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UniProtKB - O74462 (TAF6_SCHPO)
Protein
Transcription initiation factor TFIID subunit 6
Gene
taf6
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription.
By similarityGO - Molecular functioni
- protein heterodimerization activity Source: InterPro
- RNA polymerase II general transcription initiation factor activity Source: PomBase
- transcription coactivator activity Source: GO_Central
GO - Biological processi
- chromatin remodeling Source: PomBase
- RNA polymerase II preinitiation complex assembly Source: GO_Central
- transcription initiation from RNA polymerase II promoter Source: PomBase
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-SPO-674695, RNA Polymerase II Pre-transcription Events R-SPO-6807505, RNA polymerase II transcribes snRNA genes R-SPO-73776, RNA Polymerase II Promoter Escape R-SPO-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-SPO-75953, RNA Polymerase II Transcription Initiation R-SPO-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor TFIID subunit 6By similarityAlternative name(s): TBP-associated factor 50 kDaBy similarity Short name: TAFII-50By similarity Short name: TAFII50By similarity TBP-associated factor 6By similarity |
Gene namesi | ORF Names:SPCC16C4.18c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPCC16C4.18c, taf6 |
VEuPathDBi | FungiDB:SPCC16C4.18c |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: PomBase
Nucleus
- nucleus Source: PomBase
- SAGA complex Source: PomBase
- transcription factor TFIID complex Source: PomBase
Other locations
- chromatin Source: PomBase
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Cells lacking taf6 are not viable.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000361054 | 1 – 452 | Transcription initiation factor TFIID subunit 6Add BLAST | 452 |
Proteomic databases
MaxQBi | O74462 |
PaxDbi | O74462 |
Interactioni
Subunit structurei
Component of the TFIID and SAGA complexes. TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) whose MWs range from 25-150 kDa (By similarity).
Interacts with gcn5, taf5 and taf73.
By similarity1 PublicationGO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 275705, 12 interactors |
IntActi | O74462, 2 interactors |
MINTi | O74462 |
STRINGi | 4896.SPCC16C4.18c.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 68 | Histone-foldSequence analysisAdd BLAST | 65 |
Sequence similaritiesi
Belongs to the TAF6 family.Sequence analysis
Phylogenomic databases
eggNOGi | KOG2549, Eukaryota |
HOGENOMi | CLU_021711_3_0_1 |
InParanoidi | O74462 |
OMAi | TFTLKQM |
PhylomeDBi | O74462 |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR009072, Histone-fold IPR037796, TAF6 IPR011442, TAF6_C IPR004823, TAF_TATA-bd |
PANTHERi | PTHR10221, PTHR10221, 1 hit |
Pfami | View protein in Pfam PF02969, TAF, 1 hit PF07571, TAF6_C, 1 hit |
SMARTi | View protein in SMART SM00803, TAF, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit SSF48371, SSF48371, 1 hit |
i Sequence
Sequence statusi: Complete.
O74462-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLTVWNIES IKDVAEMLGI GNLADEPAAA IAMDLEYRIH QVVQEATKFM
60 70 80 90 100
VHSKRTVLTS ADISSALRTL NVEPLYGFNN SRPLEFHEAA VGAGQNSLYY
110 120 130 140 150
LDDEEVDFEK IINAPLPKVP RNISYSAHWL AIEGVQPAIP QNPTPSDHTV
160 170 180 190 200
GEWASKGTSG VMPGASTAAK EARNGVTSMD NVEIKPLVRH VLSKELQLYF
210 220 230 240 250
ERITSALLDE TNVELRDAAL SSLRDDPGLH QLLPYFIMFL SDSVTRNLGN
260 270 280 290 300
LVVLTTLMHM AWALLDNPNL FVEPYVQQLM PSILTCLVAK RLGSDPNNHE
310 320 330 340 350
HYALRDLAAF LLGIVCDRFG NVYYTLKPRV TRTALKAFLD NTKPYSTHYG
360 370 380 390 400
AIKGLKTMGK EAIRVLVVPN IKVYEVLVRK TLEKGNEEEI YEANKCMDAL
410 420 430 440 450
YDALLLLRDD QLPNQRTLPP NASGLLEKNV GSLMAEKIMK ENDTSLLLGL
LE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA20756.1 |
PIRi | T41108 |
RefSeqi | NP_587928.1, NM_001022919.2 |
Genome annotation databases
EnsemblFungii | SPCC16C4.18c.1; SPCC16C4.18c.1:pep; SPCC16C4.18c |
GeneIDi | 2539133 |
KEGGi | spo:SPCC16C4.18c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA20756.1 |
PIRi | T41108 |
RefSeqi | NP_587928.1, NM_001022919.2 |
3D structure databases
SMRi | O74462 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 275705, 12 interactors |
IntActi | O74462, 2 interactors |
MINTi | O74462 |
STRINGi | 4896.SPCC16C4.18c.1 |
Proteomic databases
MaxQBi | O74462 |
PaxDbi | O74462 |
Genome annotation databases
EnsemblFungii | SPCC16C4.18c.1; SPCC16C4.18c.1:pep; SPCC16C4.18c |
GeneIDi | 2539133 |
KEGGi | spo:SPCC16C4.18c |
Organism-specific databases
PomBasei | SPCC16C4.18c, taf6 |
VEuPathDBi | FungiDB:SPCC16C4.18c |
Phylogenomic databases
eggNOGi | KOG2549, Eukaryota |
HOGENOMi | CLU_021711_3_0_1 |
InParanoidi | O74462 |
OMAi | TFTLKQM |
PhylomeDBi | O74462 |
Enzyme and pathway databases
Reactomei | R-SPO-674695, RNA Polymerase II Pre-transcription Events R-SPO-6807505, RNA polymerase II transcribes snRNA genes R-SPO-73776, RNA Polymerase II Promoter Escape R-SPO-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-SPO-75953, RNA Polymerase II Transcription Initiation R-SPO-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
Miscellaneous databases
PROi | PR:O74462 |
Family and domain databases
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR009072, Histone-fold IPR037796, TAF6 IPR011442, TAF6_C IPR004823, TAF_TATA-bd |
PANTHERi | PTHR10221, PTHR10221, 1 hit |
Pfami | View protein in Pfam PF02969, TAF, 1 hit PF07571, TAF6_C, 1 hit |
SMARTi | View protein in SMART SM00803, TAF, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TAF6_SCHPO | |
Accessioni | O74462Primary (citable) accession number: O74462 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 20, 2009 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families