Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA mismatch repair protein msh6

Gene

msh6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in post-replicative DNA-mismatch repair. Has a role towards base-base mispairs and insertion-deletion loops.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1024 – 1031ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • maintenance of DNA repeat elements Source: PomBase
  • mismatch repair Source: PomBase

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein msh6
Gene namesi
Name:msh6
ORF Names:SPCC285.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC285.16c
PomBaseiSPCC285.16c msh6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001152121 – 1254DNA mismatch repair protein msh6Add BLAST1254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205Phosphoserine1 Publication1
Modified residuei299Phosphoserine1 Publication1
Modified residuei307Phosphoserine1 Publication1
Modified residuei309Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74502
PaxDbiO74502
PRIDEiO74502

PTM databases

iPTMnetiO74502

Interactioni

Subunit structurei

Heterodimer of msh2 and msh6.By similarity

Protein-protein interaction databases

BioGridi275785, 41 interactors
STRINGi4896.SPCC285.16c.1

Structurei

3D structure databases

ProteinModelPortaliO74502
SMRiO74502
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

HOGENOMiHOG000189303
InParanoidiO74502
KOiK08737
OMAiELRHPCM
OrthoDBiEOG092C0EWT
PhylomeDBiO74502

Family and domain databases

Gene3Di3.30.420.110, 1 hit
3.40.1170.10, 1 hit
InterProiView protein in InterPro
IPR015536 DNA_mismatch_repair_MSH6_C
IPR007695 DNA_mismatch_repair_MutS-lik_N
IPR017261 DNA_mismatch_repair_MutS/MSH
IPR000432 DNA_mismatch_repair_MutS_C
IPR007861 DNA_mismatch_repair_MutS_clamp
IPR007696 DNA_mismatch_repair_MutS_core
IPR016151 DNA_mismatch_repair_MutS_N
IPR036187 DNA_mismatch_repair_MutS_sf
IPR007860 DNA_mmatch_repair_MutS_con_dom
IPR036678 MutS_con_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR11361:SF31 PTHR11361:SF31, 1 hit
PfamiView protein in Pfam
PF01624 MutS_I, 1 hit
PF05188 MutS_II, 1 hit
PF05192 MutS_III, 1 hit
PF05190 MutS_IV, 1 hit
PF00488 MutS_V, 1 hit
PIRSFiPIRSF037677 DNA_mis_repair_Msh6, 1 hit
SMARTiView protein in SMART
SM00534 MUTSac, 1 hit
SM00533 MUTSd, 1 hit
SUPFAMiSSF48334 SSF48334, 1 hit
SSF52540 SSF52540, 1 hit
SSF53150 SSF53150, 1 hit
SSF55271 SSF55271, 1 hit
PROSITEiView protein in PROSITE
PS00486 DNA_MISMATCH_REPAIR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O74502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVGNVGKQR EKTKDSSAKT KQKTLFGFFS KIPNVKQEKS DSTLSSSSNH
60 70 80 90 100
DSNHDTPADV DNSSNVNKNS SSPERELPTS PSHHANTEID SSSSMLPPPS
110 120 130 140 150
SDPFSSPLSS SLHRSSPKRP HDSLGEESPG KLLRTSVKQE PDSEEEIDSP
160 170 180 190 200
TKKKSFKSLD TSIFQAEDQF RHPVSSKLEN SELSEVDKPF IASRRSRKPV
210 220 230 240 250
SYAESDEDED FDDAPTKGSR HKRIVSDDES DDYVEPDHIS EASSEASLPI
260 270 280 290 300
DEVESMDEDV DGYSDHSVSV AAPIPKKESR KESSNSLYES YRLGSQIASP
310 320 330 340 350
SPSVSGSASP TKSNKNGVLN REEKRRQRME AFKKENNERY EWLLDVRDAD
360 370 380 390 400
QNRVGDPNYD PRTLYIPPSA WATFKPFEKQ FWKIKKDLMD TVVFFQKGKF
410 420 430 440 450
YELYENDAAI GHQVFSLKLT DRVNMKMVGI PEASFDYWAS QFIAKGYRIA
460 470 480 490 500
RVDQLETALG KEIKDRQRTQ KEEKVVQRGL TQVLTSGTLV DEAMLTSDLS
510 520 530 540 550
TYCMAIKESL QSDNEEPSFG ICFIDTSTGG FHMCEFTDDI HRTKLDTLLT
560 570 580 590 600
QVRPKELILE KSKISQKSIR AIKYCVSSSS IWNFIKPYTE FWDNERVERE
610 620 630 640 650
IIAGDYFKNG LEGAPKILKS YLSEKPLAIS AFGALFWYLR QLKLDKDMCS
660 670 680 690 700
MGNFDEYDAS QQSTSLLMNG QTLKNLEIFS NSFDGGSEGT LFHLLCRCVT
710 720 730 740 750
PFGKRLFHTW LCHPLRSGTA INARLDVVEL IADNPVIRDT IWGFLHKLPD
760 770 780 790 800
LERLISRVHA GRSKPADFVR VLEGFQRINS AFDQLREEFM EVAEGTLLGE
810 820 830 840 850
IIQSAPNMKE ELEAWTRAFN WQKASEEGVF EPEIGFEAEY DTSQKYQSEL
860 870 880 890 900
KNELYALLEQ YKKQLRCSSL NFKNIGKEVY QVEVPSDVKV PVNWCKMSGT
910 920 930 940 950
KKTNRYYNDE LRKKIKKLLE AEELHLAIMS RMQEKFYIRF DSNYEQWLAL
960 970 980 990 1000
IKYTASIDCF FSLSQAAAAL GEPYCRPEII EQKDGHLYFE ELRHPCINAS
1010 1020 1030 1040 1050
AASTFVPNDV VLGGESPNMI VLTGPNMAGK STLLRQVCIA VIMAQLGCWV
1060 1070 1080 1090 1100
PAKRASITPM TSIYTRLGAN DDIMSARSTF MVELSETKKI LDECGPKSLV
1110 1120 1130 1140 1150
ILDELGRGTS TYDGHAIAYA VLHHLVSNIG CLGFFSTHYQ SLCVDFMHHR
1160 1170 1180 1190 1200
QVRLMQMAAA VDEKIRRVTF LYKLEDGICP KSYGMNVASM AGLPEKVIDA
1210 1220 1230 1240 1250
AEEKASELEQ ASASFINASD DIALMSDFLQ VLRISKSIEP LTAVNIPLIL

DSFE
Length:1,254
Mass (Da):141,512
Last modified:November 1, 1998 - v1
Checksum:i7A28EC8DD8D2845B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207839 Genomic DNA Translation: AAF20943.1
CU329672 Genomic DNA Translation: CAA20855.1
PIRiT41262
RefSeqiNP_588344.1, NM_001023335.2

Genome annotation databases

EnsemblFungiiSPCC285.16c.1; SPCC285.16c.1:pep; SPCC285.16c
GeneIDi2539215
KEGGispo:SPCC285.16c

Similar proteinsi

Entry informationi

Entry nameiMSH6_SCHPO
AccessioniPrimary (citable) accession number: O74502
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: November 1, 1998
Last modified: February 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health