UniProtKB - O74433 (QCR9_SCHPO)
Cytochrome b-c1 complex subunit 9
qcr9
Functioni
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
By similarityGO - Biological processi
- mitochondrial electron transport, ubiquinol to cytochrome c Source: PomBase
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Enzyme and pathway databases
Reactomei | R-SPO-611105, Respiratory electron transport |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-c1 complex subunit 9Alternative name(s): Complex III subunit 9 Cytochrome c1 non-heme 7.3 kDa protein Ubiquinol-cytochrome c reductase complex 7.3 kDa protein |
Gene namesi | Name:qcr9 ORF Names:SPCC1682.01 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPCC1682.01, qcr9 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity
Mitochondrion
- mitochondrial respiratory chain complex III Source: PomBase
- mitochondrion Source: PomBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | Mitochondrial matrixBy similarityAdd BLAST | 17 | |
Transmembranei | 18 – 43 | HelicalBy similarityAdd BLAST | 26 | |
Topological domaini | 44 – 67 | Mitochondrial intermembraneBy similarityAdd BLAST | 24 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193557 | 1 – 67 | Cytochrome b-c1 complex subunit 9Add BLAST | 67 |
Proteomic databases
MaxQBi | O74433 |
PaxDbi | O74433 |
PRIDEi | O74433 |
Interactioni
Subunit structurei
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
By similarityProtein-protein interaction databases
STRINGi | 4896.SPCC1682.01.1 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3494, Eukaryota |
InParanoidi | O74433 |
PhylomeDBi | O74433 |
Family and domain databases
Gene3Di | 1.20.5.260, 1 hit |
InterProi | View protein in InterPro IPR008027, QCR9 IPR036656, QCR9_sf |
PANTHERi | PTHR12980, PTHR12980, 1 hit |
Pfami | View protein in Pfam PF05365, UCR_UQCRX_QCR9, 1 hit |
SUPFAMi | SSF81514, SSF81514, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MASSTIYNIF FRRNSSFYAT IFVSAFFAKI GFDVFTDSVW KRANAGLTWD
60
EVKPRFLNKD EDAEDDE
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA20667.1 Different initiation. |
PIRi | T41058 |
RefSeqi | NP_587794.3, NM_001022787.3 |
Genome annotation databases
GeneIDi | 2539153 |
KEGGi | spo:SPCC1682.01 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA20667.1 Different initiation. |
PIRi | T41058 |
RefSeqi | NP_587794.3, NM_001022787.3 |
3D structure databases
SMRi | O74433 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4896.SPCC1682.01.1 |
Proteomic databases
MaxQBi | O74433 |
PaxDbi | O74433 |
PRIDEi | O74433 |
Genome annotation databases
GeneIDi | 2539153 |
KEGGi | spo:SPCC1682.01 |
Organism-specific databases
PomBasei | SPCC1682.01, qcr9 |
Phylogenomic databases
eggNOGi | KOG3494, Eukaryota |
InParanoidi | O74433 |
PhylomeDBi | O74433 |
Enzyme and pathway databases
Reactomei | R-SPO-611105, Respiratory electron transport |
Miscellaneous databases
PROi | PR:O74433 |
Family and domain databases
Gene3Di | 1.20.5.260, 1 hit |
InterProi | View protein in InterPro IPR008027, QCR9 IPR036656, QCR9_sf |
PANTHERi | PTHR12980, PTHR12980, 1 hit |
Pfami | View protein in Pfam PF05365, UCR_UQCRX_QCR9, 1 hit |
SUPFAMi | SSF81514, SSF81514, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QCR9_SCHPO | |
Accessioni | O74433Primary (citable) accession number: O74433 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families