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Entry version 140 (10 Feb 2021)
Sequence version 1 (01 Nov 1998)
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Protein

Probable arginine--tRNA ligase, cytoplasmic

Gene

mrs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei160L-arginineBy similarity1
Binding sitei359L-arginineBy similarity1
Binding sitei363L-arginineBy similarity1
Binding sitei387L-arginineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mrs1
Synonyms:rrs1
ORF Names:SPBC25B2.09c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC25B2.09c, mrs1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC25B2.09c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001516631 – 618Probable arginine--tRNA ligase, cytoplasmicAdd BLAST618

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O74781

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O74781

PRoteomics IDEntifications database

More...
PRIDEi
O74781

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O74781

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4896.SPBC25B2.09c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O74781

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni60 – 61Interaction with tRNABy similarity2
Regioni104 – 109Interaction with tRNABy similarity6
Regioni146 – 151L-arginine bindingBy similarity6
Regioni496 – 510Interaction with tRNABy similarityAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi149 – 160'HIGH' regionAdd BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1195, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006406_6_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O74781

Identification of Orthologs from Complete Genome Data

More...
OMAi
YEFKWER

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O74781

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00671, ArgRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1360.70, 1 hit
3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR001278, Arg-tRNA-ligase
IPR005148, Arg-tRNA-synth_N
IPR036695, Arg-tRNA-synth_N_sf
IPR035684, ArgRS_core
IPR008909, DALR_anticod-bd
IPR014729, Rossmann-like_a/b/a_fold
IPR009080, tRNAsynth_Ia_anticodon-bd

The PANTHER Classification System

More...
PANTHERi
PTHR11956, PTHR11956, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05746, DALR_1, 1 hit
PF00750, tRNA-synt_1d, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01038, TRNASYNTHARG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01016, Arg_tRNA_synt_N, 1 hit
SM00836, DALR_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47323, SSF47323, 1 hit
SSF55190, SSF55190, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00456, argS, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O74781-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSVDQISK SLSTLGLQDL PVFREADIHH NPVDVYRSYI SSELSKINGV
60 70 80 90 100
DVSLIYPALE TSISKDSADL NLPVPRLRVK GKPQELAQKW AEAFPKDLVE
110 120 130 140 150
VTANGIFLRF NFNGPSLTKL ILPIIWEQRE NYGRNESGSG KVAVIEFSSP
160 170 180 190 200
NIAKPFHAGH LRSTIIGSFL ANLHESQGWK VHRVNYLGDW GKQFGLLAIG
210 220 230 240 250
YKKYGDEDQL KSNPIRHLYD VYVKVNADAT EEDEKIQKDK AEAESKGLPY
260 270 280 290 300
TPPLSLHDKA REFFKRMEDG DEESLKVWAR FRDLSITKLK DTYDRLNIHY
310 320 330 340 350
DEYDGESQVS LELMNKMVDE LRSLNLIEED GGALLIDLSK HDKKLGKAIV
360 370 380 390 400
QKRDGTTLYL TRDIGTAYKR YEKYKFDKSI YVVSSQQDMY FSQLFKIFEL
410 420 430 440 450
MGFDWAKKCV HINYGLVQGM STRKGKAVFL DDIMEVAKEE MHKVMQKNEE
460 470 480 490 500
KYAQVENPEE VADIVGKTAI RIQDSTGKRI NNYAFDWSRM TSFEGDTGPY
510 520 530 540 550
LQYAHSRLSS VRRNVNYTDE EIMGANLELL TEPDAYDLVR LLGQYPDVLK
560 570 580 590 600
NAFRFQETST VVTYLFKLTH AVSKLYDILW VRGRERDIQL ARLALFGAAK
610
QVLNNGMTLL GLTPLERM
Length:618
Mass (Da):70,689
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69BDECEA3B2853F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti359Y → S in BAA13762 (PubMed:9501991).Curated1
Sequence conflicti401M → T in BAA13762 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21267.1
D89099 mRNA Translation: BAA13762.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T39985
T42007

NCBI Reference Sequences

More...
RefSeqi
NP_596077.1, NM_001021989.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC25B2.09c.1; SPBC25B2.09c.1:pep; SPBC25B2.09c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540548

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC25B2.09c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21267.1
D89099 mRNA Translation: BAA13762.1
PIRiT39985
T42007
RefSeqiNP_596077.1, NM_001021989.2

3D structure databases

SMRiO74781
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4896.SPBC25B2.09c.1

PTM databases

iPTMnetiO74781

Proteomic databases

MaxQBiO74781
PaxDbiO74781
PRIDEiO74781

Genome annotation databases

EnsemblFungiiSPBC25B2.09c.1; SPBC25B2.09c.1:pep; SPBC25B2.09c
GeneIDi2540548
KEGGispo:SPBC25B2.09c

Organism-specific databases

PomBaseiSPBC25B2.09c, mrs1
VEuPathDBiFungiDB:SPBC25B2.09c

Phylogenomic databases

eggNOGiKOG1195, Eukaryota
HOGENOMiCLU_006406_6_2_1
InParanoidiO74781
OMAiYEFKWER
PhylomeDBiO74781

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O74781

Family and domain databases

CDDicd00671, ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR001278, Arg-tRNA-ligase
IPR005148, Arg-tRNA-synth_N
IPR036695, Arg-tRNA-synth_N_sf
IPR035684, ArgRS_core
IPR008909, DALR_anticod-bd
IPR014729, Rossmann-like_a/b/a_fold
IPR009080, tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956, PTHR11956, 1 hit
PfamiView protein in Pfam
PF05746, DALR_1, 1 hit
PF00750, tRNA-synt_1d, 1 hit
PRINTSiPR01038, TRNASYNTHARG
SMARTiView protein in SMART
SM01016, Arg_tRNA_synt_N, 1 hit
SM00836, DALR_1, 1 hit
SUPFAMiSSF47323, SSF47323, 1 hit
SSF55190, SSF55190, 1 hit
TIGRFAMsiTIGR00456, argS, 1 hit
PROSITEiView protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYRC_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O74781
Secondary accession number(s): P78751
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1998
Last modified: February 10, 2021
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  3. SIMILARITY comments
    Index of protein domains and families
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