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Entry version 128 (13 Nov 2019)
Sequence version 1 (01 Nov 1998)
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Protein

Transcription factor tau subunit sfc4

Gene

sfc4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Sfc4 is the TFIIIB assembling subunit of TFIIIC.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SPO-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor tau subunit sfc4
Alternative name(s):
TFIIIC subunit sfc4
Transcription factor C subunit 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sfc4Imported
Synonyms:tfc4By similarity
ORF Names:SPCC16C4.14c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPCC16C4.14c

Schizosaccharomyces pombe database

More...
PomBasei
SPCC16C4.14c sfc4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003077951 – 1006Transcription factor tau subunit sfc4Add BLAST1006

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O74458

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O74458

PRoteomics IDEntifications database

More...
PRIDEi
O74458

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O74458

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the TFIIIC complex including sfc1, sfc3, sfc4, sfc6 and sfc7. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker.

Interacts with sfc1, sfc3 and sfc6.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
275758, 14 interactors

Protein interaction database and analysis system

More...
IntActi
O74458, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPCC16C4.14c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O74458

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati133 – 166TPR 1Sequence analysisAdd BLAST34
Repeati205 – 238TPR 2Sequence analysisAdd BLAST34
Repeati277 – 310TPR 3Sequence analysisAdd BLAST34
Repeati396 – 429TPR 4Sequence analysisAdd BLAST34
Repeati431 – 464TPR 5Sequence analysisAdd BLAST34
Repeati466 – 499TPR 6Sequence analysisAdd BLAST34
Repeati841 – 874TPR 7Sequence analysisAdd BLAST34
Repeati924 – 957TPR 8Sequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili506 – 554Sequence analysisAdd BLAST49

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O74458

KEGG Orthology (KO)

More...
KOi
K15201

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLIAWMA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O74458

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039340 Tfc4/TFIIIC-102/Sfc4
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23082 PTHR23082, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181 TPR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 8 hits
PS50293 TPR_REGION, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O74458-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQNGGNSYV DSNMNETQND TTDNFDAEMQ DLNGYISEIV DEARNVSEVD
60 70 80 90 100
AKFLGDTSAL QAEGLWSDEE SDYEGSDDES NFSKTASRTE DDIANEEWEE
110 120 130 140 150
NLKAVAGFRK VRKGHKGRGR VSRADMLPSV EVQQMLSLAN HLFAQEGNFD
160 170 180 190 200
EAQKLAEEIV RIDNNVIAAW KMLGECHRQR GNGRVNIEKC LIAWMAAAHL
210 220 230 240 250
KPKDHELWFT CAKLSESLEF WDQADYCYNR AVSAKPPNKS ELKKYIWNRS
260 270 280 290 300
VLNKEHGSLK KAAEGFKFLL QSSPYNASIL KNLAEIYIKI HAPREILKQF
310 320 330 340 350
EIAWKYFYQY PAPPIGNDIF DLPTLNLYAE LLLLDHQWSN LIRLINRGVR
360 370 380 390 400
WFRGRKSESF WDEFDDDREW DVDERRREFP NASEEHTNKE AYLLPHLFRT
410 420 430 440 450
KLGIARLKTG ELPEAELHFS VIKNLPPDYA WGMLYDIAKA YMDIERLDLA
460 470 480 490 500
LEYFVLICNH EPAQNIGLWY NMGVCYLELK EYEHAQQCME AILIVDNSNT
510 520 530 540 550
NALIKLAEIN ELQDNRDAAL EIVTNIFEQR RNINELEREQ SQNEDHEKNV
560 570 580 590 600
GSQLFVGNQK VPQDKWEKRA RISRSKEEAR QFTIWKTEET QRRFHKLDIL
610 620 630 640 650
RQSLKKEENV SESLNEWLAI ASELIDEFVS IKAFFPSEKK ARARAGLLTR
660 670 680 690 700
RTRYASLNDQ LTSMINRLND SLTRTKYGDL DLDTILRTGY FRNVSIDAWY
710 720 730 740 750
QLFVEFSLRL TKVGSVQQAY DVLTTAMGAI LFDQDTIKRQ NLRWCMLACS
760 770 780 790 800
MYARDPQGAL TPLRWVFTTF QFRQDTYRLF SAVLSQGYEC SRAFVDSANQ
810 820 830 840 850
KFLLRLIKLM DQLMSNSLVS GAATLVKNDD GLATVPTSYD PVLVLLYGHI
860 870 880 890 900
MARNRSWIPA INYYSRAFAI NPDCPITNLS LGLAYLHRAM QRLSDNRHYQ
910 920 930 940 950
ILQGFTFLYR YYDLRVNEGL GEKQEALYNL GKAYHFIGLE HYAVKYYEAV
960 970 980 990 1000
LGLSPMSQGD KMTSSESTVS TTYDFGFEAA YNLRLIYICS GNIKLAFQIS

SKYLIF
Length:1,006
Mass (Da):116,401
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7000AC42E602E2B2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA20753.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T41104

NCBI Reference Sequences

More...
RefSeqi
NP_587924.1, NM_001022915.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC16C4.14c.1; SPCC16C4.14c.1:pep; SPCC16C4.14c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539187

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC16C4.14c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA20753.1
PIRiT41104
RefSeqiNP_587924.1, NM_001022915.2

3D structure databases

SMRiO74458
ModBaseiSearch...

Protein-protein interaction databases

BioGridi275758, 14 interactors
IntActiO74458, 1 interactor
STRINGi4896.SPCC16C4.14c.1

PTM databases

iPTMnetiO74458

Proteomic databases

MaxQBiO74458
PaxDbiO74458
PRIDEiO74458

Genome annotation databases

EnsemblFungiiSPCC16C4.14c.1; SPCC16C4.14c.1:pep; SPCC16C4.14c
GeneIDi2539187
KEGGispo:SPCC16C4.14c

Organism-specific databases

EuPathDBiFungiDB:SPCC16C4.14c
PomBaseiSPCC16C4.14c sfc4

Phylogenomic databases

InParanoidiO74458
KOiK15201
OMAiCLIAWMA
PhylomeDBiO74458

Enzyme and pathway databases

ReactomeiR-SPO-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SPO-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O74458

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR039340 Tfc4/TFIIIC-102/Sfc4
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR23082 PTHR23082, 1 hit
PfamiView protein in Pfam
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 7 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 8 hits
PS50293 TPR_REGION, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFC4_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O74458
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 1, 1998
Last modified: November 13, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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