UniProtKB - O74794 (CCHL_SCHPO)
Protein
Putative holocytochrome-c synthase
Gene
SPBC26H8.12
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.By similarity
Catalytic activityi
GO - Molecular functioni
- holocytochrome-c synthase activity Source: PomBase
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cytochrome c-heme linkage Source: PomBase
- mitochondrion organization Source: PomBase
Keywordsi
Molecular function | Lyase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Putative holocytochrome-c synthaseBy similarity (EC:4.4.1.17By similarity)Alternative name(s): Cytochrome c heme lyaseBy similarity Short name: CCHL |
Gene namesi | ORF Names:SPBC26H8.12 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC26H8.12 |
VEuPathDBi | FungiDB:SPBC26H8.12 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity
- Mitochondrion intermembrane space By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrial intermembrane space Source: PomBase
- mitochondrion Source: PomBase
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121716 | 1 – 377 | Putative holocytochrome-c synthaseAdd BLAST | 377 |
Proteomic databases
MaxQBi | O74794 |
PaxDbi | O74794 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 114 – 119 | HRM 1 | 6 | |
Repeati | 124 – 129 | HRM 2 | 6 |
Sequence similaritiesi
Belongs to the cytochrome c-type heme lyase family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3996, Eukaryota |
HOGENOMi | CLU_048602_0_0_1 |
InParanoidi | O74794 |
OMAi | NAVNEQC |
PhylomeDBi | O74794 |
Family and domain databases
InterProi | View protein in InterPro IPR000511, Cyt_C/C1_haem_lyase |
PANTHERi | PTHR12743, PTHR12743, 1 hit |
Pfami | View protein in Pfam PF01265, Cyto_heme_lyase, 1 hit |
PROSITEi | View protein in PROSITE PS00821, CYTO_HEME_LYASE_1, 1 hit PS00822, CYTO_HEME_LYASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O74794-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSSETTTDH PRTGKCPIDH SKFARSNEAN PDAYINGIKK DQQSSSWWNS
60 70 80 90 100
LWSRNTDVAS EPDVAMLHKK PSTVDTHDHP LANPPPGCPM HKASNENSTG
110 120 130 140 150
FFSNLFGREK QNSEATPAVQ PPATCPMSNS NQKPAGVSEV LTGVDSKQQS
160 170 180 190 200
YVPEGCPVAT PKRGWFNWFG NNDDQKQEAY EVDKSNMMYK NIPQTAVDDQ
210 220 230 240 250
VVGLETTRTT SSIPKVDGKN WEYPSPQQMY NAMWRKGYRD SGENVPIMVQ
260 270 280 290 300
VHNFLNEGAW SEIKAWEREA GENTEPKLLR FEGNANKRTP RALWYMMLGR
310 320 330 340 350
INPNRWGSGE GPFDRHDWYV QRKDNSIVRY VIDYYEAPDS ADGKPVFSLD
360 370
VRPAVDSFES VALRWKHWRA MRQMQQQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA21104.1 |
PIRi | T40024 |
RefSeqi | NP_596655.1, NM_001022577.2 |
Genome annotation databases
EnsemblFungii | SPBC26H8.12.1; SPBC26H8.12.1:pep; SPBC26H8.12 |
GeneIDi | 2540445 |
KEGGi | spo:SPBC26H8.12 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA21104.1 |
PIRi | T40024 |
RefSeqi | NP_596655.1, NM_001022577.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 4896.SPBC26H8.12.1 |
Proteomic databases
MaxQBi | O74794 |
PaxDbi | O74794 |
Genome annotation databases
EnsemblFungii | SPBC26H8.12.1; SPBC26H8.12.1:pep; SPBC26H8.12 |
GeneIDi | 2540445 |
KEGGi | spo:SPBC26H8.12 |
Organism-specific databases
PomBasei | SPBC26H8.12 |
VEuPathDBi | FungiDB:SPBC26H8.12 |
Phylogenomic databases
eggNOGi | KOG3996, Eukaryota |
HOGENOMi | CLU_048602_0_0_1 |
InParanoidi | O74794 |
OMAi | NAVNEQC |
PhylomeDBi | O74794 |
Miscellaneous databases
PROi | PR:O74794 |
Family and domain databases
InterProi | View protein in InterPro IPR000511, Cyt_C/C1_haem_lyase |
PANTHERi | PTHR12743, PTHR12743, 1 hit |
Pfami | View protein in Pfam PF01265, Cyto_heme_lyase, 1 hit |
PROSITEi | View protein in PROSITE PS00821, CYTO_HEME_LYASE_1, 1 hit PS00822, CYTO_HEME_LYASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCHL_SCHPO | |
Accessioni | O74794Primary (citable) accession number: O74794 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families