UniProtKB - O74135 (CKI3_SCHPO)
Protein
Casein kinase I homolog 3
Gene
cki3
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 44 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 134 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 21 – 29 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: PomBase
- protein kinase activity Source: PomBase
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- endocytosis Source: GO_Central
- negative regulation of establishment of bipolar cell polarity Source: PomBase
- negative regulation of protein localization to cell tip Source: PomBase
- peptidyl-serine phosphorylation Source: GO_Central
- regulation of endocytosis Source: PomBase
- signal transduction Source: PomBase
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 5613 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:cki3 ORF Names:SPAC1805.05 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC1805.05, cki3 |
VEuPathDBi | FungiDB:SPAC1805.05 |
Subcellular locationi
Cytoplasm and Cytosol
Nucleus
- nucleus Source: GO_Central
Other locations
- cell division site Source: PomBase
- cell periphery Source: PomBase
- cell tip Source: PomBase
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000192863 | 1 – 439 | Casein kinase I homolog 3Add BLAST | 439 |
Proteomic databases
MaxQBi | O74135 |
PaxDbi | O74135 |
PRIDEi | O74135 |
PTM databases
iPTMneti | O74135 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 278859, 6 interactors |
STRINGi | 4896.SPAC1805.05.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 286 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 272 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 376 – 382 | Poly-Gln | 7 | |
Compositional biasi | 387 – 392 | Poly-Gln | 6 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1165, Eukaryota |
HOGENOMi | CLU_019279_1_0_1 |
InParanoidi | O74135 |
OMAi | HERHFIY |
PhylomeDBi | O74135 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
O74135-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTTSSHSNV VGVHYRVGKK IGEGSFGMLF QGVNLINNQP IALKFESRKS
60 70 80 90 100
EVPQLRDEYL TYKLLMGLPG IPSVYYYGQE GMYNLLVMDL LGPSLEDLFD
110 120 130 140 150
YCGRRFSPKT VAMIAKQMIT RIQSVHERHF IYRDIKPDNF LIGFPGSKTE
160 170 180 190 200
NVIYAVDFGM AKQYRDPKTH VHRPYNEHKS LSGTARYMSI NTHLGREQSR
210 220 230 240 250
RDDLESMGHV FMYFLRGSLP WQGLKAATNK QKYEKIGEKK QVTPLKELCE
260 270 280 290 300
GYPKEFLQYM IYARNLGYEE APDYDYLRSL FDSLLLRINE TDDGKYDWTL
310 320 330 340 350
LNNGKGWQYS AAKQHVVQRR HTQGTNNRRQ STIPPYARTR QNLLSSPSKQ
360 370 380 390 400
TPVNNVVDAS VATQKDGIPG KAASPQVQQQ QQTSSAQQQQ PQRVEQPAPQ
410 420 430
TTQPTQVDTQ QAAKPAPSKE KSRKKFHLRL LSCCISKQE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB010643 Genomic DNA Translation: BAA32482.1 CU329670 Genomic DNA Translation: CAB55846.1 |
PIRi | T43314 |
RefSeqi | NP_593916.1, NM_001019345.2 |
Genome annotation databases
EnsemblFungii | SPAC1805.05.1; SPAC1805.05.1:pep; SPAC1805.05 |
GeneIDi | 2542395 |
KEGGi | spo:SPAC1805.05 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB010643 Genomic DNA Translation: BAA32482.1 CU329670 Genomic DNA Translation: CAB55846.1 |
PIRi | T43314 |
RefSeqi | NP_593916.1, NM_001019345.2 |
3D structure databases
SMRi | O74135 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 278859, 6 interactors |
STRINGi | 4896.SPAC1805.05.1 |
PTM databases
iPTMneti | O74135 |
Proteomic databases
MaxQBi | O74135 |
PaxDbi | O74135 |
PRIDEi | O74135 |
Genome annotation databases
EnsemblFungii | SPAC1805.05.1; SPAC1805.05.1:pep; SPAC1805.05 |
GeneIDi | 2542395 |
KEGGi | spo:SPAC1805.05 |
Organism-specific databases
PomBasei | SPAC1805.05, cki3 |
VEuPathDBi | FungiDB:SPAC1805.05 |
Phylogenomic databases
eggNOGi | KOG1165, Eukaryota |
HOGENOMi | CLU_019279_1_0_1 |
InParanoidi | O74135 |
OMAi | HERHFIY |
PhylomeDBi | O74135 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 5613 |
Miscellaneous databases
PROi | PR:O74135 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CKI3_SCHPO | |
Accessioni | O74135Primary (citable) accession number: O74135 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families