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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Cenarchaeum symbiosum (strain A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93ElectrophileUniRule annotation1
Active sitei141Proton acceptorUniRule annotation1
Binding sitei146Substrate; via carbonyl oxygenUniRule annotation1
Binding sitei180Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:CENSYa_1177
OrganismiCenarchaeum symbiosum (strain A)
Taxonomic identifieri414004 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaCenarchaealesCenarchaeaceaeCenarchaeum
Proteomesi
  • UP000000758 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000903291 – 222Triosephosphate isomeraseAdd BLAST222

Interactioni

Subunit structurei

Homotetramer; dimer of dimers.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO74044
SMRiO74044
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 12Substrate bindingUniRule annotation3
Regioni201 – 202Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223030
KOiK01803
OMAiIPVYAQH

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_A TIM_A, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR000652 Triosephosphate_isomerase
IPR022891 Triosephosphate_isomerase_arc
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
PROSITEiView protein in PROSITE
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

O74044-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSPVLIIN CKNYKEAAGG RIDSLAAAAA GAAAKYGVRI ALAPPQHLLG
60 70 80 90 100
AVKGEDLTVL AQHIDDKGVG STTGYVVPEL LGESGVSGAL INHSEHRVSA
110 120 130 140 150
DQVASLVPRL RGLDMISVVC VKDSAEAANL SRHRPDYIAI EPPELIGSGR
160 170 180 190 200
SVSSERPELI GEAAEAIRGA DGTKLLCGAG ITSGADVRKA LELGSKGILV
210 220
ASGVVKSSDP AAAIAELAQA MS
Length:222
Mass (Da):22,562
Last modified:November 1, 1998 - v1
Checksum:i2294631735C291BC
GO

Sequence cautioni

The sequence ABK77801 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083071 Genomic DNA Translation: AAC62687.1
DP000238 Genomic DNA Translation: ABK77801.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiABK77801; ABK77801; CENSYa_1177
KEGGicsy:CENSYa_1177
PATRICifig|414004.10.peg.1071

Similar proteinsi

Entry informationi

Entry nameiTPIS_CENSY
AccessioniPrimary (citable) accession number: O74044
Secondary accession number(s): A0RWT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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