UniProtKB - O74471 (COX13_SCHPO)
Cytochrome c oxidase subunit 13, mitochondrial
cox13
Functioni
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
By similarity: oxidative phosphorylation Pathwayi
This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.
GO - Molecular functioni
- cytochrome-c oxidase activity Source: InterPro
- enzyme regulator activity Source: GO_Central
GO - Biological processi
- mitochondrial electron transport, cytochrome c to oxygen Source: PomBase
Keywordsi
Molecular function | Oxidoreductase |
Enzyme and pathway databases
UniPathwayi | UPA00705 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase subunit 13, mitochondrialAlternative name(s): Cytochrome c oxidase polypeptide VIa |
Gene namesi | Name:cox13 ORF Names:SPCC1739.09c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPCC1739.09c, cox13 |
VEuPathDBi | FungiDB:SPCC1739.09c |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity
Mitochondrion
- mitochondrial respiratory chain complex IV Source: PomBase
- mitochondrion Source: PomBase
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 61 | Mitochondrial matrixCuratedAdd BLAST | 30 | |
Transmembranei | 62 – 80 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 81 – 130 | Mitochondrial intermembraneCuratedAdd BLAST | 50 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 31 | MitochondrionSequence analysisAdd BLAST | 31 | |
ChainiPRO_0000006126 | 32 – 130 | Cytochrome c oxidase subunit 13, mitochondrialAdd BLAST | 99 |
Proteomic databases
MaxQBi | O74471 |
PaxDbi | O74471 |
Interactioni
Subunit structurei
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
By similarityProtein-protein interaction databases
STRINGi | 4896.SPCC1739.09c.1 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3469, Eukaryota |
HOGENOMi | CLU_122515_0_1_1 |
InParanoidi | O74471 |
OMAi | WRKLSLY |
PhylomeDBi | O74471 |
Family and domain databases
CDDi | cd00925, Cyt_c_Oxidase_VIa, 1 hit |
Gene3Di | 4.10.95.10, 1 hit |
InterProi | View protein in InterPro IPR001349, Cyt_c_oxidase_su6a IPR018507, Cyt_c_oxidase_su6a_CS IPR036418, Cyt_c_oxidase_su6a_sf |
PANTHERi | PTHR11504, PTHR11504, 1 hit |
Pfami | View protein in Pfam PF02046, COX6A, 1 hit |
PIRSFi | PIRSF000277, COX6A1, 1 hit |
SUPFAMi | SSF81411, SSF81411, 1 hit |
PROSITEi | View protein in PROSITE PS01329, COX6A, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSMMNRNIGF LSRTLKTSVP KRAGLLSFRA YSNEAKVNWL EEVQAEEEHA
60 70 80 90 100
KRSSEFWKKV TYYIGGPALI LASANAYYIY CKHQEHAKHV EDTDPGYSFE
110 120 130
NLRFKKYPWG DGSKTLFWND KVNHLKKDDE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA20783.1 |
PIRi | T41117 |
RefSeqi | NP_588417.1, NM_001023408.2 |
Genome annotation databases
EnsemblFungii | SPCC1739.09c.1; SPCC1739.09c.1:pep; SPCC1739.09c |
GeneIDi | 2538807 |
KEGGi | spo:SPCC1739.09c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA20783.1 |
PIRi | T41117 |
RefSeqi | NP_588417.1, NM_001023408.2 |
3D structure databases
SMRi | O74471 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4896.SPCC1739.09c.1 |
Proteomic databases
MaxQBi | O74471 |
PaxDbi | O74471 |
Genome annotation databases
EnsemblFungii | SPCC1739.09c.1; SPCC1739.09c.1:pep; SPCC1739.09c |
GeneIDi | 2538807 |
KEGGi | spo:SPCC1739.09c |
Organism-specific databases
PomBasei | SPCC1739.09c, cox13 |
VEuPathDBi | FungiDB:SPCC1739.09c |
Phylogenomic databases
eggNOGi | KOG3469, Eukaryota |
HOGENOMi | CLU_122515_0_1_1 |
InParanoidi | O74471 |
OMAi | WRKLSLY |
PhylomeDBi | O74471 |
Enzyme and pathway databases
UniPathwayi | UPA00705 |
Miscellaneous databases
PROi | PR:O74471 |
Family and domain databases
CDDi | cd00925, Cyt_c_Oxidase_VIa, 1 hit |
Gene3Di | 4.10.95.10, 1 hit |
InterProi | View protein in InterPro IPR001349, Cyt_c_oxidase_su6a IPR018507, Cyt_c_oxidase_su6a_CS IPR036418, Cyt_c_oxidase_su6a_sf |
PANTHERi | PTHR11504, PTHR11504, 1 hit |
Pfami | View protein in Pfam PF02046, COX6A, 1 hit |
PIRSFi | PIRSF000277, COX6A1, 1 hit |
SUPFAMi | SSF81411, SSF81411, 1 hit |
PROSITEi | View protein in PROSITE PS01329, COX6A, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COX13_SCHPO | |
Accessioni | O74471Primary (citable) accession number: O74471 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1998 | |
Last modified: | September 29, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families