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Protein

Pterin-4-alpha-carbinolamine dehydratase

Gene

PCBD1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity).By similarity

Catalytic activityi

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Lyase
Biological processTetrahydrobiopterin biosynthesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-GGA-71182 Phenylalanine and tyrosine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Pterin-4-alpha-carbinolamine dehydratase (EC:4.2.1.96)
Short name:
PHS
Alternative name(s):
4-alpha-hydroxy-tetrahydropterin dehydratase
Dimerization cofactor of hepatocyte nuclear factor 1-alpha
Short name:
DCoH
Short name:
Dimerization cofactor of HNF1
Short name:
cDcoH
Phenylalanine hydroxylase-stimulating protein
Pterin carbinolamine dehydratase
Short name:
PCD
Gene namesi
Name:PCBD1
Synonyms:DCOH, PCBD
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000630552 – 104Pterin-4-alpha-carbinolamine dehydrataseAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

The major tissues expressing cDcoH are hypothalamus, kidney and liver.1 Publication

Gene expression databases

BgeeiENSGALG00000027835 Expressed in 10 organ(s), highest expression level in liver
ExpressionAtlasiO73930 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO73930
SMRiO73930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 63Substrate bindingBy similarity3
Regioni78 – 81Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000007221
HOVERGENiHBG000259
InParanoidiO73930
KOiK01724
OMAiAVGWNEV
OrthoDBiEOG091G120V
PhylomeDBiO73930

Family and domain databases

Gene3Di3.30.1360.20, 1 hit
HAMAPiMF_00434 Pterin_4_alpha, 1 hit
InterProiView protein in InterPro
IPR036428 PCD_sf
IPR001533 Pterin_deHydtase
PfamiView protein in Pfam
PF01329 Pterin_4a, 1 hit
SUPFAMiSSF55248 SSF55248, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O73930-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKAHRLNA EEREQLLPNL RAVGWNEVEG RDAIFKEFHF KDFNRAFGFM
60 70 80 90 100
TRVALQAEKL DHHPEWFNVY NKVHITLSTH ECTGLSERDI NLASFIEQVA

ASLS
Length:104
Mass (Da):11,998
Last modified:January 23, 2007 - v3
Checksum:i0786C7DF71A4EA99
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5PFP9A0A1D5PFP9_CHICK
Pterin-4-alpha-carbinolamine dehydr...
PCBD1
103Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005158 Genomic DNA Translation: CAA06395.1
AJ005157 mRNA Translation: CAA06394.1
RefSeqiNP_990236.1, NM_204905.1
UniGeneiGga.427

Genome annotation databases

EnsembliENSGALT00000045018; ENSGALP00000043457; ENSGALG00000027835
GeneIDi395729
KEGGigga:395729

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005158 Genomic DNA Translation: CAA06395.1
AJ005157 mRNA Translation: CAA06394.1
RefSeqiNP_990236.1, NM_204905.1
UniGeneiGga.427

3D structure databases

ProteinModelPortaliO73930
SMRiO73930
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000045018; ENSGALP00000043457; ENSGALG00000027835
GeneIDi395729
KEGGigga:395729

Organism-specific databases

CTDi5092

Phylogenomic databases

GeneTreeiENSGT00390000007221
HOVERGENiHBG000259
InParanoidiO73930
KOiK01724
OMAiAVGWNEV
OrthoDBiEOG091G120V
PhylomeDBiO73930

Enzyme and pathway databases

ReactomeiR-GGA-71182 Phenylalanine and tyrosine catabolism

Miscellaneous databases

PROiPR:O73930

Gene expression databases

BgeeiENSGALG00000027835 Expressed in 10 organ(s), highest expression level in liver
ExpressionAtlasiO73930 baseline and differential

Family and domain databases

Gene3Di3.30.1360.20, 1 hit
HAMAPiMF_00434 Pterin_4_alpha, 1 hit
InterProiView protein in InterPro
IPR036428 PCD_sf
IPR001533 Pterin_deHydtase
PfamiView protein in Pfam
PF01329 Pterin_4a, 1 hit
SUPFAMiSSF55248 SSF55248, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHS_CHICK
AccessioniPrimary (citable) accession number: O73930
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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