UniProtKB - O74113 (CDC45_SCHPO)
Protein
Cell division control protein 45 homolog
Gene
sna41
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Required for initiation of chromosomal DNA replication. May have a role in regulating the MCM proteins nda1 and nda4.1 Publication
GO - Molecular functioni
- chromatin binding Source: PomBase
- DNA replication origin binding Source: GO_Central
- single-stranded DNA binding Source: GO_Central
GO - Biological processi
- DNA replication initiation Source: GO_Central
- double-strand break repair via break-induced replication Source: GO_Central
- mitotic DNA replication initiation Source: PomBase
- mitotic DNA replication preinitiation complex assembly Source: PomBase
- positive regulation of G1/S transition of mitotic cell cycle Source: GO_Central
- regulation of chromatin silencing at telomere Source: GO_Central
- signal transduction involved in intra-S DNA damage checkpoint Source: PomBase
Keywordsi
Biological process | Cell cycle, DNA replication |
Enzyme and pathway databases
Reactomei | R-SPO-176187, Activation of ATR in response to replication stress R-SPO-68962, Activation of the pre-replicative complex |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division control protein 45 homologAlternative name(s): Suppressor of nda4 protein |
Gene namesi | Name:sna41 ORF Names:SPAC17D4.02 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC17D4.02 |
VEuPathDBi | FungiDB:SPAC17D4.02 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: PomBase
Nucleus
- DNA replication preinitiation complex Source: PomBase
- nuclear chromatin Source: PomBase
- nuclear pre-replicative complex Source: GO_Central
- nuclear replication fork Source: PomBase
- nucleus Source: PomBase
- replication fork protection complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000192818 | 1 – 638 | Cell division control protein 45 homologAdd BLAST | 638 |
Proteomic databases
MaxQBi | O74113 |
PaxDbi | O74113 |
PRIDEi | O74113 |
PTM databases
iPTMneti | O74113 |
Interactioni
Subunit structurei
Interacts with sld3.
1 PublicationBinary interactionsi
O74113
With | #Exp. | IntAct |
---|---|---|
sld3 [Q09761] | 2 | EBI-1559427,EBI-1559416 |
Protein-protein interaction databases
BioGRIDi | 278735, 23 interactors |
IntActi | O74113, 3 interactors |
MINTi | O74113 |
STRINGi | 4896.SPAC17D4.02.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CDC45 family.Curated
Phylogenomic databases
eggNOGi | KOG2475, Eukaryota |
HOGENOMi | CLU_005871_3_0_1 |
InParanoidi | O74113 |
OMAi | PWNLANV |
PhylomeDBi | O74113 |
Family and domain databases
InterProi | View protein in InterPro IPR003874, CDC45 |
PANTHERi | PTHR10507, PTHR10507, 1 hit |
Pfami | View protein in Pfam PF02724, CDC45, 1 hit |
i Sequence
Sequence statusi: Complete.
O74113-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFIKRSDYAS AYLKIKEASV SGGCTVQLFV ALDPDALCAC KLLSTLLKGD
60 70 80 90 100
FISHKIRPVS GYRDLEQANK TLLEQNEDIK FIILLNCGTM VDLNNYLVSM
110 120 130 140 150
EDVSIYVIDS HRPHNLNNIY IENNIFVFDD GDIEEDMNKI HDAWYAFNSH
160 170 180 190 200
ELSDEENSDS SNEREEEVED DNRSVESYSS SDYQARSRRR FSEETTQRRA
210 220 230 240 250
EIKEKRKKRK EFASILSEYY EKGSWYGESI TNILFAVASM LGREDNDMLW
260 270 280 290 300
LAIVGLTCLE IHCQSSKKYF NRSYSLLKDE VNRLNPSPLE NQIVGRAHGK
310 320 330 340 350
TPHDQSIRLE DEFRFMLVRH WSLYDSMLHS AYVGSRLHIW SEEGRKRLHK
360 370 380 390 400
LLAKMGLSLV ECKQTYIHMN MDLKKTLKSS LKRFAPFYGL DDVIFHSFTR
410 420 430 440 450
TYGFKCTLSA SDVSYAISAL LEMGNTGVLL QSKTVARSPD MTEEEYLEKF
460 470 480 490 500
ENAQNQEWLH NFYDAYDALD DVDSLERALK LAMHLQRAIV RTGITLLEKR
510 520 530 540 550
AIKTLRSFRF GLINEGPDLK IFMHPLALTK MSLWIAEAIN EQEREFGKLR
560 570 580 590 600
HLPLVLAAFV EEKNRYLIVG TSTSAFTSNE DDDDDDGHGH NRFGVAFQEV
610 620 630
ANMTSATLQM DCFEASVIEC QKSDLGVFLE SLSFKTLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB001739 Genomic DNA Translation: BAA28947.1 CU329670 Genomic DNA Translation: CAC05732.1 |
PIRi | T43018 |
RefSeqi | NP_594693.1, NM_001020121.2 |
Genome annotation databases
EnsemblFungii | SPAC17D4.02.1; SPAC17D4.02.1:pep; SPAC17D4.02 |
GeneIDi | 2542266 |
KEGGi | spo:SPAC17D4.02 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB001739 Genomic DNA Translation: BAA28947.1 CU329670 Genomic DNA Translation: CAC05732.1 |
PIRi | T43018 |
RefSeqi | NP_594693.1, NM_001020121.2 |
3D structure databases
SMRi | O74113 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 278735, 23 interactors |
IntActi | O74113, 3 interactors |
MINTi | O74113 |
STRINGi | 4896.SPAC17D4.02.1 |
PTM databases
iPTMneti | O74113 |
Proteomic databases
MaxQBi | O74113 |
PaxDbi | O74113 |
PRIDEi | O74113 |
Genome annotation databases
EnsemblFungii | SPAC17D4.02.1; SPAC17D4.02.1:pep; SPAC17D4.02 |
GeneIDi | 2542266 |
KEGGi | spo:SPAC17D4.02 |
Organism-specific databases
PomBasei | SPAC17D4.02 |
VEuPathDBi | FungiDB:SPAC17D4.02 |
Phylogenomic databases
eggNOGi | KOG2475, Eukaryota |
HOGENOMi | CLU_005871_3_0_1 |
InParanoidi | O74113 |
OMAi | PWNLANV |
PhylomeDBi | O74113 |
Enzyme and pathway databases
Reactomei | R-SPO-176187, Activation of ATR in response to replication stress R-SPO-68962, Activation of the pre-replicative complex |
Miscellaneous databases
PROi | PR:O74113 |
Family and domain databases
InterProi | View protein in InterPro IPR003874, CDC45 |
PANTHERi | PTHR10507, PTHR10507, 1 hit |
Pfami | View protein in Pfam PF02724, CDC45, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDC45_SCHPO | |
Accessioni | O74113Primary (citable) accession number: O74113 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2002 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families