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Entry version 138 (12 Aug 2020)
Sequence version 1 (01 Nov 1998)
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Protein

Myosin-51

Gene

myo51

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cytokinesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi159 – 166ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-190873, Gap junction degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-51
Alternative name(s):
Myosin type V-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:myo51
ORF Names:SPBC2D10.14c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPBC2D10.14c

Schizosaccharomyces pombe database

More...
PomBasei
SPBC2D10.14c, myo51

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234821 – 1471Myosin-51Add BLAST1471

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O74805

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O74805

PRoteomics IDEntifications database

More...
PRIDEi
O74805

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
277087, 40 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC2D10.14c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O74805

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 61Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST55
Domaini65 – 749Myosin motorPROSITE-ProRule annotationAdd BLAST685
Domaini753 – 773IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini776 – 796IQ 2PROSITE-ProRule annotationAdd BLAST21
Domaini801 – 821IQ 3PROSITE-ProRule annotationAdd BLAST21
Domaini824 – 844IQ 4PROSITE-ProRule annotationAdd BLAST21
Domaini849 – 869IQ 5PROSITE-ProRule annotationAdd BLAST21
Domaini872 – 892IQ 6PROSITE-ProRule annotationAdd BLAST21
Domaini1171 – 1417DilutePROSITE-ProRule annotationAdd BLAST247

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni628 – 650Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili909 – 952Sequence analysisAdd BLAST44

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0160, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000192_9_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O74805

KEGG Orthology (KO)

