Interleukin-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: AgBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Effect of inflammatory agents and interleukin 1 on iron and zinc metabolism."
    Klasing K.C.
    Am J Physiol 247:R901-4(1984) [PubMed] [Europe PMC] [Abstract]
• interleukin-1 receptor binding Source: UniProtKB-UniRule

GO - Biological processⁱ

• acute-phase response Source: AgBase
• cellular response to cold Source: AgBase <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Cold stress equally enhances in vivo pro-inflammatory cytokine gene expression in chicken lines divergently selected for antibody responses."
    Hangalapura B.N., Kaiser M.G., Poel J.J., Parmentier H.K., Lamont S.J.
    Dev Comp Immunol 30:503-511(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine production Source: AgBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.4

    "Sequence and phylogenetic analysis of interleukin (IL)-1beta-encoding genes of five avian species and structural and functional homology among these IL-1beta proteins."
    Wu Y.F., Liu H.J., Chiou S.H., Lee L.H.
    Vet. Immunol. Immunopathol. 116:37-46(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• cortisol secretion Source: AgBaseInferred from direct assayⁱ
  • Ref.7

    "Structural and functional comparison of cytokine interleukin-1 beta from chicken and human."
    Cheng C.S., Chen W.T., Lee L.H., Chen Y.W., Chang S.Y., Lyu P.C., Yin H.S.
    Mol. Immunol. 48:947-955(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 106-267.
• cytokine-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• detection of lipopolysaccharide Source: AgBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick."
    Bar-Shira E., Friedman A.
    Dev Comp Immunol 30:930-941(2006) [PubMed] [Europe PMC] [Abstract]
• fever generation Source: AgBaseTraceable author statementⁱ
  • "Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick."
    Bar-Shira E., Friedman A.
    Dev Comp Immunol 30:930-941(2006) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• inflammatory response to antigenic stimulus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• leukocyte activation involved in inflammatory response Source: AgBaseTraceable author statementⁱ
  • "Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick."
    Bar-Shira E., Friedman A.
    Dev Comp Immunol 30:930-941(2006) [PubMed] [Europe PMC] [Abstract]
• leukocyte chemotaxis involved in inflammatory response Source: AgBaseTraceable author statementⁱ
  • "Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick."
    Bar-Shira E., Friedman A.
    Dev Comp Immunol 30:930-941(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell division Source: UniProtKB-KW
• positive regulation of gene expression Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inflammatory response Source: AgBaseTraceable author statementⁱ
  • "Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick."
    Bar-Shira E., Friedman A.
    Dev Comp Immunol 30:930-941(2006) [PubMed] [Europe PMC] [Abstract]
• response to virus Source: AgBaseInferred from expression patternⁱ
  • "Characterization of interleukin-1beta mRNA expression in chicken macrophages in response to avian reovirus."
    Wu Y.F., Liu H.J., Shien J.H., Chiou S.H., Lee L.H.
    J Gen Virol 89:1059-1068(2008) [PubMed] [Europe PMC] [Abstract]
• sexual reproduction Source: AgBaseTraceable author statementⁱ
  • "Changes in the expression of interleukin-1beta and lipopolysaccharide-induced TNF factor in the oviduct of laying hens in response to artificial insemination."
    Das S.C., Isobe N., Yoshimura Y.
    Reproduction 137:527-536(2009) [PubMed] [Europe PMC] [Abstract]
• toll-like receptor signaling pathway Source: AgBaseTraceable author statementⁱ
  • "Contrasting evolution of diversity at two disease-associated chicken genes."
    Downing T., Lynn D.J., Connell S., Lloyd A.T., Bhuiyan A.K., Silva P., Naqvi A.N., Sanfo R., Sow R.S., Podisi B., O'Farrelly C., Hanotte O., Bradley D.G.
    Immunogenetics 61:303-314(2009) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• cytokine activity Source: AgBaseInferred from direct assayⁱ
  • "Effect of inflammatory agents and interleukin 1 on iron and zinc metabolism."
    Klasing K.C.
    Am J Physiol 247:R901-4(1984) [PubMed] [Europe PMC] [Abstract]
• interleukin-1 receptor binding Source: UniProtKB-UniRule

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MAFVPDLDVL ESSSLSEETF YGPSCLCLQK KPRLDSEHTT VDVQVTVRKG 
        60         70         80         90        100
RGARSFRRAA VLVVAMTKLL RRPRSRDFAD SDLSALLEEV FEPVTFQRLE 
       110        120        130        140        150
SSYAGAPAFR YTRSQSFDIF DINQKCFVLE SPTQLVALHL QGPSSSQKVR 
       160        170        180        190        200
LNIALYRPRG PRGSAGTGQM PVALGIKGYK LYMSCVMSGT EPTLQLEEAD 
       210        220        230        240        250
VMRDIDSVEL TRFIFYRLDS PTEGTTRFES AAFPGWFICT SLQPRQPVGI 
       260 
TNQPDQVNIA TYKLSGR                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