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Protein

Argininosuccinate lyase

Gene

argH

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciMMAR267377:MMP_RS00095-MONOMER
UniPathwayi
UPA00068;UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:MMP0013
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001378651 – 481Argininosuccinate lyaseAdd BLAST481

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP0013

Structurei

3D structure databases

ProteinModelPortaliO74026
SMRiO74026
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01748 Archaea
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG093Z09KV

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit

Sequencei

Sequence statusi: Complete.

O74026-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNILRRGRLG SNVKEDVMKF TTSLEFDKEI FESDILCDIA HTTMLVEQNV
60 70 80 90 100
ISEENGKKII AELKKIAKRG MENLDLDPSL DDIHMVIESE LIKELGEDVA
110 120 130 140 150
GRMHTGRSRN DEVATDLRLS LRKKVLEIIG HLITMEKNML TVSDAHKETL
160 170 180 190 200
TVGYTHLQQA QPVTFGHQIL SHVSAIERDI SRFFDTYNRI NISPLGCGAM
210 220 230 240 250
ATTGFNLNRK RTKDLLGFYG IIENSMDGVS SRDFIVETMA NISMLGTNLS
260 270 280 290 300
KICEELVVFS SAEFNTIEIA NEYTSTSSIM PQKKNPDVAE ITRAKLSTLN
310 320 330 340 350
GELVTVLTIM KALPNTYNRD LQEISPHLWK SVYTLIDSIQ MVDGMISTVK
360 370 380 390 400
VNKERMKENA EKNYSTATEL ADTLVRECGI AFRMAHGIVG ELVKRSIEEK
410 420 430 440 450
VEIKEIISEV LEKNNLSLSQ EKIDTALDPF ENVKLRNVIG GPAPEEVERA
460 470 480
ISSFNEKISA HKDKLDEKIS EIKTAEKNLL E
Length:481
Mass (Da):54,052
Last modified:April 13, 2004 - v2
Checksum:iED96ADBBA6F62D9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73N → I in CAA76302 (PubMed:10220900).Curated1
Sequence conflicti75 – 76DL → IF in CAA76302 (PubMed:10220900).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16584 Genomic DNA Translation: CAA76302.1
BX950229 Genomic DNA Translation: CAF29569.1
RefSeqiWP_011169957.1, NC_005791.1

Genome annotation databases

EnsemblBacteriaiCAF29569; CAF29569; MMP0013
GeneIDi2761122
KEGGimmp:MMP0013
PATRICifig|267377.15.peg.13

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16584 Genomic DNA Translation: CAA76302.1
BX950229 Genomic DNA Translation: CAF29569.1
RefSeqiWP_011169957.1, NC_005791.1

3D structure databases

ProteinModelPortaliO74026
SMRiO74026
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267377.MMP0013

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF29569; CAF29569; MMP0013
GeneIDi2761122
KEGGimmp:MMP0013
PATRICifig|267377.15.peg.13

Phylogenomic databases

eggNOGiarCOG01748 Archaea
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG093Z09KV

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00114

BioCyciMMAR267377:MMP_RS00095-MONOMER

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARLY_METMP
AccessioniPrimary (citable) accession number: O74026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 13, 2004
Last modified: October 10, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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