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Protein

Transcription initiation factor TFIID subunit taf73

Gene

taf73

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-SPO-674695 RNA Polymerase II Pre-transcription Events
R-SPO-73776 RNA Polymerase II Promoter Escape
R-SPO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SPO-75953 RNA Polymerase II Transcription Initiation
R-SPO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit taf73
Alternative name(s):
Transcription initiation factor TFIID 73 kDa subunit
Short name:
TAFII-73
Gene namesi
Name:taf73
ORF Names:SPBC15D4.14
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC15D4.14
PomBaseiSPBC15D4.14 taf73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345621 – 642Transcription initiation factor TFIID subunit taf73Add BLAST642

Proteomic databases

MaxQBiO74319
PaxDbiO74319
PRIDEiO74319

PTM databases

iPTMnetiO74319

Interactioni

Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) whose MWs range from 25-150 kDa.1 Publication

Protein-protein interaction databases

BioGridi276428, 10 interactors
IntActiO74319, 4 interactors
STRINGi4896.SPBC15D4.14.1

Structurei

3D structure databases

ProteinModelPortaliO74319
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 43LisHPROSITE-ProRule annotationAdd BLAST33
Repeati347 – 386WD 1Add BLAST40
Repeati401 – 440WD 2Add BLAST40
Repeati443 – 482WD 3Add BLAST40
Repeati485 – 526WD 4Add BLAST42
Repeati528 – 566WD 5Add BLAST39
Repeati569 – 608WD 6Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat TAF5 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000212424
InParanoidiO74319
KOiK03130
OrthoDBiEOG092C10HM
PhylomeDBiO74319

Family and domain databases

CDDicd08044 TAF5_NTD2, 1 hit
Gene3Di1.25.40.500, 1 hit
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR006594 LisH
IPR037783 Taf5
IPR007582 TFIID_NTD2
IPR037264 TFIID_NTD2_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19879:SF1 PTHR19879:SF1, 1 hit
PfamiView protein in Pfam
PF04494 TFIID_NTD2, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SM00320 WD40, 6 hits
SUPFAMiSSF160897 SSF160897, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O74319-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQSSYSSGN STSDLNKIVL DYLFKKGYSR TEAMLRLEIS SVGAIPEEQQ
60 70 80 90 100
DWHIGASETY VQVYILLRDW IDGTLDLYKP KLQKVLYPIF VHSYLDLLQK
110 120 130 140 150
NDPEMAIYFF ESFRIEHEVL HGYDIRALAQ LKIASDVEEI EIAQLYRKNK
160 170 180 190 200
YRINFTRSTF DLLVQFLFEN EVNGSGIIIR LLNQYIDIKI TMPQVEGKED
210 220 230 240 250
PNVQAVYEMD EAKNEQTIIS EQEGIPGHSE QLLDYNKQSI QLGLRPLSEE
260 270 280 290 300
VVTTLKNLLE VKDKDVEGRN EALNKILHPA KNLVELLTEK ENLINESTLE
310 320 330 340 350
SPSDPPLPPT KMKDIDYFVS LLESEQNSLI LGKNATDPSV FMYTMHNTLS
360 370 380 390 400
AVNCAAFSDD ASMFALGCAD SSIHLYSSTN NGPQPLVGSQ NEPLQKSSLI
410 420 430 440 450
GHTRPVFGVS ISPQKEFILS CSEDGFTRLW SKDTKSTIVK YAGHNAPIWD
460 470 480 490 500
VQFSPFGYYF ATASHDQTAR LWDVEHAAPL RVFVGHQNDV DCVSFHPNAA
510 520 530 540 550
YLATGSSDHT TRMWDVRTGG TVRVFNAHHS PVSALCMSAD GLSLASADES
560 570 580 590 600
GIIKVWDLRS SNQHVSFVKH SSIVYSLSFS YDNKILVSGG ADTDVNFWDL
610 620 630 640
TYRNNLSDGE QSPLLFNFKT KNTIIQNLSF TRRNYCLALS SS
Length:642
Mass (Da):72,251
Last modified:November 1, 1998 - v1
Checksum:i6891234235FF6DBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA20489.1
AB039954 Genomic DNA Translation: BAB12572.1
PIRiT39490
RefSeqiNP_596254.1, NM_001022173.2

Genome annotation databases

EnsemblFungiiSPBC15D4.14.1; SPBC15D4.14.1:pep; SPBC15D4.14
GeneIDi2539882
KEGGispo:SPBC15D4.14

Similar proteinsi

Entry informationi

Entry nameiTAF73_SCHPO
AccessioniPrimary (citable) accession number: O74319
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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