More...
KOi
K10357

Identification of Orthologs from Complete Genome Data

More...
OMAi
RDIRMHL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O74805

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01380, MYSc_Myo5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002710, Dilute_dom
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR004009, Myosin_N
IPR036103, MYSc_Myo5
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843, DIL, 1 hit
PF00612, IQ, 4 hits
PF00063, Myosin_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132, DIL, 1 hit
SM00015, IQ, 5 hits
SM00242, MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50096, IQ, 4 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O74805-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHARLSVGS ECWVSNNNGH WDAARLIEIK DNGGGKVVAT VAKSSGVLET
60 70 80 90 100
VNYQQLQNRN IGQSESPSDL TNLPYLNEPS VLHALHNRYN NKQIYTYSGI
110 120 130 140 150
VLVSINPYQN LPEFYNDNLI KHFHKDPEAA KVPHLYSIAS SCYHALTTDS
160 170 180 190 200
KNQTIIVSGE SGAGKTVAAK YIMRYLTSVQ GVDHNGVVKR SVENQVLATN
210 220 230 240 250
PIMEAFGNAK TIRNDNSSRF GKYVTISFDE NLLITGANVN TYLLERSRVV
260 270 280 290 300
SLLKGERNYH IFYQLITGCT EEQRDKWFLE SASSFNYLSQ GNCDEISGVD
310 320 330 340 350
DSNDFTITCR ALSTIGISES RQEDVFCLLA ALLHLGNIEV CATRNEAQIQ
360 370 380 390 400
PGDGYLQKAA LLLGVDSSTL AKWIVKRQLK TRSETIITSS TLEHAISIRD
410 420 430 440 450
SVAKYLYSAL FLWIVHMINA SLDHNKVKRA AYKYIGVVDI YGFEHFEKNS
460 470 480 490 500
MEQFCINYAN EKLQQEFNKH VFKLEQEEYV KEGLDWRLIE YSDNQGCISL
510 520 530 540 550
IEDKLGILSL LDEECRLPSG NHQSFLQKLN NQLPTKHSQF YKKSRFNDGS
560 570 580 590 600
FMVKHYALDV SYQVHDFLAK NSDAIPDEFI SLLQNSKNEF ITYLLDFYMQ
610 620 630 640 650
LVSSQNKNPR KTAISRKPTL SSMFKSSLSQ LMTTVSSTNV HYIRCIKPNE
660 670 680 690 700
EKLPWTFSPP MVLSQLRACG VFETIRISSL GFPARFSYEE FAHRFRILLS
710 720 730 740 750
SKEWEEDNKK LTLNIVNSVI PHDNLNFQVG RSKIFFRSNV IGNFEEAHRA
760 770 780 790 800
TCSKSTVLLQ SAIRGFFTRK EYQRTVKFII KLQSVIMGWL TRQRFEREKI
810 820 830 840 850
ERAAILIQAH WRSYIQRKRY LSLIKCAIVI QSIVRKNIAY SRYINELRES
860 870 880 890 900
SATLLAKFWR AYNARKTFRG LKKSVIALQC VSRSVLTRRY LRRLQDSAGR
910 920 930 940 950
TSILYEKQKN LQASITEVSK QLKSNSKKVT VLRNKLNILN NSLSKWKCLI
960 970 980 990 1000
KKPSDFSEPV SMDFTSNDEQ LVQLLQAESK LRQASQQLYM AAKKSELGFV
1010 1020 1030 1040 1050
QSQTARENLS NYYQALQMTV SEKFEYDTEQ LPSRVLFYAM DRYFSIHKKL
1060 1070 1080 1090 1100
KQLLELVGVE NASLLPNEVV NKQTKDLLYE KRVVFLKQIK QALTVSSLFN
1110 1120 1130 1140 1150
AVGYKDGVMR LLETDQNSLL FAGVVNFLIF AGISLDLKTQ ISEFLSQLCS
1160 1170 1180 1190 1200
YFTKIVDGTV IENDKTLDFY EKPLQAVLYW FATLHKIRSF LVHLLSINSH
1210 1220 1230 1240 1250
GKQSVVEDLW NPLILKFSKH FSNLENSFHS LVQKLLSCCT EGSINALLNS
1260 1270 1280 1290 1300
KCLPEFIDAA DENTTPTGMN IYELIDRMNL IHKLLISSAL QPNLLELTIS
1310 1320 1330 1340 1350
HMLQHIGQRA FQTLIHGRSP YTWKSASQVS YNASLLINWC HQKGISYVNS
1360 1370 1380 1390 1400
SLLPLMQSPL VFCLRKNDAN DLDVILSVCN LLSPFEVVCL LNRYQPCAGE
1410 1420 1430 1440 1450
NPLPKSFSKA VEALSCKYKQ SGFTNGKITN TNGHAIPIAA SKNPLLSLEN
1460 1470
NHIYEELRLS ELINLLAKAT L
Length:1,471
Mass (Da):167,657
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC4079A033DE232ED
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21172.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40117

NCBI Reference Sequences

More...
RefSeqi
NP_596233.1, NM_001022153.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC2D10.14c.1; SPBC2D10.14c.1:pep; SPBC2D10.14c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540560

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC2D10.14c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21172.1
PIRiT40117
RefSeqiNP_596233.1, NM_001022153.2

3D structure databases

SMRiO74805
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi277087, 40 interactors
STRINGi4896.SPBC2D10.14c.1

Proteomic databases

MaxQBiO74805
PaxDbiO74805
PRIDEiO74805

Genome annotation databases

EnsemblFungiiSPBC2D10.14c.1; SPBC2D10.14c.1:pep; SPBC2D10.14c
GeneIDi2540560
KEGGispo:SPBC2D10.14c

Organism-specific databases

EuPathDBiFungiDB:SPBC2D10.14c
PomBaseiSPBC2D10.14c, myo51

Phylogenomic databases

eggNOGiKOG0160, Eukaryota
HOGENOMiCLU_000192_9_0_1
InParanoidiO74805
KOiK10357
OMAiRDIRMHL
PhylomeDBiO74805

Enzyme and pathway databases

ReactomeiR-SPO-190873, Gap junction degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O74805

Family and domain databases

CDDicd01380, MYSc_Myo5, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002710, Dilute_dom
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR004009, Myosin_N
IPR036103, MYSc_Myo5
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00612, IQ, 4 hits
PF00063, Myosin_head, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00015, IQ, 5 hits
SM00242, MYSc, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50096, IQ, 4 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO51_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O74805
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1998
Last modified: August 12, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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