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Entry version 116 (07 Apr 2021)
Sequence version 1 (01 Nov 1998)
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Protein

Cryptic loci regulator protein 1

Gene

clr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates silencing of the mat2 and mat3 loci. Organizes the chromatin structure of the mating-type region where it also participates in establishing the 'cold spot' for recombination. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1062 – 1087C2H2-typePROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cryptic loci regulator protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:clr1
ORF Names:SPBC2D10.17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

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PomBasei
SPBC2D10.17, clr1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC2D10.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus, Telomere

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002906371 – 1238Cryptic loci regulator protein 1Add BLAST1238

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O74808

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O74808

PRoteomics IDEntifications database

More...
PRIDEi
O74808

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O74808

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with clr3.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
277085, 107 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC2D10.17.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O74808

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi198 – 297Ser-richAdd BLAST100

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1062 – 1087C2H2-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_260175_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O74808

Identification of Orthologs from Complete Genome Data

More...
OMAi
LKHRRFN

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013087, Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O74808-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPDISSSE TLTELQQLRL LYFFCFYHAA PFNVKTLVHS LIPPGALSYL
60 70 80 90 100
LSTYDILRPW LMALRVREGP VNDISTIVQL YEEIVKTGFF INPPPFESYS
110 120 130 140 150
QTLVARITTL GRPKLQVQQE AQSEVYQRAS TNTQQQVSNV SHGNFKPNSS
160 170 180 190 200
VNTEPNTSIL SNSKYAGIKP FDFQSSSQNP GLVCEQKTFY QHQFRPFSNL
210 220 230 240 250
PSNKSSPVKH VSPNVKNNSK KTASSVNSNH SSIPSSITKS NISSLDVYGS
260 270 280 290 300
EKLISSGSQQ PGHGMVQTTS DKVNASASLY DRSPSKKDIT SSRNTSSYNL
310 320 330 340 350
GSMRNPSTLK NAAHANPFEG LRFQGSSAVL KEGLNSTVKK TFFDNLNSEK
360 370 380 390 400
VCPSVSPFLT PDNIASSILY STASFSRSKP DRPRLNLSLE LKLMQNELNK
410 420 430 440 450
GQLKKQFKGD LRNLADWNNL SLVSSKFPSL PITNLRPDGS FLKHRRFNEE
460 470 480 490 500
IAYNRQTLEK AIKQLDLSPD KVIQLREQNG VAVNGRVCYP TRNKHSEISA
510 520 530 540 550
QSSSSLGVTK SLASEVYSSS TVDTISKLNT DKDNYLIKSK KEPIQQKSVS
560 570 580 590 600
SETTLVKPSS TSSYIDTTNN VLKTNSSFKS SGLTSGPRNE KELLPEGIPT
610 620 630 640 650
SHNNSETQAQ TADVSNIAAS ADGIYNSDQE KPPEKLDVTK RAFGREIENS
660 670 680 690 700
NEKELLTSTF LSPSAESQVC LAEIKTIRPG LVPKKQFSVD QNNVISDNTD
710 720 730 740 750
CSLPKPSNSK LSSISSDGDA SSNRMAVPDK SPFVHAAPNS KALTKDSFST
760 770 780 790 800
HISVSSLLHS DNEISPIDST RKDYFTSKDS NLQTLKEDAS STKQAKDSGT
810 820 830 840 850
NDFDKLISGN DVSKNNSGEE QSRSALKPLI SGKLSSCESI NLTKDISTVK
860 870 880 890 900
RKEYFGIEST SSKQPFHDTG SIKIPAKRSF DTIDKDFRSS NIPFADKIKE
910 920 930 940 950
DGGDKNVISS IHITTELPKS MPVEVPTNAG AQSDQSNVVD SESLNLRENI
960 970 980 990 1000
STSVADVSLS QAGNEAVLSK KACKPLVLID PFEEKVLKAF NMLSKGYAEY
1010 1020 1030 1040 1050
RCQWEGCLAN LHSLENFIKH VLLLHHPKSC SVVKCLWASC DMVLPSEEFE
1060 1070 1080 1090 1100
MHLRGHLNNI RLNCEVSNCK KCFSNYEDMF KHLQHSHLPF KFTPESFIKI
1110 1120 1130 1140 1150
RNGNVKEEAR RTRNAYTQKS GEVECFMETC TPIAKPAPAN WYPVPPPGFN
1160 1170 1180 1190 1200
SSLLSRLTQS NQSKDKIIAA LAKRNVYKSF AGLYDSKGKN DNTGYDFDSN
1210 1220 1230
YARVGRHGSF ILPVSKSVPT PSLLIEGSIV QRKNIKIE
Length:1,238
Mass (Da):136,677
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C6F2213478758CC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21175.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40120

NCBI Reference Sequences

More...
RefSeqi
NP_596236.1, NM_001022156.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC2D10.17.1; SPBC2D10.17.1:pep; SPBC2D10.17

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540558

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC2D10.17

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21175.1
PIRiT40120
RefSeqiNP_596236.1, NM_001022156.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IKFX-ray2.80B357-500[»]
5IKJX-ray2.30B1151-1238[»]
SMRiO74808
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi277085, 107 interactors
STRINGi4896.SPBC2D10.17.1

PTM databases

iPTMnetiO74808

Proteomic databases

MaxQBiO74808
PaxDbiO74808
PRIDEiO74808

Genome annotation databases

EnsemblFungiiSPBC2D10.17.1; SPBC2D10.17.1:pep; SPBC2D10.17
GeneIDi2540558
KEGGispo:SPBC2D10.17

Organism-specific databases

PomBaseiSPBC2D10.17, clr1
VEuPathDBiFungiDB:SPBC2D10.17

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
HOGENOMiCLU_260175_0_0_1
InParanoidiO74808
OMAiLKHRRFN

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O74808

Family and domain databases

InterProiView protein in InterPro
IPR013087, Znf_C2H2_type
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLR1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O74808
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 1, 1998
Last modified: April 7, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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