWCSTRD EGTLLGILSS EFSKWFSRPI
EFKKSEDF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA21083.1 |
PIRi | T40843 |
RefSeqi | NP_587886.1, NM_001022878.2 |
Genome annotation databases
EnsemblFungii | SPCC1183.03c.1; SPCC1183.03c.1:pep; SPCC1183.03c |
GeneIDi | 2539143 |
KEGGi | spo:SPCC1183.03c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA21083.1 |
PIRi | T40843 |
RefSeqi | NP_587886.1, NM_001022878.2 |
3D structure databases
SMRi | O74831 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 275715, 1 interactor |
STRINGi | 4896.SPCC1183.03c.1 |
Proteomic databases
MaxQBi | O74831 |
PaxDbi | O74831 |
Genome annotation databases
EnsemblFungii | SPCC1183.03c.1; SPCC1183.03c.1:pep; SPCC1183.03c |
GeneIDi | 2539143 |
KEGGi | spo:SPCC1183.03c |
Organism-specific databases
PomBasei | SPCC1183.03c |
VEuPathDBi | FungiDB:SPCC1183.03c |
Phylogenomic databases
eggNOGi | KOG3413, Eukaryota |
HOGENOMi | CLU_080880_4_0_1 |
InParanoidi | O74831 |
OMAi | VYAHDGV |
PhylomeDBi | O74831 |
Enzyme and pathway databases
Reactomei | R-SPO-1268020, Mitochondrial protein import R-SPO-1362409, Mitochondrial iron-sulfur cluster biogenesis |
Miscellaneous databases
PROi | PR:O74831 |
Family and domain databases
Gene3Di | 3.30.920.10, 1 hit |
InterProi | View protein in InterPro IPR017789, Frataxin IPR002908, Frataxin/CyaY IPR036524, Frataxin/CyaY_sf IPR020895, Frataxin_CS |
PANTHERi | PTHR16821, PTHR16821, 1 hit |
Pfami | View protein in Pfam PF01491, Frataxin_Cyay, 1 hit |
PRINTSi | PR00904, FRATAXIN |
SMARTi | View protein in SMART SM01219, Frataxin_Cyay, 1 hit |
SUPFAMi | SSF55387, SSF55387, 1 hit |
TIGRFAMsi | TIGR03421, FeS_CyaY, 1 hit TIGR03422, mito_frataxin, 1 hit |
PROSITEi | View protein in PROSITE PS01344, FRATAXIN_1, 1 hit PS50810, FRATAXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FRDA_SCHPO | |
Accessioni | O74831Primary (citable) accession number: O74831 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families