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Entry version 123 (12 Aug 2020)
Sequence version 1 (01 Nov 1998)
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Protein

Vacuolar membrane-associated protein iml1

Gene

iml1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: PomBase

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar membrane-associated protein iml1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:iml1
ORF Names:SPBC26H8.04c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPBC26H8.04c

Schizosaccharomyces pombe database

More...
PomBasei
SPBC26H8.04c, iml1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003017781 – 1496Vacuolar membrane-associated protein iml1Add BLAST1496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei738Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O74788

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O74788

PRoteomics IDEntifications database

More...
PRIDEi
O74788

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O74788

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
277086, 9 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC26H8.04c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O74788

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1116 – 1191DEPPROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi575 – 673Ser-richAdd BLAST99

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IML1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3572, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000935_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O74788

KEGG Orthology (KO)

More...
KOi
K20404

Identification of Orthologs from Complete Genome Data

More...
OMAi
RMYDLQM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O74788

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000591, DEP_dom
IPR027244, IML1
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13179, PTHR13179, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610, DEP, 1 hit
PF12257, IML1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049, DEP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186, DEP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O74788-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAITLNLWTH ESSLFPNDAV LNYDLVPSAK PGDIFEIRAQ NGDEIALQHN
60 70 80 90 100
HSSTGKLHAK REKEPVYLMP SPLTDDLKRR HPNLQLSVVS HISSLLNIKN
110 120 130 140 150
REPVVVKICE DKTNLEAEHV VIFFRDQFIS RSDMWKLFRE LCGKCVYLKQ
160 170 180 190 200
RVSFIGDVPG EIRCIWRKGK KCHSAYISER TKPIFRSESA RFLIFIQMSE
210 220 230 240 250
EMWHFEEDGE LNYNKAIDGF LPDLFSFWRD LGTHHLVSII LFTRVEYSHH
260 270 280 290 300
GPMCVWQPRS QKNSEKGSSI YPQNSFNASI DNEGGPYEDF FKVVVDNVSS
310 320 330 340 350
RDWQPVLANL KLELAKFRQD VIVRKIKDEN GREIEYICGR MTGSQEGNFL
360 370 380 390 400
EVINMAVFQF QSDYIDRDLS RTGTSIIIVT PGTGLYEVNE KMLHLTSKSL
410 420 430 440 450
LNTVVGMDIV SLGKVPLFLT PIVRYKNPVK NKKRSQLTSR ISSSVSPSNV
460 470 480 490 500
IPNSLTSSVS NFSVSSFLNN LKEDTEWLYT FPIGCNISFY STTEMRSLRS
510 520 530 540 550
PWENLMREHQ FEPTAKMHEL QMMGVLEAES AKISIPLLQS DPLLKGSVFS
560 570 580 590 600
EEVQEDYDER QFTGEAAVSA NDVLSSSSPR HFSSHTPVNV DKSSYLEMNG
610 620 630 640 650
HSLSTVISGK ESISSFGAKV DDLKSTSKES ARQFGKSALT ERLQKLAGNS
660 670 680 690 700
SNVSSSLQTS SSNKSSLLTK KSSFPALLKG FLALPATVTT SANPLGFKST
710 720 730 740 750
IQRPIPIKNN EDSDSCKAFS QAPPIATKKP PTFLKPNSPE YAKTVIPKSS
760 770 780 790 800
TNLENEYQTP WKIIQNPFKL KETTADNDPV SLRWEHLYMK VQDVRKFNWL
810 820 830 840 850
SMCTPGALPL TFSYFPSEEE LNDKFEEYTY TIGIDPEFTQ MNQQELLAEM
860 870 880 890 900
ICQRLSRGYQ IVVNPAAAVS YSGNPKANKA GTITDFSRSV NNQRNGHLTV
910 920 930 940 950
GSDAVCLSLG DSQFHRLSCD SVGYNIEVKR YVKKVSGQGK MRYDYNFWSK
960 970 980 990 1000
NECKYVKSNI TFSANDSANY NWNYVDQLIC GFETYLPDSV KYWRARFVLL
1010 1020 1030 1040 1050
PMSTTSTHVF QKYQLLDHAD ALSDEEFRVE GIYKLSELLY KGKIDPMNDS
1060 1070 1080 1090 1100
NNKTPNTSPA ELLGIKFTTL PMAQYIHSEL EALRLDSSRN EQSLFMPNKR
1110 1120 1130 1140 1150
LDCSADLHTI AKEIQGPGGP KIDDITWHYR IYENCFLGSE FVSWLANTFI
1160 1170 1180 1190 1200
GINTREEALK YGNKLLSLGL FDHALKKHPL LDGYYVYRIS PDYSIKPVSN
1210 1220 1230 1240 1250
RPYRSWFSRK KDSGQKHLDN KIITESEAGP SRLELSRRIL FNADVEKKNG
1260 1270 1280 1290 1300
KSETVTVHYD LLHNPASCYH IRIEWLLATA SVIEKLLQSW SRILERYGLK
1310 1320 1330 1340 1350
LVEAPIHEIA AVGELNPFDQ VSIISLALDP PPIPERAPLV NDPVNYSKNW
1360 1370 1380 1390 1400
WNVKILEHFD FILDTEAAST FPKSITAVYS WGKPNFRYVQ YIHRTGTVLV
1410 1420 1430 1440 1450
QIDDDQRFLW LPNRLHNSKV SKLSFTKSNK STLNPNLKET AEELERKFRE
1460 1470 1480 1490
FCSNKDELDQ FYGIVNHASD DRRSIYSSAS THASNASADD ASNVNV
Length:1,496
Mass (Da):169,995
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4750327975C1BFE4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21096.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40016

NCBI Reference Sequences

More...
RefSeqi
NP_596645.1, NM_001022567.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC26H8.04c.1; SPBC26H8.04c.1:pep; SPBC26H8.04c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540559

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC26H8.04c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21096.1
PIRiT40016
RefSeqiNP_596645.1, NM_001022567.2

3D structure databases

SMRiO74788
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi277086, 9 interactors
STRINGi4896.SPBC26H8.04c.1

PTM databases

iPTMnetiO74788

Proteomic databases

MaxQBiO74788
PaxDbiO74788
PRIDEiO74788

Genome annotation databases

EnsemblFungiiSPBC26H8.04c.1; SPBC26H8.04c.1:pep; SPBC26H8.04c
GeneIDi2540559
KEGGispo:SPBC26H8.04c

Organism-specific databases

EuPathDBiFungiDB:SPBC26H8.04c
PomBaseiSPBC26H8.04c, iml1

Phylogenomic databases

eggNOGiKOG3572, Eukaryota
HOGENOMiCLU_000935_1_1_1
InParanoidiO74788
KOiK20404
OMAiRMYDLQM
PhylomeDBiO74788

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O74788

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000591, DEP_dom
IPR027244, IML1
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PANTHERiPTHR13179, PTHR13179, 1 hit
PfamiView protein in Pfam
PF00610, DEP, 1 hit
PF12257, IML1, 1 hit
SMARTiView protein in SMART
SM00049, DEP, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50186, DEP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIML1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O74788
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 1, 1998
Last modified: August 12, 2020
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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